AU2012301664A1 - Methods and compositions for the treatment and diagnosis of cancer - Google Patents

Methods and compositions for the treatment and diagnosis of cancer Download PDF

Info

Publication number
AU2012301664A1
AU2012301664A1 AU2012301664A AU2012301664A AU2012301664A1 AU 2012301664 A1 AU2012301664 A1 AU 2012301664A1 AU 2012301664 A AU2012301664 A AU 2012301664A AU 2012301664 A AU2012301664 A AU 2012301664A AU 2012301664 A1 AU2012301664 A1 AU 2012301664A1
Authority
AU
Australia
Prior art keywords
homo sapiens
protein
family
cancer
sapiens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012301664A
Other languages
English (en)
Inventor
Karen Chapman
Jennifer Lorrie KIDD
Marcus LACHER
Maria PRENDES
Joseph Wagner
Michael West
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Molecular Diagnostics Inc
Original Assignee
Oncocyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncocyte Corp filed Critical Oncocyte Corp
Publication of AU2012301664A1 publication Critical patent/AU2012301664A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2012301664A 2011-08-31 2012-08-31 Methods and compositions for the treatment and diagnosis of cancer Abandoned AU2012301664A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161529500P 2011-08-31 2011-08-31
US61/529,500 2011-08-31
US201161542403P 2011-10-03 2011-10-03
US61/542,403 2011-10-03
PCT/US2012/053472 WO2013033609A2 (en) 2011-08-31 2012-08-31 Methods and compositions for the treatment and diagnosis of cancer

Publications (1)

Publication Number Publication Date
AU2012301664A1 true AU2012301664A1 (en) 2014-02-27

Family

ID=47757190

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012301664A Abandoned AU2012301664A1 (en) 2011-08-31 2012-08-31 Methods and compositions for the treatment and diagnosis of cancer

Country Status (9)

Country Link
US (1) US20140206574A1 (enExample)
EP (1) EP2751570A4 (enExample)
JP (1) JP2014525584A (enExample)
KR (1) KR20140057361A (enExample)
CN (1) CN103890587A (enExample)
AU (1) AU2012301664A1 (enExample)
CA (1) CA2844793A1 (enExample)
HK (1) HK1199099A1 (enExample)
WO (1) WO2013033609A2 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2294216A4 (en) 2008-05-14 2011-11-23 Dermtech Int DIAGNOSIS OF MELANOMA AND SOLAR LENTIGO BY ANALYSIS OF NUCLEIC ACIDS
US20150299799A1 (en) * 2012-10-05 2015-10-22 Michael Sturzl Method for Detecting an Increased Risk or Incidence of Colorectal Cancer
EP2853596A1 (en) * 2013-09-30 2015-04-01 IKBT (Institut für Klinische Biomedizinische Forschung Thurgau) Protein phosphatase inhibitor
GB201320061D0 (en) * 2013-11-13 2013-12-25 Electrophoretics Ltd Materials nad methods for diagnosis and prognosis of liver cancer
EP2876442A1 (en) * 2013-11-22 2015-05-27 Institut de Cancérologie de l'Ouest Olfactomedin-4, neudesin and desmoplakin as biomarkers of breast cancer
US20160326594A1 (en) * 2013-12-30 2016-11-10 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer gene profiles and methods of using the same
WO2016179043A1 (en) 2015-05-01 2016-11-10 Dermtech, Inc. Non-invasive skin collection system
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
EP3825411A1 (en) * 2014-06-18 2021-05-26 Clear Gene, Inc. Methods, compositions, and devices for rapid analysis of biological markers
KR101779147B1 (ko) * 2014-07-04 2017-09-20 연세대학교 산학협력단 Kiaa1199를 이용한 췌장암의 진단 또는 치료용 조성물
CN105675735B (zh) * 2014-11-19 2018-07-17 上海市第六人民医院 乳腺癌诊断标记物组合、应用及其测定方法
JP6551967B2 (ja) * 2015-01-30 2019-07-31 国立大学法人山口大学 肝細胞がんの転移性再発リスクの予測方法
WO2016143697A1 (ja) * 2015-03-06 2016-09-15 国立大学法人名古屋大学 Ｓｙｔ１３、ｓｙｔ８、ａｎｏｓ１発現量による胃癌腹膜播種の検査方法、検査キット、分子標的治療薬スクリーニング方法、及び治療薬
GB201504502D0 (en) * 2015-03-17 2015-04-29 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers
CR20210232A (es) 2015-03-17 2022-06-24 Immatics Biotechnologies Gmbh NUEVOS PÉPTIDOS Y NUEVA COMBINACIÓN DE PÉPTIDOS PARA EL USO EN LA INMUNOTERAPIA CONTRA EL CÁNCER DE PÁNCREAS Y OTROS TIPOS DE CÁNCER (Divisional 2017-0419)
JP2016214239A (ja) * 2015-05-15 2016-12-22 国立大学法人高知大学 膵がんマーカー
JP6659250B2 (ja) * 2015-06-19 2020-03-04 国立大学法人滋賀医科大学 癌の検査方法、癌細胞増殖阻害剤、抗癌剤及び抗癌剤のスクリーニング方法
CN105463070B (zh) * 2015-07-08 2018-12-28 上海市同仁医院 Uca1基因在制备诊断结直肠癌产品中的应用
US10370647B2 (en) * 2015-07-22 2019-08-06 National University Corporation Tottori University Host regulatory factor that enhances replication and/or propagation of vaccinia virus
CN108138239B (zh) * 2015-07-24 2022-08-30 高丽大学校产学协力团 用于确定衰老、确定肥胖症和诊断癌症的生物标志物和使用其的诊断试剂盒
US20170089905A1 (en) 2015-09-28 2017-03-30 Abbott Japan Co., Ltd. Methods of diagnosing hepatocellular carcinoma and pancreatic cancer
KR20180118105A (ko) * 2015-12-04 2018-10-30 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 면역치료를 위한 slc45a2 펩티드
WO2017113565A1 (zh) * 2015-12-29 2017-07-06 中国医学科学院肿瘤医院 基于蛋白标志物psg3辅助诊断肝癌或消化道癌症患者的试剂盒
CN105504060B (zh) * 2015-12-31 2018-10-26 陆梅生 一种抗胃癌细胞表面功能性表达的足萼样蛋白前体亚型2的单克隆抗体及其制备方法和用途
US10294297B2 (en) 2016-01-29 2019-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treatment using anti-NMU agents
CN106399306B (zh) * 2016-04-12 2019-11-05 西安交通大学第一附属医院 靶向人lncRNA-UCA1抑制膀胱癌的sgRNA、基因载体及其应用
SE540173C2 (en) * 2016-04-20 2018-04-24 Hiloprobe Ab Marker genes for colorectal cancer classification, method for judging lymph node metastasis for prognosis of colorectal cancer and kit therefor
CN106047874B (zh) * 2016-06-02 2019-01-18 吉林大学 一种靶向sall4基因的脱氧核酶分子及在乳腺癌基因治疗中的应用
US10927070B2 (en) 2016-06-09 2021-02-23 Cedars-Sinai Medical Center Compositions and methods for treating cancer
CN108329387B (zh) * 2017-01-17 2021-07-27 复旦大学附属肿瘤医院 癌症相关的肿瘤特异转录本lin28b-tst及其用途
IL296349A (en) * 2017-05-16 2022-11-01 Univ Hong Kong Chinese Integrative single-cell and cell-free plasma rna analysis
WO2018218737A1 (zh) * 2017-06-01 2018-12-06 立森印迹诊断技术（无锡）有限公司 一种印记基因在膀胱肿瘤中的分级模型及其组成的系统
CN107312096B (zh) * 2017-07-17 2019-12-20 湖北大学 用于检测组蛋白位点三甲基化修饰的重组蛋白及其应用
CN107449916B (zh) * 2017-07-27 2019-05-21 北京邦菲生物科技有限公司 肺癌和肺部结节蛋白特征谱及其构建方法与应用
CN107807243B (zh) * 2017-11-24 2020-08-07 暨南大学 一种食管癌的生物标志物及其应用
CN108152496B (zh) * 2017-11-24 2020-10-27 暨南大学 Mest蛋白在制备肺癌辅助诊断和/或预后判断的试剂盒中的应用
RU2760984C1 (ru) * 2017-12-13 2021-12-02 Иновио Фармасьютикалз, Инк. Противораковые вакцины, направленные на lemd1, и их применение
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
GB201803750D0 (en) * 2018-03-08 2018-04-25 Immunocore Ltd Method
AU2019276749A1 (en) * 2018-05-29 2020-12-03 Turun Yliopisto L1TD1 as predictive biomarker of colon cancer
CN108796079B (zh) * 2018-06-06 2021-07-27 天津医科大学肿瘤医院 一种逆转录转座基因l1-fggy及其作为肺鳞癌标志物的用途
CN109116023B (zh) * 2018-06-14 2021-06-04 郑州大学第一附属医院 一种肺癌标志物抗-mmp12自身抗体及其应用
US11746387B2 (en) 2018-06-20 2023-09-05 Pontificia Universidad Catolica De Chile Non-invasive detection of gastric cancer by detecting the methylation of Reprimo-like in the blood
WO2020017676A1 (ko) * 2018-07-20 2020-01-23 주식회사 셀투인 Fresh-트레이서 기반 분리된 세포의 유전자 프로파일의 응용
CN109082473A (zh) * 2018-10-16 2018-12-25 兰州大学 一种公牛znf280ay基因拷贝数变异的检测方法及应用
CN112867495B (zh) 2018-10-19 2024-08-20 韩国生命工学研究院 包含syt11抑制剂作为活性成分的胃癌治疗组合物
JP7216995B2 (ja) * 2018-12-05 2023-02-02 学校法人関西医科大学 胸腺癌バイオマーカー及び胸腺腫瘍の予後予測マーカー
CN109371023A (zh) * 2018-12-11 2019-02-22 宁夏医科大学总医院 一种环状RNA hsa_circKIAA1199_006及其特异性扩增引物和应用
CN114127114B (zh) * 2019-04-30 2025-02-25 Absci公司 癌相关抗体组合物和使用方法
CN110218796B (zh) * 2019-06-27 2020-01-17 江门市中心医院 用于乳腺癌骨转移诊疗的新靶标pcdhb2
CN112147324A (zh) * 2019-06-28 2020-12-29 欧蒙医学实验诊断股份公司 自身抗体的检测
WO2021003246A1 (en) * 2019-07-01 2021-01-07 Accure Health Inc. Predictive liquid markers for cancer immunotherapy
CN110796625B (zh) * 2019-10-30 2023-06-20 重庆邮电大学 一种基于组稀疏表示和加权全变分的图像压缩感知重构方法
CN111218509B (zh) * 2019-12-23 2023-07-04 西南医科大学附属医院 乳腺癌的新诊断标志物ppef1及其应用
WO2021231327A2 (en) * 2020-05-12 2021-11-18 Memorial Sloan Kettering Cancer Center Methods for de-cloaking cancer from the immune system through downregulation of cancer-produced pregnancy specific glycoprotein
CN115851942A (zh) * 2020-12-22 2023-03-28 上海市第一人民医院 诊断标志物gata4在胰腺“炎癌转化”中的应用
CN115216542A (zh) * 2021-04-15 2022-10-21 复旦大学附属华山医院 一组肿瘤筛查、鉴别的标志物及应用
CN116087519B (zh) * 2021-05-17 2025-03-14 郑州大学第一附属医院 一种用于高危人群贲门腺癌早期筛查的标志物及其应用
CN113504370B (zh) * 2021-06-29 2024-02-09 广州金研生物医药研究院有限公司 Mapk15蛋白在前列腺癌的恶性程度或预后程度预测中的应用
CN115537464B (zh) * 2021-06-30 2023-06-20 武汉艾米森生命科技有限公司 一种结直肠癌或癌前病变的诊断或辅助诊断试剂、核酸组合、试剂盒及应用
CN113980963B (zh) * 2021-09-03 2024-05-28 中山大学 一种寡核苷酸rna双链分子及其在制备治疗恶性肿瘤药物中的应用
CN114807369A (zh) * 2021-11-15 2022-07-29 四川大学华西医院 一种与前列腺癌显著相关的潜在抗原、免疫分型及其构建方法和应用
CN115992229B (zh) * 2022-07-22 2023-07-07 中南大学湘雅三医院 一种胰腺癌预后风险评估的lncRNA标记物、模型及其应用
CN117486999B (zh) * 2022-08-30 2025-03-18 暨南大学 一种肿瘤T细胞抗原表位肽、pMHC及其制备和应用
CN115838804A (zh) * 2022-10-07 2023-03-24 厦门医学院 血浆外泌体lncRNAs作为靶标在急性髓系白血病诊断和疗效监测中的应用
CN115786518A (zh) * 2022-11-29 2023-03-14 广东医科大学附属医院 嗅素结构域家族蛋白4（olfm4）在结肠癌检测产品中的应用
CN116482365B (zh) * 2023-03-14 2023-10-20 南京芯原生物科技有限公司 用于检测血清抗体的蛋白组合物及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004511527A (ja) * 2000-10-18 2004-04-15 グラクソスミスクライン　バイオロジカルズ　ソシエテ　アノニム ワクチン
US7705120B2 (en) * 2001-06-21 2010-04-27 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
EP1466016A2 (en) * 2002-01-09 2004-10-13 Riken Institute Of Physical And Chemical Research Cancer profiles
US20060188889A1 (en) * 2003-11-04 2006-08-24 Christopher Burgess Use of differentially expressed nucleic acid sequences as biomarkers for cancer
WO2005039382A2 (en) * 2003-06-24 2005-05-06 Genomic Health Prediction of likelihood of cancer recurrence
US20050208499A1 (en) * 2004-02-04 2005-09-22 Graff Jonathan M Markers for diagnosing and treating breast and ovarian cancer
WO2006016110A1 (en) * 2004-08-10 2006-02-16 University College Cardiff Consultants Limited Methods and kit for the prognosis of breast cancer
WO2006133399A1 (en) * 2005-06-08 2006-12-14 Hitachi Chemical Research Center, Inc. METHOD FOR PREDICTING IMMUNE RESPONSE TO NEOPLASTIC DISEASE BASED ON mRNA EXPRESSION PROFILE IN NEOPLASTIC CELLS AND STIMULATED LEUKOCYTES
US20070218512A1 (en) * 2006-02-28 2007-09-20 Alex Strongin Methods related to mmp26 status as a diagnostic and prognostic tool in cancer management
DE102006024416A1 (de) * 2006-05-24 2008-04-30 Friedrich-Alexander-Universität Erlangen-Nürnberg Prädiktives Genexpressionsmuster für kolorektale Karzinome
EP2502628B1 (en) * 2006-06-23 2016-12-14 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
RU2473555C2 (ru) * 2006-12-19 2013-01-27 ДжинГоу, Инк. Новые способы функционального анализа большого количества экспериментальных данных и групп генов, идентифицированных из указанных данных
AT504702A1 (de) * 2006-12-22 2008-07-15 Arc Austrian Res Centers Gmbh Set von tumormarkern
US20100087330A1 (en) * 2007-01-26 2010-04-08 Brian Leyland-Jones Breast cancer gene array
EP2048242A1 (de) * 2007-10-08 2009-04-15 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Microarray für die Expressionsanalyse der zellulären Glykosylierungsmaschinerie
US20110160072A1 (en) * 2007-10-23 2011-06-30 Clinical Genomics Pty. Ltd. Method of diagnosing neoplasms
CN102027373B (zh) * 2008-05-14 2017-10-10 埃斯苏黎世公司 发现用于前列腺癌诊断和治疗之生物标志物和药物靶标的方法及其确立的生物标志物测定
EP2295564A4 (en) * 2008-05-21 2011-08-10 Toray Industries COMPOSITION AND METHOD FOR DETERMINING CREAM CANCER
JP5819728B2 (ja) * 2008-10-20 2015-11-24 ファーマテスト・サービシーズ・オサケユキテュアＰｈａｒｍａｔｅｓｔ Ｓｅｒｖｉｃｅｓ Ｏｙ Ｎａｖ３の遺伝子異常および複数遺伝子の異常発現を含む方法および使用
GB2512153B (en) * 2008-11-17 2014-11-12 Veracyte Inc Methods and compositions of molecular profiling for disease diagnostics
KR20120034593A (ko) * 2009-03-09 2012-04-12 유니버시티 오브 조지아 리서치 파운데이션 인코퍼레이티드 위암 진단용 단백질 마커의 동정
BR112012002942A2 (pt) * 2009-08-10 2015-10-13 Epitherix Llc indazóis como inibidores da trilha de sinalização de wnt/b-catenina e empregos terapêuticos destes.
MX2012009215A (es) * 2010-02-23 2012-11-23 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores.

