AU2001274588A1 - Benzoxazepinones and their use as squalene synthase inhibitors - Google Patents

Benzoxazepinones and their use as squalene synthase inhibitors

Info

Publication number
AU2001274588A1
AU2001274588A1 AU2001274588A AU7458801A AU2001274588A1 AU 2001274588 A1 AU2001274588 A1 AU 2001274588A1 AU 2001274588 A AU2001274588 A AU 2001274588A AU 7458801 A AU7458801 A AU 7458801A AU 2001274588 A1 AU2001274588 A1 AU 2001274588A1
Authority
AU
Australia
Prior art keywords
dimethoxyphenyl
tetrahydro
chloro
dimethylpropyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001274588A
Other languages
English (en)
Inventor
Masakuni Kori
Takashi Miki
Tomoyuki Nishimoto
Ryuichi Tozawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AU2001274588A1 publication Critical patent/AU2001274588A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2001274588A 2000-06-23 2001-06-22 Benzoxazepinones and their use as squalene synthase inhibitors Abandoned AU2001274588A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-190253 2000-06-23
JP2000190253 2000-06-23
PCT/JP2001/005347 WO2001098282A1 (en) 2000-06-23 2001-06-22 Benzoxazepinones and their use as squalene synthase inhibitors

Publications (1)

Publication Number Publication Date
AU2001274588A1 true AU2001274588A1 (en) 2002-01-02

Family

ID=18689751

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001274588A Abandoned AU2001274588A1 (en) 2000-06-23 2001-06-22 Benzoxazepinones and their use as squalene synthase inhibitors

Country Status (16)

Country Link
US (1) US20030078251A1 (hu)
EP (1) EP1292585A1 (hu)
KR (1) KR20030011362A (hu)
CN (1) CN1437587A (hu)
AR (1) AR028974A1 (hu)
AU (1) AU2001274588A1 (hu)
BR (1) BR0111835A (hu)
CA (1) CA2413429A1 (hu)
CZ (1) CZ20024151A3 (hu)
HU (1) HUP0301301A2 (hu)
MX (1) MXPA02012481A (hu)
NO (1) NO20026164D0 (hu)
PL (1) PL360243A1 (hu)
SK (1) SK17602002A3 (hu)
WO (1) WO2001098282A1 (hu)
ZA (1) ZA200209055B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002212741A1 (en) * 2000-11-09 2002-05-21 Takeda Chemical Industries Ltd. High-density lipoprotein-cholesterol level elevating agent
WO2003002147A1 (fr) * 2001-06-28 2003-01-09 Takeda Chemical Industries, Ltd. Medicaments destines a la prevention/au traitement de troubles fonctionnels des organes et du dysfonctionnement des organes
WO2004064865A1 (ja) * 2003-01-17 2004-08-05 Takeda Pharmaceutical Company Limited 骨格筋保護剤
US20070129348A1 (en) * 2003-04-18 2007-06-07 Fumio Itoh Receptor antagonist
US7060698B2 (en) * 2003-05-19 2006-06-13 Hoffmann-La Roche Inc. Benzoxazepinone derivatives
DE102004006325A1 (de) * 2004-02-10 2005-08-25 Bayer Healthcare Ag Tetrahydrobenzo[d]azepin-2-on-Derivate und ihre Verwendung
CN101035520A (zh) * 2004-08-09 2007-09-12 武田药品工业株式会社 Crp降低剂
AR054368A1 (es) * 2005-06-01 2007-06-20 Takeda Pharmaceutical Metodo para tratar hiperlipidemia
MX2011002793A (es) 2008-09-25 2011-04-05 Hoffmann La Roche Derivados de 3-amino-indazol o de 3-amino-4,5,6,7-tetrahidro-indaz ol.
JP6050238B2 (ja) 2011-10-19 2016-12-21 興和株式会社 新規なスピロインドリン化合物、及びそれを含有する医薬
CN112274500A (zh) * 2020-10-30 2021-01-29 河南省儿童医院郑州儿童医院 单孢菌酸在制备抗凝血药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG48855A1 (en) * 1992-04-20 1998-05-18 Takeda Chemical Industries Ltd 4,1-benzoxazepin derivatives and their use
EP0862562B1 (en) * 1995-09-13 2001-07-04 Takeda Chemical Industries, Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents

Also Published As

Publication number Publication date
PL360243A1 (en) 2004-09-06
CZ20024151A3 (cs) 2003-05-14
KR20030011362A (ko) 2003-02-07
CA2413429A1 (en) 2001-12-27
US20030078251A1 (en) 2003-04-24
MXPA02012481A (es) 2003-06-06
ZA200209055B (en) 2003-11-07
BR0111835A (pt) 2003-04-29
AR028974A1 (es) 2003-05-28
WO2001098282A1 (en) 2001-12-27
NO20026164L (no) 2002-12-20
EP1292585A1 (en) 2003-03-19
HUP0301301A2 (hu) 2003-08-28
SK17602002A3 (sk) 2003-06-03
CN1437587A (zh) 2003-08-20
NO20026164D0 (no) 2002-12-20

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