AU2006216441B2 - Tetrahydroindolone and tetrahydroindazolone derivatives - Google Patents

Tetrahydroindolone and tetrahydroindazolone derivatives Download PDF

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Publication number
AU2006216441B2
AU2006216441B2 AU2006216441A AU2006216441A AU2006216441B2 AU 2006216441 B2 AU2006216441 B2 AU 2006216441B2 AU 2006216441 A AU2006216441 A AU 2006216441A AU 2006216441 A AU2006216441 A AU 2006216441A AU 2006216441 B2 AU2006216441 B2 AU 2006216441B2
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Australia
Prior art keywords
alkyl
oxo
tetrahydro
benzamide
trimethyl
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AU2006216441A
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AU2006216441A1 (en
Inventor
Thomas Barta
Jeron Eaves
Lifeng Geng
Gunnar Hanson
Lindsay Hinkley
Kenneth He Huang
James Veal
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Serenex Inc
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Serenex Inc
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Priority to AU2011201700A priority Critical patent/AU2011201700B2/en
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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  • Plural Heterocyclic Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2006216441A 2005-02-25 2006-02-27 Tetrahydroindolone and tetrahydroindazolone derivatives Ceased AU2006216441B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011201700A AU2011201700B2 (en) 2005-02-25 2011-04-15 Tetrahydroindolone and tetrahydroindazolone derivatives

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US65623005P 2005-02-25 2005-02-25
US60/656,230 2005-02-25
US70571505P 2005-08-04 2005-08-04
US60/705,715 2005-08-04
US72796505P 2005-10-18 2005-10-18
US60/727,965 2005-10-18
PCT/US2006/006988 WO2006091963A1 (en) 2005-02-25 2006-02-27 Tetrahydroindolone and tetrahydroindazolone derivatives

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AU2006216441A1 AU2006216441A1 (en) 2006-08-31
AU2006216441B2 true AU2006216441B2 (en) 2011-03-24

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Families Citing this family (63)

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Publication number Priority date Publication date Assignee Title
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CA2582674A1 (en) * 2004-10-04 2006-04-20 Myriad Genetics, Inc. Compounds for alzheimer's disease
KR101617774B1 (ko) * 2005-02-25 2016-05-04 에사넥스, 인코포레이티드 테트라히드로인돌론 및 테트라히드로인다졸론 유도체
DE602006021306D1 (enExample) * 2005-06-27 2011-05-26 Bristol Myers Squibb Co
EP1991525A1 (en) * 2006-02-27 2008-11-19 Serenex, Inc. Cyclohexylamino, benzene, pyridine, and pyridazine derivatives
WO2007120669A1 (en) * 2006-04-13 2007-10-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
CA2652263A1 (en) 2006-05-12 2007-11-22 Myriad Genetics, Inc. Therapeutic compounds and their use in cancer
HRP20110917T1 (hr) * 2006-05-19 2012-03-31 Abbott Laboratories Derivati azabicikličkih alkana supstituirani fuzioniranim bicikloheterociklima aktivni u središnjem živčanom sustavu
WO2008005937A2 (en) * 2006-06-30 2008-01-10 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases through inhibiton of hsp90
CA2661436A1 (en) * 2006-08-24 2008-02-28 Serenex, Inc. Isoquinoline, quinazoline and phthalazine derivatives
US20080076800A1 (en) * 2006-08-24 2008-03-27 Huang Kenneth H Benzene, Pyridine, and Pyridazine Derivatives
US20080076813A1 (en) * 2006-08-24 2008-03-27 Huang Kenneth H Benzene, Pyridine, and Pyridazine Derivatives
US20080070933A1 (en) * 2006-08-24 2008-03-20 Huang Kenneth H Purine, Pyrimidine, and Azaindole Derivatives
US20080119457A1 (en) * 2006-08-24 2008-05-22 Serenex, Inc. Benzene, Pyridine, and Pyridazine Derivatives
WO2008024961A1 (en) * 2006-08-24 2008-02-28 Serenex, Inc. Dihydropyridazine, tetrahydropyridine, chromanone, and dihydronaphthalenone derivatives as heat-shock protein 90 inhibitors
US20090093452A1 (en) * 2006-08-24 2009-04-09 Pfizer Inc. Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives
FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
WO2008057246A2 (en) * 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Method for treating inflammatory disorders
CN101273991B (zh) * 2007-03-28 2010-05-26 广东同德药业有限公司 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用
US20080269193A1 (en) * 2007-04-16 2008-10-30 Kenneth He Huang Tetrahydroindole and Tetrahydroindazole Derivatives
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
WO2009051244A1 (ja) * 2007-10-18 2009-04-23 Takeda Pharmaceutical Company Limited 複素環化合物
FR2955323B1 (fr) * 2010-01-19 2015-01-16 Sanofi Aventis Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
FR2943341B1 (fr) * 2009-03-19 2011-03-11 Sanofi Aventis Nouveaux derives d'indazole inhibiteurs d'hsp90,compositions les contenant et utilisation
WO2010106290A1 (fr) * 2009-03-19 2010-09-23 Sanofi-Aventis Derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2770327B1 (en) * 2009-03-30 2017-06-14 Nordic Bioscience A/S Fibrosis biomarker assay
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
GB201009853D0 (en) 2010-06-11 2010-07-21 Chroma Therapeutics Ltd HSP90 inhibitors
CN101872359B (zh) * 2010-06-11 2013-08-14 北京邮电大学 实现演变点发现的社会网络演化分析方法及系统
CN102311389A (zh) * 2010-06-29 2012-01-11 王小龙 一种氮芳香取代吡唑衍生物、及其合成和抗癌应用
CN101955461B (zh) * 2010-10-08 2012-11-21 广州暨南生物医药研究开发基地有限公司 一种Hsp90抑制剂Xbj-B11及其制备方法与应用
CN101967125B (zh) 2010-10-08 2012-07-04 广州暨南生物医药研究开发基地有限公司 一种Hsp90抑制剂Xbj-B16-1及其制备方法与应用
BR112013023452A2 (pt) 2011-03-15 2016-12-06 Univ British Columbia combinação de oligonucleotídeo anti-clusterina com inibidor de hsp90 para o tratamento de câncer de próstata
CN102675288B (zh) * 2011-03-18 2014-01-01 北京师范大学 2-((2-(双(2-吡啶甲基)氨基)乙基)氨基)-4-(3，6，6-三甲基-4-氧-4，5，6，7-四氢吲唑基)苯甲酰胺及制备、应用
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
JP2014532712A (ja) 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法
AU2012339679A1 (en) 2011-11-14 2014-06-12 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with BRAF inhibitors
EP2879675B1 (en) 2012-08-06 2019-11-13 Duke University Compounds and methods for targeting hsp90
CN103467356B (zh) * 2013-08-12 2015-04-01 绍兴文理学院 一种四氢吲哚化合物及其制备方法与应用
SG11201700777VA (en) 2014-08-04 2017-02-27 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
EP3191473A1 (en) * 2014-09-11 2017-07-19 Esanex, Inc. Indazolyl- and indolyl-benzamide derivatives
WO2016086153A2 (en) 2014-11-26 2016-06-02 Esanex, Inc. Use of tetrahydro!ndazolylbeimzamide and tetrahydroindolylbenzamide derivatives for the treatment of human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids)
CN104592230B (zh) * 2015-01-30 2017-02-01 广州暨南生物医药研究开发基地有限公司 一种2‑（石榴皮烷‑3‑氨基）‑4‑四氢吲唑取代的苯甲酰胺化合物及其应用
CN104592203A (zh) * 2015-01-30 2015-05-06 广州暨南生物医药研究开发基地有限公司 一种2-氨基-4-四氢吲唑取代的苯甲酰胺化合物及其在制备抗肿瘤药物中的应用
US9737509B1 (en) 2015-05-26 2017-08-22 University Of South Florida Antimicrobial compositions, methods of use, and methods of treatment of infections
WO2017059434A1 (en) 2015-10-02 2017-04-06 Esanex, Inc. Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of cancer
KR102073779B1 (ko) * 2015-10-13 2020-02-05 니혼노야쿠가부시키가이샤 옥심기를 가지는 축합복소환 화합물 또는 그의 염류 및 상기 화합물을 함유하는 농원예용 살충제 및 그 사용 방법
WO2017184956A1 (en) 2016-04-22 2017-10-26 Duke University Compounds and methods for targeting hsp90
KR20190009346A (ko) * 2016-05-18 2019-01-28 에사넥스, 인코포레이티드 암의 치료를 위한 인다졸릴벤즈아미드 유도체를 이용한 조합 요법
EP3515436A1 (en) 2016-09-23 2019-07-31 Esanex, Inc. Combination therapies using indazolylbenzamide derivatives for the treatment of cancer
US11014927B2 (en) 2017-03-20 2021-05-25 Forma Therapeutics, Inc. Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
ES2989438T3 (es) 2018-09-19 2024-11-26 Novo Nordisk Healthcare Ag Activación de la piruvato cinasa R
EP4031132A4 (en) 2019-09-19 2023-09-13 Forma Therapeutics, Inc. Activating pyruvate kinase r
US11685727B2 (en) 2019-12-20 2023-06-27 Nuevolution A/S Compounds active towards nuclear receptors
JP2021098692A (ja) 2019-12-20 2021-07-01 ヌエヴォリューション・アクティーゼルスカブＮｕｅｖｏｌｕｔｉｏｎ Ａ／Ｓ 核内受容体に対して活性の化合物
JP7713954B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
MX2022012260A (es) 2020-03-31 2022-11-30 Nuevolution As Compuestos activos frente a receptores nucleares.
CN117126097A (zh) * 2020-06-11 2023-11-28 贝达药业股份有限公司 双环化合物及其应用
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN114213332B (zh) * 2022-02-21 2022-05-17 深圳市人民医院 一种四氢吲唑类化合物及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104442A (en) * 1990-08-04 1992-04-14 Hoechst Aktiengesellschaft 4,5,6,7-tetrahydro-3-aryl-indazoles and their use as herbicides
WO2002020480A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
US6395905B1 (en) * 1999-01-06 2002-05-28 Merck Sharp & Dohme Ltd. Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors
US6395766B1 (en) * 1998-06-04 2002-05-28 Merck Sharp & Dohme Limited Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition
US6716856B1 (en) * 1999-05-12 2004-04-06 Pharmacia & Tubjohn Spa 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
US20040180889A1 (en) * 2002-03-01 2004-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1431267A4 (en) 2001-08-09 2004-12-22 Ono Pharmaceutical Co COMPOUNDS DERIVED FROM CARBOXYLIC ACID AND MEDICAMENTS COMPRISING SUCH COMPOUNDS AS ACTIVE INGREDIENT
DE10148618B4 (de) * 2001-09-25 2007-05-03 Schering Ag Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel
AU2003288994A1 (en) 2002-12-10 2004-06-30 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compounds and medicinal use thereof
PE20040804A1 (es) 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
KR101617774B1 (ko) * 2005-02-25 2016-05-04 에사넥스, 인코포레이티드 테트라히드로인돌론 및 테트라히드로인다졸론 유도체
JPWO2006109846A1 (ja) 2005-04-06 2008-11-20 武田薬品工業株式会社 トリアゾール誘導体およびその用途
US20080269193A1 (en) * 2007-04-16 2008-10-30 Kenneth He Huang Tetrahydroindole and Tetrahydroindazole Derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104442A (en) * 1990-08-04 1992-04-14 Hoechst Aktiengesellschaft 4,5,6,7-tetrahydro-3-aryl-indazoles and their use as herbicides
US6395766B1 (en) * 1998-06-04 2002-05-28 Merck Sharp & Dohme Limited Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition
US6395905B1 (en) * 1999-01-06 2002-05-28 Merck Sharp & Dohme Ltd. Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors
US6716856B1 (en) * 1999-05-12 2004-04-06 Pharmacia & Tubjohn Spa 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
WO2002020480A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
US20040180889A1 (en) * 2002-03-01 2004-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Heterocycles, 1995, 41(7), 1471-1478 *
J. Med. Chem., 2002, 45, 3009-3021 *
J. of Pharm. and Bio. Analysis, 2003, 32, 531-538 *
Kimijas Serija, 1968, 2, 188-191 & CAS RN 19933-33-6 *
Synthesis, 1995, 41(7), 1471-1478 *

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