AU2001262257B2 - Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists - Google Patents

Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists Download PDF

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Publication number
AU2001262257B2
AU2001262257B2 AU2001262257A AU2001262257A AU2001262257B2 AU 2001262257 B2 AU2001262257 B2 AU 2001262257B2 AU 2001262257 A AU2001262257 A AU 2001262257A AU 2001262257 A AU2001262257 A AU 2001262257A AU 2001262257 B2 AU2001262257 B2 AU 2001262257B2
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Australia
Prior art keywords
compound
formula
free base
acid addition
addition salt
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Ceased
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AU2001262257A
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AU2001262257A1 (en
Inventor
Joachim Nozulak
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Novartis AG
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Novartis AG
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Publication of AU2001262257A1 publication Critical patent/AU2001262257A1/en
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Publication of AU2001262257B2 publication Critical patent/AU2001262257B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2001262257A 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists Ceased AU2001262257B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0010955.3 2000-05-05
GBGB0010955.3A GB0010955D0 (en) 2000-05-05 2000-05-05 Organic compounds
PCT/EP2001/005008 WO2001085727A1 (en) 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists

Publications (2)

Publication Number Publication Date
AU2001262257A1 AU2001262257A1 (en) 2002-02-07
AU2001262257B2 true AU2001262257B2 (en) 2004-11-04

Family

ID=9891092

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001262257A Ceased AU2001262257B2 (en) 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
AU6225701A Pending AU6225701A (en) 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptoragonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU6225701A Pending AU6225701A (en) 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptoragonists

Country Status (29)

Country Link
US (1) US6780861B2 (enExample)
EP (1) EP1282620B1 (enExample)
JP (1) JP4898062B2 (enExample)
KR (1) KR20020093974A (enExample)
CN (1) CN1167703C (enExample)
AR (1) AR028073A1 (enExample)
AT (1) ATE263167T1 (enExample)
AU (2) AU2001262257B2 (enExample)
BR (1) BR0110521A (enExample)
CA (1) CA2407972C (enExample)
CZ (1) CZ20023622A3 (enExample)
DE (1) DE60102581T2 (enExample)
DK (1) DK1282620T3 (enExample)
ES (1) ES2218418T3 (enExample)
GB (1) GB0010955D0 (enExample)
HK (1) HK1054223B (enExample)
HU (1) HUP0301866A2 (enExample)
IL (1) IL152417A0 (enExample)
MX (1) MXPA02010892A (enExample)
NO (1) NO20025280D0 (enExample)
NZ (1) NZ522226A (enExample)
PE (1) PE20020221A1 (enExample)
PL (1) PL357435A1 (enExample)
PT (1) PT1282620E (enExample)
RU (1) RU2002131886A (enExample)
SK (1) SK15612002A3 (enExample)
TR (1) TR200401007T4 (enExample)
WO (1) WO2001085727A1 (enExample)
ZA (1) ZA200208969B (enExample)

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Also Published As

Publication number Publication date
CZ20023622A3 (cs) 2003-02-12
GB0010955D0 (en) 2000-06-28
HUP0301866A2 (hu) 2003-09-29
BR0110521A (pt) 2003-04-08
TR200401007T4 (tr) 2004-07-21
NO20025280L (no) 2002-11-04
ES2218418T3 (es) 2004-11-16
IL152417A0 (en) 2003-05-29
PL357435A1 (en) 2004-07-26
PE20020221A1 (es) 2002-04-23
DK1282620T3 (da) 2004-07-19
SK15612002A3 (sk) 2003-04-01
MXPA02010892A (es) 2003-03-27
WO2001085727A1 (en) 2001-11-15
NZ522226A (en) 2004-08-27
CN1427840A (zh) 2003-07-02
NO20025280D0 (no) 2002-11-04
DE60102581T2 (de) 2005-02-03
CA2407972C (en) 2010-03-09
CA2407972A1 (en) 2001-11-15
JP4898062B2 (ja) 2012-03-14
AU6225701A (en) 2001-11-20
PT1282620E (pt) 2004-07-30
RU2002131886A (ru) 2004-04-10
JP2003532731A (ja) 2003-11-05
ZA200208969B (en) 2003-10-07
US20030166654A1 (en) 2003-09-04
HK1054223B (en) 2005-03-04
HK1054223A1 (en) 2003-11-21
ATE263167T1 (de) 2004-04-15
US6780861B2 (en) 2004-08-24
CN1167703C (zh) 2004-09-22
EP1282620A1 (en) 2003-02-12
EP1282620B1 (en) 2004-03-31
KR20020093974A (ko) 2002-12-16
AR028073A1 (es) 2003-04-23
DE60102581D1 (de) 2004-05-06

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