BR112012020603A2 - síntese de magnolol e seus compostos análogos. - Google Patents
síntese de magnolol e seus compostos análogos.Info
- Publication number
- BR112012020603A2 BR112012020603A2 BR112012020603A BR112012020603A BR112012020603A2 BR 112012020603 A2 BR112012020603 A2 BR 112012020603A2 BR 112012020603 A BR112012020603 A BR 112012020603A BR 112012020603 A BR112012020603 A BR 112012020603A BR 112012020603 A2 BR112012020603 A2 BR 112012020603A2
- Authority
- BR
- Brazil
- Prior art keywords
- magnolol
- synthesis
- analogous compounds
- derivative
- analog
- Prior art date
Links
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 title abstract 10
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
- C07C41/52—Preparation of compounds having groups by reactions producing groups by substitution of halogen only
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/025378 WO2011106003A1 (en) | 2010-02-25 | 2010-02-25 | Synthesis of magnolol and its analogue compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012020603A2 true BR112012020603A2 (pt) | 2017-07-11 |
Family
ID=42028117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012020603A BR112012020603A2 (pt) | 2010-02-25 | 2010-02-25 | síntese de magnolol e seus compostos análogos. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8519197B2 (https=) |
| EP (1) | EP2539310B1 (https=) |
| JP (1) | JP2013520495A (https=) |
| CN (1) | CN102884035B (https=) |
| AR (1) | AR080656A1 (https=) |
| AU (1) | AU2010346597B2 (https=) |
| BR (1) | BR112012020603A2 (https=) |
| CA (1) | CA2789140C (https=) |
| DK (1) | DK2539310T3 (https=) |
| ES (1) | ES2507615T3 (https=) |
| MX (1) | MX2012009817A (https=) |
| MY (1) | MY162466A (https=) |
| PH (1) | PH12012501619A1 (https=) |
| PL (1) | PL2539310T3 (https=) |
| RU (1) | RU2510938C1 (https=) |
| SG (1) | SG183120A1 (https=) |
| TW (1) | TWI438185B (https=) |
| WO (1) | WO2011106003A1 (https=) |
| ZA (1) | ZA201206020B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103261138B (zh) | 2010-12-21 | 2015-08-12 | 高露洁-棕榄公司 | 作为抗菌剂的卤代联苯酚 |
| RU2014128850A (ru) | 2011-12-15 | 2016-02-10 | Колгейт-Палмолив Компани | Композиция, содержащая солюбилизированный аналог магнолола |
| MY194692A (en) | 2011-12-15 | 2022-12-15 | Colgate Palmolive Co | Oral care or cleanser composition comprising solubilized magnolol analogs and ppg-1-peg-9 lauryl glycol ether |
| US9000231B2 (en) | 2011-12-20 | 2015-04-07 | Colgate-Palmolive Company | Processes for making magnolol and derivatives thereof |
| RU2014129908A (ru) | 2011-12-20 | 2016-02-10 | Колгейт-Палмолив Компани | Способы получения аналогов магнолола |
| CN105188852A (zh) | 2013-01-23 | 2015-12-23 | 高露洁-棕榄公司 | 制备厚朴酚衍生物的方法 |
| JP2015007054A (ja) * | 2014-07-24 | 2015-01-15 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | マグノロールおよびその類似体化合物の合成 |
| MX389172B (es) * | 2015-10-23 | 2025-03-20 | Colgate Palmolive Co | Sintesis mejorada de honokiol. |
| CN109053387B (zh) * | 2018-09-19 | 2021-07-09 | 九江学院 | 一种厚朴酚的合成方法 |
| CN113242751B (zh) | 2018-12-18 | 2023-09-19 | 联合利华知识产权控股有限公司 | 抗微生物组合物 |
| CN115581690A (zh) * | 2021-07-05 | 2023-01-10 | 北京红惠新医药科技有限公司 | 厚朴酚或和厚朴酚的芳环氨基取代衍生物在用于制备抗心肌缺血药物中的应用、药物组合物 |
| CN116139115A (zh) * | 2021-11-19 | 2023-05-23 | 北京红惠新医药科技有限公司 | 厚朴酚和/或和厚朴酚芳环氨基取代类衍生物的抗低氧/缺氧损伤用途及药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ276694A3 (en) * | 1991-11-25 | 1995-11-15 | Lilly Co Eli | Process for preparing diphenyl derivative |
| US6544409B2 (en) | 2001-05-16 | 2003-04-08 | Petroleo Brasileiro S.A. - Petrobras | Process for the catalytic oxidation of sulfur, nitrogen and unsaturated compounds from hydrocarbon streams |
| CN1147286C (zh) * | 2001-07-18 | 2004-04-28 | 广州美晨股份有限公司 | 一种中药牙膏 |
| US7347985B2 (en) * | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US20060140885A1 (en) | 2004-12-29 | 2006-06-29 | Abdul Gaffar | Method of reducing oral tissue inflammation using magnolia extract |
| WO2008098056A2 (en) * | 2007-02-06 | 2008-08-14 | Epix Pharmaceuticals, Inc. | High relaxivity chelates |
-
2010
- 2010-02-25 ES ES10705965.1T patent/ES2507615T3/es active Active
- 2010-02-25 MX MX2012009817A patent/MX2012009817A/es active IP Right Grant
- 2010-02-25 PH PH1/2012/501619A patent/PH12012501619A1/en unknown
- 2010-02-25 PL PL10705965T patent/PL2539310T3/pl unknown
- 2010-02-25 RU RU2012140748/04A patent/RU2510938C1/ru not_active IP Right Cessation
- 2010-02-25 CA CA2789140A patent/CA2789140C/en not_active Expired - Fee Related
- 2010-02-25 US US13/577,627 patent/US8519197B2/en active Active
- 2010-02-25 AU AU2010346597A patent/AU2010346597B2/en not_active Ceased
- 2010-02-25 BR BR112012020603A patent/BR112012020603A2/pt active Search and Examination
- 2010-02-25 CN CN201080064851.2A patent/CN102884035B/zh not_active Expired - Fee Related
- 2010-02-25 SG SG2012056404A patent/SG183120A1/en unknown
- 2010-02-25 MY MYPI2012003487A patent/MY162466A/en unknown
- 2010-02-25 DK DK10705965.1T patent/DK2539310T3/da active
- 2010-02-25 JP JP2012554971A patent/JP2013520495A/ja active Pending
- 2010-02-25 WO PCT/US2010/025378 patent/WO2011106003A1/en not_active Ceased
- 2010-02-25 EP EP10705965.1A patent/EP2539310B1/en active Active
-
2011
- 2011-02-24 TW TW100106113A patent/TWI438185B/zh not_active IP Right Cessation
- 2011-02-24 AR ARP110100579A patent/AR080656A1/es unknown
-
2012
- 2012-08-10 ZA ZA2012/06020A patent/ZA201206020B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102884035A (zh) | 2013-01-16 |
| PL2539310T3 (pl) | 2015-01-30 |
| CA2789140A1 (en) | 2011-09-01 |
| CN102884035B (zh) | 2016-01-20 |
| RU2510938C1 (ru) | 2014-04-10 |
| ES2507615T3 (es) | 2014-10-15 |
| AU2010346597B2 (en) | 2013-09-19 |
| RU2012140748A (ru) | 2014-03-27 |
| MX2012009817A (es) | 2012-09-12 |
| AU2010346597A1 (en) | 2012-08-23 |
| CA2789140C (en) | 2015-01-27 |
| AR080656A1 (es) | 2012-04-25 |
| WO2011106003A1 (en) | 2011-09-01 |
| EP2539310A1 (en) | 2013-01-02 |
| US8519197B2 (en) | 2013-08-27 |
| TWI438185B (zh) | 2014-05-21 |
| ZA201206020B (en) | 2014-01-29 |
| US20120302647A1 (en) | 2012-11-29 |
| EP2539310B1 (en) | 2014-07-16 |
| JP2013520495A (ja) | 2013-06-06 |
| SG183120A1 (en) | 2012-09-27 |
| TW201141823A (en) | 2011-12-01 |
| DK2539310T3 (da) | 2014-10-20 |
| HK1180297A1 (en) | 2013-10-18 |
| PH12012501619A1 (en) | 2014-09-24 |
| MY162466A (en) | 2017-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2450 DE 19-12-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |