AU2009212151C1 - Compositions and methods for distraction osteogenesis - Google Patents

Compositions and methods for distraction osteogenesis Download PDF

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Publication number
AU2009212151C1
AU2009212151C1 AU2009212151A AU2009212151A AU2009212151C1 AU 2009212151 C1 AU2009212151 C1 AU 2009212151C1 AU 2009212151 A AU2009212151 A AU 2009212151A AU 2009212151 A AU2009212151 A AU 2009212151A AU 2009212151 C1 AU2009212151 C1 AU 2009212151C1
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Australia
Prior art keywords
pdgf
bone
biocompatible matrix
composition
calcium phosphate
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AU2009212151A1 (en
AU2009212151B2 (en
Inventor
Michael G. Ehrlich
Charles E. Hart
Samuel E. Lynch
Douglas C. Moore
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Stryker Corp
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Stryker Corp
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Publication of AU2009212151C1 publication Critical patent/AU2009212151C1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2009212151A 2008-02-07 2009-02-09 Compositions and methods for distraction osteogenesis Active AU2009212151C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2693408P 2008-02-07 2008-02-07
US61/026,934 2008-02-07
PCT/US2009/033596 WO2009100454A1 (en) 2008-02-07 2009-02-09 Compositions and methods for distraction osteogenesis

Publications (3)

Publication Number Publication Date
AU2009212151A1 AU2009212151A1 (en) 2009-08-13
AU2009212151B2 AU2009212151B2 (en) 2015-05-21
AU2009212151C1 true AU2009212151C1 (en) 2015-09-17

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ID=40717173

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009212151A Active AU2009212151C1 (en) 2008-02-07 2009-02-09 Compositions and methods for distraction osteogenesis

Country Status (9)

Country Link
US (2) US7943573B2 (OSRAM)
EP (1) EP2259807B1 (OSRAM)
JP (3) JP5864106B2 (OSRAM)
CN (2) CN105854074B (OSRAM)
AU (1) AU2009212151C1 (OSRAM)
CA (1) CA2715254A1 (OSRAM)
ES (1) ES2422259T3 (OSRAM)
RU (1) RU2010137106A (OSRAM)
WO (1) WO2009100454A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2007061889A2 (en) 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP1991282B1 (en) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
WO2008103690A2 (en) * 2007-02-20 2008-08-28 Biomimetic Therapeutics, Inc. Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix
ES2422259T3 (es) 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
US9259320B2 (en) 2008-08-26 2016-02-16 Andy Boiangiu Apparatus and method for bone augmentation
US9861482B2 (en) 2008-08-26 2018-01-09 Andy Boiangiu Dental bone implant and implant method
AU2011343995A1 (en) * 2010-12-13 2013-06-20 Biomimetic Therapeutics, Llc Compositions and methods for spine fusion procedures
MX2017004520A (es) 2014-10-14 2018-03-15 Lynch Samuel Composiciones para tratar heridas.
RU2665962C1 (ru) * 2017-03-17 2018-09-05 Общество с ограниченной ответственностью "Матрифлекс" Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041246A2 (en) * 1997-03-20 1998-09-24 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bone
WO2003065996A2 (en) * 2002-02-05 2003-08-14 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
WO2004073563A2 (en) * 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device

