AU2013243601B2 - Improved production of fatty acid derivatives - Google Patents
Improved production of fatty acid derivatives Download PDFInfo
- Publication number
- AU2013243601B2 AU2013243601B2 AU2013243601A AU2013243601A AU2013243601B2 AU 2013243601 B2 AU2013243601 B2 AU 2013243601B2 AU 2013243601 A AU2013243601 A AU 2013243601A AU 2013243601 A AU2013243601 A AU 2013243601A AU 2013243601 B2 AU2013243601 B2 AU 2013243601B2
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- Australia
- Prior art keywords
- ala
- leu
- gly
- val
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 title claims abstract description 52
- 238000004519 manufacturing process Methods 0.000 title claims description 87
- 230000001976 improved effect Effects 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 73
- 238000004113 cell culture Methods 0.000 claims abstract description 31
- 239000000194 fatty acid Substances 0.000 claims description 219
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 217
- 229930195729 fatty acid Natural products 0.000 claims description 217
- 150000004665 fatty acids Chemical class 0.000 claims description 202
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 190
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 190
- 229920001184 polypeptide Polymers 0.000 claims description 189
- 108091033319 polynucleotide Proteins 0.000 claims description 118
- 102000040430 polynucleotide Human genes 0.000 claims description 118
- 239000002157 polynucleotide Substances 0.000 claims description 118
- 150000002191 fatty alcohols Chemical class 0.000 claims description 111
- 150000002192 fatty aldehydes Chemical class 0.000 claims description 77
- 230000014509 gene expression Effects 0.000 claims description 56
- 241000588724 Escherichia coli Species 0.000 claims description 52
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 46
- -1 C18:1 unsaturated fatty acid Chemical class 0.000 claims description 45
- 229910052799 carbon Inorganic materials 0.000 claims description 43
- 150000001336 alkenes Chemical group 0.000 claims description 38
- 150000002194 fatty esters Chemical class 0.000 claims description 32
- 108091034117 Oligonucleotide Proteins 0.000 claims description 24
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 20
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 150000002576 ketones Chemical class 0.000 claims description 15
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 15
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- 235000019387 fatty acid methyl ester Nutrition 0.000 claims description 10
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- 230000003247 decreasing effect Effects 0.000 claims description 9
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- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims description 3
- 241000192581 Synechocystis sp. Species 0.000 claims description 3
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- 101150031021 birA gene Proteins 0.000 claims description 3
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| BR122019026987B1 (pt) * | 2012-04-02 | 2022-01-18 | Genomatica, Inc | Polipeptídeo variante da ácido carboxílico redutase (car), célula hospedeira recombinante, cultura de células e método de produzir uma composição de álcool graxo com alto título, rendimento ou produtividade |
| ES2647412T3 (es) * | 2012-09-14 | 2017-12-21 | REG Life Sciences, LLC | Variantes enzimáticas con propiedades de éster sintasa mejoradas |
| EP2931742A2 (en) * | 2012-12-12 | 2015-10-21 | REG Life Sciences, LLC | Acp-mediated production of fatty acid derivatives |
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