AU2004283461B2 - Use of effectors of glutaminyl and glutamate cyclases - Google Patents
Use of effectors of glutaminyl and glutamate cyclases Download PDFInfo
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- AU2004283461B2 AU2004283461B2 AU2004283461A AU2004283461A AU2004283461B2 AU 2004283461 B2 AU2004283461 B2 AU 2004283461B2 AU 2004283461 A AU2004283461 A AU 2004283461A AU 2004283461 A AU2004283461 A AU 2004283461A AU 2004283461 B2 AU2004283461 B2 AU 2004283461B2
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- Prior art keywords
- pro
- ile
- pyrrolidine
- inhibitor
- gly
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- 150000003839 salts Chemical class 0.000 claims description 40
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Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4164—1,3-Diazoles
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Landscapes
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| US51203803P | 2003-10-15 | 2003-10-15 | |
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| PCT/EP2004/011630 WO2005039548A2 (en) | 2003-10-15 | 2004-10-15 | Use of effectors of glutaminyl and glutamate cyclases |
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| US7728031B2 (en) * | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| BRPI0712823A2 (pt) | 2006-06-23 | 2012-07-24 | Abbott Lab | derivados de ciclopropil amina como moduladores de receptor de histamina h3 |
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| EA016584B1 (ru) * | 2006-09-21 | 2012-06-29 | Пробиодруг Аг | Новые гены, родственные гену глутаминилциклазы |
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| JP5930573B2 (ja) * | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
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| JP5612860B2 (ja) * | 2007-03-09 | 2014-10-22 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体 |
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| EP2160380B1 (en) | 2007-04-18 | 2014-04-02 | Probiodrug AG | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
| WO2008128986A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| ES2473621T3 (es) | 2007-04-18 | 2014-07-07 | Probiodrug Ag | Derivados de nitrovinil-diamina como inhibidores de glutaminil ciclasa |
| ES2468551T3 (es) * | 2007-04-18 | 2014-06-16 | Probiodrug Ag | Derivados de nitrovinil-diamina como inhibidores de la glutaminil ciclasa |
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| CN101809021B (zh) * | 2007-09-11 | 2013-04-24 | 雅培制药有限公司 | 八氢-吡咯并[3,4-b]吡咯n-氧化物 |
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| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
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| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
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| JP5952816B2 (ja) | 2010-08-19 | 2016-07-13 | プロビオドルグ エージー | グルタミニルシクラーゼの結晶構造 |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| EP3316877B1 (en) * | 2015-07-02 | 2019-10-30 | Horizon Orphan LLC | Ado-resistant cysteamine analogs and uses thereof |
| EP3747438A1 (en) | 2017-07-24 | 2020-12-09 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN112107568B (zh) * | 2019-06-19 | 2022-03-25 | 北京龙嘉博创医药科技有限公司 | 二芳基酰胺类化合物及其应用 |
| CN112816581A (zh) * | 2020-12-30 | 2021-05-18 | 浙江大学 | 衍生化-固相萃取-液相色谱串联质谱检测饮用水中卤代醌亚胺的方法 |
| CN112898286A (zh) * | 2021-01-28 | 2021-06-04 | 中国药科大学 | 苯并噻吩类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途 |
| KR20240024948A (ko) | 2021-06-24 | 2024-02-26 | 인실리코 메디신 아이피 리미티드 | 질환의 치료를 위한 베타-락탐 유도체 |
| CN119234043A (zh) * | 2022-03-31 | 2024-12-31 | 南洋理工大学 | 通过级联酶促法提高pal-催化蛋白连接效率 |
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| US2961377A (en) * | 1957-08-05 | 1960-11-22 | Us Vitamin Pharm Corp | Oral anti-diabetic compositions and methods |
| US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| US3879541A (en) * | 1970-03-03 | 1975-04-22 | Bayer Ag | Antihyperglycemic methods and compositions |
| US3960949A (en) * | 1971-04-02 | 1976-06-01 | Schering Aktiengesellschaft | 1,2-Biguanides |
| CH602612A5 (https=) * | 1974-10-11 | 1978-07-31 | Hoffmann La Roche | |
| US4935493A (en) * | 1987-10-06 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Protease inhibitors |
| US5433955A (en) * | 1989-01-23 | 1995-07-18 | Akzo N.V. | Site specific in vivo activation of therapeutic drugs |
| ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| EP0528858B1 (en) | 1990-04-14 | 1997-01-22 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type iv |
| US5462928A (en) * | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US6517824B1 (en) * | 1990-05-14 | 2003-02-11 | University Of Medicine & Denistry Of New Jersey | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| WO1991017767A1 (en) | 1990-05-21 | 1991-11-28 | New England Medical Center Hospitals, Inc. | Method of treating inhibition of dipeptidyl aminopeptidase type iv |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
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- 2004-10-15 DK DK04765975.0T patent/DK1675578T3/da active
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|---|---|
| NZ546322A (en) | 2008-11-28 |
| WO2005039548A3 (en) | 2005-06-30 |
| EP1675578B9 (en) | 2014-06-25 |
| AU2004283461A1 (en) | 2005-05-06 |
| KR101121882B1 (ko) | 2012-04-12 |
| US7462599B2 (en) | 2008-12-09 |
| JP2007508347A (ja) | 2007-04-05 |
| IL174372A0 (en) | 2006-08-01 |
| MXPA06003998A (es) | 2006-06-27 |
| KR20120125379A (ko) | 2012-11-14 |
| EP1675578A2 (en) | 2006-07-05 |
| DK1675578T3 (da) | 2013-08-26 |
| CN102302781A (zh) | 2012-01-04 |
| EA010108B1 (ru) | 2008-06-30 |
| US20060189523A1 (en) | 2006-08-24 |
| CA2542419A1 (en) | 2005-05-06 |
| US8470781B2 (en) | 2013-06-25 |
| KR20120007079A (ko) | 2012-01-19 |
| JP5707014B2 (ja) | 2015-04-22 |
| WO2005039548A2 (en) | 2005-05-06 |
| KR101313975B1 (ko) | 2013-10-01 |
| EA200600618A1 (ru) | 2006-10-27 |
| KR20070017477A (ko) | 2007-02-12 |
| IL174372A (en) | 2011-09-27 |
| JP2015057400A (ja) | 2015-03-26 |
| CA2542419C (en) | 2013-06-04 |
| EP2289498A1 (en) | 2011-03-02 |
| US20090149394A1 (en) | 2009-06-11 |
| CN1867324A (zh) | 2006-11-22 |
| EP1675578B1 (en) | 2013-05-22 |
| BRPI0415409A (pt) | 2006-12-05 |
| AU2004283461A2 (en) | 2005-05-06 |
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