AU2002246688A1 - Methods for preparing purified daptomycin - Google Patents

Methods for preparing purified daptomycin

Info

Publication number
AU2002246688A1
AU2002246688A1 AU2002246688A AU2002246688A AU2002246688A1 AU 2002246688 A1 AU2002246688 A1 AU 2002246688A1 AU 2002246688 A AU2002246688 A AU 2002246688A AU 2002246688 A AU2002246688 A AU 2002246688A AU 2002246688 A1 AU2002246688 A1 AU 2002246688A1
Authority
AU
Australia
Prior art keywords
methods
relates
present
preparing purified
daptomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002246688A
Other languages
English (en)
Inventor
Chandrika Govardhan
Dennis Keith
Nazer Khalaf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cubist Pharmaceuticals LLC
Altus Biologics Inc
Original Assignee
Cubist Pharmaceuticals LLC
Altus Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27500563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2002246688(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cubist Pharmaceuticals LLC, Altus Biologics Inc filed Critical Cubist Pharmaceuticals LLC
Publication of AU2002246688A1 publication Critical patent/AU2002246688A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2002246688A 2000-12-18 2001-12-17 Methods for preparing purified daptomycin Abandoned AU2002246688A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
USNOTGIVEN 2000-12-06
US25626800P 2000-12-18 2000-12-18
US60/256,268 2000-12-18
US27474101P 2001-03-09 2001-03-09
US60/274,741 2001-03-09
US34052501P 2001-12-13 2001-12-13
US34131501P 2001-12-13 2001-12-13
PCT/US2001/048887 WO2002056829A2 (en) 2000-12-18 2001-12-17 Methods for preparing purified daptomycin

Publications (1)

Publication Number Publication Date
AU2002246688A1 true AU2002246688A1 (en) 2002-07-30

Family

ID=27500563

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2002246688A Abandoned AU2002246688A1 (en) 2000-12-18 2001-12-17 Methods for preparing purified daptomycin
AU2002246687A Ceased AU2002246687C1 (en) 2000-12-18 2001-12-17 Methods for preparing purified lipopeptides
AU2008207496A Ceased AU2008207496B2 (en) 2000-12-18 2008-08-25 Methods of preparing purified lipopeptides

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2002246687A Ceased AU2002246687C1 (en) 2000-12-18 2001-12-17 Methods for preparing purified lipopeptides
AU2008207496A Ceased AU2008207496B2 (en) 2000-12-18 2008-08-25 Methods of preparing purified lipopeptides

Country Status (12)

Country Link
US (2) US20030045484A1 (enExample)
EP (3) EP1343811A4 (enExample)
JP (2) JP2004525108A (enExample)
KR (4) KR20090122469A (enExample)
CN (3) CN1982330B (enExample)
AT (1) ATE535539T1 (enExample)
AU (3) AU2002246688A1 (enExample)
CA (1) CA2432096A1 (enExample)
ES (2) ES2377931T5 (enExample)
IL (3) IL156394A0 (enExample)
NZ (2) NZ571597A (enExample)
WO (1) WO2002056829A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
US20040077533A1 (en) * 2002-05-23 2004-04-22 Sayada Chalom B. Methods and compositions for treating bacterial infections and diseases associated therewith
WO2003099217A2 (en) * 2002-05-23 2003-12-04 Activbiotics, Inc. Methods of treating bacterial infections and diseases associated therewith
US20090149453A1 (en) * 2002-05-23 2009-06-11 Activbiotics Pharma Llc Methods and compositions for treating bacterial infections and diseases associated therewith
AU2003240545A1 (en) 2002-06-06 2003-12-22 Therapeutics Corporation Genome Use of ramoplanin to treat diseases associated with the use of antibiotics
JP2006515294A (ja) * 2002-12-12 2006-05-25 アクティブバイオティクス インコーポレイティッド アテローム性動脈硬化症およびその関連疾患を治療または予防するための方法および試薬
AU2003296963A1 (en) * 2002-12-12 2004-07-09 Activbiotics, Inc. Methods and compositions for treating and preventing ear infections
US7267624B2 (en) * 2004-07-30 2007-09-11 Acushnet Company Golf ball dimple pattern
KR20080038224A (ko) * 2006-07-20 2008-05-02 시코르, 인크. 고체 멸균 유효 약리 성분의 제조 방법
WO2009144739A1 (en) * 2008-05-26 2009-12-03 Biocon Limited Amorphous daptomycin and a method of purification thereof
PT2398817E (pt) * 2009-02-19 2015-08-28 Xellia Pharmaceuticals Aps Processo para purificar lipopéptidos
CN101830970B (zh) * 2009-03-12 2012-06-27 成都雅途生物技术有限公司 一种高纯度达托霉素(Daptomycin)的纯化制备方法
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法
DK2504353T4 (da) * 2009-11-23 2023-11-20 Cubist Pharmaceuticals Llc Lipopeptidsammensætninger og tilsvarende fremgangsmåder
JP2013511522A (ja) * 2009-11-23 2013-04-04 イーグル・ファーマシューティカルズ・インコーポレーテッド ダプトマイシン製剤
KR101151878B1 (ko) * 2010-06-08 2012-05-31 미원상사주식회사 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물
CN102276696B (zh) * 2010-06-09 2014-11-05 上海来益生物药物研究开发中心有限责任公司 达托霉素的纯化方法
TW201309346A (zh) 2011-01-05 2013-03-01 Hospira Inc 噴霧乾燥萬古黴素
KR101034663B1 (ko) * 2011-03-18 2011-05-17 김태욱 손목 피로를 저감시키는 마우스
CN102206694B (zh) * 2011-04-06 2013-10-16 山东新时代药业有限公司 一种含有癸酸的缓释组合物
JP2014515371A (ja) * 2011-05-26 2014-06-30 キュービスト ファーマシューティカルズ， インコーポレイテッド Ｃｂ−１８３，３１５組成物および関連する方法
CN102241732B (zh) * 2011-05-30 2015-01-21 浙江海正药业股份有限公司 一种脂肽化合物的纯化方法
EA032840B8 (ru) * 2011-06-22 2020-06-18 Вайоми Терапеутикс Лимитед Пролекарства на основе конъюгатов противогрибковых агентов и их применение
CN102875652A (zh) * 2011-07-13 2013-01-16 北大方正集团有限公司 一种分离纯化达托霉素的方法
WO2013012101A1 (ko) * 2011-07-15 2013-01-24 미원상사주식회사 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물
CN102718839B (zh) * 2012-07-05 2017-05-24 鲁南新时代生物技术有限公司 一种分离纯化达托霉素的方法
WO2014031681A1 (en) * 2012-08-20 2014-02-27 The University Of Chicago Inhibiting gram positive bacteria
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
CN104387444B (zh) * 2014-11-13 2017-12-08 北大医药重庆大新药业股份有限公司 一种达托霉素杂质rs‑2高纯度样品的制备方法
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
US11667674B2 (en) 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
CN109476704B (zh) * 2016-04-08 2022-08-16 港大科桥有限公司 抗菌环脂肽
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
IT201800006314A1 (it) * 2018-06-14 2019-12-14 Uso di resine a scambio cationico per la purificazione di antibiotici lipopolipeptidici
US12060439B2 (en) 2018-10-25 2024-08-13 Napp Pharmaceutical Group Limited Polymorph of echinocandin antifungal agent
CN113271922A (zh) 2018-12-21 2021-08-17 艾瑞克有限公司 新型组合物
CN112979756B (zh) * 2019-12-13 2023-01-03 浙江昌海制药有限公司 达托霉素的提纯方法
CN113480623B (zh) * 2021-08-09 2022-12-27 广州天赐高新材料股份有限公司 一种脂肽组合物及其制备方法和应用
CN116726145A (zh) * 2022-03-04 2023-09-12 海南普利制药股份有限公司 一种稳定的酯肽类药物组合物
WO2024085235A1 (ja) * 2022-10-20 2024-04-25 中外製薬株式会社 環状ペプチドの結晶の製造方法
EP4631955A1 (en) * 2022-12-28 2025-10-15 Chugai Seiyaku Kabushiki Kaisha Purification method and production method of cyclic peptide

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1021538B (de) † 1954-06-04 1957-12-27 Bristol Lab Inc Verfahren zur Herstellung und Gewinnung einer antibiotisch wirkenden Verbindung
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE32333E (en) 1978-10-16 1987-01-20 Eli Lilly And Company A-21978 Antibiotics and process for their production
USRE31396E (en) * 1978-10-16 1983-09-27 Eli Lilly And Company A-21978 Antibiotics and process for their production
USRE32455E (en) 1978-10-16 1987-07-07 Eli Lilly And Company A-21978 antibiotics and process for their production
EP0014815A3 (de) † 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
DE3376424D1 (en) 1982-02-27 1988-06-01 Beecham Group Plc Antibacterial 1-normon-2-yl-heterocyclic compounds
US4482487A (en) * 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
USRE32310E (en) * 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
USRE32311E (en) * 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4537717A (en) * 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4524135A (en) * 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
FR2533209B1 (fr) * 1982-09-22 1985-11-08 Centre Nat Rech Scient Lipopeptides, leur obtention et leur application comme emulsifiants
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4885243A (en) 1984-10-09 1989-12-05 Eli Lilly And Company Process for producing A-21978C derivatives
US4800157A (en) * 1985-09-09 1989-01-24 Eli Lilly And Company Process for producing the A-21978C antibiotics
ZA883887B (en) * 1987-06-10 1990-02-28 Lilly Co Eli Chromatographic purification process
EP0294990A3 (en) † 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
US4994270A (en) * 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
CA1337758C (en) * 1988-04-11 1995-12-19 Eli Lilly And Company Peptide antibiotics
US4886243A (en) * 1988-10-26 1989-12-12 Trumbull Christopher J Hydraulic jack ramp
EP0386951A3 (en) * 1989-03-06 1992-05-20 Eli Lilly And Company An improved diluent formulation for daptomycin
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH04167172A (ja) 1990-10-31 1992-06-15 Nec Corp ベクトルプロセッサ
JPH04224197A (ja) * 1990-12-26 1992-08-13 Fujitsu Ltd 生体高分子結晶化方法および装置
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5336756A (en) * 1991-05-01 1994-08-09 Merck & Co., Inc. Process for crystalline cyclic lipopeptides
TW213468B (enExample) * 1991-06-29 1993-09-21 Hoechst Ag
US5393528A (en) * 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
AU5541594A (en) * 1992-10-21 1994-05-09 Gynetech Laboratories, Inc. Vaginal sponge delivery system
WO1995005384A1 (en) 1993-08-13 1995-02-23 Smithkline Beecham Plc Derivatives of monic acids a and c having antibacterial, antimycoplasmatical, antifungal and herbicidal activity
DE4411025A1 (de) 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US5716960A (en) * 1995-01-13 1998-02-10 U.S. Bioscience Inc. And Individuals Crystalline trimetrexate salts and the process for making the same
JP3067972B2 (ja) * 1995-03-03 2000-07-24 新日本理化株式会社 ジアセタールの六方晶結晶、該六方晶結晶を含む核剤、該六方晶結晶を含むポリオレフィン系樹脂組成物及び成形物、並びに該組成物の成形方法
KR100431038B1 (ko) * 1995-07-17 2004-05-12 워너-램버트 캄파니 엘엘씨 결정질[ｒ-(ｒ*,ｒ*)]-2-(4-플루오로페닐)-베타,델타-디히드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카르보닐]-1ｈ-피롤-1-헵탄산 헤미 칼슘염 (아토르바스타틴)
DE19546573A1 (de) * 1995-12-13 1997-06-19 Uetikon Chemie Gmbh Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung
US5972331A (en) * 1995-12-22 1999-10-26 Schering Corporation Crystalline interferon alpha for pulmonary delivery and method for producing the same
JP4711471B2 (ja) * 1996-07-05 2011-06-29 三菱商事フードテック株式会社 結晶マルチトール及びそれを含有する含蜜結晶の製造方法
US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
US5928666A (en) * 1996-11-12 1999-07-27 Cygnus Inc. Crystalline form of estradiol and pharmaceutical formulations comprising same
JP3569422B2 (ja) * 1996-12-26 2004-09-22 シャープ株式会社 結晶型オキソチタニルフタロシアニン及びそれを用いた電子写真感光体並びに画像形成方法
US6017562A (en) * 1997-04-28 2000-01-25 Arch Chemicals, Inc. Non-spherical and non-platelet crystalline forms of pyrithione salts
US5965747A (en) * 1997-07-10 1999-10-12 Merck & Co., Inc. Crystalline forms of antibiotic side chain intermediates
AU3352999A (en) * 1998-02-18 1999-09-06 Biospace International Inc. Dynamically controlled crystallization method and apparatus and crystals obtained thereby
DE19807972A1 (de) † 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
EP1100947A4 (en) 1998-08-07 2001-09-05 Merck & Co Inc METHOD FOR PRODUCING AN ANTIBIOTIC ACTIVE SUBSTANCE
SI1115417T1 (sl) 1998-09-25 2006-08-31 Cubist Pharm Inc Uporaba daptomicina
EP2298790A1 (en) 1999-12-15 2011-03-23 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents
KR20020063228A (ko) 1999-12-15 2002-08-01 큐비스트 파마슈티컬즈 인코포레이티드 항균제로서 리포펩티드
EP1240182A2 (en) 1999-12-15 2002-09-18 Cubist Pharmaceuticals, Inc. Daptomycin analogs and their use as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
WO2002059145A1 (en) † 2000-12-18 2002-08-01 Cubist Pharmaceuticals, Inc. Methods for preparing purified lipopeptides
US9394340B2 (en) † 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides

Also Published As

Publication number Publication date
EP2261237B1 (en) 2018-08-22
WO2002056829A3 (en) 2003-03-27
AU2008207496A1 (en) 2008-09-11
CN102070703B (zh) 2014-08-06
ES2377931T5 (es) 2015-11-04
CN1982330A (zh) 2007-06-20
EP2261237A3 (en) 2011-01-26
CN102070703A (zh) 2011-05-25
US20030045484A1 (en) 2003-03-06
EP1908770A1 (en) 2008-04-09
EP2261237A2 (en) 2010-12-15
KR20110127732A (ko) 2011-11-25
EP1343811A4 (en) 2004-12-08
JP2004525108A (ja) 2004-08-19
AU2002246687B8 (en) 2008-10-02
IL230244A (en) 2017-12-31
KR20030081353A (ko) 2003-10-17
AU2002246687B2 (en) 2008-05-29
KR20080036661A (ko) 2008-04-28
NZ571597A (en) 2010-05-28
JP4927003B2 (ja) 2012-05-09
ATE535539T1 (de) 2011-12-15
KR20090122469A (ko) 2009-11-30
CN1592753A (zh) 2005-03-09
AU2002246687C1 (en) 2009-11-05
US20030045678A1 (en) 2003-03-06
ES2377931T3 (es) 2012-04-03
EP1343811A1 (en) 2003-09-17
ES2691680T3 (es) 2018-11-28
EP1908770B1 (en) 2011-11-30
WO2002056829A2 (en) 2002-07-25
AU2008207496B2 (en) 2012-06-14
CA2432096A1 (en) 2002-08-01
NZ554405A (en) 2009-04-30
JP2008214348A (ja) 2008-09-18
EP1908770B2 (en) 2015-07-15
IL156394A (en) 2015-05-31
HK1108582A1 (en) 2008-05-09
IL156394A0 (en) 2004-01-04
CN1982330B (zh) 2012-01-25

Similar Documents

Publication Publication Date Title
AU2002246688A1 (en) Methods for preparing purified daptomycin
AU5669398A (en) Novel cyclosporin derivatives, method of preparation and pharmaceutical compositions containing them
WO2001044272A3 (en) Daptomycin analogs as antibacterial agents
WO2001044271A3 (en) Daptomycin analogs and their use as antibacterial agents
AU5669298A (en) Cyclosporin derivatives, their preparation and pharmaceutical compositions containing them
YU11699A (sh) 6-supstituisani ketolidi koji imaju antibakterijsko dejstvo, postupci za njihovo dobijanje i njihovi farmaceutski preparati
WO2003004509A3 (en) C12 modified erythromycin macrolides and ketolides having antibacterial activity
IL157068A (en) Preparation of non-crystalline atorvastatin calcium
AU2002353775A1 (en) Lipopeptide stereoisomers, methods for preparing same, and useful intermediates
AP2003002942A0 (en) New derivatives of oxazolidinones as bacterial agents
IL160846A0 (en) Cross-linked glycopeptide-cephalosporin antibiotics
AU2002353768A1 (en) 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.
WO2002100327A3 (en) Substituted 1-benzazepines and derivatives thereof
WO2005016936A3 (en) Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof
ATE310010T1 (de) 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung
CA2380455A1 (en) 9a-azalides with antibacterial activity
AP2001002325A0 (en) Novel crystalline forms of a macrolide antibiotic
WO2002068438A3 (en) 9a-n-[n'-(phenylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a and of 5-0-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide a
MXPA01010409A (es) Compuestos inhibidores de beta-lactamasa.
WO2007017762A3 (en) Phosphonated fluoroquinolones, antibacterial analogs thereof, and methods for the prevention and treatment of bone and joint infections
UA70974C2 (uk) Ванкорезміцин (варіанти), штам amycolatopsis виду hil-006734, dsm 12216, що його продукує, та фармацевтична композиція, яка має антибіотичну активність
SG158899A1 (en) Peptidic compounds
CA2247232A1 (en) Antimicrobial composition
WO2002057281A3 (en) Aminoglycosides as antibiotics
CA2398848A1 (en) Anti-infective agents useful against multidrug-resistant strains of bacteria

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase