AU2008222757B2 - Transdermal analyte monitoring systems and methods for analyte detection - Google Patents
Transdermal analyte monitoring systems and methods for analyte detection Download PDFInfo
- Publication number
- AU2008222757B2 AU2008222757B2 AU2008222757A AU2008222757A AU2008222757B2 AU 2008222757 B2 AU2008222757 B2 AU 2008222757B2 AU 2008222757 A AU2008222757 A AU 2008222757A AU 2008222757 A AU2008222757 A AU 2008222757A AU 2008222757 B2 AU2008222757 B2 AU 2008222757B2
- Authority
- AU
- Australia
- Prior art keywords
- hydrogel
- sensor
- monitoring system
- analyte monitoring
- transdermal analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000012491 analyte Substances 0.000 title claims description 69
- 238000000034 method Methods 0.000 title claims description 62
- 238000012544 monitoring process Methods 0.000 title claims description 43
- 238000001514 detection method Methods 0.000 title claims description 16
- 239000000017 hydrogel Substances 0.000 claims description 135
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 108
- 239000008103 glucose Substances 0.000 claims description 108
- 239000012528 membrane Substances 0.000 claims description 72
- 239000003906 humectant Substances 0.000 claims description 60
- 239000008280 blood Substances 0.000 claims description 44
- 210000004369 blood Anatomy 0.000 claims description 40
- 108090000790 Enzymes Proteins 0.000 claims description 34
- 102000004190 Enzymes Human genes 0.000 claims description 34
- 229920001223 polyethylene glycol Polymers 0.000 claims description 33
- 239000000758 substrate Substances 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 24
- 239000001301 oxygen Substances 0.000 claims description 24
- 229910052760 oxygen Inorganic materials 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 24
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000003153 chemical reaction reagent Substances 0.000 claims description 15
- 230000001965 increasing effect Effects 0.000 claims description 15
- 229920000936 Agarose Polymers 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 6
- 239000002953 phosphate buffered saline Substances 0.000 claims description 6
- 239000000344 soap Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 125000004386 diacrylate group Chemical group 0.000 claims description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 4
- 230000006854 communication Effects 0.000 claims description 4
- FQCSIUSICFAMDD-UHFFFAOYSA-N 2-oxopyrrolidine-1-carboxylic acid;sodium Chemical group [Na].OC(=O)N1CCCC1=O FQCSIUSICFAMDD-UHFFFAOYSA-N 0.000 claims description 3
- 108090000854 Oxidoreductases Proteins 0.000 claims description 3
- 102000004316 Oxidoreductases Human genes 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000003049 inorganic solvent Substances 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- 230000035699 permeability Effects 0.000 claims description 3
- 238000002679 ablation Methods 0.000 claims description 2
- 238000005299 abrasion Methods 0.000 claims description 2
- 238000004520 electroporation Methods 0.000 claims description 2
- 238000000608 laser ablation Methods 0.000 claims description 2
- 239000004745 nonwoven fabric Substances 0.000 claims description 2
- 239000002759 woven fabric Substances 0.000 claims description 2
- RLLPVAHGXHCWKJ-IEBWSBKVSA-N (3-phenoxyphenyl)methyl (1s,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-IEBWSBKVSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 description 32
- 239000004366 Glucose oxidase Substances 0.000 description 29
- 229940088598 enzyme Drugs 0.000 description 29
- 229940116332 glucose oxidase Drugs 0.000 description 29
- 235000019420 glucose oxidase Nutrition 0.000 description 29
- 229920000557 Nafion® Polymers 0.000 description 20
- 229920006393 polyether sulfone Polymers 0.000 description 20
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 18
- 108091006146 Channels Proteins 0.000 description 17
- 238000002360 preparation method Methods 0.000 description 17
- 229920001477 hydrophilic polymer Polymers 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 206010012601 diabetes mellitus Diseases 0.000 description 14
- 239000000463 material Substances 0.000 description 14
- -1 poly(o-phenylenediamine) Polymers 0.000 description 14
- 229920000671 polyethylene glycol diacrylate Polymers 0.000 description 14
- 239000011148 porous material Substances 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 238000006116 polymerization reaction Methods 0.000 description 10
- 230000001681 protective effect Effects 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 238000000576 coating method Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 7
- 125000000524 functional group Chemical group 0.000 description 7
- 150000004676 glycans Chemical class 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 7
- 229920001282 polysaccharide Polymers 0.000 description 7
- 239000005017 polysaccharide Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 230000004907 flux Effects 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 230000037067 skin hydration Effects 0.000 description 6
- 150000003384 small molecules Chemical class 0.000 description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229920002674 hyaluronan Polymers 0.000 description 5
- 229960003160 hyaluronic acid Drugs 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 238000007619 statistical method Methods 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000000679 carrageenan Substances 0.000 description 4
- 229920001525 carrageenan Polymers 0.000 description 4
