AU2013267381B2 - Tissue repair devices and scaffolds - Google Patents
Tissue repair devices and scaffolds Download PDFInfo
- Publication number
- AU2013267381B2 AU2013267381B2 AU2013267381A AU2013267381A AU2013267381B2 AU 2013267381 B2 AU2013267381 B2 AU 2013267381B2 AU 2013267381 A AU2013267381 A AU 2013267381A AU 2013267381 A AU2013267381 A AU 2013267381A AU 2013267381 B2 AU2013267381 B2 AU 2013267381B2
- Authority
- AU
- Australia
- Prior art keywords
- scaffold
- bone
- tissue repair
- repair device
- scaffolds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000017423 tissue regeneration Effects 0.000 title claims abstract description 84
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 178
- 230000007547 defect Effects 0.000 claims abstract description 55
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims abstract description 51
- 239000000945 filler Substances 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 31
- 230000008468 bone growth Effects 0.000 claims abstract description 23
- 230000001737 promoting effect Effects 0.000 claims abstract description 16
- 230000007812 deficiency Effects 0.000 claims abstract description 15
- 208000010392 Bone Fractures Diseases 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 102000004127 Cytokines Human genes 0.000 claims abstract description 8
- 108090000695 Cytokines Proteins 0.000 claims abstract description 8
- 230000003115 biocidal effect Effects 0.000 claims abstract description 8
- 239000003102 growth factor Substances 0.000 claims abstract description 8
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 7
- 230000004069 differentiation Effects 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 210000004872 soft tissue Anatomy 0.000 claims description 20
- 238000001727 in vivo Methods 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000010146 3D printing Methods 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 239000011800 void material Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 description 85
- 239000000463 material Substances 0.000 description 24
- 230000008439 repair process Effects 0.000 description 24
- 238000013461 design Methods 0.000 description 19
- 239000000976 ink Substances 0.000 description 18
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 17
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 17
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 16
- 230000001054 cortical effect Effects 0.000 description 15
- 238000007639 printing Methods 0.000 description 15
- 239000007787 solid Substances 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 12
- 229910000389 calcium phosphate Inorganic materials 0.000 description 10
- 239000001506 calcium phosphate Substances 0.000 description 10
- 239000004068 calcium phosphate ceramic Substances 0.000 description 10
- 235000011010 calcium phosphates Nutrition 0.000 description 10
- 230000000278 osteoconductive effect Effects 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 238000007634 remodeling Methods 0.000 description 10
- 239000000919 ceramic Substances 0.000 description 8
- 235000019731 tricalcium phosphate Nutrition 0.000 description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 230000004820 osteoconduction Effects 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 230000002051 biphasic effect Effects 0.000 description 6
- 239000012876 carrier material Substances 0.000 description 6
- 230000011164 ossification Effects 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 230000037182 bone density Effects 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 239000007943 implant Substances 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 238000010603 microCT Methods 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 4
- 239000012620 biological material Substances 0.000 description 4
- 230000010478 bone regeneration Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000001125 extrusion Methods 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 210000002997 osteoclast Anatomy 0.000 description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 238000004626 scanning electron microscopy Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 102000012422 Collagen Type I Human genes 0.000 description 3
- 108010022452 Collagen Type I Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000010304 firing Methods 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 230000009545 invasion Effects 0.000 description 3
- 230000005923 long-lasting effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000005245 sintering Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 2
- 239000006057 Non-nutritive feed additive Substances 0.000 description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000002449 bone cell Anatomy 0.000 description 2
- 229940112869 bone morphogenetic protein Drugs 0.000 description 2
- 230000010072 bone remodeling Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000002149 energy-dispersive X-ray emission spectroscopy Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 238000011587 new zealand white rabbit Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010074180 Craniofacial deformity Diseases 0.000 description 1
- 208000000916 Mandibulofacial dysostosis Diseases 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 241000906034 Orthops Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 201000003199 Treacher Collins syndrome Diseases 0.000 description 1
- 101710117064 Trimethylamine corrinoid protein 1 Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000009650 craniofacial growth Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000010100 freeform fabrication Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 239000011507 gypsum plaster Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000011146 organic particle Substances 0.000 description 1
- 230000001599 osteoclastic effect Effects 0.000 description 1
- 230000002138 osteoinductive effect Effects 0.000 description 1
- 210000003455 parietal bone Anatomy 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003361 porogen Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
- A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30574—Special structural features of bone or joint prostheses not otherwise provided for with an integral complete or partial collar or flange
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30962—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using stereolithography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30968—Sintering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653019P | 2012-05-30 | 2012-05-30 | |
| US61/653,019 | 2012-05-30 | ||
| PCT/US2013/043336 WO2013181375A1 (en) | 2012-05-30 | 2013-05-30 | Tissue repair devices and scaffolds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013267381A1 AU2013267381A1 (en) | 2015-01-22 |
| AU2013267381B2 true AU2013267381B2 (en) | 2016-03-31 |
Family
ID=49673897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013267381A Ceased AU2013267381B2 (en) | 2012-05-30 | 2013-05-30 | Tissue repair devices and scaffolds |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10945845B2 (enExample) |
| EP (1) | EP2854886A4 (enExample) |
| JP (1) | JP2015517879A (enExample) |
| KR (1) | KR20150015532A (enExample) |
| CN (1) | CN104902936A (enExample) |
| AU (1) | AU2013267381B2 (enExample) |
| BR (1) | BR112014029929A2 (enExample) |
| CA (1) | CA2876855A1 (enExample) |
| HK (1) | HK1209177A1 (enExample) |
| IL (1) | IL235858A0 (enExample) |
| IN (1) | IN2014MN02576A (enExample) |
| MX (1) | MX2014014656A (enExample) |
| RU (1) | RU2014153874A (enExample) |
| SG (1) | SG11201408756UA (enExample) |
| WO (1) | WO2013181375A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8753391B2 (en) * | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
| JP6163104B2 (ja) | 2010-11-15 | 2017-07-12 | アクセラレイテッド・バイオサイエンシズ・コーポレーション | ヒト・トロホブラスト幹細胞からの神経幹細胞の生成 |
| EP3501458B1 (en) | 2011-12-23 | 2020-09-23 | The Royal Institution for the Advancement of Learning/McGill University | Bone replacement implants with mechanically biocompatible cellular material |
| MX2014014656A (es) * | 2012-05-30 | 2015-08-10 | Univ New York | Dispositivos de reparacion de tejido y andamiajes. |
| US8843229B2 (en) * | 2012-07-20 | 2014-09-23 | Biomet Manufacturing, Llc | Metallic structures having porous regions from imaged bone at pre-defined anatomic locations |
| CN113604423B (zh) | 2012-11-30 | 2025-06-03 | 艾克塞利瑞提德生物技术公司 | 通过调节mir-124分化干细胞的方法 |
| WO2014089711A1 (de) * | 2012-12-11 | 2014-06-19 | Dr.H.C. Robert Mathys Stiftung | Knochenersatz und verfahren zu dessen herstellung |
| US10842634B2 (en) | 2014-05-02 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Structural porous biomaterial and implant formed of same |
| US11638640B2 (en) | 2014-06-11 | 2023-05-02 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
| US11883275B2 (en) | 2014-06-11 | 2024-01-30 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
| AU2015321554C1 (en) * | 2014-09-25 | 2018-10-11 | Acell, Inc. | Porous foams derived from extracellular matrix, porous foam ECM medical devices, and methods of use and making thereof |
| FR3026937B1 (fr) * | 2014-10-10 | 2021-10-01 | 3Dceram | Bloc de synthese destine a combler un defaut osseux et son procede de fabrication |
| AU2015353521B2 (en) | 2014-11-26 | 2021-11-04 | Accelerated Biosciences Corp. | Induced hepatocytes and uses thereof |
| US10070962B1 (en) | 2015-02-13 | 2018-09-11 | Nextstep Arthropedix, LLC | Medical implants having desired surface features and methods of manufacturing |
| JP6085704B1 (ja) | 2016-03-28 | 2017-02-22 | 明弘 圓尾 | 抗生剤徐放器具 |
| CN105919696A (zh) * | 2016-05-04 | 2016-09-07 | 宁波傲骨生物科技有限公司 | 一种具有力学梯度仿生人工骨支架的制备方法 |
| US10806586B2 (en) * | 2016-05-19 | 2020-10-20 | University Of Pittsburgh—Of The Commonwealth System Of Higer Education | Biomimetic plywood motifs for bone tissue engineering |
| US11638645B2 (en) | 2016-05-19 | 2023-05-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biomimetic plywood motifs for bone tissue engineering |
| CN107433669A (zh) * | 2016-05-26 | 2017-12-05 | 苏州拜博机电科技有限公司 | 一种用于陶瓷3d打印机的陶瓷粉料的输出装置 |
| US10660764B2 (en) | 2016-06-14 | 2020-05-26 | The Trustees Of The Stevens Institute Of Technology | Load sustaining bone scaffolds for spinal fusion utilizing hyperbolic struts and translational strength gradients |
| WO2017223297A1 (en) * | 2016-06-23 | 2017-12-28 | Drexel University | Three dimensional porous cartilage template |
| US12016779B2 (en) * | 2016-09-29 | 2024-06-25 | University Of Southern California | Growth factor transduced cell-loaded ceramic scaffold for bone regeneration and repair |
| US12133933B2 (en) * | 2016-09-29 | 2024-11-05 | University Of Southern California | Growth factor transduced cell-loaded ceramic scaffold for bone regeneration and repair |
| US11033394B2 (en) | 2016-10-25 | 2021-06-15 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with multi-layer bone interfacing lattice |
| EP3532117B1 (en) * | 2016-10-28 | 2023-08-02 | CELLINK Bioprinting AB | Preparation and applications of 3d bioprinting bioinks for repair of bone defects, based on cellulose nanofibrils hydrogels with natural or synthetic calcium phosphate particles |
| US11116640B2 (en) | 2017-02-13 | 2021-09-14 | Rutgers, The State University Of New Jersey | Polymer filament reinforced scaffold for partial meniscus regeneration |
| CN106859817B (zh) * | 2017-02-13 | 2018-04-13 | 北京大学口腔医学院 | 一种3d打印个性化笼状牙科植骨导板 |
| US20180296343A1 (en) * | 2017-04-18 | 2018-10-18 | Warsaw Orthopedic, Inc. | 3-d printing of porous implants |
| CN107997855A (zh) * | 2017-11-30 | 2018-05-08 | 深圳先进技术研究院 | 3d多孔支架模型建立方法、装置及制备系统 |
| PT110511B (pt) * | 2018-01-15 | 2021-04-27 | Universidade Da Beira Interior | Estruturas bioativas produzidas por impressão 3d para aplicação no tratamento de lesões ósseas |
| US11844683B2 (en) | 2018-03-12 | 2023-12-19 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
| KR102203493B1 (ko) * | 2018-05-04 | 2021-01-15 | 건양대학교 산학협력단 | 환자 맞춤형 3d 프린팅 하이브리드 플레이트 |
| CN109481108B (zh) * | 2018-09-28 | 2021-01-05 | 西安点云生物科技有限公司 | 一种具有侧面孔隙结构的生物陶瓷支架及其制备方法 |
| EP3897764A4 (en) * | 2018-12-17 | 2022-07-27 | President and Fellows of Harvard College | BIOTECHNOLOGICALLY MANUFACTURED SCAFFOLDINGS FOR MODULATION OF THE IMMUNE SYSTEM AND USES THEREOF |
| CN110151362A (zh) * | 2019-03-13 | 2019-08-23 | 上海交通大学医学院附属第九人民医院 | 一种3d打印的节段性骨缺损修复装置及其制备方法 |
| CN110478089A (zh) * | 2019-07-25 | 2019-11-22 | 中国人民解放军总医院 | 一种适用于大段骨缺损修复的血管化神经化成骨活性支架 |
| JP7674357B2 (ja) * | 2019-12-20 | 2025-05-09 | テファ, インコーポレイテッド | 骨欠損部再建用の再吸収性インプラント |
| BR122023021714A2 (pt) * | 2020-03-23 | 2024-02-20 | Bard Shannon Limited | Prótese implantável que compreende estrutura de material biocompatível |
| WO2022024002A2 (en) * | 2020-07-29 | 2022-02-03 | DePuy Synthes Products, Inc. | Patient specific graft cage for craniomaxillofacial repair |
