AU2012239997A1 - Novel EGFR binding proteins - Google Patents

Novel EGFR binding proteins Download PDF

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Publication number
AU2012239997A1
AU2012239997A1 AU2012239997A AU2012239997A AU2012239997A1 AU 2012239997 A1 AU2012239997 A1 AU 2012239997A1 AU 2012239997 A AU2012239997 A AU 2012239997A AU 2012239997 A AU2012239997 A AU 2012239997A AU 2012239997 A1 AU2012239997 A1 AU 2012239997A1
Authority
AU
Australia
Prior art keywords
antigen binding
binding protein
antibody
egfr
certain embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012239997A
Other languages
English (en)
Inventor
Amy Guo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2012239997A1 publication Critical patent/AU2012239997A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2012239997A 2011-04-07 2012-04-06 Novel EGFR binding proteins Abandoned AU2012239997A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161473014P 2011-04-07 2011-04-07
US61/473,014 2011-04-07
PCT/US2012/032519 WO2012138997A1 (en) 2011-04-07 2012-04-06 Novel egfr binding proteins

Publications (1)

Publication Number Publication Date
AU2012239997A1 true AU2012239997A1 (en) 2013-10-17

Family

ID=46168610

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012239997A Abandoned AU2012239997A1 (en) 2011-04-07 2012-04-06 Novel EGFR binding proteins

Country Status (12)

Country Link
US (1) US8628773B2 (ja)
EP (1) EP2694552B1 (ja)
JP (1) JP5908972B2 (ja)
KR (1) KR102001686B1 (ja)
CN (1) CN103619881B (ja)
AR (1) AR085955A1 (ja)
AU (1) AU2012239997A1 (ja)
CA (1) CA2831957A1 (ja)
MX (1) MX2013011706A (ja)
SG (1) SG194111A1 (ja)
TW (1) TW201305213A (ja)
WO (1) WO2012138997A1 (ja)

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US9493563B2 (en) 2013-11-04 2016-11-15 Glenmark Pharmaceuticals S.A. Production of T cell retargeting hetero-dimeric immunoglobulins
EA201692109A1 (ru) * 2014-05-01 2017-03-31 Дженентек, Инк. Варианты антител к фактору d и их применение
JP6691872B2 (ja) * 2014-05-30 2020-05-13 ヘンリクス バイオテック カンパニー リミテッド 抗上皮増殖因子受容体（ｅｇｆｒ）抗体
US11773166B2 (en) 2014-11-04 2023-10-03 Ichnos Sciences SA CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
KR101776879B1 (ko) * 2015-01-19 2017-09-08 주식회사 녹십자 항-egfr 항체를 포함하는 약학 제제
EP3368090A1 (en) * 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
AU2017214692B2 (en) 2016-02-06 2021-11-04 Epimab Biotherapeutics, Inc. Fabs-in-tandem immunoglobulin and uses thereof
CN107987161B (zh) * 2016-10-26 2021-04-16 泰州迈博太科药业有限公司 一种抗egfr单克隆抗体制剂
CA3055132A1 (en) * 2017-04-03 2018-10-11 F. Hoffmann-La Roche Ag Antibodies binding to steap-1
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EP4005593A4 (en) * 2019-07-24 2023-08-16 Sinocelltech Ltd. MULTI-VARIABLE DOSE DELIVERY METHOD FOR USE IN THE TREATMENT OF CANCER IN WHICH EGFR IS STRONGLY EXPRESSED
US20230279121A1 (en) * 2020-08-05 2023-09-07 Dragonfly Therapeutics, Inc. Antibodies targeting egfr and use thereof
JP2023550148A (ja) 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
WO2022104692A1 (en) * 2020-11-20 2022-05-27 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Engineered antibody, antibody-drug conjugate, and use thereof
EP4247853A1 (en) * 2020-11-20 2023-09-27 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Modified egfr antibody with reduced affinity, drug conjugate, and use thereof
CN114496063B (zh) * 2022-01-13 2023-05-23 北京博康健基因科技有限公司 基于天然氨基酸序列的信号肽设计与二级结构从头算建模方法和装置

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Also Published As

Publication number Publication date
CN103619881A (zh) 2014-03-05
AR085955A1 (es) 2013-11-06
CN103619881B (zh) 2017-07-28
CA2831957A1 (en) 2012-10-11
SG194111A1 (en) 2013-11-29
US8628773B2 (en) 2014-01-14
US20120328511A1 (en) 2012-12-27
MX2013011706A (es) 2014-04-25
WO2012138997A1 (en) 2012-10-11
TW201305213A (zh) 2013-02-01
KR20140033038A (ko) 2014-03-17
JP2014516250A (ja) 2014-07-10
EP2694552A1 (en) 2014-02-12
KR102001686B1 (ko) 2019-07-18
JP5908972B2 (ja) 2016-04-26
EP2694552B1 (en) 2017-10-11

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