JP4898062B2 - アザ二環式カルバメートおよびアルファ−７ニコチン性アセチルコリンレセプターアゴニストとしてのその使用 - Google Patents

アザ二環式カルバメートおよびアルファ−７ニコチン性アセチルコリンレセプターアゴニストとしてのその使用 Download PDF

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Publication number
JP4898062B2
JP4898062B2 JP2001582328A JP2001582328A JP4898062B2 JP 4898062 B2 JP4898062 B2 JP 4898062B2 JP 2001582328 A JP2001582328 A JP 2001582328A JP 2001582328 A JP2001582328 A JP 2001582328A JP 4898062 B2 JP4898062 B2 JP 4898062B2
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formula
compound
free base
acid addition
oct
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JP2003532731A5 (enExample
JP2003532731A (ja
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ヨアヒム・ノツラック
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2001582328A 2000-05-05 2001-05-03 アザ二環式カルバメートおよびアルファ−７ニコチン性アセチルコリンレセプターアゴニストとしてのその使用 Expired - Fee Related JP4898062B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0010955.3 2000-05-05
GBGB0010955.3A GB0010955D0 (en) 2000-05-05 2000-05-05 Organic compounds
PCT/EP2001/005008 WO2001085727A1 (en) 2000-05-05 2001-05-03 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists

Publications (3)

Publication Number Publication Date
JP2003532731A JP2003532731A (ja) 2003-11-05
JP2003532731A5 JP2003532731A5 (enExample) 2008-06-05
JP4898062B2 true JP4898062B2 (ja) 2012-03-14

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JP2001582328A Expired - Fee Related JP4898062B2 (ja) 2000-05-05 2001-05-03 アザ二環式カルバメートおよびアルファ−７ニコチン性アセチルコリンレセプターアゴニストとしてのその使用

Country Status (29)

Country Link
US (1) US6780861B2 (enExample)
EP (1) EP1282620B1 (enExample)
JP (1) JP4898062B2 (enExample)
KR (1) KR20020093974A (enExample)
CN (1) CN1167703C (enExample)
AR (1) AR028073A1 (enExample)
AT (1) ATE263167T1 (enExample)
AU (2) AU2001262257B2 (enExample)
BR (1) BR0110521A (enExample)
CA (1) CA2407972C (enExample)
CZ (1) CZ20023622A3 (enExample)
DE (1) DE60102581T2 (enExample)
DK (1) DK1282620T3 (enExample)
ES (1) ES2218418T3 (enExample)
GB (1) GB0010955D0 (enExample)
HK (1) HK1054223B (enExample)
HU (1) HUP0301866A2 (enExample)
IL (1) IL152417A0 (enExample)
MX (1) MXPA02010892A (enExample)
NO (1) NO20025280D0 (enExample)
NZ (1) NZ522226A (enExample)
PE (1) PE20020221A1 (enExample)
PL (1) PL357435A1 (enExample)
PT (1) PT1282620E (enExample)
RU (1) RU2002131886A (enExample)
SK (1) SK15612002A3 (enExample)
TR (1) TR200401007T4 (enExample)
WO (1) WO2001085727A1 (enExample)
ZA (1) ZA200208969B (enExample)

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GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
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Also Published As

Publication number Publication date
CZ20023622A3 (cs) 2003-02-12
GB0010955D0 (en) 2000-06-28
AU2001262257B2 (en) 2004-11-04
HUP0301866A2 (hu) 2003-09-29
BR0110521A (pt) 2003-04-08
TR200401007T4 (tr) 2004-07-21
NO20025280L (no) 2002-11-04
ES2218418T3 (es) 2004-11-16
IL152417A0 (en) 2003-05-29
PL357435A1 (en) 2004-07-26
PE20020221A1 (es) 2002-04-23
DK1282620T3 (da) 2004-07-19
SK15612002A3 (sk) 2003-04-01
MXPA02010892A (es) 2003-03-27
WO2001085727A1 (en) 2001-11-15
NZ522226A (en) 2004-08-27
CN1427840A (zh) 2003-07-02
NO20025280D0 (no) 2002-11-04
DE60102581T2 (de) 2005-02-03
CA2407972C (en) 2010-03-09
CA2407972A1 (en) 2001-11-15
AU6225701A (en) 2001-11-20
PT1282620E (pt) 2004-07-30
RU2002131886A (ru) 2004-04-10
JP2003532731A (ja) 2003-11-05
ZA200208969B (en) 2003-10-07
US20030166654A1 (en) 2003-09-04
HK1054223B (en) 2005-03-04
HK1054223A1 (en) 2003-11-21
ATE263167T1 (de) 2004-04-15
US6780861B2 (en) 2004-08-24
CN1167703C (zh) 2004-09-22
EP1282620A1 (en) 2003-02-12
EP1282620B1 (en) 2004-03-31
KR20020093974A (ko) 2002-12-16
AR028073A1 (es) 2003-04-23
DE60102581D1 (de) 2004-05-06

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