AU2008269032B2 - Complexes of IL-15 and IL-15Ralpha and uses thereof - Google Patents

Complexes of IL-15 and IL-15Ralpha and uses thereof Download PDF

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Publication number
AU2008269032B2
AU2008269032B2 AU2008269032A AU2008269032A AU2008269032B2 AU 2008269032 B2 AU2008269032 B2 AU 2008269032B2 AU 2008269032 A AU2008269032 A AU 2008269032A AU 2008269032 A AU2008269032 A AU 2008269032A AU 2008269032 B2 AU2008269032 B2 AU 2008269032B2
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cell
human
nucleic acid
seq
cells
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AU2008269032A1 (en
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Barbara K. Felber
Sergio Finkielsztein
George N. Pavlakis
John N. Vournakis
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Novartis AG
US Department of Health and Human Services
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Novartis AG
Government of the United States of America
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Priority to AU2016206235A priority patent/AU2016206235B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K2039/55511—Organic adjuvants
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
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  • General Engineering & Computer Science (AREA)
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AU2008269032A 2007-06-27 2008-06-27 Complexes of IL-15 and IL-15Ralpha and uses thereof Active AU2008269032B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2013203204A AU2013203204B2 (en) 2007-06-27 2013-04-09 Complexes of il-15 and il-15r.alpha and uses thereof
AU2016206235A AU2016206235B2 (en) 2007-06-27 2016-07-19 Complexes of il-15 and il-15ralpha and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93747107P 2007-06-27 2007-06-27
US60/937,471 2007-06-27
PCT/US2008/008084 WO2009002562A2 (en) 2007-06-27 2008-06-27 Complexes of il-15 and il-15ralpha and uses thereof

Related Child Applications (1)

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AU2013203204A Division AU2013203204B2 (en) 2007-06-27 2013-04-09 Complexes of il-15 and il-15r.alpha and uses thereof

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AU2008269032A1 AU2008269032A1 (en) 2008-12-31
AU2008269032B2 true AU2008269032B2 (en) 2013-12-05

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US (3) US9931377B2 (enExample)
EP (3) EP2724727A1 (enExample)
JP (7) JP2010531878A (enExample)
AU (1) AU2008269032B2 (enExample)
CA (1) CA2691785C (enExample)
DK (1) DK2173378T3 (enExample)
ES (2) ES2716476T3 (enExample)
HK (1) HK1198421A1 (enExample)
IL (1) IL202997A (enExample)
NZ (4) NZ599338A (enExample)
WO (1) WO2009002562A2 (enExample)

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HUE037460T2 (hu) 2005-12-02 2018-08-28 Icahn School Med Mount Sinai Nem-natív felületi fehérjéket prezentáló kiméra Newcastle disease vírusok és alkalmazásuk
CA2636111C (en) 2006-01-13 2018-04-03 The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
EP2160401B1 (en) 2007-05-11 2014-09-24 Altor BioScience Corporation Fusion molecules and il-15 variants
CA2691785C (en) 2007-06-27 2017-01-10 Marine Polymer Technologies Inc. Complexes of il-15 and il-15ralpha and uses thereof
US8871191B2 (en) 2009-08-14 2014-10-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of IL-15 preparations to treat lymphopenia
WO2011032179A1 (en) * 2009-09-14 2011-03-17 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
CN101837123B (zh) * 2010-05-27 2016-05-25 四川大学 肿瘤细胞疫苗及其制备方法
EP3851459B1 (en) 2010-09-21 2024-05-01 Altor BioScience, LLC Multimeric il-15 soluble fusion molecules and methods of making and using same
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EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
LT3401402T (lt) * 2012-06-08 2020-12-28 Alkermes Pharma Ireland Limited Ligandai, modifikuoti cirkuliarinės permutacijos pagalba, kaip agonistai ir antagonistai
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JP6359019B2 (ja) * 2012-10-24 2018-07-18 ノバルティス アーゲー ＩＬ−１５Ｒα型、ＩＬ−１５Ｒα型を発現する細胞、ならびにＩＬ−１５ＲαおよびＩＬ−１５／ＩＬ−１５Ｒα複合体の治療上の使用
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