AU2007234762A1 - Spirocyclic heterocyclic derivatives and methods of their use - Google Patents
Spirocyclic heterocyclic derivatives and methods of their use Download PDFInfo
- Publication number
- AU2007234762A1 AU2007234762A1 AU2007234762A AU2007234762A AU2007234762A1 AU 2007234762 A1 AU2007234762 A1 AU 2007234762A1 AU 2007234762 A AU2007234762 A AU 2007234762A AU 2007234762 A AU2007234762 A AU 2007234762A AU 2007234762 A1 AU2007234762 A1 AU 2007234762A1
- Authority
- AU
- Australia
- Prior art keywords
- spiro
- piperidine
- disorder
- compound according
- diethylaminocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 125000000623 heterocyclic group Chemical group 0.000 title claims description 13
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 134
- -1 carboxy, hydroxy Chemical group 0.000 claims description 124
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 33
- 230000000694 effects Effects 0.000 claims description 33
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- YQYVFVRQLZMJKJ-JBBXEZCESA-N (+)-cyclazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CC1CC1 YQYVFVRQLZMJKJ-JBBXEZCESA-N 0.000 claims description 4
- UVITTYOJFDLOGI-UHFFFAOYSA-N (1,2,5-trimethyl-4-phenylpiperidin-4-yl) propanoate Chemical compound C=1C=CC=CC=1C1(OC(=O)CC)CC(C)N(C)CC1C UVITTYOJFDLOGI-UHFFFAOYSA-N 0.000 claims description 4
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- UCRLQOPRDMGYOA-DFTDUNEMSA-L zinc;(4r)-4-[[(2s)-2-[[(4r)-2-[(1s,2s)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2s,3s)-1-[[(3s,6r,9s,12r,15s,18r,21s)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2s)-butan-2-yl]-6-(carbox Chemical compound [Zn+2].C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@H](CC([O-])=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 UCRLQOPRDMGYOA-DFTDUNEMSA-L 0.000 description 1
- ZISDBYYELZLQGH-UHFFFAOYSA-M zinc;ethyl hexanoate;bromide Chemical compound Br[Zn+].CCOC(=O)CCCC[CH2-] ZISDBYYELZLQGH-UHFFFAOYSA-M 0.000 description 1
- APPDFGHVJHZDKS-UHFFFAOYSA-M zinc;ethyl propanoate;bromide Chemical compound Br[Zn+].CCOC(=O)C[CH2-] APPDFGHVJHZDKS-UHFFFAOYSA-M 0.000 description 1
Classifications
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Applications Claiming Priority (5)
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| US79041606P | 2006-04-06 | 2006-04-06 | |
| US60/790,416 | 2006-04-06 | ||
| US11/696,585 | 2007-04-04 | ||
| US11/696,585 US7576207B2 (en) | 2006-04-06 | 2007-04-04 | Spirocyclic heterocyclic derivatives and methods of their use |
| PCT/US2007/066071 WO2007118151A2 (en) | 2006-04-06 | 2007-04-05 | Spirocyclic heterocyclic derivatives and methods of their use |
Publications (1)
| Publication Number | Publication Date |
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| AU2007234762A1 true AU2007234762A1 (en) | 2007-10-18 |
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| Country | Link |
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| US (2) | US7576207B2 (enExample) |
| EP (1) | EP2001467A4 (enExample) |
| JP (1) | JP2009533353A (enExample) |
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| AU (1) | AU2007234762A1 (enExample) |
| BR (1) | BRPI0709466A2 (enExample) |
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| CO (1) | CO6140027A2 (enExample) |
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| JP4976134B2 (ja) * | 2003-10-01 | 2012-07-18 | アドラー コーポレーション | スピロ環複素環誘導体及びそれらを使用する方法 |
| US7576207B2 (en) * | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP2010503669A (ja) * | 2006-09-12 | 2010-02-04 | アドラー コーポレーション | 認知機能の強化のためのｎ含有スピロ化合物の使用 |
| FR2907121B1 (fr) * | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
| JO3126B1 (ar) * | 2007-11-14 | 2017-09-20 | Janssen Pharmaceutica Nv | مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1 |
| WO2011100659A2 (en) * | 2010-02-12 | 2011-08-18 | Kitov Pharmaceutical Ltd. | Ameliorating drug-induced elevations in blood pressure by adjunctive use of antihypertensive drugs |
| JP6215230B2 (ja) * | 2012-01-16 | 2017-10-18 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのピラン−スピロ環式ピペリジンアミド |
| EP2964022B1 (en) | 2013-03-07 | 2019-11-06 | Mindlab LLC | Pain medicine combination and uses thereof |
| EP3512600A4 (en) * | 2016-09-13 | 2020-05-27 | Mindlab LLC | DRUG COMBINATIONS AND TREATMENT OF RESTLESS LEG SYNDROME |
| CN110179988A (zh) * | 2019-07-10 | 2019-08-30 | 王大伟 | 五羟色胺再摄取抑制剂和单胺氧化酶抑制剂联合在制备治疗抑郁症或早泄药物中的应用 |
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| MX170841B (es) | 1988-09-26 | 1993-09-20 | Goodyear Tire & Rubber | Proceso mejorado para la sintesis catalizada de metacrilaminadas y acrilimidas n-substituidas |
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| CA2026389A1 (en) | 1989-09-29 | 1991-03-30 | Hideo Nakai | Chromene or thiochromene derivatives, process for preparing the same and intermediate therefor |
| JP2985322B2 (ja) | 1991-03-01 | 1999-11-29 | 東レ株式会社 | イソキノリン誘導体およびその医薬用途 |
| US5354863A (en) | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
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| US6031115A (en) | 1993-05-14 | 2000-02-29 | Smithkline Beecham Plc | Process for preparing epoxides |
| US5731322A (en) | 1993-08-06 | 1998-03-24 | Smithkline Beecham S.P.A. | Octahydro-1H-pyrrolo 3,2-g!and 2,3-g!isoquinoline derivatives |
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| US5683628A (en) | 1994-10-17 | 1997-11-04 | Seiko Epson Corp. | Photochromic composition and photochromic resin obtainable by using the same |
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| US5656420A (en) | 1995-02-24 | 1997-08-12 | University Of Kentucky Research Foundation | Method for employing the delta opioid dadle to extend tissue survival time during ischemia |
| IT1307327B1 (it) | 1995-09-12 | 2001-10-30 | Smithkline Beecham Spa | Derivati idroisochinolinici sostituiti |
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-
2007
- 2007-04-04 US US11/696,585 patent/US7576207B2/en not_active Expired - Fee Related
- 2007-04-05 EP EP07760193A patent/EP2001467A4/en not_active Withdrawn
- 2007-04-05 BR BRPI0709466-3A patent/BRPI0709466A2/pt not_active IP Right Cessation
- 2007-04-05 CA CA002648287A patent/CA2648287A1/en not_active Abandoned
- 2007-04-05 KR KR1020087027224A patent/KR20090014157A/ko not_active Ceased
- 2007-04-05 WO PCT/US2007/066071 patent/WO2007118151A2/en not_active Ceased
- 2007-04-05 MX MX2008012856A patent/MX2008012856A/es not_active Application Discontinuation
- 2007-04-05 AU AU2007234762A patent/AU2007234762A1/en not_active Abandoned
- 2007-04-05 JP JP2009504476A patent/JP2009533353A/ja active Pending
-
2008
- 2008-09-23 IL IL194292A patent/IL194292A0/en unknown
- 2008-10-21 CO CO08112132A patent/CO6140027A2/es unknown
-
2009
- 2009-07-27 US US12/509,549 patent/US20100196269A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0709466A2 (pt) | 2011-07-19 |
| EP2001467A2 (en) | 2008-12-17 |
| WO2007118151A3 (en) | 2008-07-03 |
| US7576207B2 (en) | 2009-08-18 |
| JP2009533353A (ja) | 2009-09-17 |
| US20100196269A1 (en) | 2010-08-05 |
| KR20090014157A (ko) | 2009-02-06 |
| MX2008012856A (es) | 2009-02-23 |
| US20070269374A1 (en) | 2007-11-22 |
| WO2007118151A2 (en) | 2007-10-18 |
| CA2648287A1 (en) | 2007-10-18 |
| EP2001467A4 (en) | 2009-11-18 |
| IL194292A0 (en) | 2009-09-22 |
| CO6140027A2 (es) | 2010-03-19 |
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