AU2005258000B2 - Diagnostic and screening methods and kits associated with proteolytic activity - Google Patents

Diagnostic and screening methods and kits associated with proteolytic activity Download PDF

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Publication number
AU2005258000B2
AU2005258000B2 AU2005258000A AU2005258000A AU2005258000B2 AU 2005258000 B2 AU2005258000 B2 AU 2005258000B2 AU 2005258000 A AU2005258000 A AU 2005258000A AU 2005258000 A AU2005258000 A AU 2005258000A AU 2005258000 B2 AU2005258000 B2 AU 2005258000B2
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AU
Australia
Prior art keywords
ubiquitin
ubl
cleavage
activity
proteolytic enzyme
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Ceased
Application number
AU2005258000A
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English (en)
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AU2005258000A1 (en
Inventor
Alejandro Bernal
Tauseef R. Butt
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Progenra Inc
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Progenra Inc
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Publication of AU2005258000A1 publication Critical patent/AU2005258000A1/en
Application granted granted Critical
Publication of AU2005258000B2 publication Critical patent/AU2005258000B2/en
Ceased legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2005258000A 2004-06-21 2005-06-21 Diagnostic and screening methods and kits associated with proteolytic activity Ceased AU2005258000B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58090004P 2004-06-21 2004-06-21
US60/580,900 2004-06-21
PCT/US2005/021819 WO2006002100A2 (en) 2004-06-21 2005-06-21 Diagnostic and screening methods and kits associated with proteolytic activity

Publications (2)

Publication Number Publication Date
AU2005258000A1 AU2005258000A1 (en) 2006-01-05
AU2005258000B2 true AU2005258000B2 (en) 2011-02-03

Family

ID=35782279

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005258000A Ceased AU2005258000B2 (en) 2004-06-21 2005-06-21 Diagnostic and screening methods and kits associated with proteolytic activity

Country Status (11)

Country Link
US (1) US7842460B2 (de)
EP (1) EP1792181B1 (de)
JP (1) JP5031560B2 (de)
KR (1) KR20070051257A (de)
CN (1) CN1989411B (de)
AT (1) ATE488766T1 (de)
AU (1) AU2005258000B2 (de)
CA (1) CA2570959C (de)
DE (1) DE602005024833D1 (de)
IL (1) IL180201A (de)
WO (1) WO2006002100A2 (de)

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US7297480B2 (en) * 2001-06-28 2007-11-20 Dermtech International Method for detection of melanoma
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
WO2005056752A2 (en) 2003-10-24 2005-06-23 Gencia Corporation Methods and compositions for delivering polynucleotides
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
EP1771194A2 (de) * 2004-07-07 2007-04-11 Biodevelops Pharma Entwicklung GmbH Verwendung einer deubiquitinierenden verbindung zur steigerung der expression von membranproteinen auf der zelloberfläche
CA2670014A1 (en) * 2006-11-22 2008-11-20 Emory University Production of anti-microbial peptides
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
AU2008247502A1 (en) * 2007-05-04 2008-11-13 Dermtech International Diagnosis of melanoma by nucleic acid analysis
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
WO2009009773A1 (en) * 2007-07-11 2009-01-15 The Johns Hopkins University Use of otubain enzyme to cleave lysine-48-linked polyubiquitin
US20090092502A1 (en) * 2007-10-08 2009-04-09 Emerson Climate Technologies, Inc. Compressor having a power factor correction system and method
WO2009064843A1 (en) * 2007-11-13 2009-05-22 Bayer Healthcare Llc Method to measure amino acid concentrations
CN102089444A (zh) * 2008-05-14 2011-06-08 德玛泰克国际公司 利用核酸分析方法来诊断黑素瘤和太阳能雀斑
EP2977469A1 (de) * 2008-08-28 2016-01-27 Dermtech International Bestimmung der altersbereiche von hautproben
EP2182073B1 (de) * 2008-10-30 2014-04-16 Les Laboratoires Servier Ubiquitinspezifische Proteasen für die MCL-1-Stabilität und Verwendungen davon
WO2011042874A1 (en) * 2009-10-06 2011-04-14 Ecole Polytechnique Federale De Lausanne (Epfl) Visualization of proprotein convertase activity in living cells and tissues
US8518660B2 (en) 2010-06-24 2013-08-27 Lifesensors, Inc. Di- and poly-ubiquitin deubiquitinase substrates and uses thereof
CN103930781A (zh) * 2011-09-15 2014-07-16 霍夫曼-拉罗奇有限公司 促进分化的方法
CN102558310A (zh) * 2012-02-24 2012-07-11 李兵辉 实时监测蛋白水解酶活性的指示剂的制备方法及应用方法
KR101533345B1 (ko) * 2013-08-08 2015-07-22 아주대학교산학협력단 자가저해 단백질을 이용한 프로테아제 활성 측정용 센서, 및 이를 이용한 프로테아제의 활성 측정 방법
CN103468822B (zh) * 2013-09-30 2015-08-26 吴南 一种腰椎间盘退变相关snp的检测试剂盒
GB201318728D0 (en) * 2013-10-23 2013-12-04 Mologic Ltd Detection of cleavage activity of an enzyme
WO2015148566A1 (en) * 2014-03-24 2015-10-01 Duke University Screening targets and compositions and methods for treatment of ciliopathy disorders
CN105542012A (zh) * 2015-06-17 2016-05-04 吉林大学 融合蛋白sumo1-pla2及制备方法和医用用途
CN105542013A (zh) * 2015-06-17 2016-05-04 吉林大学 融合蛋白sumo3-pla2及制备方法和医用用途
CN105886595A (zh) * 2016-04-28 2016-08-24 夏云 一种快速检测人体粪便中蛋白质水解细菌的方法
CN106636366A (zh) * 2016-11-25 2017-05-10 苏州首度基因科技有限责任公司 预测胃癌转移的基因检测试剂盒及其使用方法
RS60209B1 (sr) 2017-03-20 2020-06-30 Forma Therapeutics Inc Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr)
CN108004247A (zh) * 2017-12-06 2018-05-08 吉林大学 一种类泛素底物融合蛋白及制备方法和医用用途
EP3752645A4 (de) 2018-02-14 2022-04-13 Dermtech, Inc. Neue gen-klassifikatoren und deren verwendung bei nicht-melanom-hautkrebs
GB201804285D0 (en) * 2018-03-16 2018-05-02 Univ Dundee Ligase screening assay
US20220031671A1 (en) 2018-09-19 2022-02-03 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
CN110004228B (zh) * 2019-04-03 2023-05-23 清华大学深圳研究生院 一种与乳腺癌分子分型相关的诊断标志物及其用途
CN110412004A (zh) * 2019-08-29 2019-11-05 苏州新格诺康生物技术有限公司 一种去泛素化酶的活性检测方法
CN114829882B (zh) 2019-11-05 2023-02-28 阿比尔技术公司 植物产品中感染的预测
WO2022259904A1 (ja) * 2021-06-07 2022-12-15 国立研究開発法人理化学研究所 プロテアーゼ活性測定用の融合タンパク質基質

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5503977A (en) * 1994-04-22 1996-04-02 California Institute Of Technology Split ubiquitin protein sensor
US20040053324A1 (en) * 2002-08-30 2004-03-18 Brian Wong Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents

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US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
EP1325148A1 (de) 2000-09-29 2003-07-09 Universität Zürich Verfahren und testsystem zur detektion von membranprotein-protein wechselwirkungen
CN1164752C (zh) * 2002-01-16 2004-09-01 北京大学 拟南芥的AT4g10590基因的用途
DE10211063A1 (de) * 2002-03-13 2003-10-09 Axaron Bioscience Ag Neue Verfahren zur Detektion und Analyse von Protein-Interaktionen in vivo
KR100910844B1 (ko) 2002-07-19 2009-08-06 주식회사 파라 모노-필라멘트를 포함하는 보강용 지지체를 가지는기체분리 및 수처리용 외압식 중공사막, 그 제조방법 및제조장치
DE10318048A1 (de) * 2003-04-17 2004-11-04 Axaron Bioscience Ag Nicht fluoreszierende, durch Proteolyse zur Fluoreszenz aktivierbare Reporterproteine und ihre Verwendung zur Detektion Protease-abhängiger Ereignisse

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5503977A (en) * 1994-04-22 1996-04-02 California Institute Of Technology Split ubiquitin protein sensor
US20040053324A1 (en) * 2002-08-30 2004-03-18 Brian Wong Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents

Non-Patent Citations (1)

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Title
Gohara et al (1999) Prot Express Purif vol 17 pps 128-138 *

Also Published As

Publication number Publication date
IL180201A0 (en) 2007-07-04
JP5031560B2 (ja) 2012-09-19
DE602005024833D1 (de) 2010-12-30
IL180201A (en) 2012-08-30
JP2008503219A (ja) 2008-02-07
WO2006002100A2 (en) 2006-01-05
EP1792181A2 (de) 2007-06-06
CA2570959C (en) 2014-09-30
CN1989411A (zh) 2007-06-27
ATE488766T1 (de) 2010-12-15
EP1792181B1 (de) 2010-11-17
WO2006002100A3 (en) 2006-04-20
CA2570959A1 (en) 2006-01-05
AU2005258000A1 (en) 2006-01-05
KR20070051257A (ko) 2007-05-17
CN1989411B (zh) 2012-06-27
EP1792181A4 (de) 2008-02-20
US20060040335A1 (en) 2006-02-23
US7842460B2 (en) 2010-11-30

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired