AU2008343813B2 - Inhibitors of PI3 kinase - Google Patents
Inhibitors of PI3 kinase Download PDFInfo
- Publication number
- AU2008343813B2 AU2008343813B2 AU2008343813A AU2008343813A AU2008343813B2 AU 2008343813 B2 AU2008343813 B2 AU 2008343813B2 AU 2008343813 A AU2008343813 A AU 2008343813A AU 2008343813 A AU2008343813 A AU 2008343813A AU 2008343813 B2 AU2008343813 B2 AU 2008343813B2
- Authority
- AU
- Australia
- Prior art keywords
- pyridazin
- imidazo
- pyridin
- acetamide
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title abstract 2
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 281
- 150000003839 salts Chemical class 0.000 claims abstract description 70
- 238000000034 method Methods 0.000 claims abstract description 58
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- -1 difluoromethoxyphenyl Chemical group 0.000 claims description 117
- 125000000217 alkyl group Chemical group 0.000 claims description 66
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 61
- 229910052757 nitrogen Inorganic materials 0.000 claims description 61
- 125000001072 heteroaryl group Chemical group 0.000 claims description 52
- 125000004526 pyridazin-2-yl group Chemical group N1N(C=CC=C1)* 0.000 claims description 48
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 24
- 125000003107 substituted aryl group Chemical group 0.000 claims description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical group 0.000 claims description 18
- 239000002246 antineoplastic agent Substances 0.000 claims description 15
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- WVWKCLCEQFHKCY-UHFFFAOYSA-N n-[6-[6-chloro-5-[[3-(difluoromethoxy)phenyl]sulfonylamino]pyridin-3-yl]-3-(2-methylpyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide Chemical compound CC(=O)NC=1N=C2C=CC(C=3C=C(NS(=O)(=O)C=4C=C(OC(F)F)C=CC=4)C(Cl)=NC=3)=NN2C=1C1=CC=NC(C)=C1 WVWKCLCEQFHKCY-UHFFFAOYSA-N 0.000 claims description 8
- GTMAIZIZTDUMKQ-UHFFFAOYSA-N n-[6-[6-chloro-5-[[3-(difluoromethoxy)phenyl]sulfonylamino]pyridin-3-yl]-3-pyridin-4-ylimidazo[1,2-b]pyridazin-2-yl]acetamide Chemical compound CC(=O)NC=1N=C2C=CC(C=3C=C(NS(=O)(=O)C=4C=C(OC(F)F)C=CC=4)C(Cl)=NC=3)=NN2C=1C1=CC=NC=C1 GTMAIZIZTDUMKQ-UHFFFAOYSA-N 0.000 claims description 8
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- 239000003814 drug Substances 0.000 claims description 5
- 229940043355 kinase inhibitor Drugs 0.000 claims description 5
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 5
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- 108091007960 PI3Ks Proteins 0.000 abstract description 6
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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| US843007P | 2007-12-19 | 2007-12-19 | |
| US61/008,430 | 2007-12-19 | ||
| PCT/US2008/013940 WO2009085230A1 (en) | 2007-12-19 | 2008-12-18 | Inhibitors of pi3 kinase |
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| AU2008343813A1 AU2008343813A1 (en) | 2009-07-09 |
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| PE (1) | PE20091268A1 (enExample) |
| TW (1) | TW200940544A (enExample) |
| WO (1) | WO2009085230A1 (enExample) |
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Also Published As
| Publication number | Publication date |
|---|---|
| PE20091268A1 (es) | 2009-09-19 |
| WO2009085230A1 (en) | 2009-07-09 |
| JP5520831B2 (ja) | 2014-06-11 |
| CA2710194A1 (en) | 2009-07-09 |
| US7820665B2 (en) | 2010-10-26 |
| AR069862A1 (es) | 2010-02-24 |
| AU2008343813A1 (en) | 2009-07-09 |
| CA2710194C (en) | 2014-04-22 |
| CL2008003798A1 (es) | 2009-10-09 |
| EP2231661A1 (en) | 2010-09-29 |
| TW200940544A (en) | 2009-10-01 |
| JP2011507854A (ja) | 2011-03-10 |
| US20090163489A1 (en) | 2009-06-25 |
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