HUP0301301A2 - Benzoxazepinon-származékok és szkvalén szintáz inhibitorként való alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Benzoxazepinon-származékok és szkvalén szintáz inhibitorként való alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0301301A2 HUP0301301A2 HU0301301A HUP0301301A HUP0301301A2 HU P0301301 A2 HUP0301301 A2 HU P0301301A2 HU 0301301 A HU0301301 A HU 0301301A HU P0301301 A HUP0301301 A HU P0301301A HU P0301301 A2 HUP0301301 A2 HU P0301301A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- bond
- optionally substituted
- alkyl group
- benzoxazepinones
- Prior art date
Links
- HZRJIAKKDMLYFS-UHFFFAOYSA-N 1,2-benzoxazepin-3-one Chemical class C1=CC(=O)NOC2=CC=CC=C21 HZRJIAKKDMLYFS-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004059 squalene synthase inhibitor Substances 0.000 title 1
- -1 1-carboxyethyl group Chemical group 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ILROLYQPRYHHFG-UHFFFAOYSA-N 1-$l^{1}-oxidanylprop-2-en-1-one Chemical group [O]C(=O)C=C ILROLYQPRYHHFG-UHFFFAOYSA-N 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
A találmány új, hiperlipidémia megelőzésére és/vagy kezelésérevalamint koleszterinszint és trigliceridszint csökkentésére alkalmasbenzoxazepinonszármazékokra és ezeket tartalmazógyógyszerkészítményekre vonatkozik. Az (I) általános képletűvegyületben R1 jelentése 1-karboxi-etil-, karboxi-alkil-, alkil-szulfonil-, karboxi-cikloalkil-alkil-csoport, vagy egy -X1-X2-Ar-X3-X4-COOH általános képletű csoport, (ahol X1 és X4 jelentése kötés vagyadott esetben szubsztituált 1-4 szénatomos alkiléncsoport, X2 és X3jelentése kötés, -O- vagy -S- atom, és Ar jelentése adott esetbenszubsztituált kétvegyértékű aromás csoport, azzal a megkötéssel, hogyha X1 jelentése kötés, akkor X2 jelentése kötés, és ha X4 jelentésekötés, akkor X3 jelentése kötés), R2 jelentése adott esetben alkanoil-oxi-csoporttal és/vagy hidroxilcsoporttal szubsztituált 3-6 szénatomosalkilcsoport, R3 jelentése kis szénatomszámú alkilcsoport, és Wjelentése halogénatom, azzal a megkötéssel, hogy ha R1 jelentése adottesetben szubsztituált 1-karboxi-etil-csoport, adott esetbenszubsztituált 3-6 szénatomos egyenes szénláncú alkilcsoport, 4-karboxi-ciklohexil-metil-csoport vagy 4-karboxi-metil-fenil-csoport,akkor R2 jelentése alkanoil-oxi-csoporttal és/vagy hidroxilcsoporttalszubsztituált 3-6 szénatomos alkilcsoport vagy a vegyület egy sója. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000190253 | 2000-06-23 | ||
| PCT/JP2001/005347 WO2001098282A1 (en) | 2000-06-23 | 2001-06-22 | Benzoxazepinones and their use as squalene synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0301301A2 true HUP0301301A2 (hu) | 2003-08-28 |
Family
ID=18689751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301301A HUP0301301A2 (hu) | 2000-06-23 | 2001-06-22 | Benzoxazepinon-származékok és szkvalén szintáz inhibitorként való alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20030078251A1 (hu) |
| EP (1) | EP1292585A1 (hu) |
| KR (1) | KR20030011362A (hu) |
| CN (1) | CN1437587A (hu) |
| AR (1) | AR028974A1 (hu) |
| AU (1) | AU2001274588A1 (hu) |
| BR (1) | BR0111835A (hu) |
| CA (1) | CA2413429A1 (hu) |
| CZ (1) | CZ20024151A3 (hu) |
| HU (1) | HUP0301301A2 (hu) |
| MX (1) | MXPA02012481A (hu) |
| NO (1) | NO20026164L (hu) |
| PL (1) | PL360243A1 (hu) |
| SK (1) | SK17602002A3 (hu) |
| WO (1) | WO2001098282A1 (hu) |
| ZA (1) | ZA200209055B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038180A1 (fr) * | 2000-11-09 | 2002-05-16 | Takeda Chemical Industries, Ltd. | Agent haute densite faisant monter le taux de lipoproteine-cholesterol |
| WO2003002147A1 (fr) * | 2001-06-28 | 2003-01-09 | Takeda Chemical Industries, Ltd. | Medicaments destines a la prevention/au traitement de troubles fonctionnels des organes et du dysfonctionnement des organes |
| WO2004064865A1 (ja) * | 2003-01-17 | 2004-08-05 | Takeda Pharmaceutical Company Limited | 骨格筋保護剤 |
| WO2004091628A1 (ja) * | 2003-04-18 | 2004-10-28 | Takeda Pharmaceutical Company Limited | 受容体拮抗剤 |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| DE102004006325A1 (de) * | 2004-02-10 | 2005-08-25 | Bayer Healthcare Ag | Tetrahydrobenzo[d]azepin-2-on-Derivate und ihre Verwendung |
| WO2006016681A2 (en) * | 2004-08-09 | 2006-02-16 | Takeda Pharmaceutical Company Limited | Crp lowering agent |
| TW200714280A (en) * | 2005-06-01 | 2007-04-16 | Takeda Pharmaceuticals Co | Novel method of treating hyperlipidemia |
| KR101444988B1 (ko) | 2008-09-25 | 2014-09-26 | 에프. 호프만-라 로슈 아게 | 3-아미노-인다졸 또는 3-아미노-4,5,6,7-테트라하이드로-인다졸 유도체 |
| US8921576B2 (en) | 2011-10-19 | 2014-12-30 | Kowa Company, Ltd. | Spiroindoline compound, and medicinal agent comprising same |
| CN112274500A (zh) * | 2020-10-30 | 2021-01-29 | 河南省儿童医院郑州儿童医院 | 单孢菌酸在制备抗凝血药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567026B1 (en) * | 1992-04-20 | 2003-03-26 | Takeda Chemical Industries, Ltd. | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides |
| CN1072649C (zh) * | 1995-09-13 | 2001-10-10 | 武田药品工业株式会社 | 苯并氧杂吖庚因化合物,其生产方法和用途 |
-
2001
- 2001-06-22 US US10/203,524 patent/US20030078251A1/en not_active Abandoned
- 2001-06-22 AR ARP010102994A patent/AR028974A1/es unknown
- 2001-06-22 PL PL36024301A patent/PL360243A1/xx not_active Application Discontinuation
- 2001-06-22 EP EP01941174A patent/EP1292585A1/en not_active Withdrawn
- 2001-06-22 HU HU0301301A patent/HUP0301301A2/hu unknown
- 2001-06-22 SK SK1760-2002A patent/SK17602002A3/sk unknown
- 2001-06-22 CA CA002413429A patent/CA2413429A1/en not_active Abandoned
- 2001-06-22 MX MXPA02012481A patent/MXPA02012481A/es unknown
- 2001-06-22 WO PCT/JP2001/005347 patent/WO2001098282A1/en not_active Application Discontinuation
- 2001-06-22 AU AU2001274588A patent/AU2001274588A1/en not_active Abandoned
- 2001-06-22 CN CN01811567A patent/CN1437587A/zh active Pending
- 2001-06-22 KR KR1020027017487A patent/KR20030011362A/ko not_active Application Discontinuation
- 2001-06-22 CZ CZ20024151A patent/CZ20024151A3/cs unknown
- 2001-06-22 BR BR0111835-8A patent/BR0111835A/pt not_active Application Discontinuation
-
2002
- 2002-11-07 ZA ZA200209055A patent/ZA200209055B/en unknown
- 2002-12-20 NO NO20026164A patent/NO20026164L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001098282A1 (en) | 2001-12-27 |
| BR0111835A (pt) | 2003-04-29 |
| CA2413429A1 (en) | 2001-12-27 |
| PL360243A1 (en) | 2004-09-06 |
| CZ20024151A3 (cs) | 2003-05-14 |
| SK17602002A3 (sk) | 2003-06-03 |
| MXPA02012481A (es) | 2003-06-06 |
| US20030078251A1 (en) | 2003-04-24 |
| NO20026164D0 (no) | 2002-12-20 |
| AR028974A1 (es) | 2003-05-28 |
| AU2001274588A1 (en) | 2002-01-02 |
| KR20030011362A (ko) | 2003-02-07 |
| ZA200209055B (en) | 2003-11-07 |
| CN1437587A (zh) | 2003-08-20 |
| NO20026164L (no) | 2002-12-20 |
| EP1292585A1 (en) | 2003-03-19 |
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