AU2004289243B2 - 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) - Google Patents
4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) Download PDFInfo
- Publication number
- AU2004289243B2 AU2004289243B2 AU2004289243A AU2004289243A AU2004289243B2 AU 2004289243 B2 AU2004289243 B2 AU 2004289243B2 AU 2004289243 A AU2004289243 A AU 2004289243A AU 2004289243 A AU2004289243 A AU 2004289243A AU 2004289243 B2 AU2004289243 B2 AU 2004289243B2
- Authority
- AU
- Australia
- Prior art keywords
- methoxy
- amino
- methoxyphenyl
- methylpiperidin
- carbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 title description 25
- 150000001875 compounds Chemical class 0.000 claims description 60
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
- -1 methoxyphenyl Chemical group 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
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- 150000003839 salts Chemical class 0.000 claims description 12
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 10
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51781903P | 2003-11-06 | 2003-11-06 | |
| US60/517,819 | 2003-11-06 | ||
| PCT/US2003/035322 WO2005047259A1 (en) | 2003-11-06 | 2003-11-06 | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
| AU2003291245 | 2003-11-06 | ||
| PCT/US2004/036722 WO2005046693A1 (en) | 2003-11-06 | 2004-11-03 | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003291245A Division AU2003291245A1 (en) | 2003-11-06 | 2003-11-06 | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004289243A1 AU2004289243A1 (en) | 2005-05-26 |
| AU2004289243B2 true AU2004289243B2 (en) | 2010-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004289243A Expired AU2004289243B2 (en) | 2003-11-06 | 2004-11-03 | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7417148B2 (https=) |
| EP (1) | EP1680119A1 (https=) |
| JP (1) | JP2007533655A (https=) |
| KR (1) | KR20060118461A (https=) |
| CN (1) | CN1874776A (https=) |
| AU (1) | AU2004289243B2 (https=) |
| BR (1) | BRPI0416289A (https=) |
| CA (1) | CA2543163A1 (https=) |
| CO (1) | CO5690608A2 (https=) |
| CR (1) | CR8350A (https=) |
| EC (1) | ECSP066548A (https=) |
| IL (1) | IL175424A0 (https=) |
| MX (1) | MXPA06004744A (https=) |
| NO (1) | NO20062255L (https=) |
| RU (1) | RU2006113691A (https=) |
| SG (1) | SG146681A1 (https=) |
| WO (1) | WO2005046693A1 (https=) |
| ZA (1) | ZA200603596B (https=) |
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| SG146681A1 (en) * | 2003-11-06 | 2008-10-30 | Wyeth Corp | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
| US7468379B2 (en) | 2005-06-17 | 2008-12-23 | The Board Of Regents Of The University Of Texas System | Inhibition of osteolytic lesions by SRC kinase inhibitors |
| KR20080027275A (ko) * | 2005-06-24 | 2008-03-26 | 와이어쓰 | 암의 치료를 위한 4-아닐리노-3-퀴놀린카르보니트릴 |
| WO2008064004A2 (en) * | 2006-11-16 | 2008-05-29 | Wyeth | 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml) |
| US20080119463A1 (en) * | 2006-11-16 | 2008-05-22 | Wyeth | 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML) |
| WO2008060283A1 (en) * | 2006-11-16 | 2008-05-22 | Wyeth | 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml) |
| HUE055524T2 (hu) * | 2007-06-01 | 2021-11-29 | Wyeth Llc | A bcrabl génben 1457T>C mutációt tartalmazó, imatinibbel szemben ellenálló krónikus mielogén leukémia kezelése bozutinib vegyület alkalmazásával |
| WO2013187967A1 (en) | 2012-06-15 | 2013-12-19 | Institute For Cancer Research D/B/A The Research Institute Of Fox Case Cancer Center ("Fox Chase Cancer Center") | Sensitization of cancer cells to dna damage by inhibiting kinases essential for dna damage checkpoint control |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| IN2014CH00840A (https=) | 2014-02-20 | 2015-09-18 | Apotex Inc | |
| CN107530430A (zh) | 2015-01-13 | 2018-01-02 | 国立大学法人京都大学 | 用于预防和/或治疗肌萎缩性侧索硬化症的药剂 |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| US12398355B2 (en) | 2019-04-09 | 2025-08-26 | Massachusetts Institute Of Technology | Micro physiological model for neuronal and muscular diseases and disorders |
| WO2022053130A1 (en) | 2020-09-09 | 2022-03-17 | Sid Alex Group, S.R.O. | Antago-mir-155 for treatment of v-src, c-src-tyrosine kinase-induced cancers |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| TWI275390B (en) | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| TW200423938A (en) | 2003-02-21 | 2004-11-16 | Wyeth Corp | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury |
| SG146681A1 (en) * | 2003-11-06 | 2008-10-30 | Wyeth Corp | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
-
2004
- 2004-11-03 SG SG200807148-2A patent/SG146681A1/en unknown
- 2004-11-03 RU RU2006113691/14A patent/RU2006113691A/ru unknown
- 2004-11-03 AU AU2004289243A patent/AU2004289243B2/en not_active Expired
- 2004-11-03 CN CNA2004800323110A patent/CN1874776A/zh active Pending
- 2004-11-03 BR BRPI0416289-7A patent/BRPI0416289A/pt not_active Application Discontinuation
- 2004-11-03 CA CA002543163A patent/CA2543163A1/en not_active Abandoned
- 2004-11-03 MX MXPA06004744A patent/MXPA06004744A/es active IP Right Grant
- 2004-11-03 WO PCT/US2004/036722 patent/WO2005046693A1/en not_active Ceased
- 2004-11-03 KR KR1020067008812A patent/KR20060118461A/ko not_active Withdrawn
- 2004-11-03 JP JP2006539641A patent/JP2007533655A/ja active Pending
- 2004-11-03 US US10/980,097 patent/US7417148B2/en not_active Expired - Lifetime
- 2004-11-03 EP EP04800721A patent/EP1680119A1/en not_active Withdrawn
-
2006
- 2006-04-20 CR CR8350A patent/CR8350A/es not_active Application Discontinuation
- 2006-05-04 IL IL175424A patent/IL175424A0/en unknown
- 2006-05-05 ZA ZA200603596A patent/ZA200603596B/xx unknown
- 2006-05-05 EC EC2006006548A patent/ECSP066548A/es unknown
- 2006-05-19 NO NO20062255A patent/NO20062255L/no not_active Application Discontinuation
- 2006-05-26 CO CO06051033A patent/CO5690608A2/es not_active Application Discontinuation
-
2008
- 2008-06-16 US US12/139,834 patent/US7919625B2/en not_active Expired - Lifetime
Non-Patent Citations (3)
| Title |
|---|
| Berger et al. Bioorg. Med. Chem. Lett. (2002) vol. 12, no. 20, pages 2989-2992 * |
| Boschelli et al. Bioorg. Med. Chem. Lett. (2003) vol. 13, no. 21, pages 3797-3800 * |
| Golas et al. Cancer Research (2003) vol. 63, no. 2, pages 375-381 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG146681A1 (en) | 2008-10-30 |
| US7919625B2 (en) | 2011-04-05 |
| JP2007533655A (ja) | 2007-11-22 |
| CN1874776A (zh) | 2006-12-06 |
| WO2005046693A1 (en) | 2005-05-26 |
| IL175424A0 (en) | 2008-04-13 |
| CO5690608A2 (es) | 2006-10-31 |
| US20100029677A1 (en) | 2010-02-04 |
| BRPI0416289A (pt) | 2007-01-23 |
| CR8350A (es) | 2006-10-06 |
| US7417148B2 (en) | 2008-08-26 |
| EP1680119A1 (en) | 2006-07-19 |
| ZA200603596B (en) | 2009-12-30 |
| MXPA06004744A (es) | 2006-07-05 |
| AU2004289243A1 (en) | 2005-05-26 |
| KR20060118461A (ko) | 2006-11-23 |
| ECSP066548A (es) | 2006-10-17 |
| NO20062255L (no) | 2006-08-01 |
| US20050101780A1 (en) | 2005-05-12 |
| CA2543163A1 (en) | 2005-05-26 |
| RU2006113691A (ru) | 2007-12-20 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |