AU2007281920B2 - Tumor suppression using placental stem cells - Google Patents
Tumor suppression using placental stem cells Download PDFInfo
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- AU2007281920B2 AU2007281920B2 AU2007281920A AU2007281920A AU2007281920B2 AU 2007281920 B2 AU2007281920 B2 AU 2007281920B2 AU 2007281920 A AU2007281920 A AU 2007281920A AU 2007281920 A AU2007281920 A AU 2007281920A AU 2007281920 B2 AU2007281920 B2 AU 2007281920B2
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| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| KR100915483B1 (ko) | 2000-12-06 | 2009-09-03 | 로버트 제이 하리리 | 태반 줄기 세포의 회수 방법 |
| AU2002251935B2 (en) * | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| MX348185B (es) | 2001-02-14 | 2017-06-02 | Anthrogenesis Corp | Placenta de mamíferos postparto, su uso y células madres placentales extraídas de ella. |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| BR0316695A (pt) * | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
| NZ550027A (en) * | 2004-03-26 | 2009-03-31 | Celgene Corp | Systems and methods for providing a stem cell bank |
| CA2624925C (en) * | 2005-10-13 | 2014-09-30 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| JP5203212B2 (ja) * | 2005-10-13 | 2013-06-05 | アントフロゲネシス コーポレーション | 胎盤由来幹細胞からのオリゴデンドロサイトの産生 |
| US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
| US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
| US8067237B2 (en) | 2005-12-13 | 2011-11-29 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| PT2471904T (pt) | 2005-12-29 | 2019-02-25 | Celularity Inc | População de células estaminais placentárias |
| KR20080097190A (ko) * | 2005-12-29 | 2008-11-04 | 안트로제네시스 코포레이션 | 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법 |
| AU2006332679A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| CA3028279C (en) | 2006-01-23 | 2021-08-03 | Athersys, Inc. | Mapc therapeutics without adjunctive immunosuppressive treatment |
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| CA2677397C (en) | 2007-02-12 | 2016-04-05 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
| JP2010518812A (ja) * | 2007-02-12 | 2010-06-03 | アンスロジェネシス コーポレーション | 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにcd34+、cd45−胎盤幹細胞の濃縮細胞集団 |
| EP2164953A4 (en) | 2007-06-18 | 2010-06-30 | Childrens Hosp & Res Ct Oak | METHOD OF ISOLATING STAIN AND PRECIPITATING CELLS FROM PLAZENTA |
| US9770535B2 (en) * | 2007-06-21 | 2017-09-26 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| EP2254602B1 (en) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Continuous cell programming devices |
| RU2384618C2 (ru) * | 2008-03-27 | 2010-03-20 | Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" | Способ получения фибробластоподобных клеток из пупочного канатика новорожденного |
| KR20200011604A (ko) | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| AU2009283217B2 (en) | 2008-08-20 | 2015-09-17 | Celularity Inc. | Treatment of stroke using isolated placental cells |
| ES2552556T3 (es) | 2008-08-22 | 2015-11-30 | Anthrogenesis Corporation | Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias |
| NZ592726A (en) | 2008-11-19 | 2012-12-21 | Anthrogenesis Corp | Amnion derived adherent cells |
| CA2747794C (en) * | 2008-12-19 | 2018-10-30 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of lung and pulmonary diseases and disorders |
| US8771677B2 (en) | 2008-12-29 | 2014-07-08 | Vladimir B Serikov | Colony-forming unit cell of human chorion and method to obtain and use thereof |
| CA2756594C (en) * | 2009-03-25 | 2021-03-23 | Anthrogenesis Corporation | Treatment of viral infection using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| NZ597436A (en) | 2009-07-02 | 2014-08-29 | Anthrogenesis Corp | Method of producing erythrocytes without feeder cells |
| WO2011014871A1 (en) | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
| EP2333047A1 (en) * | 2009-12-09 | 2011-06-15 | Fresenius Medical Care Deutschland GmbH | Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease |
| JP2013518108A (ja) * | 2010-01-26 | 2013-05-20 | アントフロゲネシス コーポレーション | 胎盤幹細胞を用いる骨関連癌の治療 |
| LT2556145T (lt) | 2010-04-07 | 2016-11-10 | Anthrogenesis Corporation | Angiogenezė naudojant placentos kamienines ląsteles |
| WO2011127113A1 (en) | 2010-04-08 | 2011-10-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| CN101856496B (zh) * | 2010-06-07 | 2013-09-18 | 四川大学 | 胎盘干细胞抗肿瘤疫苗及其制备方法与应用 |
| NZ605505A (en) | 2010-07-13 | 2015-02-27 | Anthrogenesis Corp | Methods of generating natural killer cells |
| CN101919378B (zh) * | 2010-08-06 | 2013-09-11 | 青岛奥克生物开发有限公司 | 一种直接静脉应用的间充质干细胞冻存液 |
| CA2813751C (en) | 2010-10-06 | 2019-11-12 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
| US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| CN102210707B (zh) * | 2011-04-01 | 2014-04-30 | 四川大学 | 协同刺激分子修饰胎盘成体干细胞活制剂及其制备与应用 |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| US10045947B2 (en) | 2011-04-28 | 2018-08-14 | President And Fellows Of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
| ES2707579T3 (es) | 2011-06-01 | 2019-04-04 | Celularity Inc | Tratamiento del dolor usando citoblastos placentarios |
| EP2714073B1 (en) | 2011-06-03 | 2021-03-10 | President and Fellows of Harvard College | In situ antigen-generating cancer vaccine |
| US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| CN107137357B (zh) | 2012-04-16 | 2020-11-24 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| ITTO20120859A1 (it) * | 2012-10-02 | 2014-04-03 | Univ Degli Studi Torino | Nuova applicazione terapeutica di un mezzo condizionato da cellule staminali mesenchimali placentari |
| CN115282165A (zh) | 2013-02-05 | 2022-11-04 | 细胞结构公司 | 来自胎盘的自然杀伤细胞 |
| JP6235795B2 (ja) * | 2013-05-29 | 2017-11-22 | 国立大学法人 東京医科歯科大学 | 細胞のリプログラミングのための組成物 |
| CN103331374A (zh) * | 2013-06-13 | 2013-10-02 | 南京惠德机械有限公司 | 一种线材成型快换模 |
| EP3038630B1 (en) * | 2013-08-30 | 2020-03-18 | MIMEDX Group Inc. | Micronized placental compositions comprising a chelator |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| CN105316283B (zh) * | 2014-08-01 | 2019-02-12 | 深圳华大基因科技有限公司 | 一种临床级胎盘间充质干细胞制备方法 |
| CN104212761A (zh) * | 2014-08-20 | 2014-12-17 | 北京瑞思德生物科技有限公司 | 用于制备胎盘干细胞的试剂盒 |
| WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| ES2861381T3 (es) * | 2015-03-06 | 2021-10-06 | Univ Ajou Ind Academic Coop Found | Agente terapéutico celular para el tratamiento del cáncer y politerapia con el mismo |
| CN107864627A (zh) * | 2015-03-23 | 2018-03-30 | 普拉里斯坦有限公司 | 包含粘附基质细胞的方法和组合物 |
| EP3280464A4 (en) | 2015-04-10 | 2018-09-26 | President and Fellows of Harvard College | Immune cell trapping devices and methods for making and using the same |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| CN115487351A (zh) | 2016-02-06 | 2022-12-20 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
| WO2017141181A1 (en) * | 2016-02-18 | 2017-08-24 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
| WO2017156341A1 (en) | 2016-03-09 | 2017-09-14 | Beijing Percans Oncology Co. Ltd. | Tumor cell suspension cultures and related methods |
| DK3484448T3 (da) | 2016-07-13 | 2025-06-10 | Harvard College | Antigenpræsenterende cellemimetiske stilladser og fremgangsmåder til fremstilling og brug af disse |
| JP7274214B2 (ja) | 2016-08-02 | 2023-05-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫応答を調節するための生体材料 |
| JP7076126B2 (ja) * | 2016-10-11 | 2022-05-27 | 国立大学法人富山大学 | 羊膜間葉系幹細胞の抗腫瘍薬としての使用 |
| CN110462028A (zh) * | 2016-11-21 | 2019-11-15 | 北京智康博药肿瘤医学研究有限公司 | 上皮肿瘤细胞培养物 |
| SG10202111394XA (en) | 2017-04-13 | 2021-12-30 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| CN108904799A (zh) * | 2018-07-09 | 2018-11-30 | 夏荣木 | 一种抗肿瘤制剂及制备的方法 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| EP3866813A4 (en) | 2018-10-17 | 2022-08-03 | Senti Biosciences, Inc. | COMBINATORY CANCER IMMUNOTHERAPY |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| WO2021071127A1 (ko) * | 2019-10-11 | 2021-04-15 | 경북대학교 산학협력단 | 엑소좀 pd-l1의 발현에 대한 억제제를 유효성분으로 포함하는 항암 효과 증진용 조성물 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007047465A1 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Production of oligodendrocytes from placenta-derived stem cells |
| WO2007047468A2 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| WO2007079184A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| WO2007079185A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
| WO2007079183A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Placental stem cell populations |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US396397A (en) * | 1889-01-22 | Revolving mold-board for plows | ||
| US24280A (en) * | 1859-06-07 | Machine for bubring wool and ginning cotton | ||
| US104164A (en) * | 1870-06-14 | Hubert l | ||
| US136471A (en) * | 1873-03-04 | Improvement in ironing apparatus | ||
| US53805A (en) * | 1866-04-10 | Improved amalgamator | ||
| US240956A (en) * | 1881-05-03 | Magnet for separating iron chips | ||
| US213228A (en) * | 1879-03-11 | Improvement in grates | ||
| US175824A (en) * | 1876-04-11 | Improvement in sleighs | ||
| US226595A (en) * | 1880-04-20 | Eichabd f | ||
| US206343A (en) * | 1878-07-23 | Improvement in embalming compositions | ||
| US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
| US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US6010696A (en) * | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| EP0627003A1 (en) * | 1991-12-23 | 1994-12-07 | British Bio-Technology Limited | Stem cell inhibiting proteins |
| US5426098A (en) * | 1993-09-02 | 1995-06-20 | Celtrix Pharmaceuticals, Inc. | Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor beta |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| EP0952792B1 (en) * | 1994-06-06 | 2003-08-27 | Case Western Reserve University | Biomatrix for tissue regeneration |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| WO1997018298A1 (en) * | 1995-11-14 | 1997-05-22 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
| ES2329953T3 (es) * | 1996-04-19 | 2009-12-02 | Osiris Therapeutics, Inc. | Regeneracion e incremento de hueso utilizando celulas madre mesenquimales. |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US5916202A (en) * | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
| US5945337A (en) * | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| US6387369B1 (en) * | 1997-07-14 | 2002-05-14 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US7514074B2 (en) * | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| AU9127098A (en) * | 1997-09-04 | 1999-03-22 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
| BR9907852A (pt) | 1998-02-12 | 2000-10-24 | Immunivest Corp | Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes |
| EP1062321B1 (en) * | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
| ES2258329T3 (es) | 1998-03-18 | 2006-08-16 | Osiris Therapeutics, Inc. | Celulas madre mesenquimaticas para la prevencion y tratamiento de respuestas inmunes en trasplantes. |
| US6368636B1 (en) * | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| DK1066060T3 (da) | 1998-04-03 | 2003-11-24 | Osiris Therapeutics Inc | Mesenkymale stamceller som immunsuppresive midler |
| US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| US6225119B1 (en) | 1998-05-22 | 2001-05-01 | Osiris Therapeutics, Inc. | Production of megakaryocytes by the use of human mesenchymal stem cells |
| DK1082410T3 (da) * | 1998-05-29 | 2007-11-26 | Osiris Therapeutics Inc | Humane CD45 - og/eller fibroblast mesenchymale stamceller |
| CA2680649A1 (en) * | 1998-06-08 | 1999-12-16 | Osiris Therapeutics, Inc. | Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells |
| DE69937966D1 (de) | 1998-11-12 | 2008-02-21 | Cytomatrix Llc | Produktion lymphoider gewebsspezifischer zellen von hämatopoietischen vorläuferzellen in einem dreidimensionalen system |
| US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US6685936B2 (en) * | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| DE19954421A1 (de) | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen |
| MXPA02006778A (es) * | 2000-01-12 | 2004-04-05 | Ventana Inc | Metodo para determinar la respuesta a una terapia de cancer. |
| US20010038836A1 (en) | 2000-04-04 | 2001-11-08 | Matthew During | Application of myeloid-origin cells to the nervous system |
| DE10021977A1 (de) * | 2000-05-05 | 2001-11-08 | Meto International Gmbh | Radiofrequenz (RF) - Sicherungselement, Spule und Kondensator für ein RF-Sicherungselement und Verfahren zu deren Herstellung |
| KR100915483B1 (ko) | 2000-12-06 | 2009-09-03 | 로버트 제이 하리리 | 태반 줄기 세포의 회수 방법 |
| US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| MX348185B (es) | 2001-02-14 | 2017-06-02 | Anthrogenesis Corp | Placenta de mamíferos postparto, su uso y células madres placentales extraídas de ella. |
| CA2438501C (en) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| AU2002251935B2 (en) * | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US20030044977A1 (en) * | 2001-08-10 | 2003-03-06 | Norio Sakuragawa | Human stem cells originated from human amniotic mesenchymal cell layer |
| DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| US20030044976A1 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| DE60233248D1 (de) * | 2001-11-15 | 2009-09-17 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
| US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| US20040018178A1 (en) | 2002-01-22 | 2004-01-29 | Advanced Cell Technology | Stem cell-derived endothelial cells modified to disrupt tumor angiogenesis |
| US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7736892B2 (en) * | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| WO2003086373A1 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| US20050118715A1 (en) * | 2002-04-12 | 2005-06-02 | Hariri Robert J. | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US20040161419A1 (en) * | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| US20030235563A1 (en) | 2002-04-19 | 2003-12-25 | Strom Stephen C. | Placental derived stem cells and uses thereof |
| CA2488013A1 (en) * | 2002-05-30 | 2003-12-11 | Celgene Corporation | Methods of using jnk or mkk inhibitors to modulate cell differentiation and to treat myeloproliferative disorders and myelodysplastic syndromes |
| US7422736B2 (en) * | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| JP4603883B2 (ja) | 2002-07-31 | 2010-12-22 | サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− | 脂肪組織由来の幹細胞および前記細胞から分化した細胞 |
| BR0316695A (pt) | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
| ES2351386T3 (es) * | 2003-02-11 | 2011-02-03 | John E. Davies | Células progenitoras procedentes de la gelatina de wharton de cordón umbilical humano . |
| MXPA05008445A (es) * | 2003-02-13 | 2005-10-18 | Anthrogenesis Corp | Uso de sangre del cordon umbilical para tratar individuos que tienen una enfermedad, un trastorno o una afeccion. |
| CN1548529A (zh) | 2003-05-09 | 2004-11-24 | 中国人民解放军军事医学科学院基础医 | 一种人胎盘间充质干细胞的分离方法 |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| JP4948166B2 (ja) * | 2003-06-27 | 2012-06-06 | エチコン、インコーポレイテッド | 分娩後由来細胞を用いた軟骨と骨の修復と再生 |
| US20050042595A1 (en) * | 2003-08-14 | 2005-02-24 | Martin Haas | Banking of multipotent amniotic fetal stem cells |
| US20050089513A1 (en) | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| EP1682654A2 (en) | 2003-11-10 | 2006-07-26 | Amgen Inc. | Methods of using g-csf mobilized c-kit+cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy |
| JP2005151907A (ja) | 2003-11-27 | 2005-06-16 | Shigeo Saito | 胎盤又は羊膜由来ヒト幹細胞及びその樹立方法並びに臓器への分化誘導方法 |
| US20050143420A1 (en) * | 2003-12-02 | 2005-06-30 | Moutouh-De Parseval Laure | Methods and compositions for the treatment and management of hemoglobinopathy and anemia |
| US20050176139A1 (en) | 2004-01-12 | 2005-08-11 | Yao-Chang Chen | Placental stem cell and methods thereof |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| EP2298863B1 (en) | 2004-03-22 | 2015-07-22 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| NZ550027A (en) | 2004-03-26 | 2009-03-31 | Celgene Corp | Systems and methods for providing a stem cell bank |
| JP2006006249A (ja) | 2004-06-28 | 2006-01-12 | Hiroshima Univ | 羊膜由来細胞の培養方法及びその利用 |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| BRPI0514387B8 (pt) * | 2004-08-16 | 2021-05-25 | Cellresearch Corp Pte Ltd | método para isolar células-tronco epiteliais ou mesenquimais/progenitoras da membrana amniótica do cordão umbilical, método in vitro para cultivar células-tronco mesenquimais/progenitoras, composição farmacêutica e uso de uma célula-tronco epitelial ou mesenquimal/progenitora |
| US7909806B2 (en) | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US20060171930A1 (en) | 2004-12-21 | 2006-08-03 | Agnieszka Seyda | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060166361A1 (en) * | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| PT1835924E (pt) | 2004-12-23 | 2013-11-19 | Ethicon Inc | Tratamento da doença de parkinson e desordens relacionadas usando células derivadas do pós-parto |
| EP1831356B1 (en) | 2004-12-23 | 2017-01-25 | DePuy Synthes Products, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
| WO2006074308A2 (en) * | 2005-01-07 | 2006-07-13 | Wake Forest University Health Sciences | Regeneration of pancreatic islets by amniotic fluid stem cell therapy |
| US20060222634A1 (en) | 2005-03-31 | 2006-10-05 | Clarke Diana L | Amnion-derived cell compositions, methods of making and uses thereof |
| AU2006202209B2 (en) * | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| NZ564563A (en) | 2005-06-10 | 2011-03-31 | Celgene Corp | Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions |
| CN101252957A (zh) | 2005-06-30 | 2008-08-27 | 人类起源公司 | 使用胎盘源胶原生物纤维的鼓膜修复 |
| US20070021762A1 (en) | 2005-07-13 | 2007-01-25 | Qing Liu | Ocular plug formed from placenta derived collagen biofabric |
| EP1919500A2 (en) | 2005-07-13 | 2008-05-14 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| CN101374946B (zh) | 2005-12-16 | 2017-07-18 | 伊西康公司 | 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法 |
| EP1979050B1 (en) * | 2005-12-28 | 2017-04-19 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using postpartum-derived cells |
| US20070253931A1 (en) | 2006-01-12 | 2007-11-01 | Osiris Therapeutics, Inc. | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| US9944900B2 (en) | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
| EP1845154A1 (en) | 2006-04-12 | 2007-10-17 | RNL Bio Co., Ltd. | Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same |
| CA2654716A1 (en) | 2006-06-09 | 2007-12-21 | Anthrogenesis Corporation | Placental niche and use thereof to culture stem cells |
| US20070287176A1 (en) | 2006-06-13 | 2007-12-13 | Alireza Rezania | Chorionic villus derived cells |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| WO2008021391A1 (en) | 2006-08-15 | 2008-02-21 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
| US8122763B2 (en) * | 2006-09-01 | 2012-02-28 | Avair, Llc | Breathing gas supply visual broadcast apparatus |
| US20080131522A1 (en) | 2006-10-03 | 2008-06-05 | Qing Liu | Use of placental biomaterial for ocular surgery |
| WO2008060377A2 (en) | 2006-10-04 | 2008-05-22 | Anthrogenesis Corporation | Placental or umbilical cord tissue compositions |
| NZ612094A (en) | 2006-10-06 | 2015-02-27 | Anthrogenesis Corp | Native (telopeptide) placental collagen compositions |
| US8562972B2 (en) | 2006-10-23 | 2013-10-22 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| JP2010518812A (ja) | 2007-02-12 | 2010-06-03 | アンスロジェネシス コーポレーション | 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにcd34+、cd45−胎盤幹細胞の濃縮細胞集団 |
| CA2677397C (en) | 2007-02-12 | 2016-04-05 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
| KR20160092062A (ko) | 2007-09-26 | 2016-08-03 | 안트로제네시스 코포레이션 | 인간 태반 관류액으로부터의 혈관형성 세포 |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| US20090136471A1 (en) | 2007-11-07 | 2009-05-28 | Anthrogenesis Corporation | Treatment of premature birth complications |
| JP2011524421A (ja) * | 2008-06-16 | 2011-09-01 | イミュノジェン・インコーポレーテッド | 新規の相乗効果 |
| AU2009283217B2 (en) * | 2008-08-20 | 2015-09-17 | Celularity Inc. | Treatment of stroke using isolated placental cells |
| KR20200011604A (ko) * | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| ES2552556T3 (es) * | 2008-08-22 | 2015-11-30 | Anthrogenesis Corporation | Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias |
| NZ592726A (en) * | 2008-11-19 | 2012-12-21 | Anthrogenesis Corp | Amnion derived adherent cells |
| ES2731340T3 (es) * | 2008-11-21 | 2019-11-15 | Celularity Inc | Tratamiento de enfermedades, trastornos o afecciones pulmonares utilizando células placentarias |
| NZ597436A (en) * | 2009-07-02 | 2014-08-29 | Anthrogenesis Corp | Method of producing erythrocytes without feeder cells |
-
2007
- 2007-08-03 US US11/888,926 patent/US7993918B2/en active Active
- 2007-08-06 CA CA002660014A patent/CA2660014A1/en not_active Abandoned
- 2007-08-06 AU AU2007281920A patent/AU2007281920B2/en not_active Ceased
- 2007-08-06 NZ NZ574951A patent/NZ574951A/en not_active IP Right Cessation
- 2007-08-06 ZA ZA200900956A patent/ZA200900956B/xx unknown
- 2007-08-06 WO PCT/US2007/017622 patent/WO2008019148A2/en not_active Ceased
- 2007-08-06 JP JP2009522903A patent/JP5469457B2/ja not_active Expired - Fee Related
- 2007-08-06 NZ NZ595938A patent/NZ595938A/xx not_active IP Right Cessation
- 2007-08-06 EP EP07836619.2A patent/EP2054508B1/en active Active
- 2007-08-06 ES ES07836619T patent/ES2432148T3/es active Active
- 2007-08-06 KR KR1020097004531A patent/KR101438554B1/ko not_active Expired - Fee Related
- 2007-08-06 EP EP13171916.3A patent/EP2705848A1/en not_active Withdrawn
- 2007-08-06 MX MX2009001311A patent/MX2009001311A/es active IP Right Grant
- 2007-08-06 CN CN200780037355A patent/CN101720354A/zh active Pending
-
2009
- 2009-02-03 IL IL196884A patent/IL196884A0/en active IP Right Grant
-
2010
- 2010-06-14 ZA ZA2010/04218A patent/ZA201004218B/en unknown
-
2011
- 2011-06-20 US US13/164,378 patent/US20110250185A1/en not_active Abandoned
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2012
- 2012-11-20 IL IL223158A patent/IL223158A0/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007047465A1 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Production of oligodendrocytes from placenta-derived stem cells |
| WO2007047468A2 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| WO2007079184A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| WO2007079185A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
| WO2007079183A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Placental stem cell populations |
Non-Patent Citations (1)
| Title |
|---|
| Zhang Y et al, Experimental Hematology, 2004, 32(7):657-664 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201004218B (en) | 2012-12-27 |
| EP2054508B1 (en) | 2013-07-24 |
| ZA200900956B (en) | 2010-09-29 |
| CN101720354A (zh) | 2010-06-02 |
| KR20090111800A (ko) | 2009-10-27 |
| EP2054508A2 (en) | 2009-05-06 |
| US20080152624A1 (en) | 2008-06-26 |
| US7993918B2 (en) | 2011-08-09 |
| EP2705848A1 (en) | 2014-03-12 |
| WO2008019148A2 (en) | 2008-02-14 |
| ES2432148T3 (es) | 2013-12-02 |
| MX2009001311A (es) | 2009-08-12 |
| JP5469457B2 (ja) | 2014-04-16 |
| NZ595938A (en) | 2013-11-29 |
| IL196884A0 (en) | 2011-08-01 |
| AU2007281920A1 (en) | 2008-02-14 |
| NZ574951A (en) | 2012-03-30 |
| CA2660014A1 (en) | 2008-02-14 |
| KR101438554B1 (ko) | 2014-09-05 |
| US20110250185A1 (en) | 2011-10-13 |
| IL223158A0 (en) | 2012-12-31 |
| WO2008019148A3 (en) | 2008-08-07 |
| JP2010501159A (ja) | 2010-01-21 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
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Owner name: CELULARITY, INC. Free format text: FORMER OWNER(S): ANTHROGENESIS CORPORATION |
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