Family Cites Families (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943072A (en) * 1971-12-15 1976-03-09 United Kingdom Atomic Energy Authority Separation of molecules
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
NL8402158A (nl) 1983-07-09 1985-02-01 Sumitomo Cement Co Poreus keramisch materiaal en werkwijze voor de bereiding daarvan.
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5629191A (en) 1985-01-03 1997-05-13 Integra Lifesciences Corporation Method of making a porous matrix particle
US5045633A (en) 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5516896A (en) * 1985-02-25 1996-05-14 Zymogenetics, Inc. Biologically active B-chain homodimers
CA1260391A (en) 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5019559A (en) * 1986-11-14 1991-05-28 President And Fellows Of Harvard College Wound healing using PDGF and IGF-II
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
DE3785758T2 (de) 1986-11-14 1993-08-05 Harvard College Wundheilung und knochenregeneration.
CA1322714C (en) 1986-11-14 1993-10-05 Harry N. Antoniades Wound healing and bone regeneration
US5219759A (en) * 1987-04-22 1993-06-15 Chiron Corporation Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US4874746A (en) 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF
US5759815A (en) * 1988-02-11 1998-06-02 Creative Biomolecules, Inc. Production of platelet derived growth factor (PDGF) an muteins thereof
US4975526A (en) 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5053212A (en) 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US4904259A (en) * 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US5219576A (en) 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US5034375A (en) * 1988-08-10 1991-07-23 Institute Of Molecular Biology, Inc. Process of wound healing using PDGF and EGF
US5035887A (en) * 1989-09-07 1991-07-30 Institute Of Moelcular Biology, Inc. Wound healing composition of IL-1 and PDGF or IGF-1
US5599558A (en) 1989-09-15 1997-02-04 Curative Technologies, Inc. Selecting amounts of platelet releasate for efficacious treatment of tissue
US5112354A (en) * 1989-11-16 1992-05-12 Northwestern University Bone allograft material and method
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
JP3159216B2 (ja) 1990-02-01 2001-04-23 ユニバーシティ オブ サウス フロリダ 白血球由来の成長因子
TW199858B (OSRAM) * 1990-03-30 1993-02-11 Fujirebio Kk
ATE156363T1 (de) 1990-04-10 1997-08-15 Inst Molecular Biology Inc Wundheilung
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5149691A (en) 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US5837258A (en) 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
JP2524858Y2 (ja) * 1991-10-01 1997-02-05 矢崎総業株式会社 ねじ締め型コネクタ
CN1104257C (zh) * 1993-03-29 2003-04-02 津莫吉尼蒂克斯公司 含pdgf和维生素d的刺激成骨细胞生长的组合物
JP2562112B2 (ja) * 1993-07-07 1996-12-11 三ツ星ベルト株式会社 Ｖリブドベルト及びｖリブドベルト用グラインダーホイール
US5531794A (en) * 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
JP3362267B2 (ja) 1993-12-29 2003-01-07 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US6180606B1 (en) * 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5651766A (en) 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
US5614206A (en) 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6541037B1 (en) * 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
ES2293137T3 (es) * 1995-10-11 2008-03-16 Novartis Vaccines And Diagnostics, Inc. Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas.
US5783217A (en) 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US5747273A (en) 1996-05-07 1998-05-05 Diagnostic Systems Laboratories, Inc. Immunoassay of total insulin-like growth factor binding protein-1
AU2759397A (en) * 1996-05-28 1998-01-05 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
FR2749756B1 (fr) * 1996-06-14 1998-09-11 Bioland Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
CA2268156C (en) 1996-10-16 2007-05-29 Etex Corporation Bioceramic compositions
US6037519A (en) * 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
DE19646782C2 (de) 1996-11-13 2000-05-25 Merck Patent Gmbh Bioresorbierbare Polymerisationsprodukte aus strahlungshärtbaren Bindemittelsystemen
WO1998026080A1 (en) 1996-12-13 1998-06-18 Chiron Corporation Method for expression of heterologous proteins in yeast
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
FR2758988B1 (fr) 1997-02-05 2000-01-21 S H Ind Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee
EP1350525A3 (en) 1997-02-07 2003-12-10 Stryker Corporation Matrix-free osteogenic devices, implants and methods thereof
DE69823955T2 (de) 1997-03-04 2005-06-16 Technology Finance Corp. (Pty.) Ltd., Sandton Als knochenimplantat geeignetes erzeugnis
US20020098222A1 (en) 1997-03-13 2002-07-25 John F. Wironen Bone paste
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
JP3334558B2 (ja) * 1997-04-23 2002-10-15 富士レビオ株式会社 酵素免疫測定方法及び試験片
GB2325934A (en) 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
US6063624A (en) 1997-06-09 2000-05-16 Baxter International Inc. Platelet suspensions and methods for resuspending platelets
EP0896825B1 (en) 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
US6136029A (en) 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US20020018796A1 (en) * 1998-01-28 2002-02-14 John F. Wironen Thermally sterilized bone paste
PT1100488E (pt) 1998-07-28 2003-09-30 Synthes Ag Utilizacao de compostos de creatina para tratamento das celulas e tecidos do osso ou cartilagem
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6224635B1 (en) * 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
US6663870B2 (en) * 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6231528B1 (en) 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
EP1025871A1 (en) 1999-01-28 2000-08-09 F. Hoffmann-La Roche Ag Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
ES2209820T3 (es) * 1999-02-04 2004-07-01 Sdgi Holdings, Inc. Composiciones esponjosas osteogenicas altamente mineralizadas, y usos de las mismas.
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
KR20010043639A (ko) 1999-03-15 2001-05-25 키이스 디 혈소판 수거 시스템
US6296602B1 (en) * 1999-03-17 2001-10-02 Transfusion Technologies Corporation Method for collecting platelets and other blood components from whole blood
ES2199815T3 (es) 1999-03-19 2004-03-01 The Regents Of The University Of Michigan Mineralizacion y desarrollo celular supeerficial sobre biomateriales.
JP4892133B2 (ja) * 1999-04-12 2012-03-07 ハーベスト・テクノロジーズ・コーポレイション 血小板富有血漿及び／又は血小板濃縮物を製造する方法
SE515227C2 (sv) * 1999-04-28 2001-07-02 Bruce Medical Ab Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen
US6468543B1 (en) * 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
US6710025B1 (en) * 1999-05-26 2004-03-23 The Brigham And Women's Hospital, Inc. Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin
AU5444800A (en) 1999-05-27 2000-12-18 Research Foundation Of State University Of New York, The LTiGTin vitroLT/iGT cell culture device including cartilage and methods of usingthe same
DE19926083A1 (de) 1999-06-08 2000-12-14 Universitaetsklinikum Freiburg Biologisches Gelenkkonstrukt
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
DE19940717A1 (de) * 1999-08-26 2001-03-01 Gerontocare Gmbh Resorblerbares Knochenersatz- und Knochenaufbaumaterial
US6280191B1 (en) * 1999-09-03 2001-08-28 Christopher B. Gordon Distractor suitable for permanent implantation into bone
US6451059B1 (en) 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
WO2001041822A1 (en) 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US6479418B2 (en) * 1999-12-16 2002-11-12 Isotis N.V. Porous ceramic body
US20030103960A1 (en) 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
CA2396016A1 (en) 1999-12-29 2001-07-05 Andy Bernhardt System for reconstituting pastes and methods of using same
AU4234901A (en) 2000-01-28 2001-08-07 Dot Dunnschicht Und Oberflache Inorganic resorbable bone substitute material and production method
WO2001057083A1 (en) * 2000-02-04 2001-08-09 Zymogenetics, Inc. Methods for promoting growth of bone, ligament, and cartilage using zvegf4
AU2001241594A1 (en) 2000-02-18 2001-08-27 Regeneration Technologies, Inc. Implantable tissues infused with growth factors and other additives
IT1316769B1 (it) * 2000-02-18 2003-05-12 Getters Spa Pannello evacuato per isolamento termico con ridotta conduzione dicalore ai bordi
US7022506B2 (en) 2000-02-23 2006-04-04 The Trustees Of The University Of Pennsylvania Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee
US20030055511A1 (en) * 2000-03-03 2003-03-20 Schryver Jeffrey E. Shaped particle comprised of bone material and method of making the particle
AU784377B2 (en) 2000-03-14 2006-03-23 Arthur V. Sampaio Compositions and methods for affecting osteogenesis
US20020006437A1 (en) * 2000-05-01 2002-01-17 Grooms Jamie M. Non-migration tissue capsule
AU2001262605A1 (en) 2000-05-19 2001-11-26 Europrint Holdings Limited Method and system for implementing a game
US20020022885A1 (en) * 2000-05-19 2002-02-21 Takahiro Ochi Biomaterial
CN1471412B8 (zh) * 2000-06-29 2016-06-15 生物合成技术加拿大公司 用于修复和再生软骨和其它组织的组合物以及该组合物的用途
DK177997B1 (da) * 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Knoglemateriale og collagenkombination til opheling af beskadigede led
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US6739112B1 (en) * 2000-08-21 2004-05-25 Nu Vasive, Inc. Bone allograft packaging system
US6773723B1 (en) 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
US20020127265A1 (en) 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US7192604B2 (en) * 2000-12-22 2007-03-20 Ethicon, Inc. Implantable biodegradable devices for musculoskeletal repair or regeneration
JP2004533276A (ja) 2001-01-25 2004-11-04 リジェネレーション テクノロジーズ インク． 注射可能な多孔性骨グラフト材料
US7005135B2 (en) * 2001-01-30 2006-02-28 Ethicon Inc. Glass scaffolds with controlled resorption rates and methods for making same
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6743232B2 (en) * 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US20030049328A1 (en) * 2001-03-02 2003-03-13 Dalal Paresh S. Porous beta-tricalcium phosphate granules and methods for producing same
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20030109537A1 (en) * 2001-07-09 2003-06-12 Turner Russell T. Methods and materials for treating bone conditions
CA2460026C (en) 2001-09-24 2011-06-28 Millenium Biologix Inc. Porous ceramic composite bone grafts
DE60224822T2 (de) * 2001-10-19 2009-01-22 Zymogenetics, Inc., Seattle Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
US7045105B2 (en) * 2001-12-21 2006-05-16 Lagow Richard J Calcium phosphate bone replacement materials and methods of use thereof
AU2003210996A1 (en) 2002-02-11 2003-09-04 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
US7879107B2 (en) * 2002-02-20 2011-02-01 The Cleveland Clinic Foundation Composition and method for inducing bone growth and healing
JP3739715B2 (ja) * 2002-03-19 2006-01-25 オリンパス株式会社 人工骨および組織工学用担体
KR100460685B1 (ko) 2002-04-10 2004-12-09 재단법인서울대학교산학협력재단 인산칼슘계 화합물을 이용한 인공 골 충진재 및 그 제조방법
AU2003228587A1 (en) 2002-04-18 2003-11-03 University Of Florida Biomimetic organic/inorganic composites, processes for their production, and methods of use
CA2485090A1 (en) * 2002-05-02 2003-12-24 Osteoscreen, Inc. Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate)
US20040033949A1 (en) * 2002-05-06 2004-02-19 Genentech, Inc. Use of VEGF for treating bone defects
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7041309B2 (en) 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
CA2432583A1 (en) 2002-06-20 2003-12-20 Merck Patent Gesellschaft Mit Beschraenkter Haftung Method of preparing alpha- and beta-tricalcium phosphate powders
US20040002770A1 (en) * 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
ES2242916T3 (es) * 2002-07-11 2005-11-16 Biomet Deutschland Gmbh Metodos de preparacion de segmentos y granulos de fosfato de calcio poroso mediante procesamiento con gelatina.
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
EP1563846B1 (en) 2002-10-10 2012-08-29 Ono Pharmaceutical Co., Ltd. Endogenous repair factor production promoters
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
AU2003203316B2 (en) 2003-02-13 2007-01-11 Synthes Gmbh Injectable bone-replacement mixture
WO2004078069A2 (en) 2003-03-05 2004-09-16 Therics, Inc. Process for manufacturing biomedical articles by infiltrating biocompatible metal alloys in porous matrices
US20040193270A1 (en) 2003-03-31 2004-09-30 Depuyacromed, Inc. Implantable bone graft
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
KR20060031808A (ko) 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 뼈 임플란트 및 그의 제조 방법
US6974862B2 (en) 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
ATE396669T1 (de) 2003-06-24 2008-06-15 Robert Mathys Foundation Dr H Prothesenvorrichtung zur wiederherstellung von knorpel
DE10328892A1 (de) 2003-06-26 2005-05-12 Curasan Ag Knochenaufbaumittel und Herstellungsverfahren
ES2564044T3 (es) 2003-06-27 2016-03-17 DePuy Synthes Products, Inc. Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas
FI20031120A0 (fi) 2003-07-31 2003-07-31 Bci Bioabsorbable Concepts Ltd Monifunktionaalinen implanttilaite
US7163920B2 (en) 2003-09-30 2007-01-16 Ethicon, Inc. Peptide with osteogenic activity
CU23352A1 (es) * 2003-10-16 2009-03-16 Centro Nacional De Investigaciones Cientificas Biomateriales compuestos para implantes óseos
NZ547140A (en) 2003-10-22 2009-09-25 Encelle Inc Bioactive hydrogel compositions in dehydrated form for regenerating connective tissue
US20050098915A1 (en) * 2003-11-07 2005-05-12 Smith & Nephew Inc. Manufacture of bone graft substitutes
MXPA06005358A (es) 2003-11-14 2006-07-10 Univ Pennsylvania Metodo y aparato para el tratamiento de la osteoartritis, enfermedades de los cartilagos, defectos y lesiones en la cadena humana.
DE10355559A1 (de) 2003-11-21 2005-06-23 Orthogen Ag Transskin
EP1537839A1 (en) 2003-12-02 2005-06-08 Dr. h. c. Robert Mathys Foundation Prosthetic device for cartilage repair
WO2005072656A1 (en) 2004-01-27 2005-08-11 Osteotech, Inc. Stabilized bone graft
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US7928059B2 (en) 2004-02-24 2011-04-19 Wisconsin Alumni Research Foundation Use of neuropeptides for traumatic cartilage injury
KR101013999B1 (ko) 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
US20070190101A1 (en) 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
CN101060821A (zh) 2004-09-21 2007-10-24 麻省理工学院 梯度支架及其制备方法
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
JP2006122518A (ja) * 2004-10-29 2006-05-18 Univ Nagoya 骨又は歯周組織形成用組成物
WO2006050493A2 (en) 2004-11-03 2006-05-11 The Regents Of The University Of Michigan Biodegradable implant for intertransverse process fusion
WO2007008250A2 (en) 2004-12-07 2007-01-18 Gelwell Biotech Corporation Biomaterials for guided tissue regeneration and target drug delivery
US20060151383A1 (en) 2005-01-12 2006-07-13 Aaf-Mcquay Inc. Pleated corrugated media and method of making
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
EP1909810B2 (en) 2005-06-07 2017-08-23 The Regents of the University of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival
WO2007061889A2 (en) * 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US7749555B2 (en) 2006-01-25 2010-07-06 Medtronic, Inc Modification of chemical forces of bone constructs
WO2007090102A2 (en) 2006-01-27 2007-08-09 The Regents Of The University Of California Biomimetic scaffolds
US20070178159A1 (en) 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
EP1991282B1 (en) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US7833270B2 (en) 2006-05-05 2010-11-16 Warsaw Orthopedic, Inc Implant depots to deliver growth factors to treat osteoporotic bone
WO2007133451A1 (en) 2006-05-08 2007-11-22 Nuvasive, Inc. Cancellous bone treated with collegenase and essentially free of blood cells
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2656278C (en) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
US8106008B2 (en) * 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
WO2008103690A2 (en) * 2007-02-20 2008-08-28 Biomimetic Therapeutics, Inc. Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix
CN101820895A (zh) 2007-06-04 2010-09-01 生物模拟治疗公司 用于治疗脊柱的组合物和方法
CA2690457C (en) * 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
WO2009042514A1 (en) * 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
ES2422259T3 (es) 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
KR20110067035A (ko) 2008-09-09 2011-06-20 바이오미메틱 세라퓨틱스, 인크. 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법
BRPI0923015A2 (pt) 2008-12-19 2015-12-15 Biomimetic Therapeutics Inc enxertos ósseos com atividade de protease reduzida e métodos de seleção e uso
AU2010221089A1 (en) 2009-03-05 2011-09-15 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041246A2 (en) * 1997-03-20 1998-09-24 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bone
WO2003065996A2 (en) * 2002-02-05 2003-08-14 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
WO2004073563A2 (en) * 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device

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