AU2004295409B2 - Strain of Rhodococcus rhodochrous NCIMB 41164 and its use as producer of nitrile hydratase - Google Patents
Strain of Rhodococcus rhodochrous NCIMB 41164 and its use as producer of nitrile hydratase Download PDFInfo
- Publication number
- AU2004295409B2 AU2004295409B2 AU2004295409A AU2004295409A AU2004295409B2 AU 2004295409 B2 AU2004295409 B2 AU 2004295409B2 AU 2004295409 A AU2004295409 A AU 2004295409A AU 2004295409 A AU2004295409 A AU 2004295409A AU 2004295409 B2 AU2004295409 B2 AU 2004295409B2
- Authority
- AU
- Australia
- Prior art keywords
- urea
- microorganism
- biocatalyst
- derivative
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 108010024026 Nitrile hydratase Proteins 0.000 title claims abstract description 83
- 241000187693 Rhodococcus rhodochrous Species 0.000 title claims abstract description 74
- 108090000790 Enzymes Proteins 0.000 claims abstract description 126
- 102000004190 Enzymes Human genes 0.000 claims abstract description 126
- 239000011942 biocatalyst Substances 0.000 claims abstract description 95
- 239000004202 carbamide Substances 0.000 claims abstract description 83
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 81
- 244000005700 microbiome Species 0.000 claims abstract description 80
- 238000000034 method Methods 0.000 claims abstract description 71
- 150000003672 ureas Chemical class 0.000 claims abstract description 44
- 239000001963 growth medium Substances 0.000 claims abstract description 42
- 150000002825 nitriles Chemical class 0.000 claims abstract description 36
- 150000001408 amides Chemical class 0.000 claims abstract description 32
- 230000008569 process Effects 0.000 claims abstract description 27
- 238000012258 culturing Methods 0.000 claims abstract description 20
- 239000012736 aqueous medium Substances 0.000 claims abstract description 11
- 238000006703 hydration reaction Methods 0.000 claims abstract description 9
- 238000003860 storage Methods 0.000 claims description 35
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 34
- 239000002609 medium Substances 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 22
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 16
- 230000002210 biocatalytic effect Effects 0.000 claims description 10
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 description 54
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- 238000000855 fermentation Methods 0.000 description 35
- 230000004151 fermentation Effects 0.000 description 35
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
- 230000000813 microbial effect Effects 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 239000001301 oxygen Substances 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
- 239000000306 component Substances 0.000 description 11
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 229940041514 candida albicans extract Drugs 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 239000000411 inducer Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 239000012138 yeast extract Substances 0.000 description 7
- 239000001888 Peptone Substances 0.000 description 6
- 108010080698 Peptones Proteins 0.000 description 6
- 239000000470 constituent Substances 0.000 description 6
- 235000019319 peptone Nutrition 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002028 Biomass Substances 0.000 description 5
- 108010033272 Nitrilase Proteins 0.000 description 5
- 241000316848 Rhodococcus <scale insect> Species 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 5
- 239000010941 cobalt Substances 0.000 description 5
- 229910017052 cobalt Inorganic materials 0.000 description 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 5
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- GFHNAMRJFCEERV-UHFFFAOYSA-L cobalt chloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].[Cl-].[Co+2] GFHNAMRJFCEERV-UHFFFAOYSA-L 0.000 description 4
- 229910001429 cobalt ion Inorganic materials 0.000 description 4
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 description 4
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 4
- 235000019797 dipotassium phosphate Nutrition 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 4
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- 238000004321 preservation Methods 0.000 description 4
- 230000002035 prolonged effect Effects 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- RYECOJGRJDOGPP-UHFFFAOYSA-N Ethylurea Chemical compound CCNC(N)=O RYECOJGRJDOGPP-UHFFFAOYSA-N 0.000 description 3
- MGJKQDOBUOMPEZ-UHFFFAOYSA-N N,N'-dimethylurea Chemical compound CNC(=O)NC MGJKQDOBUOMPEZ-UHFFFAOYSA-N 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
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- 150000001875 compounds Chemical class 0.000 description 3
- -1 hydrates nitriles Chemical class 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
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- 239000012533 medium component Substances 0.000 description 3
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- 108020004465 16S ribosomal RNA Proteins 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000186146 Brevibacterium Species 0.000 description 2
- 229940127463 Enzyme Inducers Drugs 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 241001646398 Pseudomonas chlororaphis Species 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
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- 230000015556 catabolic process Effects 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
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- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- PRIRPDNGQLRQQT-UHFFFAOYSA-N 1,3-dimethylurea;urea Chemical compound NC(N)=O.CNC(=O)NC PRIRPDNGQLRQQT-UHFFFAOYSA-N 0.000 description 1
- GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000590020 Achromobacter Species 0.000 description 1
- 241000589291 Acinetobacter Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241000607534 Aeromonas Species 0.000 description 1
- 241000589158 Agrobacterium Species 0.000 description 1
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- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000588923 Citrobacter Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
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- 241000187603 Pseudonocardia Species 0.000 description 1
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- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Applications Claiming Priority (5)
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| GB0327907.2 | 2003-12-02 | ||
| GBGB0327907.2A GB0327907D0 (en) | 2003-12-02 | 2003-12-02 | Microorganism |
| GB0422070A GB0422070D0 (en) | 2004-10-06 | 2004-10-06 | Microorganism |
| GB0422070.3 | 2004-10-06 | ||
| PCT/EP2004/013252 WO2005054456A1 (en) | 2003-12-02 | 2004-11-22 | Strain of rhodococcus rhodochrous ncimb 41164 and its use as producer of nitrile hydratase |
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| AU2004295409A1 AU2004295409A1 (en) | 2005-06-16 |
| AU2004295409B2 true AU2004295409B2 (en) | 2010-07-29 |
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| AU2004295409A Ceased AU2004295409B2 (en) | 2003-12-02 | 2004-11-22 | Strain of Rhodococcus rhodochrous NCIMB 41164 and its use as producer of nitrile hydratase |
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| GB0416101D0 (en) * | 2004-07-19 | 2004-08-18 | Ciba Spec Chem Water Treat Ltd | Process for preparing monomers and polymers thereof |
| KR20110038183A (ko) * | 2005-10-07 | 2011-04-13 | 미쓰이 가가쿠 가부시키가이샤 | 아미드 화합물의 제조방법 |
| CA2976962A1 (en) * | 2006-01-30 | 2007-08-09 | Georgia State University Research Foundation, Inc. | Induction and stabilizing of enzymatic activity in microorganisms |
| WO2007132601A1 (ja) * | 2006-05-15 | 2007-11-22 | Mitsui Chemicals, Inc. | （メタ）アクリルアミドの製造方法 |
| US8986971B2 (en) * | 2006-09-22 | 2015-03-24 | Triphase Research And Development I Corp. | Salt formulations for the fermentation of marine microorganisms |
| WO2009113654A1 (ja) * | 2008-03-14 | 2009-09-17 | ダイヤニトリックス株式会社 | アミド化合物の製造方法 |
| CN102286409B (zh) * | 2009-07-16 | 2013-04-24 | 浙江工业大学 | 紫红红球菌及其催化亚氨基二乙腈制备亚氨基二乙酸 |
| CN102329744B (zh) * | 2010-07-13 | 2014-04-23 | 中国环境科学研究院 | 异养型硝化细菌、包含其的生物传感器、及检测水体毒性的方法 |
| CN103620030B (zh) * | 2011-01-14 | 2016-06-01 | 三菱丽阳株式会社 | 微生物菌体的运输方法 |
| AU2013227585B2 (en) | 2012-02-28 | 2016-02-25 | Mitsubishi Chemical Corporation | Method for preserving enzyme |
| RU2520870C1 (ru) | 2012-12-27 | 2014-06-27 | Кемира Оюй | Штамм бактерий rhodococcus aetherivorans bkm ac-2610d - продуцент нитрилгидратазы, способ его культивирования и способ получения акриламида |
| RU2706533C2 (ru) | 2014-09-30 | 2019-11-19 | Басф Се | Способ получения водного раствора акриламида с низкой концентрацией акриловой кислоты |
| CN107075494B (zh) * | 2014-09-30 | 2021-11-23 | 巴斯夫欧洲公司 | 制备具有较少丙烯酸的酰胺化合物的手段和方法 |
| WO2017055518A1 (en) * | 2015-09-30 | 2017-04-06 | Basf Se | Means and methods for producing an amide compound |
| AR113387A1 (es) | 2017-10-25 | 2020-04-29 | Basf Se | Proceso y planta modular y reubicable para producir soluciones acuosas de poliacrilamida |
| AU2018354767B2 (en) | 2017-10-25 | 2024-01-11 | Basf Se | Process for producing aqueous polyacrylamide solutions |
| US20200308314A1 (en) | 2017-10-25 | 2020-10-01 | Basf Se | Process for producing aqueous polyacrylamide solutions |
| WO2019081330A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS POLYACRYLAMIDE SOLUTIONS |
| WO2019081003A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS POLYACRYLAMIDE SOLUTIONS |
| WO2019081004A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS POLYACRYLAMIDE SOLUTIONS |
| AR113375A1 (es) | 2017-10-25 | 2020-04-22 | Basf Se | Proceso para producir soluciones acuosas de poliacrilamida |
| WO2019081008A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS ACRYLAMIDE SOLUTION |
| WO2020079119A1 (en) | 2018-10-18 | 2020-04-23 | Basf Se | Method of providing aqueous polyacrylamide concentrates |
| MX2021004421A (es) | 2018-10-18 | 2021-07-06 | Basf Se | Proceso de fracturamiento de formaciones subterraneas. |
| US11643491B2 (en) | 2018-10-18 | 2023-05-09 | Basf Se | Process for producing an aqueous polyacrylamide concentrate |
| WO2020079124A1 (en) | 2018-10-18 | 2020-04-23 | Basf Se | Process for producing aqueous polyacrylamide compositions |
| MY205863A (en) | 2018-10-18 | 2024-11-18 | Basf Se | Process for producing ammonium (meth-) acrylate |
| RU2731289C2 (ru) * | 2018-12-13 | 2020-09-01 | Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) | Способ конструирования на основе бактерий рода Rhodococcus штамма-биокатализатора, обладающего нитрилазной активностью и повышенной операционной стабильностью, рекомбинантный штамм бактерий Rhodococcus rhodochrous, полученный таким способом, способ синтеза акриловой кислоты с использованием этого штамма в качестве биокатализатора |
| AR120393A1 (es) * | 2019-11-05 | 2022-02-09 | Basf Se | Método de almacenamiento de un biocatalizador |
| AU2022219778A1 (en) | 2021-02-10 | 2023-06-22 | Mitsubishi Chemical Corporation | Improvement of reactivity of nitrile hydratase by aldehyde |
| WO2023041515A2 (en) | 2021-09-15 | 2023-03-23 | Basf Se | Method for preparing an aqueous (meth) acrylamide solution |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0362829A2 (en) * | 1988-10-06 | 1990-04-11 | YAMADA, Hideaki | Method for cultivation of bacteria |
| EP0444640A2 (en) * | 1990-02-28 | 1991-09-04 | YAMADA, Hideaki | Process for biological production of organic acids |
| EP0445646A2 (en) * | 1990-02-28 | 1991-09-11 | Nitto Chemical Industry Co., Ltd. | DNA fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the DNA fragment and a process for the production of amides using the transformant |
| US6146861A (en) * | 1995-08-09 | 2000-11-14 | Ciba Specialty Chemicals Water Treatment Limited | Processes for the production of amidase |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3281247A (en) | 1963-12-16 | 1966-10-25 | Commercial Solvents Corp | Process for producing monosodium glutamate |
| JPS62259586A (ja) | 1986-05-02 | 1987-11-11 | Nitto Chem Ind Co Ltd | ニトリル水和活性の保持方法 |
| MX169933B (es) | 1987-09-18 | 1993-08-02 | Hideaki Yamada | Procedimiento para la produccion biologica de amidas |
| JPH0753103B2 (ja) * | 1988-10-06 | 1995-06-07 | 秀明 山田 | 細菌の培養法 |
| SU1731814A1 (ru) | 1990-05-17 | 1992-05-07 | Саратовский филиал Всесоюзного научно-исследовательского института генетики и селекции промышленныхмикроорганизмов | Штамм бактерий RноDососсUS RноDоснRоUS - продуцент нитрилгидратазы |
| RU2053300C1 (ru) | 1993-12-17 | 1996-01-27 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Штамм бактерий rhodococcus rhodochrous - продуцент нитрилгидратазы |
| JP3014262B2 (ja) | 1994-01-11 | 2000-02-28 | 三菱レイヨン株式会社 | 生体触媒固定化用担体および固定化生体触媒 |
| JP3163224B2 (ja) | 1994-10-14 | 2001-05-08 | 三菱レイヨン株式会社 | 菌体または固定化菌体の懸濁液の保存方法 |
| RU2077588C1 (ru) | 1996-01-16 | 1997-04-20 | Государственное унитарное предприятие Саратовский научно-исследовательский институт биокатализа | Способ получения акриламида |
| US6368804B1 (en) | 1999-07-12 | 2002-04-09 | E. I. Du Pont De Nemours & Company | Method for stabilizing nitrilase activity and preserving microbial cells |
| EP1352965B1 (en) | 2000-12-20 | 2008-03-05 | Dia-Nitrix Co., Ltd. | Process for producing amide compound by using microbial catalyst |
| DE10120546A1 (de) | 2001-04-26 | 2002-10-31 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator |
| DE10120550A1 (de) | 2001-04-26 | 2002-10-31 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator |
| ATE449860T1 (de) * | 2003-12-02 | 2009-12-15 | Ciba Spec Chem Water Treat Ltd | Herstellung von amiden |
-
2004
- 2004-11-22 RU RU2006123429/13A patent/RU2403280C2/ru active
- 2004-11-22 JP JP2006541837A patent/JP4963414B2/ja not_active Expired - Lifetime
- 2004-11-22 SG SG200808924-5A patent/SG148992A1/en unknown
- 2004-11-22 US US10/580,448 patent/US7575912B2/en active Active
- 2004-11-22 WO PCT/EP2004/013252 patent/WO2005054456A1/en active Application Filing
- 2004-11-22 AU AU2004295409A patent/AU2004295409B2/en not_active Ceased
- 2004-11-22 KR KR1020067010946A patent/KR101106943B1/ko not_active Expired - Fee Related
- 2004-11-22 AT AT04819608T patent/ATE532859T1/de active
- 2004-11-22 CA CA2547393A patent/CA2547393C/en not_active Expired - Lifetime
- 2004-11-22 BR BRPI0417244-2A patent/BRPI0417244B1/pt not_active IP Right Cessation
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- 2004-11-22 EP EP04819608A patent/EP1689861B1/en not_active Expired - Lifetime
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0362829A2 (en) * | 1988-10-06 | 1990-04-11 | YAMADA, Hideaki | Method for cultivation of bacteria |
| EP0444640A2 (en) * | 1990-02-28 | 1991-09-04 | YAMADA, Hideaki | Process for biological production of organic acids |
| EP0445646A2 (en) * | 1990-02-28 | 1991-09-11 | Nitto Chemical Industry Co., Ltd. | DNA fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the DNA fragment and a process for the production of amides using the transformant |
| US6146861A (en) * | 1995-08-09 | 2000-11-14 | Ciba Specialty Chemicals Water Treatment Limited | Processes for the production of amidase |
Non-Patent Citations (6)
| Title |
|---|
| LEONOVA. E. T., et al., Applied Biochemistry and Biotechnology, 2000, Vol. 88, pages 231-241 * |
| NAGASAWA, T. et al., Appl Microbiol Biotechnol, 1991, Vol. 34, pages 783-788 * |
| NAGASAWA, T. et al., Appl Microbiol Biotechnol, 1993, Vol. 40, pages 189-195 * |
| PRECIGOU, S. et al., FEMS MICROBIOLOGY LETTERS, 2001, Vol. 204, No.1, pages 155-161 * |
| WATANABE, I. et al., Agric. Biol. Chem, 1987, Vol. 51, No.12, pages 3193-3199 * |
| YANENKO, S. A. et al., Russ bio (Biotekhnol), 1995, pages 127-132 * |
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| US20090269822A1 (en) | 2009-10-29 |
| WO2005054456A1 (en) | 2005-06-16 |
| CA2547393A1 (en) | 2005-06-16 |
| JP2007512820A (ja) | 2007-05-24 |
| US20070077634A1 (en) | 2007-04-05 |
| BRPI0417244B1 (pt) | 2015-05-26 |
| KR101106943B1 (ko) | 2012-01-19 |
| EP1689861B1 (en) | 2011-11-09 |
| US8153406B2 (en) | 2012-04-10 |
| MXPA06006234A (es) | 2006-07-31 |
| ES2376218T3 (es) | 2012-03-12 |
| SG148992A1 (en) | 2009-01-29 |
| RU2006123429A (ru) | 2008-01-10 |
| AU2004295409A1 (en) | 2005-06-16 |
| EP1689861A1 (en) | 2006-08-16 |
| RU2403280C2 (ru) | 2010-11-10 |
| KR20060123248A (ko) | 2006-12-01 |
| CA2547393C (en) | 2013-08-27 |
| JP4963414B2 (ja) | 2012-06-27 |
| BRPI0417244A (pt) | 2007-03-06 |
| ATE532859T1 (de) | 2011-11-15 |
| US7575912B2 (en) | 2009-08-18 |
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