Also Published As

Publication number Publication date
US20140206574A1 (en) 2014-07-24
JP2014525584A (ja) 2014-09-29
EP2751570A2 (en) 2014-07-09
WO2013033609A3 (en) 2013-06-27
EP2751570A4 (en) 2015-08-12
HK1199099A1 (en) 2015-06-19
CA2844793A1 (en) 2013-03-07
WO2013033609A2 (en) 2013-03-07
CN103890587A (zh) 2014-06-25
KR20140057361A (ko) 2014-05-12

Similar Documents

Publication Publication Date Title
US20140206574A1 (en) Methods and Compositons for the Treatment and Diagnosis of Cancer
CN103975078B (zh) 治疗和诊断膀胱癌的方法和组合物
AU2012296405B2 (en) Methods and compositions for the treatment and diagnosis of breast cancer
US20140221244A1 (en) Methods and Compositions for the Treatment and Diagnosis of Colorectal Cancer
US20150018235A1 (en) Methods and Compositions for the Treatment and Diagnosis of Pancreatic Cancer
US20140141996A1 (en) Methods and Compositions for the Treatment and Diagnosis of Cancer
CA2840472A1 (en) Methods and compositions for the treatment and diagnosis of bladder cancer
US20140315743A1 (en) Methods and Compositions for the Treatment and Diagnosis of Ovarian Cancer
KR102216590B1 (ko) 췌장 신경내분비종양의 진단을 위한 조성물
WO2015013455A2 (en) Methods and compositions for the treatment and diagnosis of cancer
WO2017181163A2 (en) Methods and compositions for detection and diagnosis of breast cancer
WO2017214189A1 (en) Methods and compositions for detection and diagnosis of bladder cancer
WO2019074920A1 (en) METHODS AND COMPOSITIONS FOR THE DETECTION AND DIAGNOSIS OF BREAST CANCER

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted