AU2001282162A1 - Inhibitors of copper-containing amine oxidases - Google Patents
Inhibitors of copper-containing amine oxidasesInfo
- Publication number
- AU2001282162A1 AU2001282162A1 AU2001282162A AU8216201A AU2001282162A1 AU 2001282162 A1 AU2001282162 A1 AU 2001282162A1 AU 2001282162 A AU2001282162 A AU 2001282162A AU 8216201 A AU8216201 A AU 8216201A AU 2001282162 A1 AU2001282162 A1 AU 2001282162A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- optionally substituted
- heterocyclic ring
- taken together
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 108010028700 Amine Oxidase (Copper-Containing) Proteins 0.000 title claims description 11
- 239000003112 inhibitor Substances 0.000 title description 21
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- 238000000034 method Methods 0.000 claims description 55
- 239000001257 hydrogen Substances 0.000 claims description 54
- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 125000000623 heterocyclic group Chemical group 0.000 claims description 48
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 36
- 201000010099 disease Diseases 0.000 claims description 35
- 125000004432 carbon atom Chemical group C* 0.000 claims description 34
- 125000002837 carbocyclic group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 31
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- 150000002431 hydrogen Chemical group 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 229910052736 halogen Chemical group 0.000 claims description 22
- 150000002367 halogens Chemical group 0.000 claims description 22
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 claims description 22
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 16
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
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- NZVZVGPYTICZBZ-UHFFFAOYSA-N 1-benzylpiperidine Chemical compound C=1C=CC=CC=1CN1CCCCC1 NZVZVGPYTICZBZ-UHFFFAOYSA-N 0.000 claims description 4
- HCNVXDPRTRLNFX-UHFFFAOYSA-N 2h-1,3,4-oxadiazine Chemical compound C1OC=CN=N1 HCNVXDPRTRLNFX-UHFFFAOYSA-N 0.000 claims description 4
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- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 3
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- 238000000338 in vitro Methods 0.000 claims description 3
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- PHEUXAHXXJOOLQ-UHFFFAOYSA-N 9-benzyl-4-methyl-1-oxa-4,5,9-triazaspiro[5.5]undecane Chemical compound N1N(C)CCOC11CCN(CC=2C=CC=CC=2)CC1 PHEUXAHXXJOOLQ-UHFFFAOYSA-N 0.000 claims 1
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21634100P | 2000-07-05 | 2000-07-05 | |
| US60216341 | 2000-07-05 | ||
| PCT/FI2001/000637 WO2002002541A2 (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001282162A1 true AU2001282162A1 (en) | 2002-01-14 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
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| AU2001282163A Ceased AU2001282163B2 (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
| AU2001282162A Abandoned AU2001282162A1 (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
| AU8216301A Pending AU8216301A (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| AU2001282163A Ceased AU2001282163B2 (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU8216301A Pending AU8216301A (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6624202B2 (enExample) |
| EP (2) | EP1301495A2 (enExample) |
| JP (2) | JP2004502682A (enExample) |
| CN (2) | CN1450997A (enExample) |
| AU (3) | AU2001282163B2 (enExample) |
| CA (2) | CA2414807A1 (enExample) |
| HU (2) | HUP0301625A3 (enExample) |
| IL (2) | IL153767A0 (enExample) |
| NO (2) | NO20026283L (enExample) |
| NZ (2) | NZ523463A (enExample) |
| PL (2) | PL360374A1 (enExample) |
| RU (2) | RU2003103291A (enExample) |
| WO (2) | WO2002002541A2 (enExample) |
| ZA (2) | ZA200300063B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2004502682A (ja) | 2000-07-05 | 2004-01-29 | バイオティ セラピーズ コーポレイション | 銅含有アミン・オキシダーゼの阻害剤 |
| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| US7125901B2 (en) * | 2003-01-27 | 2006-10-24 | Astellas Pharma Inc. | Thiazole derivatives |
| EP1608365B1 (en) | 2003-03-31 | 2013-10-02 | R-Tech Ueno, Ltd. | Method for treating vascular hyperpermeable disease |
| DE602004023939D1 (de) * | 2003-05-26 | 2009-12-17 | Biotie Therapies Corp | Kristalliner vap-1 und verwendung |
| FI20031927A0 (fi) * | 2003-12-31 | 2003-12-31 | Faron Pharmaceuticals Oy | Terapeuttisesti vaikuttavia aineita ja niiden käyttö |
| FI20040136A0 (fi) * | 2004-01-30 | 2004-01-30 | Faron Pharmaceuticals Oy | Erityisesti diabeetikoille soveltuvia koostumuksia |
| US8119651B2 (en) | 2004-01-30 | 2012-02-21 | Biotie Therapies Corp. | Compositions useful especially for treatment or prevention of metabolic syndrome |
| EP1708711B1 (en) * | 2004-01-30 | 2010-03-17 | Faron Pharmaceuticals OY | Compositions useful especially for treatment or prevention of metabolic syndrome |
| FI20040270A0 (fi) * | 2004-02-20 | 2004-02-20 | Biotie Therapies Oyj | Kuparia sisältävien amiinioksidaasien imhibiittoreina käyttökelpoiset hydratsinoalkoholijohdannaiset |
| JP4978464B2 (ja) * | 2004-07-27 | 2012-07-18 | アステラス製薬株式会社 | Ｖａｐ−１阻害剤活性を有するチアゾール誘導体 |
| WO2006028269A2 (en) * | 2004-09-09 | 2006-03-16 | Astellas Pharma Inc. | Thiazole derivatives having vap-1 ihibitory activity |
| JP4140630B2 (ja) * | 2005-11-10 | 2008-08-27 | Ｔｄｋ株式会社 | 磁気ヘッドアセンブリ及び磁気ヘッドアセンブリの製造方法 |
| US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
| US8372399B2 (en) | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| FI20061156A0 (fi) | 2006-12-27 | 2006-12-27 | Elina Kivi | Uusia peptidejä |
| WO2009061830A1 (en) * | 2007-11-06 | 2009-05-14 | Massachusetts Eye & Ear Infirmary | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap-1) inhibitor |
| CN101917845A (zh) | 2007-11-21 | 2010-12-15 | 法马克西斯制药公司 | Ssao/vap-1的卤代烯丙胺抑制剂及其用途 |
| TWI437986B (zh) | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途 |
| TWI490214B (zh) * | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| US8906642B2 (en) | 2008-09-03 | 2014-12-09 | Universitat Autonoma De Barcelona | Methods and compositions for the treatment and diagnosis of haemorrhagic conversion |
| RU2400233C1 (ru) | 2009-07-07 | 2010-09-27 | Общество с ограниченной ответственностью "Вирфарм" | Способ лечения заболеваний печени различного генеза |
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| MX2012003324A (es) | 2009-09-16 | 2012-04-30 | Astellas Pharma Inc | Compuesto de glicina. |
| RU2010145439A (ru) * | 2010-11-08 | 2012-05-20 | Виктор Вениаминович Тец (RU) | Средство для лечения поражений печени, вызванных воздействием химических или биологических агентов |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| UA110515C2 (ru) | 2011-03-15 | 2016-01-12 | Astellas Pharma Inc | Гуанідинова сполука |
| CA2915163A1 (en) | 2013-06-12 | 2014-12-18 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| HUE042625T2 (hu) | 2014-04-15 | 2019-07-29 | Pecsi Tudomanyegyetem | Szemikarbazid-szenzitiv amin-oxidáz gátlók fájdalomcsillapítóként való alkalmazásra traumás neuropátiában és neurogén gyulladásban |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| RU2595868C1 (ru) | 2015-03-27 | 2016-08-27 | Виктор Вениаминович Тец | Лекарственное средство с гепатопротекторной активностью |
| JP2018076236A (ja) | 2015-06-05 | 2018-05-17 | 株式会社アールテック・ウエノ | がんを処置するための医薬組成物 |
| AU2016366635A1 (en) | 2015-12-07 | 2018-06-21 | Benevolentai Cambridge Limited | VAP-1 inhibitors for treating pain |
| CN109810041B (zh) * | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 |
Family Cites Families (11)
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| US3377345A (en) * | 1966-09-23 | 1968-04-09 | Dow Chemical Co | Substituted 3, 4, 5, 6-tetrahydro-2h-1, 3, 4-oxadiazin-2-one compounds and method ofpreparation thereof |
| US3486916A (en) | 1966-12-22 | 1969-12-30 | William A Cordon | Cement mixes and the production of articles therefrom |
| SE320311B (enExample) | 1968-07-15 | 1970-02-02 | Mo Och Domsjoe Ab | |
| EP0639972A1 (en) * | 1992-05-15 | 1995-03-01 | University Of Saskatchewan | Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis |
| US5413634A (en) | 1993-08-06 | 1995-05-09 | Arco Chemical Technology, L.P. | Cement composition |
| CA2117585C (en) | 1993-09-14 | 2001-06-05 | Edward T. Shawl | Cement composition |
| AU2696795A (en) | 1994-08-25 | 1996-03-14 | W.R. Grace & Co.-Conn. | Shrinkage reduction cement composition |
| US5618344A (en) | 1995-03-06 | 1997-04-08 | W. R. Grace & Co.-Conn. | Cement composition |
| US5556460A (en) | 1995-09-18 | 1996-09-17 | W.R. Grace & Co.-Conn. | Drying shrinkage cement admixture |
| US5603760A (en) | 1995-09-18 | 1997-02-18 | W. R. Grace & Co.-Conn. | Cement admixture capable of inhibiting drying shrinkage and method of using same |
| JP2004502682A (ja) | 2000-07-05 | 2004-01-29 | バイオティ セラピーズ コーポレイション | 銅含有アミン・オキシダーゼの阻害剤 |
-
2001
- 2001-07-04 JP JP2002507795A patent/JP2004502682A/ja not_active Withdrawn
- 2001-07-04 NZ NZ523463A patent/NZ523463A/en unknown
- 2001-07-04 IL IL15376701A patent/IL153767A0/xx unknown
- 2001-07-04 PL PL36037401A patent/PL360374A1/xx not_active Application Discontinuation
- 2001-07-04 PL PL36035301A patent/PL360353A1/xx not_active Application Discontinuation
- 2001-07-04 WO PCT/FI2001/000637 patent/WO2002002541A2/en not_active Ceased
- 2001-07-04 RU RU2003103291/04A patent/RU2003103291A/ru not_active Application Discontinuation
- 2001-07-04 AU AU2001282163A patent/AU2001282163B2/en not_active Ceased
- 2001-07-04 CA CA002414807A patent/CA2414807A1/en not_active Abandoned
- 2001-07-04 AU AU2001282162A patent/AU2001282162A1/en not_active Abandoned
- 2001-07-04 RU RU2003103286/15A patent/RU2003103286A/ru not_active Application Discontinuation
- 2001-07-04 HU HU0301625A patent/HUP0301625A3/hu unknown
- 2001-07-04 IL IL15376601A patent/IL153766A0/xx unknown
- 2001-07-04 WO PCT/FI2001/000638 patent/WO2002002090A2/en not_active Ceased
- 2001-07-04 CA CA002414799A patent/CA2414799A1/en not_active Abandoned
- 2001-07-04 JP JP2002506712A patent/JP2004501962A/ja not_active Withdrawn
- 2001-07-04 AU AU8216301A patent/AU8216301A/xx active Pending
- 2001-07-04 NZ NZ523464A patent/NZ523464A/en unknown
- 2001-07-04 HU HU0301336A patent/HUP0301336A3/hu unknown
- 2001-07-04 EP EP01960763A patent/EP1301495A2/en not_active Withdrawn
- 2001-07-04 CN CN01815101A patent/CN1450997A/zh active Pending
- 2001-07-04 EP EP01960764A patent/EP1313718A2/en not_active Withdrawn
- 2001-07-04 CN CN01815102A patent/CN1450998A/zh active Pending
- 2001-07-05 US US09/898,003 patent/US6624202B2/en not_active Expired - Fee Related
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2002
- 2002-12-30 NO NO20026283A patent/NO20026283L/no not_active Application Discontinuation
- 2002-12-30 NO NO20026282A patent/NO20026282L/no not_active Application Discontinuation
-
2003
- 2003-01-03 ZA ZA200300063A patent/ZA200300063B/en unknown
- 2003-01-03 ZA ZA200300064A patent/ZA200300064B/en unknown
- 2003-07-21 US US10/622,581 patent/US20040106654A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |