AU2012245301B2 - Method of drug delivery for PTH, PTHrP and related peptides - Google Patents

Method of drug delivery for PTH, PTHrP and related peptides Download PDF

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Publication number
AU2012245301B2
AU2012245301B2 AU2012245301A AU2012245301A AU2012245301B2 AU 2012245301 B2 AU2012245301 B2 AU 2012245301B2 AU 2012245301 A AU2012245301 A AU 2012245301A AU 2012245301 A AU2012245301 A AU 2012245301A AU 2012245301 B2 AU2012245301 B2 AU 2012245301B2
Authority
AU
Australia
Prior art keywords
aib
glu
lys
hpthrp
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012245301A
Other languages
English (en)
Other versions
AU2012245301A1 (en
Inventor
Amy S. Determan
Kris J. Hansen
Gary Hattersley
Ying Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Radius Health Inc
Original Assignee
3M Innovative Properties Co
Radius Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co, Radius Health Inc filed Critical 3M Innovative Properties Co
Publication of AU2012245301A1 publication Critical patent/AU2012245301A1/en
Application granted granted Critical
Publication of AU2012245301B2 publication Critical patent/AU2012245301B2/en
Priority to AU2016216584A priority Critical patent/AU2016216584A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AU2012245301A 2011-04-22 2012-04-20 Method of drug delivery for PTH, PTHrP and related peptides Ceased AU2012245301B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016216584A AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161478466P 2011-04-22 2011-04-22
US61/478,466 2011-04-22
US201161578120P 2011-12-20 2011-12-20
US61/578,120 2011-12-20
PCT/US2012/034510 WO2012145665A2 (en) 2011-04-22 2012-04-20 Method of drug delivery for pth, pthrp and related peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016216584A Division AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Publications (2)

Publication Number Publication Date
AU2012245301A1 AU2012245301A1 (en) 2013-12-12
AU2012245301B2 true AU2012245301B2 (en) 2016-05-19

Family

ID=47042187

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012245301A Ceased AU2012245301B2 (en) 2011-04-22 2012-04-20 Method of drug delivery for PTH, PTHrP and related peptides
AU2016216584A Abandoned AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016216584A Abandoned AU2016216584A1 (en) 2011-04-22 2016-08-16 Method of drug delivery for PTH, PTHrP and related peptides

Country Status (14)

Country Link
US (6) US20130006217A1 (cg-RX-API-DMAC7.html)
EP (2) EP3332799A1 (cg-RX-API-DMAC7.html)
JP (2) JP6033280B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140047043A (cg-RX-API-DMAC7.html)
CN (1) CN103917242A (cg-RX-API-DMAC7.html)
AU (2) AU2012245301B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013027153A2 (cg-RX-API-DMAC7.html)
CA (1) CA2833571A1 (cg-RX-API-DMAC7.html)
ES (1) ES2648864T3 (cg-RX-API-DMAC7.html)
IL (1) IL228942A0 (cg-RX-API-DMAC7.html)
MX (1) MX2013012349A (cg-RX-API-DMAC7.html)
RU (1) RU2013151314A (cg-RX-API-DMAC7.html)
SG (1) SG194570A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012145665A2 (cg-RX-API-DMAC7.html)

