AU2008256871B2 - Hydroxymethyl substituted RNA oligonucleotides and RNA complexes - Google Patents

Hydroxymethyl substituted RNA oligonucleotides and RNA complexes Download PDF

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Publication number
AU2008256871B2
AU2008256871B2 AU2008256871A AU2008256871A AU2008256871B2 AU 2008256871 B2 AU2008256871 B2 AU 2008256871B2 AU 2008256871 A AU2008256871 A AU 2008256871A AU 2008256871 A AU2008256871 A AU 2008256871A AU 2008256871 B2 AU2008256871 B2 AU 2008256871B2
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rna
oligonucleotide
monomer
monomers
hydroxymethyl
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AU2008256871A1 (en
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Jesper Wengel
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Arcturus Therapeutics Inc
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Arcturus Therapeutics Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3231Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity
    • C12N2320/51Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2008256871A 2007-05-22 2008-05-21 Hydroxymethyl substituted RNA oligonucleotides and RNA complexes Active AU2008256871B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013273719A AU2013273719B2 (en) 2007-05-22 2013-12-19 UNA amidites for therapeutic oligomers

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA200700751 2007-05-22
DKPA200700751 2007-05-22
DKPA200701718 2007-11-30
DKPA200701718 2007-11-30
DKPA200701785 2007-12-14
DKPA200701785 2007-12-14
DKPA200800534 2008-04-11
DKPA200800534 2008-04-11
PCT/US2008/064417 WO2008147824A2 (en) 2007-05-22 2008-05-21 Hydroxymethyl substituted rna oligonucleotides and rna complexes

Related Child Applications (1)

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AU2013273719A Division AU2013273719B2 (en) 2007-05-22 2013-12-19 UNA amidites for therapeutic oligomers

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AU2008256871A1 AU2008256871A1 (en) 2008-12-04
AU2008256871B2 true AU2008256871B2 (en) 2013-09-19

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US (6) US8314227B2 (cg-RX-API-DMAC7.html)
EP (2) EP3045535B1 (cg-RX-API-DMAC7.html)
JP (2) JP5726520B2 (cg-RX-API-DMAC7.html)
KR (2) KR101750640B1 (cg-RX-API-DMAC7.html)
CN (2) CN101679978B (cg-RX-API-DMAC7.html)
AU (1) AU2008256871B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0811170B8 (cg-RX-API-DMAC7.html)
CA (1) CA2687850C (cg-RX-API-DMAC7.html)
DK (1) DK2162538T3 (cg-RX-API-DMAC7.html)
ES (1) ES2573936T3 (cg-RX-API-DMAC7.html)
IL (1) IL202040A (cg-RX-API-DMAC7.html)
MX (1) MX2009012568A (cg-RX-API-DMAC7.html)
MY (1) MY153691A (cg-RX-API-DMAC7.html)
NZ (1) NZ580712A (cg-RX-API-DMAC7.html)
PL (1) PL2162538T3 (cg-RX-API-DMAC7.html)
WO (1) WO2008147824A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200907529B (cg-RX-API-DMAC7.html)

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