AU2008331815A1 - Systems and methods for delivery of materials - Google Patents
Systems and methods for delivery of materials Download PDFInfo
- Publication number
- AU2008331815A1 AU2008331815A1 AU2008331815A AU2008331815A AU2008331815A1 AU 2008331815 A1 AU2008331815 A1 AU 2008331815A1 AU 2008331815 A AU2008331815 A AU 2008331815A AU 2008331815 A AU2008331815 A AU 2008331815A AU 2008331815 A1 AU2008331815 A1 AU 2008331815A1
- Authority
- AU
- Australia
- Prior art keywords
- polymer
- cyc
- moieties
- drug
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
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Classifications
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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| CA3045436C (en) | 2009-01-29 | 2025-10-07 | Forsight Vision4 Inc | Posterior segment drug delivery |
| EP2440192A4 (en) * | 2009-06-11 | 2013-08-28 | Landec Corp | COMPOSITIONS AND PROCESSES FOR MATERIAL DELIVERY |
| US9233063B2 (en) | 2009-12-17 | 2016-01-12 | Air Products And Chemicals, Inc. | Polymeric compositions for personal care products |
| US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
| US10189773B2 (en) | 2010-05-07 | 2019-01-29 | Medicus Biosciences, Llc | In-vivo gelling pharmaceutical pre-formulation |
| CN103153316B (zh) | 2010-08-05 | 2015-08-19 | 弗赛特影像4股份有限公司 | 组合药物递送方法和设备 |
| HUE054113T2 (hu) | 2010-08-05 | 2021-08-30 | Forsight Vision4 Inc | Injekciós készülék gyógyszerbejuttatáshoz |
| HUE057267T2 (hu) | 2010-08-05 | 2022-05-28 | Forsight Vision4 Inc | Berendezés szem kezelésére |
| US9387281B2 (en) | 2010-10-20 | 2016-07-12 | Dsm Ip Assets B.V. | Pendant hydrophile bearing biodegradable compositions and related devices |
| EP2640360A2 (en) | 2010-11-19 | 2013-09-25 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| US10398592B2 (en) | 2011-06-28 | 2019-09-03 | Forsight Vision4, Inc. | Diagnostic methods and apparatus |
| US10111985B2 (en) | 2011-08-10 | 2018-10-30 | Medicus Biosciences, Llc | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| US11083821B2 (en) | 2011-08-10 | 2021-08-10 | C.P. Medical Corporation | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| SI2755600T1 (sl) | 2011-09-16 | 2021-08-31 | Forsight Vision4, Inc. | Naprava za izmenjavo tekočine |
| US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
| EP2846847B1 (en) | 2012-05-11 | 2020-03-25 | C.P. Medical Corporation | Biocompatible hydrogel treatments for retinal detachment |
| HK1219440A1 (zh) * | 2013-03-14 | 2017-04-07 | 塞乐杰利克斯公司 | 基於聚二醇的固体生物相容性预制剂 |
| AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| ES2972168T3 (es) | 2013-03-28 | 2024-06-11 | Forsight Vision4 Inc | Implante oftálmico para administración de sustancias terapéuticas |
| WO2016011191A1 (en) | 2014-07-15 | 2016-01-21 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
| CA2957548A1 (en) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
| CA2958542C (en) * | 2014-08-18 | 2022-06-28 | Nof Corporation | Cationic lipid for nucleic acid delivery |
| BR112017009660A2 (pt) | 2014-11-10 | 2017-12-19 | Forsight Vision4 Inc | dispositivos de administração de fármacos expansíveis e métodos de utilização |
| WO2017040244A1 (en) | 2015-08-28 | 2017-03-09 | Landec Corporation | Coated substrates and compositions for coating substrates |
| JP6912475B2 (ja) | 2015-11-20 | 2021-08-04 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | 持続放出性薬物送達機器用の多孔質構造体 |
| AR108177A1 (es) | 2016-04-05 | 2018-07-25 | Forsight Vision4 Inc | Dispositivos de suministro de fármacos oculares implantables |
| CN115607358A (zh) | 2017-11-21 | 2023-01-17 | 弗赛特影像4股份有限公司 | 用于可扩展端口递送系统的流体交换装置及使用方法 |
| WO2021211915A1 (en) * | 2020-04-17 | 2021-10-21 | University Of Connecticut | Polycannabinoids, compounds, compositions and methods of use |
| JP7620825B2 (ja) | 2020-10-28 | 2025-01-24 | パナソニックIpマネジメント株式会社 | 芳香徐放性を有する植物繊維含有複合樹脂成形体 |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
Family Cites Families (179)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US44514A (en) | 1864-10-04 | Improved vessel for refrigerating liquids | ||
| US142461A (en) | 1873-09-02 | Charles e | ||
| US3608549A (en) * | 1970-01-15 | 1971-09-28 | Merrill Edward Wilson | Method of administering drugs and capsule therefor |
| US3698549A (en) * | 1971-03-10 | 1972-10-17 | Jacob A Glassman | Packages for small articles |
| CA1170070A (en) | 1981-05-01 | 1984-07-03 | Robert J. Quint | Temperature controlled release composition |
| US4558690A (en) * | 1982-01-26 | 1985-12-17 | University Of Scranton | Method of administration of chemotherapy to tumors |
| NL194389C (nl) | 1984-06-14 | 2002-03-04 | Novartis Ag | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
| GB8417810D0 (en) | 1984-07-12 | 1984-08-15 | Graham N B | Temperature/fluid sensitive devices |
| JPS6242918A (ja) | 1985-08-20 | 1987-02-24 | Kaken Pharmaceut Co Ltd | 持続性製剤 |
| US4830855A (en) * | 1987-11-13 | 1989-05-16 | Landec Labs, Inc. | Temperature-controlled active agent dispenser |
| DE3825211A1 (de) * | 1988-07-25 | 1990-02-01 | Henkel Kgaa | Verbesserte koerperresorbierbare knochenwachse (iii) |
| US5254354A (en) | 1990-12-07 | 1993-10-19 | Landec Corporation | Food package comprised of polymer with thermally responsive permeability |
| US5156911A (en) * | 1989-05-11 | 1992-10-20 | Landec Labs Inc. | Skin-activated temperature-sensitive adhesive assemblies |
| DE69028528T2 (de) * | 1989-05-11 | 1997-04-24 | Landec Corp | Von der temperatur aktivierte bindemitteleinheiten |
| DK469989D0 (da) | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| JP2920956B2 (ja) | 1989-10-06 | 1999-07-19 | 藤沢薬品工業株式会社 | ニルバジピン含有持続性錠剤 |
| US5665822A (en) * | 1991-10-07 | 1997-09-09 | Landec Corporation | Thermoplastic Elastomers |
| US5129180A (en) * | 1990-12-07 | 1992-07-14 | Landec Labs, Inc. | Temperature sensitive seed germination control |
| US5120349A (en) * | 1990-12-07 | 1992-06-09 | Landec Labs, Inc. | Microcapsule having temperature-dependent permeability profile |
| US6524274B1 (en) * | 1990-12-28 | 2003-02-25 | Scimed Life Systems, Inc. | Triggered release hydrogel drug delivery system |
| DE69225586T2 (de) * | 1991-02-12 | 1999-01-28 | Landec Corp., Menlo Park, Calif. | Temperaturzonen spezifische druckempfindliche klebmittelzusammensetzungen, klebmittelgebinde und damit verbundene verfahren zu ihrer benutzung |
| EP0544097A1 (de) * | 1991-10-23 | 1993-06-02 | Boehringer Ingelheim Kg | Halbfeste Mischungen aus Oligomeren und/oder Polymeren auf der Basis von Milchsäure, Verfahren zur deren Herstellung und deren Verwendung als resorbierbare Implantate |
| US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
| US5752926A (en) | 1992-04-29 | 1998-05-19 | Landec Corporation | Orthopedic casts |
| US5429654A (en) | 1992-04-30 | 1995-07-04 | Exxon Research & Engineering Co. | Coated agricultural products |
| US5469867A (en) * | 1992-09-02 | 1995-11-28 | Landec Corporation | Cast-in place thermoplastic channel occluder |
| CA2144449C (en) | 1992-09-28 | 2008-09-09 | Joachim Clauss | Polymer composition |