- 235000010418 carrageenan Nutrition 0.000 description 4
- 229940113118 carrageenan Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 238000006213 oxygenation reaction Methods 0.000 description 4
- 239000001540 sodium lactate Substances 0.000 description 4
- 235000011088 sodium lactate Nutrition 0.000 description 4
- 229940005581 sodium lactate Drugs 0.000 description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000007822 coupling agent Substances 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 229940001447 lactate Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229920005615 natural polymer Polymers 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 description 2
- BDNKZNFMNDZQMI-UHFFFAOYSA-N 1,3-diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 2
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 description 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 2
- 208000035874 Excoriation Diseases 0.000 description 2
- 108090000862 Ion Channels Proteins 0.000 description 2
- 102000004310 Ion Channels Human genes 0.000 description 2
- 229920002873 Polyethylenimine Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 229940064804 betadine Drugs 0.000 description 2
- AFYNADDZULBEJA-UHFFFAOYSA-N bicinchoninic acid Chemical compound C1=CC=CC2=NC(C=3C=C(C4=CC=CC=C4N=3)C(=O)O)=CC(C(O)=O)=C21 AFYNADDZULBEJA-UHFFFAOYSA-N 0.000 description 2
- 239000000227 bioadhesive Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 150000001718 carbodiimides Chemical class 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000021615 conjugation Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- BGRWYRAHAFMIBJ-UHFFFAOYSA-N diisopropylcarbodiimide Natural products CC(C)NC(=O)NC(C)C BGRWYRAHAFMIBJ-UHFFFAOYSA-N 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 229940031575 hydroxyethyl urea Drugs 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002357 osmotic agent Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 239000004627 regenerated cellulose Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000007614 solvation Methods 0.000 description 2
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- LLXVXPPXELIDGQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate Chemical compound C=1C=CC(N2C(C=CC2=O)=O)=CC=1C(=O)ON1C(=O)CCC1=O LLXVXPPXELIDGQ-UHFFFAOYSA-N 0.000 description 1
- PVGATNRYUYNBHO-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O PVGATNRYUYNBHO-UHFFFAOYSA-N 0.000 description 1
- GKSPIZSKQWTXQG-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate Chemical compound C=1C=C(C(=O)ON2C(CCC2=O)=O)C=CC=1C(C)SSC1=CC=CC=N1 GKSPIZSKQWTXQG-UHFFFAOYSA-N 0.000 description 1
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- AASYSXRGODIQGY-UHFFFAOYSA-N 1-[1-(2,5-dioxopyrrol-1-yl)hexyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C(CCCCC)N1C(=O)C=CC1=O AASYSXRGODIQGY-UHFFFAOYSA-N 0.000 description 1
- FPKVOQKZMBDBKP-UHFFFAOYSA-N 1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 FPKVOQKZMBDBKP-UHFFFAOYSA-N 0.000 description 1
- YRJADZYFKNSORZ-UHFFFAOYSA-N 2-[(2-methylphenyl)disulfanyl]pyridine Chemical compound CC1=CC=CC=C1SSC1=CC=CC=N1 YRJADZYFKNSORZ-UHFFFAOYSA-N 0.000 description 1
- JMUAKWNHKQBPGJ-UHFFFAOYSA-N 3-(pyridin-2-yldisulfanyl)-n-[4-[3-(pyridin-2-yldisulfanyl)propanoylamino]butyl]propanamide Chemical compound C=1C=CC=NC=1SSCCC(=O)NCCCCNC(=O)CCSSC1=CC=CC=N1 JMUAKWNHKQBPGJ-UHFFFAOYSA-N 0.000 description 1
- HCZBMENVWKFZDJ-UHFFFAOYSA-N 3-trimethylsilylpropane-1-thiol Chemical compound C[Si](C)(C)CCCS HCZBMENVWKFZDJ-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N 5-oxoproline Chemical compound OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 244000186140 Asperula odorata Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000008526 Galium odoratum Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101000945318 Homo sapiens Calponin-1 Proteins 0.000 description 1
- 101000652736 Homo sapiens Transgelin Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 241001415846 Procellariidae Species 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 102100031013 Transgelin Human genes 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001299 aldehydes Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000014117 bile duct papillary neoplasm Diseases 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000009141 biological interaction Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229910021393 carbon nanotube Inorganic materials 0.000 description 1
- 239000002041 carbon nanotube Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000003411 electrode reaction Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229910021397 glassy carbon Inorganic materials 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- SJXULIRYGQTEJK-UHFFFAOYSA-N n'-(2-morpholin-4-ylethyl)methanediimine Chemical compound N=C=NCCN1CCOCC1 SJXULIRYGQTEJK-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 229920000962 poly(amidoamine) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920000128 polypyrrole Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- ULARYIUTHAWJMU-UHFFFAOYSA-M sodium;1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O ULARYIUTHAWJMU-UHFFFAOYSA-M 0.000 description 1
- VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 1
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000006163 transport media Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Computer Networks & Wireless Communication (AREA)
- Hematology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89356307P | 2007-03-07 | 2007-03-07 | |
| US60/893,563 | 2007-03-07 | ||
| PCT/US2008/056032 WO2008109739A1 (en) | 2007-03-07 | 2008-03-06 | Transdermal analyte monitoring systems and methods for analyte detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008222757A1 AU2008222757A1 (en) | 2008-09-12 |
| AU2008222757B2 true AU2008222757B2 (en) | 2011-06-09 |
Family
ID=39639050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008222757A Ceased AU2008222757B2 (en) | 2007-03-07 | 2008-03-06 | Transdermal analyte monitoring systems and methods for analyte detection |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8812071B2 (https=) |
| EP (1) | EP2124723A1 (https=) |
| JP (3) | JP5508861B2 (https=) |
| KR (2) | KR101318087B1 (https=) |
| CN (1) | CN101707875B (https=) |
| AU (1) | AU2008222757B2 (https=) |
| CA (1) | CA2680213C (https=) |
| NZ (1) | NZ580179A (https=) |
| RU (1) | RU2444980C2 (https=) |
| WO (1) | WO2008109739A1 (https=) |
| ZA (1) | ZA200906959B (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9788771B2 (en) | 2006-10-23 | 2017-10-17 | Abbott Diabetes Care Inc. | Variable speed sensor insertion devices and methods of use |
| US7697967B2 (en) | 2005-12-28 | 2010-04-13 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
| US11298058B2 (en) | 2005-12-28 | 2022-04-12 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) * | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US20100198034A1 (en) | 2009-02-03 | 2010-08-05 | Abbott Diabetes Care Inc. | Compact On-Body Physiological Monitoring Devices and Methods Thereof |
| EP4252648A3 (en) | 2009-07-23 | 2024-01-03 | Abbott Diabetes Care Inc. | Continuous analyte measurement systems and systems and methods for implanting them |
| US20120252046A1 (en) * | 2009-12-17 | 2012-10-04 | Bayer Healthcare Llc | Transdermal systems, devices, and methods for biological analysis |
| WO2011075575A1 (en) | 2009-12-17 | 2011-06-23 | Bayer Healthcare Llc | Transdermal systems, devices, and methods to optically analyze an analyte |
| AT509355B1 (de) * | 2010-02-10 | 2012-04-15 | Univ Graz Tech | Testanordnung |
| US20130072768A1 (en) * | 2010-02-19 | 2013-03-21 | Barry Colin Crane | Intravascular glucose sensor |
| AU2011217067A1 (en) * | 2010-02-19 | 2012-09-06 | Lightship Medical Limited | Subcutaneous glucose sensor |
| DK3622883T3 (da) | 2010-03-24 | 2021-07-19 | Abbott Diabetes Care Inc | Indførerer til medicinsk indretning og fremgangsmåder til at indføre og anvende medicinske indretninger |
| US8702928B2 (en) * | 2010-11-22 | 2014-04-22 | Abbott Diabetes Care Inc. | Modular analyte measurement system with extendable strip port |
| CN101999931B (zh) * | 2010-12-10 | 2012-11-14 | 上海导向医疗系统有限公司 | 一种覆盖可膨胀水凝胶的冷热消融探针壳体及其制备方法 |
| PL2697388T3 (pl) | 2011-03-28 | 2015-11-30 | Hoffmann La Roche | Ulepszona warstwa dyfuzyjna dla czujnika enzymatycznego in-vivo |
| US9474451B2 (en) * | 2011-04-01 | 2016-10-25 | Raba Equity Partners Ii, Llc | Systems and methods for varying blood flow to identify autoregulatory ranges in a patient |
| US9861293B2 (en) * | 2011-04-28 | 2018-01-09 | Myolex Inc. | Sensors, including disposable sensors, for measuring tissue |
| FI3300658T3 (fi) | 2011-12-11 | 2024-03-01 | Abbott Diabetes Care Inc | Analyyttianturimenetelmiä |
| RU2611038C2 (ru) * | 2012-03-27 | 2017-02-20 | Ф.Хоффманн-Ля Рош Аг | Улучшенная спейсерная мембрана для ферментного датчика in vivo |
| US9121050B2 (en) | 2013-03-15 | 2015-09-01 | American Sterilizer Company | Non-enzyme based detection method for electronic monitoring of biological indicator |
| US8858884B2 (en) | 2013-03-15 | 2014-10-14 | American Sterilizer Company | Coupled enzyme-based method for electronic monitoring of biological indicator |
| RU2580288C2 (ru) * | 2013-04-29 | 2016-04-10 | Общество С Ограниченной Ответственностью "Русенс" | Способ изготовления микробиосенсора для определения глюкозы или лактата |
| WO2014198868A1 (en) * | 2013-06-13 | 2014-12-18 | Koninklijke Philips N.V. | Device and method for determining a partial carbon dioxide pressure in a subject of interest |
| US9750445B2 (en) | 2013-06-28 | 2017-09-05 | Verily Life Sciences Llc | Porous polymeric formulation prepared using porogens |
| US9441258B2 (en) | 2013-06-28 | 2016-09-13 | Verily Life Sciences LLP | Enzyme immobilization by crosslinking |
| US9617578B2 (en) * | 2013-12-06 | 2017-04-11 | Verily Life Sciences Llc | Sensor membrane with low temperature coefficient |
| US9354195B2 (en) * | 2013-12-12 | 2016-05-31 | Intel Corporation | Highly selective coated-electrode nanogap transducers for the detection of redox molecules |
| US9855359B2 (en) | 2013-12-23 | 2018-01-02 | Verily Life Sciences Llc | Analyte sensors with ethylene oxide immunity |
| WO2015123346A1 (en) * | 2014-02-11 | 2015-08-20 | The Board Of Trustees Of The Leland Stanford Junior University | Rapid small volume detection of blood ammonia |
| WO2016036944A1 (en) * | 2014-09-03 | 2016-03-10 | Echo Therapeutics, Inc. | Transdermal analyte monitoring systems corrected for on-skin and break-in currents |
| AU2016260547B2 (en) | 2015-05-14 | 2020-09-03 | Abbott Diabetes Care Inc. | Compact medical device inserters and related systems and methods |
| US20170087272A1 (en) * | 2015-07-22 | 2017-03-30 | Hans P.I. Claesson | Collagen based materials and methods of using them |
| RU2679887C2 (ru) * | 2015-12-14 | 2019-02-14 | Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации | Способ получения материалов для высокогидрофильного покрытия гемосовместимых мембран |
| US20190067725A1 (en) * | 2016-02-26 | 2019-02-28 | Case Western Reserve University | Composite membranes for flow batteries |
| EP3275362B1 (de) * | 2016-07-28 | 2022-12-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zur überwachung eines zustands eines lebewesens |
| RU2672354C2 (ru) * | 2016-11-09 | 2018-11-14 | Общество с ограниченной ответственностью "БЕТА-ТЕХ" | Способ непрерывного мониторинга содержания аналита в крови |
| KR101885631B1 (ko) | 2016-12-30 | 2018-08-06 | (주)파이버피아 | 혈중 암모니아 모니터링을 위한 실시간 모니터링 시스템 및 그 방법 |
| CA3050721A1 (en) | 2017-01-23 | 2018-07-26 | Abbott Diabetes Care Inc. | Systems, devices and methods for analyte sensor insertion |
| GB2559627A (en) * | 2017-02-14 | 2018-08-15 | Ndm Tech Ltd | Device |
| EP3619531A4 (en) * | 2017-05-04 | 2020-05-06 | Siemens Healthcare Diagnostics Inc. | BIOSENSORS FROM ENZYMES WITH REDUCED SOLUBILITY AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| CN107014877B (zh) * | 2017-05-27 | 2023-06-20 | 北京怡唐生物科技有限公司 | 一种动态连续血糖监测系统 |
| CN119924827A (zh) | 2018-06-07 | 2025-05-06 | 雅培糖尿病护理公司 | 用于分析物监测系统的聚焦灭菌和已灭菌的子组件 |
| CN113195022A (zh) | 2018-12-21 | 2021-07-30 | 雅培糖尿病护理公司 | 用于分析物传感器插入的系统、装置和方法 |
| CN109646801B (zh) * | 2019-01-23 | 2024-12-10 | 深圳市明唐通信有限公司 | 一种兼容水分检测和rf射频的电路及美容仪 |
| JP7220598B2 (ja) * | 2019-03-15 | 2023-02-10 | 本田技研工業株式会社 | 生体情報測定センサ、生体情報測定装置及び生体情報測定方法 |
| CN111248924B (zh) * | 2019-06-24 | 2023-04-25 | 深圳硅基传感科技有限公司 | 葡萄糖监测探头的工作电极及其制作方法 |
| US11819339B2 (en) * | 2019-07-01 | 2023-11-21 | Nanowear Inc. | Thermosensitive nanosensor for instantaneous transcutaneous biological measurement |
| US12575774B2 (en) * | 2020-05-13 | 2026-03-17 | Welch Allyn, Inc. | Hydrogel pad |
| RU2736504C1 (ru) * | 2020-05-22 | 2020-11-17 | Общество с ограниченной ответственностью "ВЕК ПРОМ" | Система энхансеров трансдермального переноса и косметические композиции на ее основе |
| CA3188510A1 (en) | 2020-08-31 | 2022-03-03 | Vivek S. RAO | Systems, devices, and methods for analyte sensor insertion |
| CA3186905A1 (en) | 2020-09-15 | 2022-03-24 | Abbott Diabetes Care Inc. | Systems, devices, and methods for an analyte sensor |
| US12569168B2 (en) | 2020-09-15 | 2026-03-10 | Abbott Diabetes Care Inc. | Systems, devices, and methods for analyte monitoring |
| US20240366353A1 (en) * | 2021-04-29 | 2024-11-07 | Shear Kershman Laboratories, Inc. | Two Phase System to Administer a Dose of an Active to Animals |
| US20220397545A1 (en) * | 2021-06-15 | 2022-12-15 | Laxmi Therapeutic Devices, Inc. | Photochemical-based method for enzyme immobilization on biosensor electrodes |
| CN114874975B (zh) * | 2022-05-09 | 2024-04-19 | 中山大学附属第七医院(深圳) | 一种利用弹性蛋白水凝胶培养类器官的方法 |
| JP7782692B2 (ja) * | 2022-06-10 | 2025-12-09 | 株式会社村田製作所 | 光センサ及び検出装置 |
| CN117100328A (zh) * | 2023-10-25 | 2023-11-24 | 南京师范大学 | 一种皮肤持久性有机污染物自动采样装置及自动采样方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405366A (en) * | 1991-11-12 | 1995-04-11 | Nepera, Inc. | Adhesive hydrogels having extended use lives and process for the preparation of same |
| WO2000009203A1 (en) * | 1998-08-17 | 2000-02-24 | Minnesota Mining And Manufacturing Company | Electrodes |
| US20060094944A1 (en) * | 2004-10-28 | 2006-05-04 | Sontra Medical Corporation | System and method for analyte sampling and analysis with error correction |
Family Cites Families (194)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551554A (en) | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
| US3711606A (en) | 1970-09-02 | 1973-01-16 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active steroidal agents with dmso |
| US3711602A (en) | 1970-10-30 | 1973-01-16 | Crown Zellerbach Corp | Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso |
| US4002221A (en) | 1972-09-19 | 1977-01-11 | Gilbert Buchalter | Method of transmitting ultrasonic impulses to surface using transducer coupling agent |
| US3828769A (en) | 1973-02-28 | 1974-08-13 | H Mettler | Method and apparatus for ultrasonic treatment of lower tissues simultaneous with heating of subcutaneous, outer muscle and lower tissues |
| SU445433A1 (ru) | 1973-03-22 | 1974-10-05 | Центральный Научно-Исследовательский Институт Курортологии И Физиотерапии | Способ физиотерапевтического лечени больных с заболевани ми опорно-двигательного аппарата обменного характера |
| SU506421A1 (ru) | 1974-08-06 | 1978-03-05 | Московское Ордена Ленина И Ордена Трудового Красного Знамени Высшее Техническое Училище Имени Н.Э.Баумана | Способ лечени инфицированных ран |
| US4020830A (en) | 1975-03-12 | 1977-05-03 | The University Of Utah | Selective chemical sensitive FET transducers |
| US4144646A (en) | 1975-12-05 | 1979-03-20 | Lion Hamigaki Kabushiki Kaisha | Torsional ultrasonic vibrators |
| US4127125A (en) | 1975-12-22 | 1978-11-28 | Lion Hamigaki Kabushiki Kaisha | Devices for transmitting ultrasonic waves to teeth |
| SU556805A1 (ru) | 1976-01-23 | 1977-05-05 | Каунасский Медицинский Институт | Способ введени лекарственных веществ |
| US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
| CA1083040A (en) | 1976-02-09 | 1980-08-05 | Mostafa Fahim | Topical application of medication by ultrasound with coupling agent |
| SU591186A1 (ru) | 1976-07-23 | 1978-02-05 | Serov Vilenin Nikolaevich | Устройство дл лечени заболеваний глаз |
| DE2756460A1 (de) | 1977-12-17 | 1979-06-21 | Fraunhofer Ges Forschung | Verfahren zur lokal begrenzten applikation von therpeutika durch die oberflaeche von lebenden koerpern oder koerperorganen |
| US4176664A (en) | 1978-03-13 | 1979-12-04 | Stanley Kalish | Impregnated bandage |
| US4280494A (en) | 1979-06-26 | 1981-07-28 | Cosgrove Robert J Jun | System for automatic feedback-controlled administration of drugs |
| US4249531A (en) | 1979-07-05 | 1981-02-10 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
| SU910157A1 (ru) | 1980-02-29 | 1982-03-07 | Московское Ордена Ленина,Ордена Трудового Красного Знамени Высшее Техническое Училище Им.Баумана | Способ лечени инфицированных ран |
| CA1165240A (en) | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| US4372296A (en) | 1980-11-26 | 1983-02-08 | Fahim Mostafa S | Treatment of acne and skin disorders and compositions therefor |
| US4457748A (en) | 1982-01-11 | 1984-07-03 | Medtronic, Inc. | Non-invasive diagnosis method |
| US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
| US4563184A (en) | 1983-10-17 | 1986-01-07 | Bernard Korol | Synthetic resin wound dressing and method of treatment using same |
| US4557943A (en) | 1983-10-31 | 1985-12-10 | Advanced Semiconductor Materials America, Inc. | Metal-silicide deposition using plasma-enhanced chemical vapor deposition |
| US4646725A (en) | 1983-11-16 | 1987-03-03 | Manoutchehr Moasser | Method for treating herpes lesions and other infectious skin conditions |
| US4605670A (en) | 1984-02-01 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering metoclopramide |
| DK8601218A (https=) | 1984-07-18 | 1986-03-17 | ||
| US4732153A (en) | 1984-07-18 | 1988-03-22 | Michael Phillips | Transdermal dosimeter |
| US4657543A (en) | 1984-07-23 | 1987-04-14 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
| US4779806A (en) | 1984-07-23 | 1988-10-25 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
| US4834978A (en) | 1984-10-01 | 1989-05-30 | Biotek, Inc. | Method of transdermal drug delivery |
| US4680268A (en) * | 1985-09-18 | 1987-07-14 | Children's Hospital Medical Center | Implantable gas-containing biosensor and method for measuring an analyte such as glucose |
| US4698058A (en) | 1985-10-15 | 1987-10-06 | Albert R. Greenfeld | Ultrasonic self-cleaning catheter system for indwelling drains and medication supply |
| US4683242A (en) | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| DE246341T1 (de) | 1986-05-20 | 1989-03-30 | Massachusetts Institute Of Technology, Cambridge, Mass. | Bioerodierbare erzeugnisse zur verwendung als implantate oder prothese mit einem voraussehbaren resorbierungsgrad. |
| GB8612861D0 (en) | 1986-05-27 | 1986-07-02 | Cambridge Life Sciences | Immobilised enzyme biosensors |
| US4981779A (en) | 1986-06-26 | 1991-01-01 | Becton, Dickinson And Company | Apparatus for monitoring glucose |
| US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
| US4948587A (en) | 1986-07-08 | 1990-08-14 | Massachusetts Institute Of Technology | Ultrasound enhancement of transbuccal drug delivery |
| JPS6336172A (ja) | 1986-07-29 | 1988-02-16 | Toshiba Corp | 超音波カプラ |
| US4863970A (en) | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
| JPS63132889A (ja) | 1986-11-21 | 1988-06-04 | Tanabe Seiyaku Co Ltd | キナゾリノン誘導体 |
| US4786277A (en) | 1986-11-21 | 1988-11-22 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation |
| JPS63135179A (ja) | 1986-11-26 | 1988-06-07 | 立花 俊郎 | 薬物の経皮投与具 |
| US5001051A (en) | 1986-12-12 | 1991-03-19 | Regents Of The University Of California | Dose critical in-vivo detection of anti-cancer drug levels in blood |
| US5006342A (en) | 1986-12-22 | 1991-04-09 | Cygnus Corporation | Resilient transdermal drug delivery device |
| EP0278599A3 (en) | 1987-02-02 | 1988-12-07 | Seiko Epson Corporation | Photographic transfer type image forming apparatus |
| US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| US4780212A (en) | 1987-07-31 | 1988-10-25 | Massachusetts Institute Of Technology | Ultrasound enchancement of membrane permeability |
| US4821733A (en) | 1987-08-18 | 1989-04-18 | Dermal Systems International | Transdermal detection system |
| US4820720A (en) | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
| US4805623A (en) | 1987-09-04 | 1989-02-21 | Vander Corporation | Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment |
| JPH01140054A (ja) | 1987-11-26 | 1989-06-01 | Nec Corp | グルコースセンサ |
| EP0398960B1 (en) | 1988-01-21 | 1995-12-06 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| JP2907342B2 (ja) | 1988-01-29 | 1999-06-21 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | イオン滲透非侵襲的サンプリングまたは送出装置 |
| US5362307A (en) | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| US4866050A (en) | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
| US5078144A (en) | 1988-08-19 | 1992-01-07 | Olympus Optical Co. Ltd. | System for applying ultrasonic waves and a treatment instrument to a body part |
| US5076273A (en) | 1988-09-08 | 1991-12-31 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
| EP0363504A1 (en) | 1988-10-10 | 1990-04-18 | Dräger Nederland B.V. | Method of providing a substrate with a layer comprising a polyvinylbased hydrogel and a biochemically active material |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5250419A (en) | 1988-12-16 | 1993-10-05 | L'oreal | Method for the direct measurement of at least one chemical parameter of skin using a biosensor |
| US5086229A (en) | 1989-01-19 | 1992-02-04 | Futrex, Inc. | Non-invasive measurement of blood glucose |
| US4933062A (en) | 1989-03-07 | 1990-06-12 | University Of Connecticut | Modified composite electrodes with renewable surface for electrochemical applications and method of making same |
| US4953552A (en) | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
| US5118404A (en) | 1989-04-28 | 1992-06-02 | Nec Corporation | Enzyme electrode and a method of determining concentration of an analyte in a sample solution |
| EP0396788A1 (en) | 1989-05-08 | 1990-11-14 | Dräger Nederland B.V. | Process and sensor for measuring the glucose content of glucosecontaining fluids |
| US5139023A (en) | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
| US5069908A (en) | 1989-06-19 | 1991-12-03 | Henley International, Inc. | Crosslinked hydrogel and method for making same |
| US5120544A (en) | 1989-06-19 | 1992-06-09 | Henley International, Inc. | Crosslinked hydrogel and method for making same |
| US4986271A (en) | 1989-07-19 | 1991-01-22 | The University Of New Mexico | Vivo refillable glucose sensor |
| US5050604A (en) | 1989-10-16 | 1991-09-24 | Israel Reshef | Apparatus and method for monitoring the health condition of a subject |
| US5140985A (en) | 1989-12-11 | 1992-08-25 | Schroeder Jon M | Noninvasive blood glucose measuring device |
| US5016615A (en) | 1990-02-20 | 1991-05-21 | Riverside Research Institute | Local application of medication with ultrasound |
| US5115805A (en) | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
| US5231975A (en) | 1990-02-23 | 1993-08-03 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
| CA2196746A1 (en) | 1990-02-23 | 1991-08-24 | The Regents Of The University Of California | Ultrasound-enhanced delivery of materials through the skin |
| US5161532A (en) | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
| US5165407A (en) | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
| US5119819A (en) | 1990-05-02 | 1992-06-09 | Miles Inc. | Method and apparatus for non-invasive monitoring of blood glucose |
| EP0533816B1 (en) | 1990-06-15 | 1995-06-14 | Cortrak Medical, Inc. | Drug delivery apparatus |
| US5197946A (en) | 1990-06-27 | 1993-03-30 | Shunro Tachibana | Injection instrument with ultrasonic oscillating element |
| US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| WO1992006701A1 (en) | 1990-10-18 | 1992-04-30 | Huffstutler, M., Conrad, Jr. | Preparation of concentrated fluid symphytum extracts, therapeutic forms and methods of use |
| JP2646848B2 (ja) | 1990-11-30 | 1997-08-27 | 日本電気株式会社 | グルコースセンサの測定方法 |
| DK0568651T3 (da) | 1991-02-01 | 2002-08-05 | Massachusetts Inst Technology | Bionedbrydelige polymerblandinger til afgivelse af lægemidler |
| AU1442592A (en) | 1991-02-20 | 1992-09-15 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| US5135753A (en) | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| ATE146073T1 (de) | 1991-03-22 | 1996-12-15 | Katsuro Tachibana | Verstärker zur ultraschalltherapie von erkrankungen sowie diesen enthaltende flüssige arzneimittelzusammensetzungen |
| JP2684871B2 (ja) | 1991-05-16 | 1997-12-03 | 日本電気株式会社 | 体液成分測定方法および測定装置 |
| JP3181071B2 (ja) | 1991-06-28 | 2001-07-03 | 俊郎 立花 | 血液処理装置 |
| US5171215A (en) | 1991-08-22 | 1992-12-15 | Flanagan Dennis F | Endermic method and apparatus |
| US5215520A (en) | 1991-09-17 | 1993-06-01 | Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) | Method for delivering an active substance topically or percutaneously |
| US5230334A (en) | 1992-01-22 | 1993-07-27 | Summit Technology, Inc. | Method and apparatus for generating localized hyperthermia |
| WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
| US5165418B1 (en) | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
| US5405614A (en) | 1992-04-08 | 1995-04-11 | International Medical Associates, Inc. | Electronic transdermal drug delivery system |
| NL9200731A (nl) | 1992-04-22 | 1993-11-16 | Jacob Korf | Werkwijze en inrichting voor het niet-invasief bewaken van de concentratie van stoffen in bloed. |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| JPH0670987A (ja) | 1992-08-28 | 1994-03-15 | Katsuro Tachibana | 薬物投与・体液採取ユニット及び装置 |
| ATE189736T1 (de) | 1992-09-09 | 2000-02-15 | Clock Spring Company L P | Verfahren zur reparatur von rohren |
| TW259806B (https=) | 1992-09-16 | 1995-10-11 | Sekisui Plastics | |
| US5421816A (en) | 1992-10-14 | 1995-06-06 | Endodermic Medical Technologies Company | Ultrasonic transdermal drug delivery system |
| US5364838A (en) | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| US5267985A (en) | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
| CA2114968A1 (en) | 1993-02-25 | 1994-08-26 | John Wille | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
| US5667487A (en) | 1993-04-07 | 1997-09-16 | Henley; Julian L. | Ionosonic drug delivery apparatus |
| US5581438A (en) | 1993-05-21 | 1996-12-03 | Halliop; Wojtek | Supercapacitor having electrodes with non-activated carbon fibers |
| US5413550A (en) | 1993-07-21 | 1995-05-09 | Pti, Inc. | Ultrasound therapy system with automatic dose control |
| US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
| US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
| DE69322968T2 (de) | 1993-10-22 | 1999-07-08 | Rijksuniversiteit Te Groningen, Groningen | Verfahren und Vorrichtung zur kontinuierlichen Überwachung eines Anolytpegels |
| US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
| US5445611A (en) | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
| US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| US5443080A (en) | 1993-12-22 | 1995-08-22 | Americate Transtech, Inc. | Integrated system for biological fluid constituent analysis |
| US5771890A (en) | 1994-06-24 | 1998-06-30 | Cygnus, Inc. | Device and method for sampling of substances using alternating polarity |
| US5429735A (en) | 1994-06-27 | 1995-07-04 | Miles Inc. | Method of making and amperometric electrodes |
| JP3170172B2 (ja) | 1995-03-30 | 2001-05-28 | ティーディーケイ株式会社 | チップ部品供給装置及び該装置に用いるチップ部品供給ケース |
| US5569198A (en) | 1995-01-23 | 1996-10-29 | Cortrak Medical Inc. | Microporous catheter |
| US5626554A (en) | 1995-02-21 | 1997-05-06 | Exogen, Inc. | Gel containment structure |
| US5573778A (en) | 1995-03-17 | 1996-11-12 | Adhesives Research, Inc. | Drug flux enhancer-tolerant pressure sensitive adhesive composition |
| US5646221A (en) | 1995-03-31 | 1997-07-08 | Kowa Co., Ltd. | Adhesive base material |
| CA2226176C (en) | 1995-07-12 | 2003-09-16 | Cygnus, Inc. | Hydrogel patch |
| US6002961A (en) | 1995-07-25 | 1999-12-14 | Massachusetts Institute Of Technology | Transdermal protein delivery using low-frequency sonophoresis |
| US6041253A (en) | 1995-12-18 | 2000-03-21 | Massachusetts Institute Of Technology | Effect of electric field and ultrasound for transdermal drug delivery |
| US5947921A (en) | 1995-12-18 | 1999-09-07 | Massachusetts Institute Of Technology | Chemical and physical enhancers and ultrasound for transdermal drug delivery |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US5989409A (en) | 1995-09-11 | 1999-11-23 | Cygnus, Inc. | Method for glucose sensing |
| US5735273A (en) | 1995-09-12 | 1998-04-07 | Cygnus, Inc. | Chemical signal-impermeable mask |
| US5902603A (en) | 1995-09-14 | 1999-05-11 | Cygnus, Inc. | Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use |
| US5833647A (en) | 1995-10-10 | 1998-11-10 | The Penn State Research Foundation | Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery |
| US6689265B2 (en) | 1995-10-11 | 2004-02-10 | Therasense, Inc. | Electrochemical analyte sensors using thermostable soybean peroxidase |
| US5618275A (en) | 1995-10-27 | 1997-04-08 | Sonex International Corporation | Ultrasonic method and apparatus for cosmetic and dermatological applications |
| US5711861A (en) | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
| CA2212826C (en) | 1995-12-28 | 2002-02-19 | Cygnus, Inc. | Methods for monitoring a physiological analyte |
| DE19602861C2 (de) | 1996-01-28 | 1997-12-11 | Meinhard Prof Dr Knoll | Probenahmesystem für in Trägerflüssigkeiten enthaltene Analyte sowie Verfahren zu seiner Herstellung |
| US6009343A (en) | 1996-02-23 | 1999-12-28 | Abbott Laboratories | Enhanced transdermal transport of fluid using vacuum |
| US5895362A (en) | 1996-02-23 | 1999-04-20 | Abbott Laboratories | Transdermal transport using ultrasonic standing waves |
| US5655539A (en) | 1996-02-26 | 1997-08-12 | Abbott Laboratories | Method for conducting an ultrasound procedure using an ultrasound transmissive pad |
| GB9604673D0 (en) * | 1996-03-05 | 1996-05-01 | Procter & Gamble | Skin care compositions |
| US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
| EP0925088A2 (en) | 1996-06-28 | 1999-06-30 | Sontra Medical, L.P. | Ultrasound enhancement of transdermal transport |
| US7105352B2 (en) | 1996-11-06 | 2006-09-12 | University Of Pittsburgh | Intelligent polymerized crystalline colloidal array carbohydrate sensors |
| WO1998020331A1 (en) | 1996-11-07 | 1998-05-14 | Cambridge Sensors Limited | Electrodes and their use in assays |
| US6063039A (en) | 1996-12-06 | 2000-05-16 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| US5913833A (en) | 1997-02-07 | 1999-06-22 | Abbott Laboratories | Method and apparatus for obtaining biological fluids |
| US6741877B1 (en) | 1997-03-04 | 2004-05-25 | Dexcom, Inc. | Device and method for determining analyte levels |
| US7899511B2 (en) * | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6139718A (en) | 1997-03-25 | 2000-10-31 | Cygnus, Inc. | Electrode with improved signal to noise ratio |
| US5961451A (en) | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
| ATE290417T1 (de) | 1997-04-14 | 2005-03-15 | Univ Alabama Res Found | Implantierbarer dreiphasenwellenformdefibrillator |
| US6503198B1 (en) | 1997-09-11 | 2003-01-07 | Jack L. Aronowtiz | Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods |
| US6117643A (en) | 1997-11-25 | 2000-09-12 | Ut Battelle, Llc | Bioluminescent bioreporter integrated circuit |
| US6579690B1 (en) | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
| US8287483B2 (en) | 1998-01-08 | 2012-10-16 | Echo Therapeutics, Inc. | Method and apparatus for enhancement of transdermal transport |
| US20060015058A1 (en) | 1998-01-08 | 2006-01-19 | Kellogg Scott C | Agents and methods for enhancement of transdermal transport |
| US7066884B2 (en) | 1998-01-08 | 2006-06-27 | Sontra Medical, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
| US6190315B1 (en) | 1998-01-08 | 2001-02-20 | Sontra Medical, Inc. | Sonophoretic enhanced transdermal transport |
| CA2265119C (en) | 1998-03-13 | 2002-12-03 | Cygnus, Inc. | Biosensor, iontophoretic sampling system, and methods of use thereof |
| PT1077636E (pt) | 1998-05-13 | 2004-06-30 | Cygnus Therapeutic Systems | Processamento de sinal para medicao de analitos fisiologicos |
| US6535753B1 (en) | 1998-08-20 | 2003-03-18 | Microsense International, Llc | Micro-invasive method for painless detection of analytes in extra-cellular space |
| US6602678B2 (en) * | 1998-09-04 | 2003-08-05 | Powderject Research Limited | Non- or minimally invasive monitoring methods |
| IL141774A0 (en) | 1998-09-04 | 2002-03-10 | Powderject Res Ltd | Monitoring methods using particle delivery methods |
| US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
| US20040171980A1 (en) | 1998-12-18 | 2004-09-02 | Sontra Medical, Inc. | Method and apparatus for enhancement of transdermal transport |
| CA2369336A1 (en) | 1999-04-22 | 2000-11-02 | Cygnus, Inc. | Hydrogel in an iontophoretic device to measure glucose |
| GB9909349D0 (en) * | 1999-04-23 | 1999-06-16 | First Water Ltd | Process |
| US6251083B1 (en) | 1999-09-07 | 2001-06-26 | Amira Medical | Interstitial fluid methods and devices for determination of an analyte in the body |
| AU781149B2 (en) | 2000-03-17 | 2005-05-05 | Echo Therapeutics, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
| US7181261B2 (en) | 2000-05-15 | 2007-02-20 | Silver James H | Implantable, retrievable, thrombus minimizing sensors |
| CA2409826C (en) * | 2000-06-01 | 2010-02-02 | Science Applications International Corporation | Systems and methods for monitoring health and delivering drugs transdermally |
| US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
| US6487447B1 (en) | 2000-10-17 | 2002-11-26 | Ultra-Sonic Technologies, L.L.C. | Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation |
| JP2002162353A (ja) | 2000-11-27 | 2002-06-07 | Denso Corp | 生化学成分測定装置、および血糖値測定装置 |
| GB2369799B (en) * | 2000-12-07 | 2004-07-07 | Johnson & Johnson Medical Ltd | Layered polyurethane materials |
| US6837988B2 (en) | 2001-06-12 | 2005-01-04 | Lifescan, Inc. | Biological fluid sampling and analyte measurement devices and methods |
| US6766817B2 (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
| US6887239B2 (en) | 2002-04-17 | 2005-05-03 | Sontra Medical Inc. | Preparation for transmission and reception of electrical signals |
| US6960617B2 (en) | 2002-04-22 | 2005-11-01 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
| US7150975B2 (en) | 2002-08-19 | 2006-12-19 | Animas Technologies, Llc | Hydrogel composition for measuring glucose flux |
| JP4061381B2 (ja) * | 2002-08-30 | 2008-03-19 | バイオチェック カンパニー リミテッド | グルコース抽出装置用パッチおよびその製作方法 |
| US20040234962A1 (en) | 2003-05-02 | 2004-11-25 | Javier Alarcon | Multicoated or multilayer entrapment matrix for protein biosensor |
| US7108778B2 (en) | 2003-07-25 | 2006-09-19 | Dexcom, Inc. | Electrochemical sensors including electrode systems with increased oxygen generation |
| US8060173B2 (en) | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| AU2005262444A1 (en) * | 2004-07-01 | 2006-01-19 | Vivomedical, Inc. | Non-invasive glucose measurement |
| JP5502279B2 (ja) * | 2004-10-28 | 2014-05-28 | エコー セラピューティクス， インコーポレイテッド | ヒドロゲルを使用した検体のサンプリングおよび分析のためのシステムおよび方法 |
| AU2005302584B2 (en) * | 2004-10-28 | 2011-08-11 | Echo Therapeutics, Inc. | System and method for analyte sampling and analysis with hydrogel |
| US20060263839A1 (en) * | 2005-05-17 | 2006-11-23 | Isense Corporation | Combined drug delivery and analyte sensor apparatus |
| US7963917B2 (en) | 2005-12-05 | 2011-06-21 | Echo Therapeutics, Inc. | System and method for continuous non-invasive glucose monitoring |
| US7432069B2 (en) | 2005-12-05 | 2008-10-07 | Sontra Medical Corporation | Biocompatible chemically crosslinked hydrogels for glucose sensing |
-
2008
- 2008-03-06 RU RU2009136998/14A patent/RU2444980C2/ru not_active IP Right Cessation
- 2008-03-06 JP JP2009552888A patent/JP5508861B2/ja not_active Expired - Fee Related
- 2008-03-06 CN CN200880014204.3A patent/CN101707875B/zh not_active Expired - Fee Related
- 2008-03-06 US US12/043,469 patent/US8812071B2/en not_active Expired - Fee Related
- 2008-03-06 KR KR1020097020981A patent/KR101318087B1/ko not_active Expired - Fee Related
- 2008-03-06 NZ NZ580179A patent/NZ580179A/en not_active IP Right Cessation
- 2008-03-06 WO PCT/US2008/056032 patent/WO2008109739A1/en not_active Ceased
- 2008-03-06 AU AU2008222757A patent/AU2008222757B2/en not_active Ceased
- 2008-03-06 EP EP08731530A patent/EP2124723A1/en not_active Withdrawn
- 2008-03-06 KR KR1020137013526A patent/KR101433550B1/ko not_active Expired - Fee Related
- 2008-03-06 CA CA2680213A patent/CA2680213C/en not_active Expired - Fee Related
-
2009
- 2009-10-06 ZA ZA200906959A patent/ZA200906959B/xx unknown
-
2013
- 2013-08-19 JP JP2013169786A patent/JP5965364B2/ja not_active Expired - Fee Related
-
2015
- 2015-06-17 JP JP2015121984A patent/JP2015163906A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405366A (en) * | 1991-11-12 | 1995-04-11 | Nepera, Inc. | Adhesive hydrogels having extended use lives and process for the preparation of same |
| WO2000009203A1 (en) * | 1998-08-17 | 2000-02-24 | Minnesota Mining And Manufacturing Company | Electrodes |
| US20060094944A1 (en) * | 2004-10-28 | 2006-05-04 | Sontra Medical Corporation | System and method for analyte sampling and analysis with error correction |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2444980C2 (ru) | 2012-03-20 |
| US20080281178A1 (en) | 2008-11-13 |
| RU2009136998A (ru) | 2011-04-20 |
| JP5965364B2 (ja) | 2016-08-03 |
| KR20130066708A (ko) | 2013-06-20 |
| KR101318087B1 (ko) | 2013-10-15 |
| KR20090120504A (ko) | 2009-11-24 |
| JP2013230403A (ja) | 2013-11-14 |
| JP2015163906A (ja) | 2015-09-10 |
| KR101433550B1 (ko) | 2014-08-27 |
| JP2010519938A (ja) | 2010-06-10 |
| WO2008109739A1 (en) | 2008-09-12 |
| NZ580179A (en) | 2011-06-30 |
| AU2008222757A1 (en) | 2008-09-12 |
| EP2124723A1 (en) | 2009-12-02 |
| JP5508861B2 (ja) | 2014-06-04 |
| CN101707875A (zh) | 2010-05-12 |
| CA2680213C (en) | 2014-10-14 |
| US8812071B2 (en) | 2014-08-19 |
| CA2680213A1 (en) | 2008-09-12 |
| ZA200906959B (en) | 2010-06-30 |
| CN101707875B (zh) | 2014-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2008222757B2 (en) | Transdermal analyte monitoring systems and methods for analyte detection | |
| US8224414B2 (en) | System and method for analyte sampling and analysis with hydrogel | |
| AU2005302584B2 (en) | System and method for analyte sampling and analysis with hydrogel | |
| US20230113717A1 (en) | Microneedle Electrodes for Biosensing | |
| JP5502279B2 (ja) | ヒドロゲルを使用した検体のサンプリングおよび分析のためのシステムおよび方法 | |
| US20180242913A1 (en) | Method Of Making A Multi-Layer Pad For Use In Determining An Analyte Concentration | |
| HK1143052B (en) | Transdermal analyte monitoring systems and methods for analyte detection | |
| HK1143052A (en) | Transdermal analyte monitoring systems and methods for analyte detection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |