AU2013277372B2 - Analogs of glucagon exhibiting GIP receptor activity - Google Patents

Analogs of glucagon exhibiting GIP receptor activity Download PDF

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Publication number
AU2013277372B2
AU2013277372B2 AU2013277372A AU2013277372A AU2013277372B2 AU 2013277372 B2 AU2013277372 B2 AU 2013277372B2 AU 2013277372 A AU2013277372 A AU 2013277372A AU 2013277372 A AU2013277372 A AU 2013277372A AU 2013277372 B2 AU2013277372 B2 AU 2013277372B2
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AU
Australia
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misc
feature
ala
ser
gly
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AU2013277372A
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English (en)
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AU2013277372A1 (en
Inventor
Konrad H. BLEICHER
Richard D. Dimarchi
Eric A. Kitas
David L. Smiley
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Novo Nordisk AS
Indiana University Research and Technology Corp
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Novo Nordisk AS
Indiana University Research and Technology Corp
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Assigned to NOVO NORDISK A/S, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION reassignment NOVO NORDISK A/S Request for Assignment Assignors: F. HOFFMANN-LA ROCHE AG, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013277372A 2012-06-21 2013-06-18 Analogs of glucagon exhibiting GIP receptor activity Ceased AU2013277372B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261662874P 2012-06-21 2012-06-21
US61/662,874 2012-06-21
US201361787973P 2013-03-15 2013-03-15
US61/787,973 2013-03-15
PCT/US2013/046229 WO2013192130A1 (en) 2012-06-21 2013-06-18 Analogs of glucagon exhibiting gip receptor activity

Publications (2)

Publication Number Publication Date
AU2013277372A1 AU2013277372A1 (en) 2014-12-11
AU2013277372B2 true AU2013277372B2 (en) 2018-03-29

Family

ID=48692696

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013277372A Ceased AU2013277372B2 (en) 2012-06-21 2013-06-18 Analogs of glucagon exhibiting GIP receptor activity

Country Status (30)

Country Link
US (2) US9868772B2 (enExample)
EP (1) EP2864350B1 (enExample)
JP (1) JP6300239B2 (enExample)
KR (1) KR20150039748A (enExample)
CN (1) CN104583233B (enExample)
AR (1) AR091478A1 (enExample)
AU (1) AU2013277372B2 (enExample)
BR (1) BR112014031671A2 (enExample)
CA (1) CA2877127A1 (enExample)
CL (1) CL2014003421A1 (enExample)
CO (1) CO7170125A2 (enExample)
CR (1) CR20150015A (enExample)
DK (1) DK2864350T3 (enExample)
EA (1) EA029025B1 (enExample)
ES (1) ES2674946T3 (enExample)
HR (1) HRP20180936T1 (enExample)
HU (1) HUE039267T2 (enExample)
IL (1) IL236386B (enExample)
MX (1) MX356000B (enExample)
MY (1) MY185217A (enExample)
PE (1) PE20150863A1 (enExample)
PH (1) PH12014502857A1 (enExample)
PL (1) PL2864350T3 (enExample)
PT (1) PT2864350T (enExample)
RS (1) RS57347B1 (enExample)
SG (1) SG11201408491SA (enExample)
SI (1) SI2864350T1 (enExample)
TR (1) TR201808818T4 (enExample)
TW (1) TWI644920B (enExample)
WO (1) WO2013192130A1 (enExample)

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WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
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TW201625670A (zh) * 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
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US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
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CN115304666B (zh) * 2017-11-24 2025-09-19 浙江道尔生物科技有限公司 一种治疗代谢疾病的胰高血糖素类似物
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CN113493503B (zh) * 2020-04-08 2022-08-05 浙江道尔生物科技有限公司 一种肠促胰岛素类似物及其制备方法和用途
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CN114621327B (zh) * 2020-12-10 2023-08-18 江苏中新医药有限公司 GLP-1、GIP和Gcg多重受体激动蛋白质
US20240059752A1 (en) 2020-12-23 2024-02-22 Zhejiang Doer Biologics Co., Ltd. Long-acting glucagon derivative
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Also Published As

Publication number Publication date
PT2864350T (pt) 2018-05-14
HRP20180936T1 (hr) 2018-12-14
MY185217A (en) 2021-04-30
SG11201408491SA (en) 2015-01-29
PH12014502857A1 (en) 2015-02-23
US9868772B2 (en) 2018-01-16
JP6300239B2 (ja) 2018-03-28
TR201808818T4 (tr) 2018-07-23
MX2014015556A (es) 2015-03-05
IL236386B (en) 2019-09-26
AR091478A1 (es) 2015-02-04
JP2015528795A (ja) 2015-10-01
PE20150863A1 (es) 2015-06-11
TWI644920B (zh) 2018-12-21
CL2014003421A1 (es) 2015-05-22
SI2864350T1 (en) 2018-08-31
HUE039267T2 (hu) 2018-12-28
US20150368310A1 (en) 2015-12-24
EA029025B1 (ru) 2018-01-31
PL2864350T3 (pl) 2019-01-31
CR20150015A (es) 2015-04-24
CA2877127A1 (en) 2013-12-27
EP2864350A1 (en) 2015-04-29
IL236386A0 (en) 2015-02-26
RS57347B1 (sr) 2018-08-31
AU2013277372A1 (en) 2014-12-11
TW201402603A (zh) 2014-01-16
WO2013192130A1 (en) 2013-12-27
MX356000B (es) 2018-05-08
ES2674946T3 (es) 2018-07-05
CN104583233B (zh) 2018-10-23
CO7170125A2 (es) 2015-01-28
BR112014031671A2 (pt) 2018-08-07
DK2864350T3 (en) 2018-05-28
US20180105569A1 (en) 2018-04-19
CN104583233A (zh) 2015-04-29
EA201590065A1 (ru) 2015-07-30
EP2864350B1 (en) 2018-03-28
KR20150039748A (ko) 2015-04-13

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Free format text: FORMER OWNER(S): F. HOFFMANN-LA ROCHE AG; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

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Free format text: FORMER OWNER(S): F. HOFFMANN-LA ROCHE AG; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

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