EA013521B1 - Производные тетрагидроиндазолона - Google Patents

Производные тетрагидроиндазолона Download PDF

Info

Publication number
EA013521B1
EA013521B1 EA200701808A EA200701808A EA013521B1 EA 013521 B1 EA013521 B1 EA 013521B1 EA 200701808 A EA200701808 A EA 200701808A EA 200701808 A EA200701808 A EA 200701808A EA 013521 B1 EA013521 B1 EA 013521B1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxo
benzamide
alkyl
tetrahydro
amino
Prior art date
Application number
EA200701808A
Other languages
English (en)
Russian (ru)
Other versions
EA200701808A1 (ru
Inventor
Кеннет Хэ Хуан
Джерон Ивз
Джеймс Вил
Томас Барта
Лифэн Гэн
Линдзи Хинкли
Гуннар Дж. Хансон
Original Assignee
Серенекс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Серенекс, Инк. filed Critical Серенекс, Инк.
Publication of EA200701808A1 publication Critical patent/EA200701808A1/ru
Publication of EA013521B1 publication Critical patent/EA013521B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EA200701808A 2005-02-25 2006-02-27 Производные тетрагидроиндазолона EA013521B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65623005P 2005-02-25 2005-02-25
US70571505P 2005-08-04 2005-08-04
US72796505P 2005-10-18 2005-10-18
PCT/US2006/006988 WO2006091963A1 (en) 2005-02-25 2006-02-27 Tetrahydroindolone and tetrahydroindazolone derivatives

Publications (2)

Publication Number Publication Date
EA200701808A1 EA200701808A1 (ru) 2008-02-28
EA013521B1 true EA013521B1 (ru) 2010-06-30

Family

ID=36581601

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701808A EA013521B1 (ru) 2005-02-25 2006-02-27 Производные тетрагидроиндазолона

Country Status (24)

Country Link
US (8) US7358370B2 (enExample)
EP (2) EP2380879B1 (enExample)
JP (1) JP4377942B2 (enExample)
KR (3) KR101617774B1 (enExample)
CN (1) CN101180275B (enExample)
AR (1) AR054186A1 (enExample)
AU (2) AU2006216441B2 (enExample)
BR (1) BRPI0607739A2 (enExample)
CA (1) CA2598993C (enExample)
DK (1) DK1856057T3 (enExample)
EA (1) EA013521B1 (enExample)
ES (1) ES2527770T3 (enExample)
GE (1) GEP20104994B (enExample)
IL (1) IL185280A (enExample)
MA (1) MA29713B1 (enExample)
MX (1) MX2007010227A (enExample)
NO (1) NO20074274L (enExample)
NZ (2) NZ588960A (enExample)
PL (1) PL1856057T3 (enExample)
PT (1) PT1856057E (enExample)
SI (1) SI1856057T1 (enExample)
TW (1) TWI382015B (enExample)
UA (1) UA92907C2 (enExample)
WO (1) WO2006091963A1 (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
EP2813498B1 (en) * 2004-10-04 2016-04-20 Manfredi, John Compounds for Alzheimer's disease
EP2380879B1 (en) 2005-02-25 2017-07-12 Esanex, Inc. Tetrahydroindolone and tetrahydroindazolone derivatives
US7728008B2 (en) 2005-06-27 2010-06-01 Bristol-Myers Squibb Company N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US20070207984A1 (en) * 2006-02-27 2007-09-06 Huang Kenneth H Cyclohexylamino Benzene, Pyridine, and Pyridazine Derivatives
EP2004614B1 (en) * 2006-04-13 2016-10-19 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
NZ572600A (en) 2006-05-12 2011-08-26 Myrexis Inc 6-Amino-purine derivatives for the treatment of cancer and fibrogenetic disorders
ATE529423T1 (de) * 2006-05-19 2011-11-15 Abbott Lab Cns-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische alkanderivate
ES2645095T3 (es) * 2006-06-30 2017-12-04 Sloan-Kettering Institute For Cancer Research Tratamiento de enfermedades neurodegenerativas a través de la inhibición de Hsp90
US20080070918A1 (en) * 2006-08-24 2008-03-20 Huang Kenneth H Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives
US20080119457A1 (en) * 2006-08-24 2008-05-22 Serenex, Inc. Benzene, Pyridine, and Pyridazine Derivatives
US7678803B2 (en) 2006-08-24 2010-03-16 Serenex, Inc. Quinazoline derivatives for the treatment of cancer
WO2008024980A2 (en) * 2006-08-24 2008-02-28 Serenex, Inc. Pyrrole, thiophene, furan, imidazole, oxazole, and thiazole derivatives
WO2008024963A1 (en) * 2006-08-24 2008-02-28 Serenex, Inc. Benzene, pyridine, and pyridazine derivatives
WO2008024970A2 (en) * 2006-08-24 2008-02-28 Serenex, Inc. Tetrahydroindolone and tetrahydroindazolone derivatives
WO2008024981A1 (en) * 2006-08-24 2008-02-28 Serenex, Inc. Piperazine-substituted benzothiophenes for treatment of mental disorders
FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
WO2008057246A2 (en) * 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Method for treating inflammatory disorders
CN101273991B (zh) * 2007-03-28 2010-05-26 广东同德药业有限公司 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用
EP2146967A2 (en) * 2007-04-16 2010-01-27 Serenex, Inc. Tetrahydroindole and tetrahydroindazole derivatives
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
US8586571B2 (en) * 2007-10-18 2013-11-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
FR2943341B1 (fr) * 2009-03-19 2011-03-11 Sanofi Aventis Nouveaux derives d'indazole inhibiteurs d'hsp90,compositions les contenant et utilisation
FR2955323B1 (fr) * 2010-01-19 2015-01-16 Sanofi Aventis Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
RU2011142151A (ru) * 2009-03-19 2013-04-27 Санофи Производные индазола-ингибиторы hsp90, содержащие их композиции и применение
DK3173792T3 (da) * 2009-03-30 2019-08-05 Novartis Ag Crp neo-epitop fibrose-assay
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CN101872359B (zh) * 2010-06-11 2013-08-14 北京邮电大学 实现演变点发现的社会网络演化分析方法及系统
GB201009853D0 (en) 2010-06-11 2010-07-21 Chroma Therapeutics Ltd HSP90 inhibitors
CN102311389A (zh) * 2010-06-29 2012-01-11 王小龙 一种氮芳香取代吡唑衍生物、及其合成和抗癌应用
CN101955461B (zh) * 2010-10-08 2012-11-21 广州暨南生物医药研究开发基地有限公司 一种Hsp90抑制剂Xbj-B11及其制备方法与应用
CN101967125B (zh) 2010-10-08 2012-07-04 广州暨南生物医药研究开发基地有限公司 一种Hsp90抑制剂Xbj-B16-1及其制备方法与应用
CA2830195A1 (en) 2011-03-15 2012-09-20 Martin E. Gleave Combination of anti-clusterin oligonucleotide with hsp90 inhibitor for the treatment of prostate cancer
CN102675288B (zh) * 2011-03-18 2014-01-01 北京师范大学 2-((2-(双(2-吡啶甲基)氨基)乙基)氨基)-4-(3，6，6-三甲基-4-氧-4，5，6，7-四氢吲唑基)苯甲酰胺及制备、应用
CA2853799A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
US20140286902A1 (en) 2011-11-02 2014-09-25 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
WO2013074594A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
WO2014025395A1 (en) 2012-08-06 2014-02-13 Duke University Compounds and methods for targeting hsp90
CN103467356B (zh) * 2013-08-12 2015-04-01 绍兴文理学院 一种四氢吲哚化合物及其制备方法与应用
MA40552A (fr) 2014-08-04 2021-05-19 Nuevolution As Derives de pyrimidine eventuellement condensee substituee par un heterocycle utiles dans le traitement de maladies inflammatoires, metaboliques, oncologiques et auto-immunes
EP3191473A1 (en) * 2014-09-11 2017-07-19 Esanex, Inc. Indazolyl- and indolyl-benzamide derivatives
US20160143884A1 (en) * 2014-11-26 2016-05-26 Esanex, Inc. Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids)
CN104592230B (zh) * 2015-01-30 2017-02-01 广州暨南生物医药研究开发基地有限公司 一种2‑（石榴皮烷‑3‑氨基）‑4‑四氢吲唑取代的苯甲酰胺化合物及其应用
CN104592203A (zh) * 2015-01-30 2015-05-06 广州暨南生物医药研究开发基地有限公司 一种2-氨基-4-四氢吲唑取代的苯甲酰胺化合物及其在制备抗肿瘤药物中的应用
US9737509B1 (en) 2015-05-26 2017-08-22 University Of South Florida Antimicrobial compositions, methods of use, and methods of treatment of infections
WO2017059434A1 (en) 2015-10-02 2017-04-06 Esanex, Inc. Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of cancer
CN108137568A (zh) 2015-10-13 2018-06-08 日本农药株式会社 具有肟基的稠杂环化合物或其盐类及含有该化合物的农业园艺用杀虫剂以及其使用方法
US11261187B2 (en) 2016-04-22 2022-03-01 Duke University Compounds and methods for targeting HSP90
US20190134003A1 (en) * 2016-05-18 2019-05-09 Esanex, Inc. Combination therapies using indazolylbenzamide derivatives for the treatment of cancer
CN110035752A (zh) 2016-09-23 2019-07-19 埃萨内克斯股份有限公司 使用吲唑基苯甲酰胺衍生物治疗癌症的组合疗法
AU2018240172C1 (en) 2017-03-20 2019-10-24 Novo Nordisk Health Care Ag Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
JP7450610B2 (ja) 2018-09-19 2024-03-15 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ピルビン酸キナーゼｒの活性化
BR112022004376A2 (pt) 2019-09-19 2022-06-07 Forma Therapeutics Inc Ativação de piruvato quinase r
AU2020408107A1 (en) 2019-12-20 2022-04-14 Nuevolution A/S Compounds active towards nuclear receptors
US11447479B2 (en) 2019-12-20 2022-09-20 Nuevolution A/S Compounds active towards nuclear receptors
CA3174252A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
JP7713954B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
CN115884966B (zh) * 2020-06-11 2024-10-22 贝达药业股份有限公司 双环化合物及其应用
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN114213332B (zh) * 2022-02-21 2022-05-17 深圳市人民医院 一种四氢吲唑类化合物及其制备方法和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104442A (en) * 1990-08-04 1992-04-14 Hoechst Aktiengesellschaft 4,5,6,7-tetrahydro-3-aryl-indazoles and their use as herbicides
WO2002020480A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
US6395905B1 (en) * 1999-01-06 2002-05-28 Merck Sharp & Dohme Ltd. Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors
US6395766B1 (en) * 1998-06-04 2002-05-28 Merck Sharp & Dohme Limited Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition
US20030212121A1 (en) * 2001-09-25 2003-11-13 Martin Kruger Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production and use as pharmaceutical agents
US6716856B1 (en) * 1999-05-12 2004-04-06 Pharmacia & Tubjohn Spa 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
US20040180889A1 (en) * 2002-03-01 2004-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160253A0 (en) * 2001-08-09 2004-07-25 Ono Pharmaceutical Co Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
EP1571146A4 (en) 2002-12-10 2010-09-01 Ono Pharmaceutical Co NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE
PE20040804A1 (es) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
EP2380879B1 (en) * 2005-02-25 2017-07-12 Esanex, Inc. Tetrahydroindolone and tetrahydroindazolone derivatives
WO2006109846A1 (ja) 2005-04-06 2006-10-19 Takeda Pharmaceutical Company Limited トリアゾール誘導体およびその用途
EP2146967A2 (en) * 2007-04-16 2010-01-27 Serenex, Inc. Tetrahydroindole and tetrahydroindazole derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104442A (en) * 1990-08-04 1992-04-14 Hoechst Aktiengesellschaft 4,5,6,7-tetrahydro-3-aryl-indazoles and their use as herbicides
US6395766B1 (en) * 1998-06-04 2002-05-28 Merck Sharp & Dohme Limited Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition
US6395905B1 (en) * 1999-01-06 2002-05-28 Merck Sharp & Dohme Ltd. Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors
US6716856B1 (en) * 1999-05-12 2004-04-06 Pharmacia & Tubjohn Spa 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
WO2002020480A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
US20030212121A1 (en) * 2001-09-25 2003-11-13 Martin Kruger Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production and use as pharmaceutical agents
US20040180889A1 (en) * 2002-03-01 2004-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CROCE P.D. ET AL. "A CONVENIENT SYNTHESIS OF INDAZOLES", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, 1984, pages 982-983, XP000999177, ISSN: 0039-7881, examples 3aa,3ba,3ca *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, XP002386617, Database accession no., 1968: 486902, abstract & STRAKOVA ET AL. "3-Methyl-6-phenyl and -6-.alpha.-furyl-4,5,6,7-tetrahydroindazol-4-one and their derivatives", LATVIJAS PSR ZINATNU AKADEMIJAS VESTIS, KIMIJAS SERIJA, vol. 2, 1968, pages 188-191, * see RN: 19933-33-6 * *
DYMOCK B.W. ET AL. "INHIBITORS OF HSP90 AND OTHER CHAPERONES FOR THE TREATMENT OF CANCER", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 14, no. 6, 2004, pages 837-847, XP001204795, ISSN: 1354-3776, the whole document *
FUKUMOTO ET AL., J. MED. CHEM., vol. 45, no. 14, 2002, pages 3009-3021, XP002386434, compound 37B *
GERHARD U. ET AL. Accelerated metabolite identification by "extraction-NMR", J. PHARM. BIOMED. ANAL., vol. 32, 2003, pages 531-538, XP002386433, compound 3 *
JIN IL KIM ET AL. "A VERSATILE SYNTHESIS OF SUBSTITUTED INDAZOLES", HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 41, no. 7, 1995, pages 1471-1478, XP001000793, ISSN: 0385-5414, examples 2a-d *
MALONEY A ET AL. "HSP90 AS A NEW THERAPEUTIC TARGET FOR CANCER THERAPY: THE STORY UNFOLDS", EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 2, no. 1, January 2002 (2002-01), pages 3-24, XP009053600, ISSN: 1471-2598, the whole document *

Also Published As

Publication number Publication date
EP2380879A1 (en) 2011-10-26
US7358370B2 (en) 2008-04-15
US20110183977A1 (en) 2011-07-28
TWI382015B (zh) 2013-01-11
CN101180275A (zh) 2008-05-14
US20170260174A1 (en) 2017-09-14
AR054186A1 (es) 2007-06-06
US20090163493A9 (en) 2009-06-25
IL185280A0 (en) 2008-02-09
US8309548B2 (en) 2012-11-13
US20200071308A1 (en) 2020-03-05
UA92907C2 (uk) 2010-12-27
GEP20104994B (en) 2010-05-25
NO20074274L (no) 2007-11-23
PT1856057E (pt) 2015-02-04
US20080096887A1 (en) 2008-04-24
EP1856057A1 (en) 2007-11-21
AU2006216441A1 (en) 2006-08-31
CA2598993A1 (en) 2006-08-31
US20110034529A1 (en) 2011-02-10
EP1856057B1 (en) 2014-10-15
SI1856057T1 (sl) 2015-05-29
EP2380879B1 (en) 2017-07-12
TW200720250A (en) 2007-06-01
CA2598993C (en) 2013-09-03
AU2011201700A1 (en) 2011-05-12
BRPI0607739A2 (pt) 2009-09-29
KR20070114763A (ko) 2007-12-04
EA200701808A1 (ru) 2008-02-28
PL1856057T3 (pl) 2015-04-30
NZ588960A (en) 2012-06-29
AU2011201700B2 (en) 2013-08-22
NZ560685A (en) 2010-12-24
KR101617774B1 (ko) 2016-05-04
US7906529B2 (en) 2011-03-15
US20130137686A1 (en) 2013-05-30
US20060211737A1 (en) 2006-09-21
JP4377942B2 (ja) 2009-12-02
MA29713B1 (fr) 2008-09-01
KR20150029766A (ko) 2015-03-18
AU2006216441B2 (en) 2011-03-24
US20140343037A1 (en) 2014-11-20
IL185280A (en) 2014-09-30
WO2006091963A1 (en) 2006-08-31
JP2008531599A (ja) 2008-08-14
HK1117535A1 (en) 2009-01-16
ES2527770T3 (es) 2015-01-29
KR20130103801A (ko) 2013-09-24
MX2007010227A (es) 2007-11-07
CN101180275B (zh) 2014-09-10
DK1856057T3 (en) 2015-01-19
US7928135B2 (en) 2011-04-19
US9656956B2 (en) 2017-05-23

Similar Documents

Publication Publication Date Title
EA013521B1 (ru) Производные тетрагидроиндазолона
US20080076800A1 (en) Benzene, Pyridine, and Pyridazine Derivatives
JP2010501593A (ja) イソキノリン、キナゾリンおよびフタラジン誘導体
WO2008024980A2 (en) Pyrrole, thiophene, furan, imidazole, oxazole, and thiazole derivatives
US20080076813A1 (en) Benzene, Pyridine, and Pyridazine Derivatives
HK1117535B (en) Tetrahydroindolone and tetrahydroindazolone derivatives
HK1163095A (en) Tetrahydroindolone and tetrahydroindazolone derivatives
US20150329493A1 (en) Omega-amino acid derivatives of benzene, pyridine, and pyridazine compounds

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU