AU2007286807B2 - Aza-benzothiophenyl compounds and methods of use - Google Patents
Aza-benzothiophenyl compounds and methods of use Download PDFInfo
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- AU2007286807B2 AU2007286807B2 AU2007286807A AU2007286807A AU2007286807B2 AU 2007286807 B2 AU2007286807 B2 AU 2007286807B2 AU 2007286807 A AU2007286807 A AU 2007286807A AU 2007286807 A AU2007286807 A AU 2007286807A AU 2007286807 B2 AU2007286807 B2 AU 2007286807B2
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- Prior art keywords
- alkyl
- compound
- formula
- cr19r20
- compounds
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- MYZTVQHPEQVBIS-UHFFFAOYSA-N 7-fluoro-3-(2-fluoro-4-iodoanilino)thieno[3,2-c]pyridine-2-carboxylic acid Chemical compound OC(=O)C=1SC2=C(F)C=NC=C2C=1NC1=CC=C(I)C=C1F MYZTVQHPEQVBIS-UHFFFAOYSA-N 0.000 claims 1
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- 125000001424 substituent group Chemical group 0.000 description 19
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- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 9
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- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 8
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- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 6
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Virology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83916306P | 2006-08-21 | 2006-08-21 | |
| US60/839,163 | 2006-08-21 | ||
| US87160006P | 2006-12-22 | 2006-12-22 | |
| US60/871,600 | 2006-12-22 | ||
| US91762407P | 2007-05-11 | 2007-05-11 | |
| US60/917,624 | 2007-05-11 | ||
| PCT/US2007/076340 WO2008024724A1 (en) | 2006-08-21 | 2007-08-20 | Aza-benzothiophenyl compounds and methods of use |
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| AU2007286807A1 AU2007286807A1 (en) | 2008-02-28 |
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| Country | Link |
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| US (1) | US7893085B2 (show.php) |
| EP (1) | EP2069359B1 (show.php) |
| JP (1) | JP5349306B2 (show.php) |
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| AR (1) | AR062469A1 (show.php) |
| AU (1) | AU2007286807B2 (show.php) |
| BR (1) | BRPI0714629A2 (show.php) |
| CA (1) | CA2660963A1 (show.php) |
| CL (1) | CL2007002431A1 (show.php) |
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| PE (2) | PE20081359A1 (show.php) |
| TW (1) | TWI426078B (show.php) |
| WO (1) | WO2008024724A1 (show.php) |
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| AU2007286808B2 (en) * | 2006-08-21 | 2012-12-06 | Genentech, Inc. | Aza-benzofuranyl compounds and methods of use |
| WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
| AU2011221227B2 (en) | 2010-02-25 | 2015-07-09 | Dana-Farber Cancer Institute, Inc. | BRAF mutations conferring resistance to BRAF inhibitors |
| ES2714875T3 (es) | 2010-03-09 | 2019-05-30 | Dana Farber Cancer Inst Inc | Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer |
| EP2844655A1 (en) | 2012-05-02 | 2015-03-11 | Lupin Limited | Substituted pyridine compounds as crac modulators |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| AU2013337702A1 (en) | 2012-11-02 | 2015-05-21 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a MEK inhibitor |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| JP7114076B2 (ja) | 2015-12-22 | 2022-08-08 | シャイ・セラピューティクス・エルエルシー | がん及び炎症性疾患の処置のための化合物 |
| CN109072311A (zh) | 2016-04-15 | 2018-12-21 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| JP7237941B2 (ja) | 2017-05-19 | 2023-03-13 | エヌフレクション セラピューティクス インコーポレイテッド | 皮膚障害の処置用の融合複素環式芳香族アニリン化合物 |
| MA49141A (fr) | 2017-05-19 | 2020-03-25 | Nflection Therapeutics Inc | Composés pyrrolopyridine-aniline destinés au traitement d'affections de la peau |
| CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| CN111373055B (zh) | 2017-09-08 | 2024-07-23 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| US20210008047A1 (en) | 2018-02-13 | 2021-01-14 | Vib Vzw | Targeting minimal residual disease in cancer with rxr antagonists |
| EP3820870A1 (en) | 2018-07-09 | 2021-05-19 | Boehringer Ingelheim Animal Health USA Inc. | Anthelminthic heterocyclic compounds |
| US12378240B2 (en) | 2018-11-20 | 2025-08-05 | Nflection Therapeutics, Inc. | Naphthyridinone-aniline compounds for treatment of dermal disorders |
| WO2020106306A1 (en) | 2018-11-20 | 2020-05-28 | Nflection Therapeutics, Inc. | Cyanoaryl-aniline compounds for treatment of dermal disorders |
| JP7546297B2 (ja) | 2018-11-20 | 2024-09-06 | エヌフレクション セラピューティクス インコーポレイテッド | 皮膚障害の処置のためのチエニル－アニリン化合物 |
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- 2007-08-20 EP EP07814268.4A patent/EP2069359B1/en active Active
- 2007-08-20 MX MX2009001875A patent/MX2009001875A/es active IP Right Grant
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- 2007-08-20 WO PCT/US2007/076340 patent/WO2008024724A1/en not_active Ceased
- 2007-08-20 AU AU2007286807A patent/AU2007286807B2/en not_active Ceased
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- 2007-08-20 KR KR1020097005785A patent/KR101475088B1/ko not_active Expired - Fee Related
- 2007-08-21 TW TW096130981A patent/TWI426078B/zh not_active IP Right Cessation
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| BRPI0714629A2 (pt) | 2013-05-07 |
| JP5349306B2 (ja) | 2013-11-20 |
| KR20090047538A (ko) | 2009-05-12 |
| US20080081821A1 (en) | 2008-04-03 |
| IL197060A0 (en) | 2009-11-18 |
| PE20081359A1 (es) | 2008-11-27 |
| EP2069359A1 (en) | 2009-06-17 |
| TW200823222A (en) | 2008-06-01 |
| PE20120049A1 (es) | 2012-02-16 |
| JP2010501584A (ja) | 2010-01-21 |
| WO2008024724A1 (en) | 2008-02-28 |
| MX2009001875A (es) | 2009-03-02 |
| AR062469A1 (es) | 2008-11-12 |
| AU2007286807A1 (en) | 2008-02-28 |
| US7893085B2 (en) | 2011-02-22 |
| ES2528797T3 (es) | 2015-02-12 |
| EP2069359B1 (en) | 2014-11-12 |
| CA2660963A1 (en) | 2008-02-28 |
| KR101475088B1 (ko) | 2014-12-23 |
| TWI426078B (zh) | 2014-02-11 |
| NO20091198L (no) | 2009-05-20 |
| CL2007002431A1 (es) | 2008-03-14 |
| IL197060A (en) | 2014-12-31 |
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