| US5618911A (en) * | 1993-08-19 | 1997-04-08 | Toyo Boseki Kabushiki Kaisha | Polymer containing lactic acid as its constituting unit and method for producing the same |
| ATE185578T1 (de) | 1993-08-23 | 1999-10-15 | Procter & Gamble | Thermoplastische und elastomere silikonpfropfcopolymere und diese enthaltende haar- und hautpflegemittel |
| PT715638E (pt) | 1993-08-23 | 2000-10-31 | Procter & Gamble | Copolimeros elastomeros termoplasticos enxertados com silicone e composicoes para cuidado do cabelo e pele contendo os mesmos |
| US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| DE4424267C2 (de) * | 1994-07-09 | 1996-07-11 | Hewlett Packard Gmbh | Vorrichtung zur kontinuierlichen Erfassung von Blutparametern |
| US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
| US6255367B1 (en) * | 1995-03-07 | 2001-07-03 | Landec Corporation | Polymeric modifying agents |
| US6831116B2 (en) * | 1995-03-07 | 2004-12-14 | Landec Corporation | Polymeric modifying agents |
| EP1215229B1 (en) | 1995-05-30 | 2007-08-01 | Landec Corporation | Gas permeable membrane |
| US5662711A (en) * | 1995-06-07 | 1997-09-02 | Douglas; William | Flow adjustable artery shunt |
| RU2092161C1 (ru) | 1995-06-23 | 1997-10-10 | Санкт-Петербургская Государственная Химико-Фармацевтическая Академия | Средство с регулируемым высвобождением пентоксифиллина |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US20020114827A1 (en) * | 1995-07-28 | 2002-08-22 | Jie Zhang | Methods and apparatus for improved administration of analgesics |
| FR2739285B1 (fr) | 1995-09-29 | 1997-11-07 | Oreal | Composition pour le traitement des matieres keratiniques comprenant au moins un polymere silicone greffe et au moins un polymere ou copolymere epaississant de (meth)acrylamide ou d'un derive de (meth)acrylamide et ses applications |
| DE19545327C2 (de) | 1995-12-05 | 2001-04-19 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von hydrophobierten resorbierbaren Polyestern und deren Verwendung |
| US5662892A (en) | 1996-03-15 | 1997-09-02 | The Procter & Gamble Company | Personal care compositions containing hydrophobic linear copolymer and hydrophobic, volatile, branched hydrocarbon solvent |
| SE506983C2 (sv) * | 1996-07-02 | 1998-03-09 | Akzo Nobel Nv | Ortoesterbaserad polymer, förfarande för dess framställning och användning därav |
| WO1998011166A1 (en) * | 1996-09-12 | 1998-03-19 | Landec Corporation | Polymer composition comprising a modifying agent |
| US6540984B2 (en) * | 1996-12-12 | 2003-04-01 | Landec Corporation | Aqueous dispersions of crystalline polymers and uses |
| US6199318B1 (en) * | 1996-12-12 | 2001-03-13 | Landec Corporation | Aqueous emulsions of crystalline polymers for coating seeds |
| US5736125A (en) | 1997-01-10 | 1998-04-07 | National Starch And Chemical Investment Holding Corporation | Compositions containing copolymers as a thickening agent |
| US6113883A (en) | 1997-04-25 | 2000-09-05 | The Procter & Gamble Company | Hair styling compositions comprising silicone-containing copolymers |
| US6074628A (en) | 1997-04-25 | 2000-06-13 | Procter & Gamble | Hairspray compositions containing silicon block copolymers |
| US5852117A (en) * | 1997-08-26 | 1998-12-22 | National Starch And Chemical Investment Holding Corporation | Process for making lactide graft copolymers |
| US6583251B1 (en) * | 1997-09-08 | 2003-06-24 | Emory University | Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof |
| US6013293A (en) | 1997-09-10 | 2000-01-11 | Landec Corporation | Packing respiring biological materials with atmosphere control member |
