AU2013338305B2 - Methods and compositions for treating progesterone-dependent conditions - Google Patents

Methods and compositions for treating progesterone-dependent conditions Download PDF

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Publication number
AU2013338305B2
AU2013338305B2 AU2013338305A AU2013338305A AU2013338305B2 AU 2013338305 B2 AU2013338305 B2 AU 2013338305B2 AU 2013338305 A AU2013338305 A AU 2013338305A AU 2013338305 A AU2013338305 A AU 2013338305A AU 2013338305 B2 AU2013338305 B2 AU 2013338305B2
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AU
Australia
Prior art keywords
administered
dose
sprm
administration
cdb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013338305A
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English (en)
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AU2013338305A1 (en
Inventor
Joseph S. Podolski
Ronald D. Wiehle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Pharmaceuticals International Ltd
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Allergan Pharmaceuticals International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of AU2013338305A1 publication Critical patent/AU2013338305A1/en
Application granted granted Critical
Publication of AU2013338305B2 publication Critical patent/AU2013338305B2/en
Assigned to Allergan pharmaceuticals International Ltd. reassignment Allergan pharmaceuticals International Ltd. Request for Assignment Assignors: REPROS THERAPEUTICS INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2013338305A 2012-11-02 2013-10-22 Methods and compositions for treating progesterone-dependent conditions Ceased AU2013338305B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722095P 2012-11-02 2012-11-02
US61/722,095 2012-11-02
PCT/US2013/066095 WO2014070517A1 (en) 2012-11-02 2013-10-22 Methods and compositions for treating progesterone-dependent conditions

Publications (2)

Publication Number Publication Date
AU2013338305A1 AU2013338305A1 (en) 2015-05-14
AU2013338305B2 true AU2013338305B2 (en) 2018-06-07

Family

ID=49510593

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013338305A Ceased AU2013338305B2 (en) 2012-11-02 2013-10-22 Methods and compositions for treating progesterone-dependent conditions

Country Status (11)

Country Link
US (1) US9545411B2 (enExample)
EP (1) EP2914268B1 (enExample)
JP (2) JP6343619B2 (enExample)
CN (1) CN104755087A (enExample)
AU (1) AU2013338305B2 (enExample)
CA (1) CA2888377C (enExample)
ES (1) ES2688821T3 (enExample)
HK (1) HK1211852A1 (enExample)
IL (1) IL238403B (enExample)
MX (1) MX2015004821A (enExample)
WO (1) WO2014070517A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA42103A (fr) * 2015-05-18 2018-03-28 Bayer Pharma AG Régime posologique à base de modulateur sélectif du récepteur de la progestérone (rpm)
US20190008804A1 (en) * 2016-01-12 2019-01-10 Repros Therapeutics Inc. Trans-Clomiphene and Progesterone Receptor Antagonist Combination Therapy for Treating Hormone-Dependent Conditions
CN113905760A (zh) 2019-02-28 2022-01-07 詹森生物科技公司 用于治疗化脓性汗腺炎的抗IL-α抗体
CN115702023A (zh) 2020-04-16 2023-02-14 詹森生物科技公司 化脓性汗腺炎的治疗

Citations (3)

* Cited by examiner, † Cited by third party
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WO2009134718A1 (en) * 2008-04-28 2009-11-05 Repros Therapeutics Inc. Pregesteron antagonists such as cdb-4124 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer etc
WO2012087389A1 (en) * 2010-12-23 2012-06-28 Repros Therapeutics Inc. Novel 19-nor-steroids and their use for treating progesterone-dependent conditions
WO2012121767A1 (en) * 2011-03-09 2012-09-13 Arstat, Inc. Treatment of uterine fibroids by intravaginal administration of a low dose of selective progesterone receptor modulator (sprm), anti-progestin, or anti-progestational agent

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FR2521565B1 (fr) 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2522328B1 (fr) 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR2534487B1 (fr) 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
JPH0830004B2 (ja) 1983-11-14 1996-03-27 コロンビア ラボラトリーズ インコーポレイテッド 生物接着性組成物およびそれにより治療する方法
FR2598421B1 (fr) 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
US5077211A (en) 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5468741A (en) 1993-05-28 1995-11-21 The Regents Of The University Of California Use of low levels of mifepristone to treat leiomyomata
US5543150A (en) 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
DE4426601A1 (de) 1994-07-27 1996-02-01 Schering Ag Verwendung eines Kombinationsproduktes enthaltend einen kompetitiven Progesteronantagonisten und ein Gestagen zur Herstellung eines Arzneimittels zur Behandlung der Endometriose oder des Leiomyomata uteri
ATE235907T1 (de) 1995-02-02 2003-04-15 Schering Ag Verwendung von kompetitiven progesteronantagonisten für die herstellung von arzneimitteln zur behandlung von dysfunktionellen uterinen blutungen
ES2152671T3 (es) 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
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UA74168C2 (uk) 1999-10-05 2005-11-15 Коламбіа Леборетеріс (Бермуда) Лімітед Лікування ендометріозу або безпліддя, або покращення плідності та застосування бета-адренергічного агоніста для виробництва лікарського засобу
ATE396197T1 (de) 2000-03-17 2008-06-15 Us Gov Health & Human Serv 17-alpha-substituierte-11-beta-substituierte-4- aryl und 21-substituierte 19-norpregnadienedione mit antigestagener aktivität
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CA2423017C (en) 2000-10-18 2009-01-06 Bayer Schering Pharma Aktiengesellschaft Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases
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JP4898431B2 (ja) 2003-04-29 2012-03-14 ザ ジェネラル ホスピタル コーポレイション 複数薬物の持続放出のための方法およびデバイス
EP1593376A1 (en) 2004-05-04 2005-11-09 Warner-Lambert Company LLC Improved pullulan capsules
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GT200500185A (es) 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009134718A1 (en) * 2008-04-28 2009-11-05 Repros Therapeutics Inc. Pregesteron antagonists such as cdb-4124 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer etc
WO2012087389A1 (en) * 2010-12-23 2012-06-28 Repros Therapeutics Inc. Novel 19-nor-steroids and their use for treating progesterone-dependent conditions
WO2012121767A1 (en) * 2011-03-09 2012-09-13 Arstat, Inc. Treatment of uterine fibroids by intravaginal administration of a low dose of selective progesterone receptor modulator (sprm), anti-progestin, or anti-progestational agent

Also Published As

Publication number Publication date
ES2688821T3 (es) 2018-11-07
AU2013338305A1 (en) 2015-05-14
CA2888377A1 (en) 2014-05-08
WO2014070517A1 (en) 2014-05-08
IL238403B (en) 2019-01-31
EP2914268B1 (en) 2018-07-04
CA2888377C (en) 2021-02-02
US20150297612A1 (en) 2015-10-22
IL238403A0 (en) 2015-06-30
JP2015535282A (ja) 2015-12-10
JP6343619B2 (ja) 2018-06-13
US9545411B2 (en) 2017-01-17
CN104755087A (zh) 2015-07-01
MX2015004821A (es) 2015-08-14
EP2914268A1 (en) 2015-09-09
HK1211852A1 (en) 2016-06-03
JP2018062530A (ja) 2018-04-19

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ALLERGAN PHARMACEUTICALS INTERNATIONAL LTD.

Free format text: FORMER OWNER(S): REPROS THERAPEUTICS INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired