AU2007215247B2 - Benzazole derivatives, compositions, and methods of use as Aurora kinase inhibitors - Google Patents
Benzazole derivatives, compositions, and methods of use as Aurora kinase inhibitors Download PDFInfo
- Publication number
- AU2007215247B2 AU2007215247B2 AU2007215247A AU2007215247A AU2007215247B2 AU 2007215247 B2 AU2007215247 B2 AU 2007215247B2 AU 2007215247 A AU2007215247 A AU 2007215247A AU 2007215247 A AU2007215247 A AU 2007215247A AU 2007215247 B2 AU2007215247 B2 AU 2007215247B2
- Authority
- AU
- Australia
- Prior art keywords
- indazol
- carboxylic acid
- cancer
- amide
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77249706P | 2006-02-10 | 2006-02-10 | |
| US60/772,497 | 2006-02-10 | ||
| US79118706P | 2006-04-11 | 2006-04-11 | |
| US60/791,187 | 2006-04-11 | ||
| PCT/US2007/003579 WO2007095124A2 (en) | 2006-02-10 | 2007-02-09 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007215247A1 AU2007215247A1 (en) | 2007-08-23 |
| AU2007215247B2 true AU2007215247B2 (en) | 2012-12-13 |
Family
ID=38157823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007215247A Ceased AU2007215247B2 (en) | 2006-02-10 | 2007-02-09 | Benzazole derivatives, compositions, and methods of use as Aurora kinase inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7820821B2 (enExample) |
| EP (2) | EP1987028A2 (enExample) |
| JP (1) | JP5188988B2 (enExample) |
| CN (2) | CN102633783A (enExample) |
| AU (1) | AU2007215247B2 (enExample) |
| BR (1) | BRPI0708034A2 (enExample) |
| CA (1) | CA2641744C (enExample) |
| IL (1) | IL192580A0 (enExample) |
| WO (1) | WO2007095124A2 (enExample) |
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| EA020777B1 (ru) * | 2007-11-16 | 2015-01-30 | Инсайт Корпорейшн | 4-пиразолил-n-арилпиримидин-2-амины, 4-пиразолил-n-пиразолилпиримидин-2-амины и 4-пиразолил-n-пиридилпиримидин-2-амины в качестве ингибиторов киназ janus |
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| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
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| CN102361857B (zh) | 2008-09-26 | 2015-09-16 | 默沙东公司 | 可用作抗糖尿病剂的环状苯并咪唑衍生物 |
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2007
- 2007-02-09 CN CN2012101215887A patent/CN102633783A/zh active Pending
- 2007-02-09 CA CA2641744A patent/CA2641744C/en not_active Expired - Fee Related
- 2007-02-09 BR BRPI0708034-4A patent/BRPI0708034A2/pt not_active IP Right Cessation
- 2007-02-09 EP EP07750418A patent/EP1987028A2/en not_active Withdrawn
- 2007-02-09 WO PCT/US2007/003579 patent/WO2007095124A2/en not_active Ceased
- 2007-02-09 US US11/704,431 patent/US7820821B2/en not_active Expired - Fee Related
- 2007-02-09 EP EP10194622A patent/EP2295432A1/en not_active Withdrawn
- 2007-02-09 CN CN2007800047858A patent/CN101379060B/zh not_active Expired - Fee Related
- 2007-02-09 AU AU2007215247A patent/AU2007215247B2/en not_active Ceased
- 2007-02-09 JP JP2008554398A patent/JP5188988B2/ja not_active Expired - Fee Related
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2008
- 2008-07-02 IL IL192580A patent/IL192580A0/en unknown
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| WO2003053939A1 (fr) * | 2001-12-21 | 2003-07-03 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derives de benzimidazole et leur utilisation comme antagonistes de gnrh |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2641744A1 (en) | 2007-08-23 |
| CN101379060B (zh) | 2012-05-23 |
| US20100152170A1 (en) | 2010-06-17 |
| EP1987028A2 (en) | 2008-11-05 |
| US8377983B2 (en) | 2013-02-19 |
| JP5188988B2 (ja) | 2013-04-24 |
| CA2641744C (en) | 2012-09-25 |
| WO2007095124A2 (en) | 2007-08-23 |
| US7820821B2 (en) | 2010-10-26 |
| EP2295432A1 (en) | 2011-03-16 |
| JP2009526072A (ja) | 2009-07-16 |
| CN101379060A (zh) | 2009-03-04 |
| CN102633783A (zh) | 2012-08-15 |
| WO2007095124A3 (en) | 2007-11-01 |
| IL192580A0 (en) | 2009-02-11 |
| HK1125631A1 (en) | 2009-08-14 |
| US20070219235A1 (en) | 2007-09-20 |
| BRPI0708034A2 (pt) | 2011-05-17 |
| AU2007215247A1 (en) | 2007-08-23 |
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