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AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
EP2637562B1 (en) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
US9675675B2 (en) * 2011-11-30 2017-06-13 3M Innovative Properties Company Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
CN104602752A (zh) * 2012-08-30 2015-05-06 帝人株式会社 涂布有药物组合物的微针阵列
FI3122426T3 (fi) 2014-03-28 2023-03-31 Univ Duke Rintasyövän hoitaminen käyttäen selektiivisiä estrogeenin reseptorin modulaattoreita
WO2016141250A1 (en) * 2015-03-03 2016-09-09 Radius Health, Inc. USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK
RU2747228C2 (ru) 2015-04-29 2021-04-29 Радиус Фармасьютикалз, Инк. Способы лечения рака
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
CN108135837B (zh) 2015-10-09 2022-05-31 3M创新有限公司 用于涂布微针阵列的锌组合物
AU2016334378B2 (en) * 2015-10-09 2021-12-02 Kindeva Drug Delivery L.P. Formulations of PTHrP analogues, transdermal patches thereof, and uses thereof
CA3020333A1 (en) * 2016-04-18 2017-10-26 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
EP3474841B1 (en) 2016-06-22 2022-03-16 Ellipses Pharma Ltd Ar+ breast cancer treatment methods
JP7649624B2 (ja) * 2016-11-30 2025-03-21 パーデュー リサーチ ファウンデーション 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生
LT3565542T (lt) 2017-01-05 2024-07-10 Radius Pharmaceuticals, Inc. Polimorfinės rad1901-2hcl formos
US9968767B1 (en) 2017-10-10 2018-05-15 King Saud University Combination microarray patch for drug delivery and electrochemotherapy device
WO2019232283A1 (en) 2018-05-30 2019-12-05 Purdue Research Foundation Targeting anabolic drugs for accelerated fracture repair
JP7473486B2 (ja) 2018-07-04 2024-04-23 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形形態
KR20210127961A (ko) 2019-02-12 2021-10-25 래디어스 파마슈티컬스, 인코포레이티드 방법 및 화합물
EP4110371A1 (en) 2020-01-24 2023-01-04 Radius Health, Inc. Methods of stimulating bone growth with abalopartide and denosumab
CN115734798A (zh) 2020-04-28 2023-03-03 提克纳有限责任公司 微针组件
US20230210762A1 (en) * 2020-05-01 2023-07-06 Emergex USA Corporation Transdermal drug delivery devices having psilocybin, lysergic acid diethylamide or 3,4-methylenedioxymethamphetamine coated microprotrusions
JP2024502334A (ja) * 2021-01-05 2024-01-18 ラジウス ヘルス，インコーポレイテッド アバロパラチドを用いた長骨骨折の治療
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US12029562B2 (en) 2021-04-14 2024-07-09 Satio, Inc. Dermal patch system
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip

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WO2008063279A2 (en) * 2006-10-03 2008-05-29 Radius Health, Inc. A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof
US20090117158A1 (en) * 2007-10-23 2009-05-07 Mahmoud Ameri Transdermal sustained release drug delivery
WO2009137093A1 (en) * 2008-05-09 2009-11-12 Radius Health, Inc. Method of subcutaneous drug delivery of pthrp analogs

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US20090117158A1 (en) * 2007-10-23 2009-05-07 Mahmoud Ameri Transdermal sustained release drug delivery
WO2009137093A1 (en) * 2008-05-09 2009-11-12 Radius Health, Inc. Method of subcutaneous drug delivery of pthrp analogs

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Also Published As

Publication number Publication date
US20190290738A1 (en) 2019-09-26
SG194570A1 (en) 2013-12-30
NZ618003A (en) 2016-05-27
MX2013012349A (es) 2014-07-09
EP2699252B1 (en) 2017-10-25
ES2648864T3 (es) 2018-01-08
JP6033280B2 (ja) 2016-11-30
RU2013151314A (ru) 2015-05-27
JP2017036323A (ja) 2017-02-16
US20130006217A1 (en) 2013-01-03
US20140046293A1 (en) 2014-02-13
US20170189493A1 (en) 2017-07-06
BR112013027153A2 (pt) 2016-11-29
IL228942A0 (en) 2013-12-31
JP2014517825A (ja) 2014-07-24
CA2833571A1 (en) 2012-10-26
AU2016216584A1 (en) 2016-09-01
US20210052705A1 (en) 2021-02-25
WO2012145665A3 (en) 2014-04-24
EP2699252A4 (en) 2015-05-27
EP2699252A2 (en) 2014-02-26
CN103917242A (zh) 2014-07-09
KR20140047043A (ko) 2014-04-21
US20140046292A1 (en) 2014-02-13
EP3332799A1 (en) 2018-06-13
WO2012145665A2 (en) 2012-10-26

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