AU2001256755A1 - Biosensor and method for manufacturing the same - Google Patents
Biosensor and method for manufacturing the sameInfo
- Publication number
- AU2001256755A1 AU2001256755A1 AU2001256755A AU5675501A AU2001256755A1 AU 2001256755 A1 AU2001256755 A1 AU 2001256755A1 AU 2001256755 A AU2001256755 A AU 2001256755A AU 5675501 A AU5675501 A AU 5675501A AU 2001256755 A1 AU2001256755 A1 AU 2001256755A1
- Authority
- AU
- Australia
- Prior art keywords
- biosensor
- manufacturing
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-143340 | 2000-05-16 | ||
JP2000143340 | 2000-05-16 | ||
PCT/JP2001/004055 WO2001088526A1 (fr) | 2000-05-16 | 2001-05-15 | Biocapteur et production de ce biocapteur |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001256755A1 true AU2001256755A1 (en) | 2001-11-26 |
Family
ID=18650178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001256755A Abandoned AU2001256755A1 (en) | 2000-05-16 | 2001-05-15 | Biosensor and method for manufacturing the same |
Country Status (6)
Country | Link |
---|---|
US (1) | US7063775B2 (zh) |
EP (1) | EP1291650B1 (zh) |
JP (1) | JP4761688B2 (zh) |
CN (1) | CN1198137C (zh) |
AU (1) | AU2001256755A1 (zh) |
WO (1) | WO2001088526A1 (zh) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7749174B2 (en) | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
JP4149911B2 (ja) | 2001-06-12 | 2008-09-17 | ペリカン テクノロジーズ インコーポレイテッド | 電気式ランセットアクチュエータ |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
ES2336081T3 (es) | 2001-06-12 | 2010-04-08 | Pelikan Technologies Inc. | Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas. |
EP1404232B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Blood sampling apparatus and method |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
ATE497731T1 (de) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute |
US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
ES2490740T3 (es) | 2003-06-06 | 2014-09-04 | Sanofi-Aventis Deutschland Gmbh | Aparato para toma de muestras de fluido sanguíneo y detección de analitos |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US7387714B2 (en) * | 2003-11-06 | 2008-06-17 | 3M Innovative Properties Company | Electrochemical sensor strip |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US8057740B2 (en) * | 2004-06-23 | 2011-11-15 | Tesa Se | Medical biosensor by means of which biological liquids are analyzed |
MX2007006127A (es) * | 2004-11-22 | 2007-07-13 | Home Diagnostics Inc | Bionsensores que comprenden electrodos semiconductores o mediadores que contienen rutenio y metodo de uso de los mismos. |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
JP2006201136A (ja) * | 2005-01-24 | 2006-08-03 | Sumitomo Electric Ind Ltd | センサチップの製造方法及びセンサチップ |
EP2102658B1 (en) * | 2007-01-19 | 2019-05-15 | Circassia Ab | Analysis device and method for detecting nitric oxide in a gas phase |
WO2009057793A1 (ja) * | 2007-10-31 | 2009-05-07 | Arkray, Inc. | 分析用具、分析装置、試料不足の検知方法および試料分析方法 |
JP5234749B2 (ja) * | 2007-12-27 | 2013-07-10 | 株式会社堀場製作所 | 被検液分析用チップ |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
KR100972108B1 (ko) * | 2008-07-09 | 2010-07-26 | 주식회사 올메디쿠스 | 바이오센서 |
JP4677642B2 (ja) * | 2008-09-26 | 2011-04-27 | 独立行政法人産業技術総合研究所 | バイオセンサ連接シートの製造方法 |
JP5162031B2 (ja) * | 2008-10-09 | 2013-03-13 | 紅電醫學科技股▲分▼有限公司 | 液体の検査方法 |
EP2339019B1 (en) | 2008-10-17 | 2013-08-14 | Actherm Inc. | A fluid test strip and method thereof |
CN102171566B (zh) | 2008-10-17 | 2013-10-23 | 红电医学科技股份有限公司 | 流体检测试片及其测试方法 |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
WO2010108310A1 (zh) | 2009-03-23 | 2010-09-30 | 红电医学科技股份有限公司 | 流体检测试片及其制造方法 |
EP2417442A4 (en) * | 2009-04-07 | 2013-06-26 | Senova Systems Inc | DEVICE FOR DETECTION OF AN ANALYTE IN A FLOWABLE SAMPLE |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
JP5937592B2 (ja) | 2010-07-26 | 2016-06-22 | セノバ システムズ インコーポレイテッド | 分析物センサー |
US20130228266A1 (en) * | 2010-12-10 | 2013-09-05 | Wen-Pin Hsieh | Manufacturing method of a test strip |
GB2509166B (en) * | 2012-12-21 | 2014-11-05 | Cilag Gmbh Int | Analytical test strip with co-planar electrodes and a reagent diffusion bridge |
CN105683742B (zh) | 2013-06-10 | 2018-12-25 | 豪夫迈·罗氏有限公司 | 制造测试元件的方法和设备 |
DE102013110042A1 (de) * | 2013-09-12 | 2015-03-12 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Elektrochemischer Sensor |
US11448611B2 (en) * | 2019-07-03 | 2022-09-20 | Medtronic Minimed, Inc. | Structurally reinforced sensor and method for manufacturing the same |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5627643A (en) * | 1979-08-14 | 1981-03-18 | Toshiba Corp | Electrochemical measuring device |
US4774039A (en) * | 1980-03-14 | 1988-09-27 | Brunswick Corporation | Dispersing casting of integral skinned highly asymmetric polymer membranes |
US4629563B1 (en) * | 1980-03-14 | 1997-06-03 | Memtec North America | Asymmetric membranes |
JPS60173458A (ja) * | 1984-02-20 | 1985-09-06 | Matsushita Electric Ind Co Ltd | バイオセンサ |
US4938860A (en) * | 1985-06-28 | 1990-07-03 | Miles Inc. | Electrode for electrochemical sensors |
US4981786A (en) * | 1987-09-04 | 1991-01-01 | Syntex (U.S.A.) Inc. | Multiple port assay device |
DE68924026T3 (de) * | 1988-03-31 | 2008-01-10 | Matsushita Electric Industrial Co., Ltd., Kadoma | Biosensor und dessen herstellung. |
US5135716A (en) * | 1989-07-12 | 1992-08-04 | Kingston Diagnostics, L.P. | Direct measurement of HDL cholesterol via dry chemistry strips |
WO1991009139A1 (en) * | 1989-12-15 | 1991-06-27 | Boehringer Mannheim Corporation | Redox mediator reagent and biosensor |
CN1057479C (zh) * | 1994-03-04 | 2000-10-18 | Usf过滤和分离集团公司 | 聚合物膜及其制法和用途 |
CA2156226C (en) * | 1994-08-25 | 1999-02-23 | Takayuki Taguchi | Biological fluid analyzing device and method |
AUPN363995A0 (en) * | 1995-06-19 | 1995-07-13 | Memtec Limited | Electrochemical cell |
DE19523049A1 (de) * | 1995-06-24 | 1997-01-02 | Boehringer Mannheim Gmbh | Mehrschichtiges Analysenelement zur Bestimmung eines Analyten in einer Flüssigkeit |
US5906742A (en) * | 1995-07-05 | 1999-05-25 | Usf Filtration And Separations Group Inc. | Microfiltration membranes having high pore density and mixed isotropic and anisotropic structure |
JPH09102180A (ja) * | 1995-10-03 | 1997-04-15 | Sony Corp | テープカートリッジ |
JPH09101280A (ja) | 1995-10-05 | 1997-04-15 | Casio Comput Co Ltd | バイオセンサ |
JP3365184B2 (ja) * | 1996-01-10 | 2003-01-08 | 松下電器産業株式会社 | バイオセンサ |
DE19605583A1 (de) * | 1996-02-15 | 1997-08-21 | Bayer Ag | Elektrochemische Sensoren mit verbesserter Selektivität und erhöhter Empfindlichkeit |
DE69720391T2 (de) | 1996-12-20 | 2004-02-12 | Matsushita Electric Industrial Co., Ltd., Kadoma | Cholesterinsensor und Verfahren zu seiner Herstellung |
JP3529081B2 (ja) * | 1996-12-20 | 2004-05-24 | 松下電器産業株式会社 | コレステロールセンサおよびその製造方法 |
JP3487396B2 (ja) | 1997-01-31 | 2004-01-19 | 松下電器産業株式会社 | バイオセンサとその製造方法 |
AU6157898A (en) * | 1997-02-06 | 1998-08-26 | E. Heller & Company | Small volume (in vitro) analyte sensor |
US6669905B1 (en) * | 1998-05-21 | 2003-12-30 | Baxter International Inc. | Systems and methods for collecting plasma that is free or virtually free of cellular blood species |
JP3487410B2 (ja) | 1998-05-29 | 2004-01-19 | 松下電器産業株式会社 | バイオセンサ |
US6338790B1 (en) * | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6596544B1 (en) * | 2000-03-31 | 2003-07-22 | The Regents Of The University Of California | Functional assay of high-density lipoprotein |
US6849184B1 (en) * | 2001-12-12 | 2005-02-01 | Hydration Technologies Inc. | Forward osmosis pressurized device and process for generating potable water |
-
2001
- 2001-05-15 AU AU2001256755A patent/AU2001256755A1/en not_active Abandoned
- 2001-05-15 EP EP01930170.4A patent/EP1291650B1/en not_active Expired - Lifetime
- 2001-05-15 WO PCT/JP2001/004055 patent/WO2001088526A1/ja active Application Filing
- 2001-05-15 US US10/276,473 patent/US7063775B2/en not_active Expired - Lifetime
- 2001-05-15 JP JP2001584871A patent/JP4761688B2/ja not_active Expired - Lifetime
- 2001-05-15 CN CN01809503.8A patent/CN1198137C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1291650A4 (en) | 2009-05-13 |
WO2001088526A1 (fr) | 2001-11-22 |
EP1291650A1 (en) | 2003-03-12 |
JP4761688B2 (ja) | 2011-08-31 |
CN1198137C (zh) | 2005-04-20 |
CN1429337A (zh) | 2003-07-09 |
EP1291650B1 (en) | 2014-04-02 |
US20030111344A1 (en) | 2003-06-19 |
US7063775B2 (en) | 2006-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001256755A1 (en) | Biosensor and method for manufacturing the same | |
AU2001252973A1 (en) | Biosensor and related method | |
AU2001279683A1 (en) | Biosensor and method for production thereof | |
AU2002213831A1 (en) | Actuating member and method for producing the same | |
AU5104700A (en) | Thermoelectric material and method for manufacturing the same | |
AU2001288249A1 (en) | Biosensors and methods for their use | |
AU2002359046A1 (en) | Dehumidifying element and manufacturing method for the same | |
EP1172826A3 (en) | Flat cable and its manufacturing method | |
AU2001276295A1 (en) | Electric component, method for the production thereof, and its use | |
AU2001279850A1 (en) | Method and arrangement for studsystem | |
AU4112401A (en) | Hydrophilic member and method for manufacture thereof | |
AU2001295579A1 (en) | Pants and method for the production thereof | |
AU5057600A (en) | Component and method for the production thereof | |
AU2002241739A1 (en) | Antimycobacterial compounds and method for making the same | |
AU2001291288A1 (en) | Webpad and method for using the same | |
AU2002237253A1 (en) | Biosensor and method of producing the same | |
AU2000239097A1 (en) | Manufacturing apparatus and method | |
AU2001237530A1 (en) | Method | |
AU2001264134A1 (en) | Microconnectors and method for their production | |
AU2001241636A1 (en) | Halotherapy method | |
AU2002348998A1 (en) | N-methyl-homocystines, use thereof and method for the production thereof | |
AU4645401A (en) | Flat composite component and method for the production thereof | |
AU2002221190A1 (en) | Paper quilt and method for manufacturing the same | |
AU4235201A (en) | Indentor and method for producing the same | |
AU2001283030A1 (en) | Process for making 3-hydroxyalkanenitriles and hydroxyaminoalkanes |