AU2002363658B2 - Solubilized topoisomerase poisons - Google Patents

Solubilized topoisomerase poisons Download PDF

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Publication number
AU2002363658B2
AU2002363658B2 AU2002363658A AU2002363658A AU2002363658B2 AU 2002363658 B2 AU2002363658 B2 AU 2002363658B2 AU 2002363658 A AU2002363658 A AU 2002363658A AU 2002363658 A AU2002363658 A AU 2002363658A AU 2002363658 B2 AU2002363658 B2 AU 2002363658B2
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AU
Australia
Prior art keywords
compound
alkyl
substituted
groups
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002363658A
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English (en)
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AU2002363658A1 (en
Inventor
Edmond J. Lavoie
Leroy F. Liu
Alexander L. Ruchelman
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Rutgers State University of New Jersey
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Rutgers State University of New Jersey
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Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of AU2002363658A1 publication Critical patent/AU2002363658A1/en
Assigned to RUTGERS, THE STATE UNIVERSITY reassignment RUTGERS, THE STATE UNIVERSITY Request for Assignment Assignors: LAVOIE, EDMOND, LIU, LEROY, RUCHELMAN, ALEXANDER, RUTGERS, THE STATE UNIVERSITY
Application granted granted Critical
Publication of AU2002363658B2 publication Critical patent/AU2002363658B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Toys (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Confectionery (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2002363658A 2001-11-14 2002-11-14 Solubilized topoisomerase poisons Ceased AU2002363658B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33273401P 2001-11-14 2001-11-14
US60/332,734 2001-11-14
PCT/US2002/036901 WO2003041660A2 (en) 2001-11-14 2002-11-14 Solubilized topoisomerase poisons

Publications (2)

Publication Number Publication Date
AU2002363658A1 AU2002363658A1 (en) 2003-07-24
AU2002363658B2 true AU2002363658B2 (en) 2008-09-11

Family

ID=23299632

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002363658A Ceased AU2002363658B2 (en) 2001-11-14 2002-11-14 Solubilized topoisomerase poisons

Country Status (15)

Country Link
US (4) US7049315B2 (https=)
EP (3) EP2196205A1 (https=)
JP (3) JP4628675B2 (https=)
KR (1) KR20050044491A (https=)
AT (1) ATE456952T1 (https=)
AU (1) AU2002363658B2 (https=)
CA (1) CA2467774C (https=)
CY (1) CY1110631T1 (https=)
DE (1) DE60235287D1 (https=)
DK (1) DK1465625T3 (https=)
ES (1) ES2340473T3 (https=)
MX (1) MXPA04004606A (https=)
PT (1) PT1465625E (https=)
SI (1) SI1465625T1 (https=)
WO (1) WO2003041660A2 (https=)

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EP1453812B1 (en) 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
MXPA04004607A (es) 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
US6989387B2 (en) 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
US6992088B2 (en) 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
CA2510337C (en) 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
WO2006010127A2 (en) * 2004-07-09 2006-01-26 Medisyn Technologies, Inc. Therapeutic compound and treatments
US7601732B2 (en) * 2006-05-24 2009-10-13 Dr. Reddy's Laboratories Limited Crystalline form of 5(S)-(2-hydroxyethoxy)-20(S)-camptothecin
CN102256966B (zh) 2008-10-17 2016-02-10 白头生物医学研究所 可溶性mTOR复合物和其调节剂
TW201038578A (en) * 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) * 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2010127360A1 (en) * 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2012015875A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating hematological malignancies
WO2012015901A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating gastric and pancreatic malignancies
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons
CN111925370B (zh) * 2020-09-01 2023-07-21 湖北科苑生物药业有限公司 一种吡嗪并吡唑并萘啶类化合物及其制备方法与应用
CN117241834A (zh) * 2021-04-29 2023-12-15 上海汇连生物医药有限公司 抗体偶联药物的制备方法及应用
CN114335101B (zh) * 2021-12-28 2024-11-22 深圳市华星光电半导体显示技术有限公司 显示面板及其制备方法

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AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
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US6989387B2 (en) * 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
US6992088B2 (en) 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
CA2510337C (en) * 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents

Also Published As

Publication number Publication date
JP4628675B2 (ja) 2011-02-09
JP2005511617A (ja) 2005-04-28
EP2286812A1 (en) 2011-02-23
EP1465625A4 (en) 2005-06-08
US20050009824A1 (en) 2005-01-13
WO2003041660A3 (en) 2003-10-16
ES2340473T3 (es) 2010-06-04
JP2010184942A (ja) 2010-08-26
US7781587B2 (en) 2010-08-24
CY1110631T1 (el) 2015-04-29
JP5337104B2 (ja) 2013-11-06
US20060052381A1 (en) 2006-03-09
US20090239871A1 (en) 2009-09-24
ATE456952T1 (de) 2010-02-15
EP1465625B1 (en) 2010-02-03
US8389721B2 (en) 2013-03-05
DE60235287D1 (de) 2010-03-25
CA2467774A1 (en) 2003-05-22
EP1465625A2 (en) 2004-10-13
PT1465625E (pt) 2010-03-09
EP2196205A1 (en) 2010-06-16
DK1465625T3 (da) 2010-05-31
US7517883B2 (en) 2009-04-14
KR20050044491A (ko) 2005-05-12
CA2467774C (en) 2011-09-20
WO2003041660A2 (en) 2003-05-22
SI1465625T1 (sl) 2010-06-30
US20110136812A1 (en) 2011-06-09
US7049315B2 (en) 2006-05-23
JP2013166801A (ja) 2013-08-29
MXPA04004606A (es) 2004-09-10

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: RUTGERS, THE STATE UNIVERSITY

Free format text: FORMER APPLICANT(S): RUTGERS, THE STATE UNIVERSITY; LAVOIE, EDMOND; RUCHELMAN, ALEXANDER; LIU, LEROY

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired