AU2010346597B2 - Synthesis of magnolol and its analogue compounds - Google Patents

Synthesis of magnolol and its analogue compounds Download PDF

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Publication number
AU2010346597B2
AU2010346597B2 AU2010346597A AU2010346597A AU2010346597B2 AU 2010346597 B2 AU2010346597 B2 AU 2010346597B2 AU 2010346597 A AU2010346597 A AU 2010346597A AU 2010346597 A AU2010346597 A AU 2010346597A AU 2010346597 B2 AU2010346597 B2 AU 2010346597B2
Authority
AU
Australia
Prior art keywords
compound
formula
magnolol
organic solvent
bisphenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010346597A
Other languages
English (en)
Other versions
AU2010346597A1 (en
Inventor
Basi V. Subba Reddy
Ravi Subramanyam
Jhillu S. Yadav
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indian Institute of Chemical Technology
Colgate Palmolive Co
Original Assignee
Indian Institute Of Chemical Tech
Indian Institute of Chemical Technology
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indian Institute Of Chemical Tech, Indian Institute of Chemical Technology, Colgate Palmolive Co filed Critical Indian Institute Of Chemical Tech
Publication of AU2010346597A1 publication Critical patent/AU2010346597A1/en
Application granted granted Critical
Publication of AU2010346597B2 publication Critical patent/AU2010346597B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/52—Preparation of compounds having groups by reactions producing groups by substitution of halogen only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2010346597A 2010-02-25 2010-02-25 Synthesis of magnolol and its analogue compounds Ceased AU2010346597B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/025378 WO2011106003A1 (en) 2010-02-25 2010-02-25 Synthesis of magnolol and its analogue compounds

Publications (2)

Publication Number Publication Date
AU2010346597A1 AU2010346597A1 (en) 2012-08-23
AU2010346597B2 true AU2010346597B2 (en) 2013-09-19

Family

ID=42028117

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010346597A Ceased AU2010346597B2 (en) 2010-02-25 2010-02-25 Synthesis of magnolol and its analogue compounds

Country Status (19)

Country Link
US (1) US8519197B2 (https=)
EP (1) EP2539310B1 (https=)
JP (1) JP2013520495A (https=)
CN (1) CN102884035B (https=)
AR (1) AR080656A1 (https=)
AU (1) AU2010346597B2 (https=)
BR (1) BR112012020603A2 (https=)
CA (1) CA2789140C (https=)
DK (1) DK2539310T3 (https=)
ES (1) ES2507615T3 (https=)
MX (1) MX2012009817A (https=)
MY (1) MY162466A (https=)
PH (1) PH12012501619A1 (https=)
PL (1) PL2539310T3 (https=)
RU (1) RU2510938C1 (https=)
SG (1) SG183120A1 (https=)
TW (1) TWI438185B (https=)
WO (1) WO2011106003A1 (https=)
ZA (1) ZA201206020B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103261138B (zh) 2010-12-21 2015-08-12 高露洁-棕榄公司 作为抗菌剂的卤代联苯酚
BR112014014026B1 (pt) 2011-12-15 2018-06-05 Colgate-Palmolive Company Composições compreendendo análogos de magnolol solubilizados
US9155693B2 (en) 2011-12-15 2015-10-13 Colgate-Palmolive Company Solubilized magnolol analogs
MX2014007554A (es) 2011-12-20 2014-08-01 Colgate Palmolive Co Procesos para la preparacion de analogos de magnolol.
US9000231B2 (en) 2011-12-20 2015-04-07 Colgate-Palmolive Company Processes for making magnolol and derivatives thereof
EP2948220B1 (en) 2013-01-23 2018-07-04 Colgate-Palmolive Company Processes for making magnolol derivatives
JP2015007054A (ja) * 2014-07-24 2015-01-15 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ マグノロールおよびその類似体化合物の合成
AU2016340992B2 (en) * 2015-10-23 2020-10-08 Colgate-Palmolive Company Improved synthesis of honokiol
CN109053387B (zh) * 2018-09-19 2021-07-09 九江学院 一种厚朴酚的合成方法
CN113242751B (zh) 2018-12-18 2023-09-19 联合利华知识产权控股有限公司 抗微生物组合物
CN115581690A (zh) * 2021-07-05 2023-01-10 北京红惠新医药科技有限公司 厚朴酚或和厚朴酚的芳环氨基取代衍生物在用于制备抗心肌缺血药物中的应用、药物组合物
CN116139115A (zh) * 2021-11-19 2023-05-23 北京红惠新医药科技有限公司 厚朴酚和/或和厚朴酚芳环氨基取代类衍生物的抗低氧/缺氧损伤用途及药物组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060140885A1 (en) * 2004-12-29 2006-06-29 Abdul Gaffar Method of reducing oral tissue inflammation using magnolia extract

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0544488B1 (en) * 1991-11-25 1998-03-11 Eli Lilly And Company Substituted phenyl phenol leukotriene antagonists
US6544409B2 (en) 2001-05-16 2003-04-08 Petroleo Brasileiro S.A. - Petrobras Process for the catalytic oxidation of sulfur, nitrogen and unsaturated compounds from hydrocarbon streams
CN1147286C (zh) * 2001-07-18 2004-04-28 广州美晨股份有限公司 一种中药牙膏
US7347985B2 (en) * 2002-06-25 2008-03-25 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060140885A1 (en) * 2004-12-29 2006-06-29 Abdul Gaffar Method of reducing oral tissue inflammation using magnolia extract

Also Published As

Publication number Publication date
BR112012020603A2 (pt) 2017-07-11
DK2539310T3 (da) 2014-10-20
CA2789140A1 (en) 2011-09-01
RU2510938C1 (ru) 2014-04-10
HK1180297A1 (en) 2013-10-18
US8519197B2 (en) 2013-08-27
EP2539310B1 (en) 2014-07-16
ZA201206020B (en) 2014-01-29
AR080656A1 (es) 2012-04-25
TWI438185B (zh) 2014-05-21
RU2012140748A (ru) 2014-03-27
EP2539310A1 (en) 2013-01-02
CA2789140C (en) 2015-01-27
WO2011106003A1 (en) 2011-09-01
TW201141823A (en) 2011-12-01
JP2013520495A (ja) 2013-06-06
AU2010346597A1 (en) 2012-08-23
CN102884035A (zh) 2013-01-16
MY162466A (en) 2017-06-15
MX2012009817A (es) 2012-09-12
SG183120A1 (en) 2012-09-27
PH12012501619A1 (en) 2014-09-24
ES2507615T3 (es) 2014-10-15
PL2539310T3 (pl) 2015-01-30
CN102884035B (zh) 2016-01-20
US20120302647A1 (en) 2012-11-29

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired