AU2009244453B2 - Method of treating cancer using a cMET and AXL inhibitor and an erbB inhibitor - Google Patents

Method of treating cancer using a cMET and AXL inhibitor and an erbB inhibitor Download PDF

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Publication number
AU2009244453B2
AU2009244453B2 AU2009244453A AU2009244453A AU2009244453B2 AU 2009244453 B2 AU2009244453 B2 AU 2009244453B2 AU 2009244453 A AU2009244453 A AU 2009244453A AU 2009244453 A AU2009244453 A AU 2009244453A AU 2009244453 B2 AU2009244453 B2 AU 2009244453B2
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AU
Australia
Prior art keywords
erbb
compound
cmet
cancer
inhibitor
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Ceased
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AU2009244453A
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English (en)
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AU2009244453A1 (en
Inventor
Tona M. Gilmer
James G. Greger
Li Liu
Hong Shi
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GlaxoSmithKline LLC
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GlaxoSmithKline LLC
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Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of AU2009244453A1 publication Critical patent/AU2009244453A1/en
Application granted granted Critical
Publication of AU2009244453B2 publication Critical patent/AU2009244453B2/en
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2009244453A 2008-05-05 2009-05-05 Method of treating cancer using a cMET and AXL inhibitor and an erbB inhibitor Ceased AU2009244453B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5032208P 2008-05-05 2008-05-05
US61/050,322 2008-05-05
PCT/US2009/042768 WO2009137429A1 (en) 2008-05-05 2009-05-05 Method of treating cancer using a cmet and axl inhibitor and an erbb inhibitor

Publications (2)

Publication Number Publication Date
AU2009244453A1 AU2009244453A1 (en) 2009-11-12
AU2009244453B2 true AU2009244453B2 (en) 2012-07-19

Family

ID=41257222

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009244453A Ceased AU2009244453B2 (en) 2008-05-05 2009-05-05 Method of treating cancer using a cMET and AXL inhibitor and an erbB inhibitor

Country Status (19)

Country Link
US (3) US20090274693A1 (enExample)
EP (1) EP2274304A4 (enExample)
JP (1) JP2011519941A (enExample)
KR (1) KR20110004462A (enExample)
CN (1) CN102083824A (enExample)
AR (1) AR071631A1 (enExample)
AU (1) AU2009244453B2 (enExample)
BR (1) BRPI0912582A2 (enExample)
CA (1) CA2723699A1 (enExample)
CL (1) CL2009001063A1 (enExample)
EA (1) EA020779B1 (enExample)
IL (1) IL209057A0 (enExample)
MX (1) MX2010012101A (enExample)
PE (1) PE20091832A1 (enExample)
SG (1) SG190623A1 (enExample)
TW (1) TW201006829A (enExample)
UY (1) UY31800A (enExample)
WO (1) WO2009137429A1 (enExample)
ZA (1) ZA201007722B (enExample)

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Also Published As

Publication number Publication date
US20130150363A1 (en) 2013-06-13
US20090274693A1 (en) 2009-11-05
JP2011519941A (ja) 2011-07-14
SG190623A1 (en) 2013-06-28
US20130142790A1 (en) 2013-06-06
MX2010012101A (es) 2010-11-30
KR20110004462A (ko) 2011-01-13
IL209057A0 (en) 2011-01-31
UY31800A (es) 2009-11-10
CA2723699A1 (en) 2009-11-12
EA020779B1 (ru) 2015-01-30
EP2274304A4 (en) 2012-05-30
BRPI0912582A2 (pt) 2015-07-28
CN102083824A (zh) 2011-06-01
CL2009001063A1 (es) 2010-09-24
AU2009244453A1 (en) 2009-11-12
TW201006829A (en) 2010-02-16
AR071631A1 (es) 2010-06-30
WO2009137429A1 (en) 2009-11-12
PE20091832A1 (es) 2009-12-25
EA201071268A1 (ru) 2011-06-30
EP2274304A1 (en) 2011-01-19
ZA201007722B (en) 2011-08-31

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