AU2006236378B2 - Combination cancer therapy with bis(thiohydrazide) amide compounds - Google Patents

Combination cancer therapy with bis(thiohydrazide) amide compounds Download PDF

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Publication number
AU2006236378B2
AU2006236378B2 AU2006236378A AU2006236378A AU2006236378B2 AU 2006236378 B2 AU2006236378 B2 AU 2006236378B2 AU 2006236378 A AU2006236378 A AU 2006236378A AU 2006236378 A AU2006236378 A AU 2006236378A AU 2006236378 B2 AU2006236378 B2 AU 2006236378B2
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AU
Australia
Prior art keywords
bis
cancer
methyl
taxane
paclitaxel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006236378A
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English (en)
Other versions
AU2006236378A1 (en
Inventor
Thomas A. Dahl
Matthew Mcleod
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Publication of AU2006236378A1 publication Critical patent/AU2006236378A1/en
Application granted granted Critical
Publication of AU2006236378B2 publication Critical patent/AU2006236378B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2006236378A 2005-04-15 2006-04-13 Combination cancer therapy with bis(thiohydrazide) amide compounds Ceased AU2006236378B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67213905P 2005-04-15 2005-04-15
US60/672,139 2005-04-15
PCT/US2006/014531 WO2006113695A1 (en) 2005-04-15 2006-04-13 Combination cancer therapy with bis(thiohydrazide) amide compounds

Publications (2)

Publication Number Publication Date
AU2006236378A1 AU2006236378A1 (en) 2006-10-26
AU2006236378B2 true AU2006236378B2 (en) 2010-12-02

Family

ID=36694110

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006236378A Ceased AU2006236378B2 (en) 2005-04-15 2006-04-13 Combination cancer therapy with bis(thiohydrazide) amide compounds

Country Status (11)

Country Link
US (2) US8017654B2 (OSRAM)
EP (1) EP1877048A1 (OSRAM)
JP (1) JP2008536875A (OSRAM)
AU (1) AU2006236378B2 (OSRAM)
BR (1) BRPI0610219A2 (OSRAM)
CA (1) CA2604907A1 (OSRAM)
IL (1) IL186662A (OSRAM)
MX (1) MX2007012688A (OSRAM)
NZ (1) NZ562572A (OSRAM)
WO (1) WO2006113695A1 (OSRAM)
ZA (1) ZA200708703B (OSRAM)

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MX2007014314A (es) 2005-05-16 2008-02-11 Synta Pharmaceuticals Corp Sintesis de sales de bis(tio-hidrazida amida).
KR20080035642A (ko) 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
US20080226588A1 (en) * 2006-08-21 2008-09-18 Mcleod Matthew Treating melanoma with bis(thiohydrazide amides)
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
RU2475478C2 (ru) 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Соединения для лечения пролиферативных расстройств
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
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WO2008033494A2 (en) 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
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WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
AU2009308511B2 (en) 2008-10-22 2013-03-07 Synta Pharmaceutical Corp. Transition metal complexes of a bis[thiohydrazide amide] compound
CA2741189A1 (en) 2008-10-22 2010-04-29 Synta Pharmaceuticals Corp. Transition metal complexes of bis[thiohydrazide amide] compounds
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AU2009322603B2 (en) 2008-12-01 2013-08-29 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
WO2011133673A1 (en) 2010-04-20 2011-10-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
AU2012335105A1 (en) * 2011-11-10 2014-06-19 Synta Pharmaceuticals Corp. Administration of a bis(thiohydrazide amide) compound for treating cancers
US20150057357A1 (en) 2012-01-05 2015-02-26 The Board Of Trustees Of The Leland Stanford Junior University Bis (thiohydrazide amide) compounds for treating cancers

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Also Published As

Publication number Publication date
BRPI0610219A2 (pt) 2010-06-08
US20120232134A1 (en) 2012-09-13
JP2008536875A (ja) 2008-09-11
ZA200708703B (en) 2008-11-26
NZ562572A (en) 2011-01-28
US8017654B2 (en) 2011-09-13
EP1877048A1 (en) 2008-01-16
CA2604907A1 (en) 2006-10-26
AU2006236378A1 (en) 2006-10-26
IL186662A0 (en) 2008-06-05
US20090137682A1 (en) 2009-05-28
WO2006113695A1 (en) 2006-10-26
IL186662A (en) 2014-01-30
MX2007012688A (es) 2008-03-14

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