| CN112137768B (zh) * | 2020-10-23 | 2025-04-15 | 上海交通大学医学院附属第九人民医院 | 一种分层仿生孔道-多孔复合支架 |
| CN112552035A (zh) * | 2020-12-11 | 2021-03-26 | 湖北联结生物材料有限公司 | 一种可诱导生物活性3d打印陶瓷及其制备方法 |
| EP4166112A4 (en) * | 2021-08-27 | 2024-03-06 | Nanobiosystem Co., Ltd. | Scaffold for bone regeneration and construction method therefor |
| AU2022398612A1 (en) * | 2021-11-26 | 2024-05-23 | Poriferous, LLC | Implant |
| CN114668536A (zh) * | 2022-04-21 | 2022-06-28 | 北京航空航天大学 | 可降解支架 |
| USD1073937S1 (en) | 2022-08-05 | 2025-05-06 | Akihiro MARUO | Perfusion instrument |
| WO2024159732A1 (zh) * | 2023-01-30 | 2024-08-08 | 李岩峰 | 一种用于断骨再生的骨重建支架 |
| CN115887069B (zh) * | 2023-02-15 | 2023-05-16 | 吉林大学 | 一种股骨干多层复合仿生自固定假体 |
| CN116570406B (zh) * | 2023-07-12 | 2023-09-19 | 中科硅诺(太仓)生物材料科技有限公司 | 光固化3d打印制备而成的骨修复材料支架及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080206297A1 (en) * | 2007-02-28 | 2008-08-28 | Roeder Ryan K | Porous composite biomaterials and related methods |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5133755A (en) * | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
| US5904717A (en) * | 1986-01-28 | 1999-05-18 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
| US6005161A (en) * | 1986-01-28 | 1999-12-21 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
| GB2215209B (en) * | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
| US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
| US5282861A (en) * | 1992-03-11 | 1994-02-01 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
| US20010039454A1 (en) * | 1993-11-02 | 2001-11-08 | John Ricci | Orthopedic implants having ordered microgeometric surface patterns |
| US6419491B1 (en) | 1993-11-02 | 2002-07-16 | Bio-Lok International, Inc. | Dental implant system with repeating microgeometric surface patterns |
| AUPN174495A0 (en) * | 1995-03-15 | 1995-04-06 | Ketharanathan, Vettivetpillai | Surgical prostheses |
| ATE250666T1 (de) * | 1996-06-04 | 2003-10-15 | Sulzer Orthopedics Ltd | Verfahren zur herstellung von knorpelgewebe und von implantaten |
| FR2766716B1 (fr) * | 1997-08-01 | 2000-02-18 | Cogent Sarl | Prothese composite pour la prevention des adherences post-chirurgicales et son procede d'obtention |
| US6977095B1 (en) * | 1997-10-01 | 2005-12-20 | Wright Medical Technology Inc. | Process for producing rigid reticulated articles |
| US6187329B1 (en) * | 1997-12-23 | 2001-02-13 | Board Of Regents Of The University Of Texas System | Variable permeability bone implants, methods for their preparation and use |
| US6027744A (en) * | 1998-04-24 | 2000-02-22 | University Of Massachusetts Medical Center | Guided development and support of hydrogel-cell compositions |
| US20030225355A1 (en) * | 1998-10-01 | 2003-12-04 | Butler Charles E. | Composite material for wound repair |
| CA2345982A1 (en) * | 1998-10-12 | 2000-04-20 | Jill K. Sherwood | Composites for tissue regeneration and methods of manufacture thereof |
| US6283997B1 (en) * | 1998-11-13 | 2001-09-04 | The Trustees Of Princeton University | Controlled architecture ceramic composites by stereolithography |
| US8133421B2 (en) * | 1999-02-23 | 2012-03-13 | Warsaw Orthopedic, Inc. | Methods of making shaped load-bearing osteoimplant |
| US20020090725A1 (en) * | 2000-11-17 | 2002-07-11 | Simpson David G. | Electroprocessed collagen |
| US7491235B2 (en) * | 1999-05-10 | 2009-02-17 | Fell Barry M | Surgically implantable knee prosthesis |
| DE19957388A1 (de) * | 1999-11-24 | 2001-06-13 | Michael Sittinger | Chondroinduktive und implantierbare Substrate zur Knorpelheilung und -protektion |
| NZ519068A (en) * | 1999-12-03 | 2003-11-28 | Univ Leeds | Fixation technology |
| US6520997B1 (en) * | 1999-12-08 | 2003-02-18 | Baxter International Inc. | Porous three dimensional structure |
| US7635390B1 (en) * | 2000-01-14 | 2009-12-22 | Marctec, Llc | Joint replacement component having a modular articulating surface |
| US9314339B2 (en) * | 2000-03-27 | 2016-04-19 | Formae, Inc. | Implants for replacing cartilage, with negatively-charged hydrogel surfaces and flexible matrix reinforcement |
| US7001551B2 (en) * | 2000-07-13 | 2006-02-21 | Allograft Research Technologies, Inc. | Method of forming a composite bone material implant |
| US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| EP1199354B1 (en) * | 2000-10-20 | 2005-04-20 | Sony International (Europe) GmbH | A method of forming a cell pattern on a surface |
| US6599323B2 (en) * | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| WO2002053105A2 (en) * | 2001-01-02 | 2002-07-11 | Advanced Ceramics Research, Inc. | Compositions and methods for biomedical applications |
| WO2002083194A1 (en) * | 2001-04-12 | 2002-10-24 | Therics, Inc. | Method and apparatus for engineered regenerative biostructures |
| EP1492475B1 (en) * | 2001-04-16 | 2011-12-21 | Wright Medical Technology, Inc. | Dense/porous structures for use as bone substitutes |
| WO2002085246A2 (en) * | 2001-04-19 | 2002-10-31 | Case Western Reserve University | Fabrication of a polymeric prosthetic implant |
| US7087200B2 (en) * | 2001-06-22 | 2006-08-08 | The Regents Of The University Of Michigan | Controlled local/global and micro/macro-porous 3D plastic, polymer and ceramic/cement composite scaffold fabrication and applications thereof |
| US7914808B2 (en) * | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
| US20030220696A1 (en) * | 2002-05-23 | 2003-11-27 | Levine David Jerome | Implantable porous metal |
| US7066962B2 (en) * | 2002-07-23 | 2006-06-27 | Porex Surgical, Inc. | Composite surgical implant made from macroporous synthetic resin and bioglass particles |
| AU2003290858A1 (en) * | 2002-11-12 | 2004-06-03 | The Regents Of The University Of California | Nano-porous fibers and protein membranes |
| KR20050120674A (ko) * | 2003-04-01 | 2005-12-22 | 올림푸스 가부시키가이샤 | 생체 조직 보충재 및 그의 제조 방법 |
| US7655047B2 (en) * | 2003-04-16 | 2010-02-02 | Porex Surgical, Inc. | Craniofacial implant |
| US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7488348B2 (en) * | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| JP4680771B2 (ja) * | 2003-05-26 | 2011-05-11 | Hoya株式会社 | リン酸カルシウム含有複合多孔体及びその製造方法 |
| EP2397110B1 (en) * | 2003-06-25 | 2016-03-02 | Biedermann Technologies GmbH & Co. KG | Tissue integration design for seamless implant fixation |
| US20050020899A1 (en) * | 2003-07-25 | 2005-01-27 | Rubicor Medical, Inc. | Post-biopsy cavity treatmetn implants and methods |
| DE10348219A1 (de) * | 2003-10-13 | 2005-05-12 | Aesculap Ag & Co Kg | Knorpelersatzimplantat und Verfahren zur Herstellung eines Knorpelersatzimplantats |
| CN1972644B (zh) * | 2003-11-21 | 2010-08-25 | 骨棚国际私人有限公司 | 用于骨组织再生的生物可吸收插销式植入体和方法 |
| US6974625B2 (en) * | 2003-12-16 | 2005-12-13 | Smith & Nephew, Inc. | Oxidized zirconium on a porous structure for bone implant use |
| US20120245703A1 (en) * | 2004-01-02 | 2012-09-27 | Meredith Thomas L | Composite bone material implant and method |
| US7189263B2 (en) * | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
| EP1741456B1 (en) * | 2004-04-19 | 2013-04-17 | Kawasumi Laboratories, Inc. | Artificial dura mater and process for producing the same |
| US8221780B2 (en) * | 2004-04-20 | 2012-07-17 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
| US20070190108A1 (en) * | 2004-05-17 | 2007-08-16 | Arindam Datta | High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair |
| US8796015B2 (en) * | 2004-11-09 | 2014-08-05 | Proxy Biomedical Limited | Tissue scaffold |
| WO2006060555A1 (en) * | 2004-11-30 | 2006-06-08 | Mansmann Kevin A | Anchoring systems and interfaces for flexible surgical implants for replacing cartilage |
| ITPD20040312A1 (it) * | 2004-12-15 | 2005-03-15 | Fidia Advanced Biopolymers Srl | Protesi e o supporto per la sostituzione, riparazione, rigenerazione del menisco |
| US7789888B2 (en) * | 2005-02-14 | 2010-09-07 | Bartee Chad M | PTFE composite multi-layer material |
| US9427496B2 (en) * | 2005-02-18 | 2016-08-30 | Drexel University | Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering |
| JP2008536539A (ja) * | 2005-03-07 | 2008-09-11 | ジョージア テック リサーチ コーポレイション | 組織再生のためのナノフィラメントの足場 |
| EP1875234B1 (en) * | 2005-04-26 | 2011-06-22 | Aarhus Universitet | Biosurface structure array |
| US20060247790A1 (en) * | 2005-04-30 | 2006-11-02 | Mckay William F | Shaped osteochondral grafts and methods of using same |
| EP1764117A1 (en) * | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
| WO2007062057A2 (en) * | 2005-11-18 | 2007-05-31 | Ceramatec, Inc. | Porous, load-bearing, ceramic or metal implant |
| US7427293B2 (en) * | 2006-03-28 | 2008-09-23 | Sdgi Holdings, Inc. | Osteochondral plug graft, kit and method |
| US7855062B2 (en) * | 2005-12-14 | 2010-12-21 | The Invention Science Fund I, Llc | Bone cell delivery device |
| US20070150064A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Methods and devices for intervertebral augmentation |
| US9327056B2 (en) * | 2006-02-14 | 2016-05-03 | Washington State University | Bone replacement materials |
| JP2009529374A (ja) * | 2006-03-07 | 2009-08-20 | アクスル インターナショナル | 治療及び癒着防止用生物活性スキャホールド |
| EP1997521A4 (en) * | 2006-03-17 | 2012-09-12 | Hi Lex Corp | MEDICAL MATERIAL |
| US7572291B2 (en) * | 2006-03-28 | 2009-08-11 | Warsaw Orthopedic, Inc. | Osteochondral repair assembly including retracting spacer, kit and method |
| EP2031968B1 (en) * | 2006-04-21 | 2017-11-22 | Wake Forest University Health Sciences | Structurally modified acellular tissue engineering scaffolds and methods of production |
| US20070276506A1 (en) * | 2006-05-25 | 2007-11-29 | Biomet Manufacturing Corp. | Demineralized osteochondral plug |
| WO2008021127A2 (en) * | 2006-08-08 | 2008-02-21 | Howmedica Osteonics Corp. | Expandable cartilage implant |
| US20080058955A1 (en) * | 2006-08-29 | 2008-03-06 | Vance Products Incorporated D/B/A Cook Urological Incorporated | Prosthetic testicle |
| JP5326164B2 (ja) * | 2006-09-26 | 2013-10-30 | 独立行政法人産業技術総合研究所 | 生体材料及びその作製方法と用途 |
| KR100805303B1 (ko) * | 2006-10-27 | 2008-02-20 | 한국기계연구원 | 다중적 기공구조를 가지는 다공성 세라믹 재료 및 그제조방법 |
| US9943410B2 (en) * | 2011-02-28 | 2018-04-17 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
| EP2114474A4 (en) * | 2006-12-08 | 2013-07-31 | Graftoss Ltd | MEDICAL PREPARATION |
| US8753391B2 (en) * | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
| JP4972725B2 (ja) * | 2007-02-14 | 2012-07-11 | 国立大学法人京都大学 | 高分子材料の直接造形法および直接造形装置 |
| EP1961433A1 (en) * | 2007-02-20 | 2008-08-27 | National University of Ireland Galway | Porous substrates for implantation |
| US7758643B2 (en) * | 2007-02-26 | 2010-07-20 | Biomet Sports Medicine, Llc | Stable cartilage defect repair plug |
| US20110052660A1 (en) * | 2007-03-16 | 2011-03-03 | Board Of Regents Of The University Of Texas System | Ceramic scaffolds for bone repair |
| EP2129517A4 (en) * | 2007-03-26 | 2012-11-21 | Univ Connecticut | ELECTRO-SPUNNED APATIT / POLYMER NANOVERBUNDGERÜSTE |
| US8210852B2 (en) * | 2007-04-11 | 2012-07-03 | Pacific Research Laboratories, Inc. | Artificial bones and methods of making same |
| US20090043398A1 (en) * | 2007-08-09 | 2009-02-12 | Zimmer, Inc. | Method of producing gradient articles by centrifugation molding or casting |
| US8916228B2 (en) * | 2007-08-09 | 2014-12-23 | The Board Of Regents Of The University Of Texas System | Bi-layered bone-like scaffolds |
| US8062655B2 (en) * | 2007-08-31 | 2011-11-22 | Phillips Plastics Corporation | Composite scaffold structure |
| CN104013479A (zh) * | 2007-09-14 | 2014-09-03 | 普渡研究基金会 | 去矿化的松质骨支架 |
| US8183225B2 (en) | 2007-11-08 | 2012-05-22 | New York University | Inhibition of bone resorption using medical implants containing adenosine receptor antagonists |
| US9931438B2 (en) * | 2008-01-28 | 2018-04-03 | Ngk Spark Plug Co., Ltd. | Article with foamed surface, implant and method of producing the same |
| US20110282451A1 (en) * | 2008-03-17 | 2011-11-17 | Sune Lund Sporring | Medical component |
| US7611653B1 (en) * | 2008-04-09 | 2009-11-03 | Active Implants Corporation | Manufacturing and material processing for prosthetic devices |
| US20100136086A1 (en) * | 2008-05-12 | 2010-06-03 | Day Thomas E | Dynamic bioactive nanofiber scaffolding |
| WO2009149093A1 (en) * | 2008-06-02 | 2009-12-10 | University Of Medicine And Dentistry Of New Jersey | Tissue engineered fibrocartilage replacement |
| TWI394597B (zh) * | 2008-06-24 | 2013-05-01 | Sunmax Biotechnology Co Ltd | 骨科用生物可分解性補綴物 |
| WO2010004057A1 (es) * | 2008-07-08 | 2010-01-14 | Histocell, S.L | MATRICES TRIDIMENSIONALES DE MONETITA POROSA ESTRUCTURADA PARA INGENIERIA TISULAR Y REGENERACION OSEA, Y METODO DE PREPARACIόN DE LAS MISMAS |
| US9289302B2 (en) * | 2008-07-28 | 2016-03-22 | Zimmer, Inc. | Mosaicplasty constructs |
| US20100049322A1 (en) * | 2008-08-19 | 2010-02-25 | Warsaw Orthopedic, Inc. | Osteochondral repair implants and methods |
| SG195588A1 (en) * | 2008-10-17 | 2013-12-30 | Univ Singapore | Resorbable scaffolds for bone repair and long bone tissue engineering |
| GB2466073A (en) * | 2008-12-12 | 2010-06-16 | Univ Manchester | Tissue repair scaffold |
| US8430930B2 (en) * | 2008-12-18 | 2013-04-30 | 4-Web, Inc. | Truss implant |
| US8353966B2 (en) | 2009-01-15 | 2013-01-15 | The Curators Of The University Of Missouri | Scaffold for bone and tissue repair in mammals |
| US20100247598A1 (en) * | 2009-03-31 | 2010-09-30 | Shetty Dhanuraj S | Thick foams for biomedical application and methods of making |
| US20100256758A1 (en) * | 2009-04-02 | 2010-10-07 | Synvasive Technology, Inc. | Monolithic orthopedic implant with an articular finished surface |
| US8556972B2 (en) * | 2009-04-02 | 2013-10-15 | Sevika Holding AG | Monolithic orthopedic implant with an articular finished surface |
| US20100310623A1 (en) * | 2009-06-05 | 2010-12-09 | Laurencin Cato T | Synergetic functionalized spiral-in-tubular bone scaffolds |
| FR2949667B1 (fr) * | 2009-09-09 | 2011-08-19 | Obl | Structure poreuse a motif controle, repete dans l'espace, pour la realisation d'implants chirurgicaux |
| US20110144763A1 (en) * | 2009-10-29 | 2011-06-16 | Prosidyan Inc. | Dynamic bioactive bone graft material having an engineered porosity |
| JP2013509261A (ja) * | 2009-10-29 | 2013-03-14 | プロシディアン・インコーポレイテッド | 骨移植材料 |
| US8338498B2 (en) * | 2010-02-18 | 2012-12-25 | Doctors Research Group, Inc. | Polymeric bone defect filler |
| US8444699B2 (en) * | 2010-02-18 | 2013-05-21 | Biomet Manufacturing Corp. | Method and apparatus for augmenting bone defects |
| US8986380B2 (en) * | 2010-06-09 | 2015-03-24 | Trustees Of Tufts College | Multilayered silk scaffolds for meniscus tissue engineering |
| US20120150299A1 (en) * | 2010-06-10 | 2012-06-14 | Ergun Asli | Integrated multi-zonal cage/core implants as bone graft substitutes and apparatus and method for their fabrication |
| US20110313532A1 (en) * | 2010-06-18 | 2011-12-22 | Jessee Hunt | Bone implant interface system and method |
| AU2011276246B2 (en) * | 2010-07-08 | 2014-12-04 | Lifecell Corporation | Method for shaping tissue matrices |
| US8936650B2 (en) * | 2011-03-23 | 2015-01-20 | The Regents Of The University Of California | Mesh enclosed tissue constructs |
| US20130123935A1 (en) * | 2011-11-03 | 2013-05-16 | Jessee Hunt | Method of length preservation during bone repair |
| WO2013115868A2 (en) * | 2011-11-04 | 2013-08-08 | President And Fellows Of Harvard College | Dynamic and switchable slippery surfaces |
| US9155607B2 (en) * | 2011-11-16 | 2015-10-13 | Purdue Research Foundation | Compositions and methods for repair or regeneration of soft tissue |
| WO2013106318A1 (en) * | 2012-01-09 | 2013-07-18 | Zimmer, Inc. | Composite device that combines porous metal and bone stimuli |
| CA2860718C (en) * | 2012-01-09 | 2020-11-10 | Matthew E. MONAGHAN | Porous metal implants with bone cement |
| US9655995B2 (en) * | 2012-01-16 | 2017-05-23 | Marshall University Research Corporation | Nanofiber scaffolds and methods for repairing damaged cardiac tissue |
| US9180010B2 (en) * | 2012-04-06 | 2015-11-10 | Howmedica Osteonics Corp. | Surface modified unit cell lattice structures for optimized secure freeform fabrication |
| MX2014014656A (es) * | 2012-05-30 | 2015-08-10 | Univ New York | Dispositivos de reparacion de tejido y andamiajes. |
| EP2855722A1 (en) * | 2012-05-31 | 2015-04-08 | Zimmer, Inc. | Anisotropic porous scaffolds and method of making anisotropic porous scaffolds |
| CN102719391A (zh) * | 2012-06-07 | 2012-10-10 | 江阴瑞康健生物医学科技有限公司 | 双相多孔三维细胞培养支架 |
| US20140025179A1 (en) * | 2012-07-20 | 2014-01-23 | Ultramet | Brittle biocompatible composites and methods |
| US9498335B2 (en) * | 2012-10-02 | 2016-11-22 | Seth McCullen | Implantable devices for musculoskeletal repair and regeneration |
| ES2582610T3 (es) * | 2012-11-09 | 2016-09-14 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Implante óseo de al menos dos materiales distintos reabsorbibles y biodegradables que pueden combinarse como material híbrido o compuesto |
| CN104981219B (zh) * | 2013-01-08 | 2018-03-06 | 实践粉体技术有限公司 | 高强度注塑模制的矫形装置 |
| US20140207248A1 (en) * | 2013-01-18 | 2014-07-24 | The Trustees Of The Stevens Institute Of Technology | Hierarchical multiscale fibrous scaffold via 3-d electrostatic deposition prototyping and conventional electrospinning |
| GB201301784D0 (en) * | 2013-02-01 | 2013-03-20 | Xiros Ltd | Connective tissue repair technology |
| US20140243995A1 (en) * | 2013-02-28 | 2014-08-28 | The Massachusetts Institute Of Technology | Stacked planar sheet tissue engineering scaffolds with 3d structural order |
| KR20150097087A (ko) * | 2014-02-18 | 2015-08-26 | 한국기계연구원 | 복합 스캐폴드 제조 방법 및 이를 이용하여 제조된 복합 스캐폴드 |
-
2013
- 2013-05-30 MX MX2014014656A patent/MX2014014656A/es unknown
- 2013-05-30 AU AU2013267381A patent/AU2013267381B2/en not_active Ceased
- 2013-05-30 US US14/402,737 patent/US10945845B2/en active Active
- 2013-05-30 CA CA2876855A patent/CA2876855A1/en not_active Abandoned
- 2013-05-30 RU RU2014153874A patent/RU2014153874A/ru not_active Application Discontinuation
- 2013-05-30 KR KR1020147036795A patent/KR20150015532A/ko not_active Withdrawn
- 2013-05-30 JP JP2015515183A patent/JP2015517879A/ja active Pending
- 2013-05-30 WO PCT/US2013/043336 patent/WO2013181375A1/en not_active Ceased
- 2013-05-30 EP EP13797721.1A patent/EP2854886A4/en not_active Withdrawn
- 2013-05-30 HK HK15109848.8A patent/HK1209177A1/xx unknown
- 2013-05-30 CN CN201380040824.5A patent/CN104902936A/zh active Pending
- 2013-05-30 IN IN2576MUN2014 patent/IN2014MN02576A/en unknown
- 2013-05-30 SG SG11201408756UA patent/SG11201408756UA/en unknown
- 2013-05-30 BR BR112014029929A patent/BR112014029929A2/pt not_active Application Discontinuation
-
2014
- 2014-11-23 IL IL235858A patent/IL235858A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080206297A1 (en) * | 2007-02-28 | 2008-08-28 | Roeder Ryan K | Porous composite biomaterials and related methods |
Non-Patent Citations (1)
| Title |
|---|
| SHERWOOD, J., et al., 'A three-dimensional osteochondral composite scaffold for articular cartilage repair', Biomaterials, 2002, Vol 23, pages 4739-4751 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013181375A1 (en) | 2013-12-05 |
| EP2854886A4 (en) | 2016-03-23 |
| SG11201408756UA (en) | 2015-03-30 |
| JP2015517879A (ja) | 2015-06-25 |
| AU2013267381A1 (en) | 2015-01-22 |
| US20150150681A1 (en) | 2015-06-04 |
| HK1209177A1 (en) | 2016-03-24 |
| RU2014153874A (ru) | 2016-07-27 |
| KR20150015532A (ko) | 2015-02-10 |
| BR112014029929A2 (pt) | 2017-06-27 |
| IL235858A0 (en) | 2015-01-29 |
| CA2876855A1 (en) | 2013-12-05 |
| US10945845B2 (en) | 2021-03-16 |
| EP2854886A1 (en) | 2015-04-08 |
| CN104902936A (zh) | 2015-09-09 |
| IN2014MN02576A (enExample) | 2015-07-24 |
| MX2014014656A (es) | 2015-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013267381B2 (en) | Tissue repair devices and scaffolds | |
| Abbasi et al. | Porous scaffolds for bone regeneration | |
| US20230077763A1 (en) | Dynamic bioactive bone graft material having an engineered porosity | |
| US10478528B2 (en) | Bone graft implants containing allograft | |
| Karageorgiou et al. | Porosity of 3D biomaterial scaffolds and osteogenesis | |
| Zhang et al. | In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly (L-lactide) | |
| US11129925B2 (en) | Bioactive porous bone graft implants | |
| KR20120101021A (ko) | 골 이식재 | |
| AU2005308667A1 (en) | Bioabsorbable composite fibres | |
| Wang et al. | A novel hydroxyapatite fiber material for the regeneration of critical-sized rabbit calvaria defects | |
| Chen et al. | Hybrid Bone Scaffold Induces Bone Bridging in Goat Calvarial Critical Size Defects Without Growth Factor Augmentation | |
| Dellinger | Development of model hydroxyapatite bone scaffolds with multiscale porosity for potential load bearing applications | |
| Wang et al. | Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins | |
| Ku et al. | The Effect of Whitlockite as an Osteoconductive Synthetic Bone Substitute Material in Animal Bony Defect Model. Materials 2022, 15, 1921 | |
| Junior et al. | Physical Characterization of Biphasic Materials With Different Granulation Sizes and Their Influence on Bone Repair and Inflammation in Rat Calvaria | |
| CN116637233A (zh) | 一种合成骨修复材料及其制备方法和使用方法 | |
| Vasiliu | Assembly of hydroxy apatite: β tricalcium phosphate: calcium sulfate bone engineering scaffolds | |
| Borden | Development and optimization of a synthetic bone replacement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ RICCI, JOHN L.; CLARK, ELIZABETH; COELHO, PAULO; REKOW, ELIZABETH DIANNE; THOMPSON, VAN P. AND SMAY, JAMES |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |