AU2004251668B2 - 5-membered heterocycle-based p-38 inhibitors - Google Patents

5-membered heterocycle-based p-38 inhibitors Download PDF

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Publication number
AU2004251668B2
AU2004251668B2 AU2004251668A AU2004251668A AU2004251668B2 AU 2004251668 B2 AU2004251668 B2 AU 2004251668B2 AU 2004251668 A AU2004251668 A AU 2004251668A AU 2004251668 A AU2004251668 A AU 2004251668A AU 2004251668 B2 AU2004251668 B2 AU 2004251668B2
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alkyl
substituted
aryl
methyl
crr
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AU2004251668A
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AU2004251668A1 (en
Inventor
Qing Dong
Fabrice Pierre
Jianqiang Wang
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Triad Therapeutics Inc
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Triad Therapeutics Inc
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2004251668A 2003-06-03 2004-06-02 5-membered heterocycle-based p-38 inhibitors Ceased AU2004251668B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47566203P 2003-06-03 2003-06-03
US60/475,662 2003-06-03
US53154103P 2003-12-19 2003-12-19
US60/531,541 2003-12-19
PCT/US2004/017580 WO2005000298A2 (en) 2003-06-03 2004-06-02 5-membered heterocycle-based p-38 inhibitors

Publications (2)

Publication Number Publication Date
AU2004251668A1 AU2004251668A1 (en) 2005-01-06
AU2004251668B2 true AU2004251668B2 (en) 2008-03-20

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AU2004251668A Ceased AU2004251668B2 (en) 2003-06-03 2004-06-02 5-membered heterocycle-based p-38 inhibitors

Country Status (13)

Country Link
US (2) US7652044B2 (enExample)
EP (1) EP1635824B1 (enExample)
JP (1) JP2006526656A (enExample)
AT (1) ATE439837T1 (enExample)
AU (1) AU2004251668B2 (enExample)
BR (1) BRPI0410905A (enExample)
CA (1) CA2528438A1 (enExample)
DE (1) DE602004022668D1 (enExample)
ES (1) ES2332135T3 (enExample)
MX (1) MXPA05013075A (enExample)
PL (1) PL1635824T3 (enExample)
PT (1) PT1635824E (enExample)
WO (1) WO2005000298A2 (enExample)

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WO2004030718A2 (en) 2002-09-20 2004-04-15 Flowmedica, Inc. Method and apparatus for intra aortic substance delivery to a branch vessel
US7585836B2 (en) 2004-05-14 2009-09-08 Goodson Iv Harry Burt Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy
JP2006526464A (ja) 2003-06-05 2006-11-24 フローメディカ，インコーポレイテッド 分枝した身体管腔において両側介入または診断を行うためのシステムおよび方法
DK1684750T3 (da) 2003-10-23 2010-08-09 Ab Science 2-aminoaryloxazol-forbindelser som tyrosinkinase-inhibitorer
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WO2005091910A2 (en) 2004-03-04 2005-10-06 Flowmedica, Inc. Sheath for use in peripheral interventions
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KR20080019578A (ko) * 2005-04-04 2008-03-04 에이비 사이언스 치환된 옥사졸 유도체 및 이의 티로신 키나제 억제제로서의용도
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JO2784B1 (en) * 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
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JP2006526656A (ja) 2006-11-24
PT1635824E (pt) 2009-11-24
DE602004022668D1 (de) 2009-10-01
US7652044B2 (en) 2010-01-26
PL1635824T3 (pl) 2010-01-29
WO2005000298A3 (en) 2005-03-03
ES2332135T3 (es) 2010-01-27
AU2004251668A1 (en) 2005-01-06
WO2005000298A2 (en) 2005-01-06
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US20040254236A1 (en) 2004-12-16
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