| US5895404A (en) * | 1997-09-29 | 1999-04-20 | Ruiz; Carlos E. | Apparatus and methods for percutaneously forming a passageway between adjacent vessels or portions of a vessel |
| US5945457A (en) * | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
| US6492462B2 (en) | 1998-01-16 | 2002-12-10 | Landec Corporation | Side chain crystalline polymer as rheology modifier for crosslinked polymer |
| US6060540A (en) | 1998-02-13 | 2000-05-09 | Landec Corporation | Modeling pastes |
| FR2774901B1 (fr) | 1998-02-13 | 2002-06-14 | Oreal | Compositions cosmetiques capillaires a base de polymeres cationiques et de polymeres associatifs non ioniques |
| EP1073419A4 (en) | 1998-03-18 | 2009-03-25 | Univ Technology Corp | COMPOSITION, CONTAINING AMORPHOUS POLYMER, FOR DELAYED RELEASE. |
| EP1077763B1 (en) * | 1998-04-27 | 2004-02-11 | The Dow Chemical Company | Encapsulated active materials und process of preparation |
| ATE466603T1 (de) * | 1998-04-27 | 2010-05-15 | Surmodics Inc | Bioaktive wirkstoffe freisetzende beschichtungen |
| US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
| US6730322B1 (en) * | 1998-04-30 | 2004-05-04 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
| GB9811059D0 (en) * | 1998-05-23 | 1998-07-22 | Univ Strathclyde | Polyamino acid vesicles |
| FR2780884B1 (fr) | 1998-07-08 | 2002-07-19 | Oreal | Procede de photostabilisation de filtres solaires derives du dibenzoylmethane, compositions cosmetiques filtrantes photostabilisees ainsi obtenues et leurs utilisations |
| US6548132B1 (en) | 1998-07-23 | 2003-04-15 | Landec Corporation | Packaging biological materials |
| FR2783159B1 (fr) | 1998-09-16 | 2000-11-17 | Oreal | Emulsion comprenant un compose epaississant hydrophile et un copolymere epaississant, compositions comprenant ladite emulsion, et utilisations |
| US6319521B1 (en) * | 1999-02-10 | 2001-11-20 | University Technology Corporation | Microparticles of lactide-co-glycolide copolymers and methods of making and using the same |
| DE19908753C2 (de) | 1999-02-20 | 2003-10-02 | Jenapharm Gmbh | Bioabbaubare, injizierbare Oligomer-Polymer-Zusammensetzung |
| US6297337B1 (en) * | 1999-05-19 | 2001-10-02 | Pmd Holdings Corp. | Bioadhesive polymer compositions |
| US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| US6210724B1 (en) | 1999-08-23 | 2001-04-03 | Landec Corporation | Temperature-responsive containers |
| US6352667B1 (en) * | 1999-08-24 | 2002-03-05 | Absorbable Polymer Technologies, Inc. | Method of making biodegradable polymeric implants |
| US7101928B1 (en) * | 1999-09-17 | 2006-09-05 | Landec Corporation | Polymeric thickeners for oil-containing compositions |
| US6569128B1 (en) * | 1999-09-22 | 2003-05-27 | Advanced Infusion Corporation | Catheter with adjustable flow restrictor |
| US6461631B1 (en) * | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| WO2001042333A2 (en) * | 1999-12-13 | 2001-06-14 | Michigan State University | Process for the preparation of polymers of dimeric cyclic esters |
| US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
| EP1252887A4 (en) | 2000-01-27 | 2009-07-29 | Mitsubishi Tanabe Pharma Corp | PREPARATION WITH EXTENDED RELEASE AND PROCESS FOR THEIR PREPARATION |
| AU1667701A (en) * | 2000-02-10 | 2001-08-16 | Rohm And Haas Company | Bioadhesive composition |
| AU5911101A (en) | 2000-04-19 | 2001-10-30 | Genentech Inc | Sustained release formulations |
| US6679605B2 (en) * | 2000-05-22 | 2004-01-20 | Medennium, Inc. | Crystalline polymeric compositions for ophthalmic devices |
| FR2810239B1 (fr) | 2000-06-15 | 2002-12-20 | Oreal | Composition cosmetique filmogene |
| FR2810238B1 (fr) | 2000-06-15 | 2002-07-19 | Oreal | Composition cosmetique filmogene |
| FR2810237B1 (fr) | 2000-06-15 | 2002-07-26 | Oreal | Composition cosmetique filmogene |
| FR2811887B1 (fr) | 2000-07-18 | 2003-01-31 | Oreal | Procede d'eclaircissement ou de teinture temporaire des cheveux, et dispositif aerosol permettant de mettre en oeuvre ce procede |
| FR2811886B1 (fr) | 2000-07-18 | 2003-01-31 | Oreal | Composition de coiffage des cheveux permettant un remodelage de la coiffure et procede de remodelage de la coiffure utilisant une telle composition |
| US20060286064A1 (en) * | 2000-08-30 | 2006-12-21 | Medivas, Llc | Therapeutic polymers and methods |
| US6858634B2 (en) * | 2000-09-15 | 2005-02-22 | Monsanto Technology Llc | Controlled release formulations and methods for their production and use |
| US8110232B2 (en) | 2000-09-26 | 2012-02-07 | Apio, Inc. | Packaging of bananas |
| US7601374B2 (en) | 2000-09-26 | 2009-10-13 | Landec Corporation | Packaging of respiring biological materials |
| EP1201220A1 (fr) | 2000-10-27 | 2002-05-02 | L'oreal | Compositions cosmétiques ou pharmaceutiques contenant des microcapsules thermostabilisatrices |
| JP2002138033A (ja) | 2000-10-30 | 2002-05-14 | Shiseido Co Ltd | 抗アクネ用皮膚外用剤 |
| DE60126641T2 (de) * | 2000-11-16 | 2008-02-07 | Biocompatibles Uk Ltd., Farnham | Polymere und polymerisationsverfahren |
| US20020106406A1 (en) * | 2000-12-08 | 2002-08-08 | Mchugh Anthony J. | Crystallizable/non-crystallizable polymer composites |
| GB0100761D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| US6656385B2 (en) * | 2001-02-21 | 2003-12-02 | The Procter & Gamble Company | Functionalized cubic liquid crystalline phase materials and methods for their preparation and use |
| DE10113302B4 (de) * | 2001-03-19 | 2009-09-24 | Fraunhofer-Gesellschaft für die angewandte Forschung e.V. | Verfahren zur Herstellung von Homo- und Copolyestern der Milchsäure |
| US20020134012A1 (en) * | 2001-03-21 | 2002-09-26 | Monsanto Technology, L.L.C. | Method of controlling the release of agricultural active ingredients from treated plant seeds |
| US20030039621A1 (en) | 2001-04-10 | 2003-02-27 | L'oreal | Two-coat make-up product, its use and a kit containing the make-up product |
| US6811770B2 (en) | 2001-04-10 | 2004-11-02 | L'oreal | Two-coat make-up process and a make-up kit containing first and second compositions |
| FR2824264B1 (fr) | 2001-05-04 | 2005-11-18 | Oreal | Composition a phase grasse liquide gelifiee par un polymere semi-cristallin |
| FR2824267B1 (fr) | 2001-05-04 | 2008-06-27 | Oreal | Composition cosmetique filmogene |
| US7129276B2 (en) | 2001-05-04 | 2006-10-31 | L'oreal S.A. | Composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer |
| US6967234B2 (en) * | 2002-12-18 | 2005-11-22 | Ethicon, Inc. | Alkyd-lactone copolymers for medical applications |
| US6815181B2 (en) * | 2001-07-09 | 2004-11-09 | Applera Corporation | Nucleic acid molecules encoding human secreted hemopexin-related proteins |
| FR2827160B1 (fr) | 2001-07-16 | 2007-01-26 | Oreal | Composition cosmetique comprenant une dispersion de particules |
| JP2005501831A (ja) * | 2001-08-01 | 2005-01-20 | スミスクライン・ビーチャム・コーポレイション | プロドラッグおよび薬剤デリバリービヒクル |
| US8303651B1 (en) * | 2001-09-07 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric coating for reducing the rate of release of a therapeutic substance from a stent |
| US6951642B2 (en) * | 2001-09-28 | 2005-10-04 | 3M Innovative Properties Company | Water-in-oil emulsions with anionic groups, compositions, and methods |
| GB0125216D0 (en) * | 2001-10-19 | 2001-12-12 | Univ Strathclyde | Dendrimers for use in targeted delivery |
| US20030082217A1 (en) * | 2001-10-25 | 2003-05-01 | Isabelle Afriat | Use of heat-stabilizing microcapsules to improve the activity or penetration of cosmetic or pharmaceutical active principles |
| ES2292834T3 (es) | 2002-01-24 | 2008-03-16 | L'oreal | Composicion que contiene una mezcla de polimeros semi-cristalinos y un aceite volatil. |
| US20040005279A1 (en) | 2002-01-24 | 2004-01-08 | L'oreal | Composition containing a semi-crystalline polymer and methods of use |
| US7255870B2 (en) | 2002-01-24 | 2007-08-14 | L'oreal | Composition containing a semicrystalline polymer, uses thereof, and method for making |
| ATE494010T1 (de) * | 2002-02-27 | 2011-01-15 | Pharmain Corp | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
| US7326426B2 (en) | 2002-03-29 | 2008-02-05 | Ethicon, Inc. | Compositions and medical devices utilizing bioabsorbable liquid polymers |
| US20050191258A1 (en) | 2002-09-06 | 2005-09-01 | L'oreal | Keratin fibre makeup composition combining high solids content with specific adhesion profile |
| US20050188474A1 (en) | 2002-09-06 | 2005-09-01 | L'oreal | Cosmetic keratin fibre care or makeup composition |
| US6964778B1 (en) * | 2002-09-06 | 2005-11-15 | Health Research, Inc. | Temperature controlled content release from liposomes |
| US20050191262A1 (en) | 2002-09-06 | 2005-09-01 | L'oreal | Waxless, non rinsed, cosmetic keratin fibre care or makeup composition |
| US20050172421A1 (en) | 2002-09-06 | 2005-08-11 | L'oreal | Keratin fibre makeup composition combining high solids content with specific rheological profile |
| US7378479B2 (en) * | 2002-09-13 | 2008-05-27 | Lubrizol Advanced Materials, Inc. | Multi-purpose polymers, methods and compositions |
| GB0221941D0 (en) * | 2002-09-20 | 2002-10-30 | Univ Strathclyde | Polysoaps |
| GB0221942D0 (en) * | 2002-09-20 | 2002-10-30 | Univ Strathclyde | Drug delivery |
| FR2848424B1 (fr) | 2002-12-13 | 2006-06-23 | Oreal | Mascara comprenant un polymere filmogene et une phase grasse |
| US6866860B2 (en) * | 2002-12-19 | 2005-03-15 | Ethicon, Inc. | Cationic alkyd polyesters for medical applications |
| US20040120981A1 (en) | 2002-12-20 | 2004-06-24 | Aruna Nathan | Crosslinked alkyd polyesters for medical applications |
| US7993632B2 (en) | 2002-12-20 | 2011-08-09 | L'oreal S.A. | Composition for coating keratin fibres having a threading nature |
| US20040228890A1 (en) | 2003-02-25 | 2004-11-18 | Xavier Blin | Two-coat cosmetic product, its uses, and makeup kit including the product |
| US20040254419A1 (en) * | 2003-04-08 | 2004-12-16 | Xingwu Wang | Therapeutic assembly |
| FR2853505B1 (fr) | 2003-04-11 | 2005-05-20 | Oreal | Ensemble de conditionnement et d'application d'un produit de maquillage et/ou de soin |
| FR2853504B1 (fr) | 2003-04-11 | 2005-05-20 | Oreal | Ensemble de conditionnement et d'application d'un produit de maquillage et/ou de soin |
| FR2857255A1 (fr) | 2003-04-11 | 2005-01-14 | Oreal | Composition cosmetique presentant un profil thermique particulier |
| FR2853528B1 (fr) | 2003-04-11 | 2008-08-29 | Oreal | Composition cosmetique comprenant un polymere filmogene amorphe et presentant un profil thermique particulier |
| UY28326A1 (es) | 2003-05-22 | 2004-06-30 | Osmotica Argentina S A | Dispositivo de ruptura de liberacion controlada con un pasaje preformado |
| US20050008667A1 (en) | 2003-05-28 | 2005-01-13 | L'oreal | Cosmetic compositions for making up and/or caring for skin |
| US7101832B2 (en) | 2003-06-19 | 2006-09-05 | Johnsondiversey, Inc. | Cleaners containing peroxide bleaching agents for cleaning paper making equipment and method |
| US8524256B2 (en) | 2003-06-27 | 2013-09-03 | Air Products And Chemicals, Inc. | Deodorant cosmetic composition comprising at least one semicrystalline polymer |
| FR2858550B1 (fr) | 2003-08-06 | 2007-05-18 | Oreal | Composition de maquillage de matieres keratiniques notamment de fibres keratiniques, comme les cils. |
| US20050249697A1 (en) * | 2003-09-24 | 2005-11-10 | Uhrich Kathryn E | Compositions and methods for the inhibition of bone growth and resorption |
| NZ546992A (en) * | 2003-10-28 | 2009-07-31 | Noven Pharma | Transdermal drug delivery device |
| US20050181049A1 (en) | 2003-11-19 | 2005-08-18 | Dong Liang C. | Composition and method for enhancing bioavailability |
| FR2863879B1 (fr) | 2003-12-19 | 2006-02-03 | Oreal | Composition cosmetique comprenant un agent cationique,un polymere semi-cristallin et une huile et procede de traitement cosmetique |
| US20050261159A1 (en) | 2003-12-19 | 2005-11-24 | Eric Parris | Detergent composition comprising at least one semi-crystalline polymer and at least one oil |
| FR2863889B1 (fr) | 2003-12-22 | 2006-02-10 | Oreal | Composition cosmetique comprenant un azurant optique et un polymere demi cristallin, et procede cosmetique d'eclaicissement mettant en oeuvre cette composition |
| US20050175570A1 (en) | 2004-01-05 | 2005-08-11 | L'oreal | Composition containing a semi-crystalline polymer and a polyvinylpyrrolidone/alpha-olefin copolymer |
| US20050180936A1 (en) | 2004-01-06 | 2005-08-18 | Karl Pays | Keratin fiber make-up composition with long-term stability |
| EP1729741A2 (en) * | 2004-03-03 | 2006-12-13 | Spherics, Inc. | Polymeric drug delivery system for hydrophobic drugs |
| US20060078519A1 (en) | 2004-06-08 | 2006-04-13 | Bertrand Lion | Compositions comprising particles of at least one polymer dispersed in a fatty phase |
| US20050287101A1 (en) | 2004-06-08 | 2005-12-29 | Lebre Caroline | Cosmetic composition comprising at least one semi-crystalline polymer, and at least one ester of dimer diol and of acid |
| US20070183997A9 (en) | 2004-06-08 | 2007-08-09 | Lebre Caroline | Composition comprising particles of at least one polymer dispersed in at least one fatty phase and at least one apolar oil |
| US20050287100A1 (en) | 2004-06-08 | 2005-12-29 | Lebre Caroline | Cosmetic composition comprising a semi-crystalline polymer and a dispersion of polymer in fatty phase |
| US20050287183A1 (en) | 2004-06-08 | 2005-12-29 | Lebre Caroline | Cosmetic composition comprising at least one apolar wax and a dispersion of polymer particles in a fatty phase |
| US20060018948A1 (en) * | 2004-06-24 | 2006-01-26 | Guire Patrick E | Biodegradable implantable medical devices, methods and systems |
| US20060024361A1 (en) | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
| WO2006023130A2 (en) * | 2004-08-12 | 2006-03-02 | Surmodics, Inc. | Biodegradable controlled release bioactive agent delivery device |
| US8211415B2 (en) | 2004-10-13 | 2012-07-03 | L'oreal | Easily removable waterproof cosmetic care and/or makeup composition comprising at least one latex or pseudolatex |
| US20060130248A1 (en) | 2004-12-21 | 2006-06-22 | L'oreal | Easily removable water resistant cosmetic makeup compositions |
| US20060216257A1 (en) | 2005-03-24 | 2006-09-28 | L'oreal | Makeup and/or care kit providing volumizing effect |
| US20060233732A1 (en) | 2005-03-25 | 2006-10-19 | Lezer Nathalie J | Keratin fiber coating composition comprising a continuous aqueous phase and at least one volatile oil |
| CN100453993C (zh) * | 2005-04-29 | 2009-01-21 | 富准精密工业(深圳)有限公司 | 真空密封产品的加速老化方法 |
| FR2885797B1 (fr) | 2005-05-17 | 2007-07-27 | Oreal | Particules d'huile gelifiee comportant au moins un filtre solaire hydrophobe |
| US20060263438A1 (en) | 2005-05-17 | 2006-11-23 | L'oreal | Gelled oil particles for targeting sebaceous glands and/or hair follicles |
| CN101188999B (zh) | 2005-06-03 | 2012-07-18 | 尹格莱特股份有限公司 | 用于递送分散在分散介质中的活性物质的药物传递系统 |
| US20060292222A1 (en) * | 2005-06-21 | 2006-12-28 | Matthew Jonasse | Drug delivery device having zero or near zero-order release kinetics |
| WO2007014246A2 (en) | 2005-07-25 | 2007-02-01 | Michael Migdal | Tooth powdering device |
| US20070023226A1 (en) | 2005-07-26 | 2007-02-01 | Hawash Suheal N | Specialized, tapered bolts for rear axle shafts |
| US20070134310A1 (en) * | 2005-09-23 | 2007-06-14 | Nedberge Diane E | Transdermal risperidone delivery system |
| US20070134192A1 (en) | 2005-12-08 | 2007-06-14 | L'oreal | Two-coat cosmetic product comprising an ester of dimerdilinoleic acid and of polyol(s) |
| US7579429B2 (en) * | 2005-12-16 | 2009-08-25 | Board Of Trustees Of Michigan State University | Cyclic alkyl substituted glycolides and polylactides therefrom |
| US20070259584A1 (en) * | 2006-05-04 | 2007-11-08 | Ronald Whitehouse | Biodegradable polymer composites and related methods |
| EP2036370B1 (en) | 2006-06-08 | 2017-08-09 | LG Electronics Inc. | Method and apparatus for providng and using public transportation information |
| US20090198183A1 (en) * | 2006-11-03 | 2009-08-06 | Krumme John F | Apparatus and methods for injecting dermal fillers |
| WO2008066657A2 (en) | 2006-11-03 | 2008-06-05 | Aesthetic Sciences Corporation | Compositions, devices and methods for modifying soft tissue |
| US20090124996A1 (en) | 2006-11-03 | 2009-05-14 | Scott Heneveld | Apparatus and methods for injecting high viscosity dermal fillers |
| EP2500015A1 (en) * | 2006-12-05 | 2012-09-19 | Landec Corporation | Delivery of drugs |
| US20090124183A1 (en) * | 2007-02-28 | 2009-05-14 | Edgar Carballo | Pneumatic adjustable sanding device |
| EP2231258A1 (en) * | 2007-12-21 | 2010-09-29 | Aesthetic Sciences Corporation | Self-contained pressurized injection device |
-
2008
- 2008-10-10 US US12/287,520 patent/US8114883B2/en not_active Expired - Fee Related
- 2008-12-03 WO PCT/US2008/013335 patent/WO2009073192A2/en not_active Ceased
- 2008-12-03 CA CA2707666A patent/CA2707666A1/en not_active Abandoned
- 2008-12-03 EP EP08857500A patent/EP2229150B1/en not_active Not-in-force
- 2008-12-03 EP EP12169129A patent/EP2502619A3/en not_active Withdrawn
- 2008-12-03 JP JP2010536926A patent/JP2011505420A/ja active Pending
- 2008-12-03 AU AU2008331815A patent/AU2008331815A1/en not_active Abandoned
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2010
- 2010-06-03 IL IL206184A patent/IL206184A0/en unknown
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2012
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|---|---|
| EP2502619A3 (en) | 2012-11-21 |
| US8114883B2 (en) | 2012-02-14 |
| EP2502619A2 (en) | 2012-09-26 |
| US8529922B2 (en) | 2013-09-10 |
| WO2009073192A2 (en) | 2009-06-11 |
| IL206184A0 (en) | 2010-12-30 |
| EP2229150B1 (en) | 2012-07-04 |
| EP2229150A2 (en) | 2010-09-22 |
| JP2011505420A (ja) | 2011-02-24 |
| US20090209558A1 (en) | 2009-08-20 |
| CA2707666A1 (en) | 2009-06-11 |
| US20120142581A1 (en) | 2012-06-07 |
| WO2009073192A3 (en) | 2009-10-22 |
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