AU2007238000B2 - Glucagon-like peptide 1(GLP-1) pharmaceutical formulations - Google Patents
Glucagon-like peptide 1(GLP-1) pharmaceutical formulations Download PDFInfo
- Publication number
- AU2007238000B2 AU2007238000B2 AU2007238000A AU2007238000A AU2007238000B2 AU 2007238000 B2 AU2007238000 B2 AU 2007238000B2 AU 2007238000 A AU2007238000 A AU 2007238000A AU 2007238000 A AU2007238000 A AU 2007238000A AU 2007238000 B2 AU2007238000 B2 AU 2007238000B2
- Authority
- AU
- Australia
- Prior art keywords
- glp
- fdkp
- diketopiperazine
- solution
- particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 7
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 title description 8
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims abstract description 809
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Classifications
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Landscapes
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013201640A AU2013201640A1 (en) | 2006-04-14 | 2013-03-19 | Glucagon-like peptide 1(GLP-1) pharmaceutical formulations |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74488206P | 2006-04-14 | 2006-04-14 | |
| US60/744,882 | 2006-04-14 | ||
| PCT/US2007/066728 WO2007121411A2 (en) | 2006-04-14 | 2007-04-16 | Glucagon-like peptide 1(glp-1) pharmaceutical formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| AU2013201640A Division AU2013201640A1 (en) | 2006-04-14 | 2013-03-19 | Glucagon-like peptide 1(GLP-1) pharmaceutical formulations |
Publications (2)
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| AU2007238000A1 AU2007238000A1 (en) | 2007-10-25 |
| AU2007238000B2 true AU2007238000B2 (en) | 2013-01-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2007238000A Ceased AU2007238000B2 (en) | 2006-04-14 | 2007-04-16 | Glucagon-like peptide 1(GLP-1) pharmaceutical formulations |
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| EP (1) | EP2010155A2 (ja) |
| JP (3) | JP5415938B2 (ja) |
| KR (3) | KR20150042304A (ja) |
| CN (2) | CN101453988A (ja) |
| AU (1) | AU2007238000B2 (ja) |
| BR (1) | BRPI0709964A2 (ja) |
| CA (1) | CA2646400A1 (ja) |
| HK (1) | HK1206241A1 (ja) |
| MX (1) | MX2008013216A (ja) |
| RU (3) | RU2542500C2 (ja) |
| WO (1) | WO2007121411A2 (ja) |
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| ATE545652T1 (de) | 1999-06-29 | 2012-03-15 | Mannkind Corp | Reinigung und stabilisierung von proteinen und peptiden in pharmaceutischen agentien |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
| US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
| CA2575692C (en) | 2004-08-20 | 2014-10-14 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
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| RU2467741C2 (ru) * | 2007-10-24 | 2012-11-27 | Маннкайнд Корпорейшн | Доставка активных веществ |
| KR101736535B1 (ko) * | 2007-10-24 | 2017-05-16 | 맨카인드 코포레이션 | Ｇｌｐ-1에 의한 유해 효과의 예방 방법 |
| EP2300011A4 (en) | 2008-05-27 | 2012-06-20 | Dmi Life Sciences Inc | METHODS AND THERAPEUTIC COMPOUNDS |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
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| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| EP2853268A1 (en) | 2009-01-08 | 2015-04-01 | Mannkind Corporation | Treatment of hyperglycemia with GLP-1 |
| TWI528982B (zh) * | 2009-03-04 | 2016-04-11 | 曼凱公司 | 改良的乾粉藥物輸送系統 |
| JP5667095B2 (ja) | 2009-03-11 | 2015-02-12 | マンカインド コーポレイション | 吸入器の抵抗を測定するための装置、システムおよび方法 |
| KR20180036807A (ko) | 2009-06-12 | 2018-04-09 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| EP3556356B1 (en) | 2009-06-12 | 2021-05-05 | MannKind Corporation | Diketopiperazine microparticles with defined isomer content |
| WO2011017554A2 (en) * | 2009-08-07 | 2011-02-10 | Mannkind Corporation | Val (8) glp-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
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| US8507496B2 (en) | 2010-09-07 | 2013-08-13 | Dmi Acquisition Corp. | Treatment of diseases |
| CN103826988B (zh) | 2011-04-01 | 2016-03-09 | 曼金德公司 | 用于药物药盒的泡罩包装 |
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| KR20140075772A (ko) | 2011-10-10 | 2014-06-19 | 앰피오 파마슈티컬스 인코퍼레이티드 | 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법 |
| PL2766029T3 (pl) | 2011-10-10 | 2020-08-24 | Ampio Pharmaceuticals, Inc. | Leczenie choroby zwyrodnieniowej stawów |
| AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
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| AU2013308693A1 (en) * | 2012-08-29 | 2015-03-12 | Mannkind Corporation | Method and composition for treating hyperglycemia |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
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| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| JP6397984B2 (ja) * | 2014-03-18 | 2018-09-26 | アペプティコ・フォルシュング・ウント・エントヴィックルング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＡｐｅｐｔｉｃｏ Ｆｏｒｓｃｈｕｎｇ Ｕｎｄ Ｅｎｔｗｉｃｋｌｕｎｇ Ｇｍｂｈ | 乾燥粉末ペプチド医薬 |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
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| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| EP3310375A4 (en) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| CN108066762B (zh) * | 2016-11-07 | 2022-04-01 | 赫兰 | Glp-1受体激动剂类药物的用途 |
| TWI705820B (zh) * | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| CN109827875A (zh) * | 2019-04-10 | 2019-05-31 | 上海市食品药品检验所 | 一种用于测定吸入制剂溶出度的装置和方法 |
| KR20210062509A (ko) | 2019-11-21 | 2021-05-31 | 대한민국(전북기계공업고등학교장) | 필터리스 다이나믹 미세먼지 공기 청정기 |
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- 2007-04-16 RU RU2010137392/15A patent/RU2542500C2/ru not_active IP Right Cessation
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- 2007-04-16 JP JP2009505655A patent/JP5415938B2/ja not_active Expired - Fee Related
- 2007-04-16 CN CNA200780013424XA patent/CN101453988A/zh active Pending
- 2007-04-16 KR KR1020157008571A patent/KR20150042304A/ko not_active Application Discontinuation
- 2007-04-16 CN CN201410514033.8A patent/CN104288756A/zh active Pending
- 2007-04-16 EP EP20070760728 patent/EP2010155A2/en not_active Withdrawn
- 2007-04-16 WO PCT/US2007/066728 patent/WO2007121411A2/en active Application Filing
- 2007-04-16 CA CA002646400A patent/CA2646400A1/en active Pending
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2014
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2015
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- 2015-11-30 JP JP2015233125A patent/JP2016104736A/ja active Pending
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| WO2001000654A2 (en) * | 1999-06-29 | 2001-01-04 | Pharmaceutical Discovery Corporation | Purification and stabilization of peptide and proteins in pharmaceutical agents |
| WO2002098348A2 (en) * | 2001-06-01 | 2002-12-12 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| US20040038865A1 (en) * | 2002-08-01 | 2004-02-26 | Mannkind Corporation | Cell transport compositions and uses thereof |
| WO2007033316A2 (en) * | 2005-09-14 | 2007-03-22 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
Also Published As
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| RU2542500C2 (ru) | 2015-02-20 |
| KR101558829B1 (ko) | 2015-10-08 |
| HK1206241A1 (en) | 2016-01-08 |
| WO2007121411A3 (en) | 2007-12-13 |
| KR20150042304A (ko) | 2015-04-20 |
| JP2014043445A (ja) | 2014-03-13 |
| KR101438839B1 (ko) | 2014-10-02 |
| JP2016104736A (ja) | 2016-06-09 |
| RU2010137392A (ru) | 2012-03-20 |
| RU2014152320A (ru) | 2016-07-20 |
| JP2009533476A (ja) | 2009-09-17 |
| CA2646400A1 (en) | 2007-10-25 |
| JP5415938B2 (ja) | 2014-02-12 |
| CN104288756A (zh) | 2015-01-21 |
| BRPI0709964A2 (pt) | 2011-08-02 |
| WO2007121411A2 (en) | 2007-10-25 |
| RU2008144965A (ru) | 2010-05-20 |
| MX2008013216A (es) | 2008-10-27 |
| AU2007238000A1 (en) | 2007-10-25 |
| JP5898156B2 (ja) | 2016-04-06 |
| RU2409349C2 (ru) | 2011-01-20 |
| KR20080111533A (ko) | 2008-12-23 |
| KR20140072138A (ko) | 2014-06-12 |
| EP2010155A2 (en) | 2009-01-07 |
| CN101453988A (zh) | 2009-06-10 |
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