AU2001253427B2 - A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group - Google Patents

A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group Download PDF

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Publication number
AU2001253427B2
AU2001253427B2 AU2001253427A AU2001253427A AU2001253427B2 AU 2001253427 B2 AU2001253427 B2 AU 2001253427B2 AU 2001253427 A AU2001253427 A AU 2001253427A AU 2001253427 A AU2001253427 A AU 2001253427A AU 2001253427 B2 AU2001253427 B2 AU 2001253427B2
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AU
Australia
Prior art keywords
compound
fused ring
hydroxyl substituent
secondary hydroxyl
reacting
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Ceased
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AU2001253427A
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AU2001253427A1 (en
Inventor
William A Kinney
Ronald Michalak
Xuehai Zhang
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Genaera Corp
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Genaera Corp
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Publication of AU2001253427B2 publication Critical patent/AU2001253427B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2001253427A 2000-04-12 2001-04-12 A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group Ceased AU2001253427B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19664600P 2000-04-12 2000-04-12
US60/196,646 2000-04-12
PCT/US2001/012004 WO2001079255A1 (en) 2000-04-12 2001-04-12 A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group

Publications (2)

Publication Number Publication Date
AU2001253427A1 AU2001253427A1 (en) 2002-01-17
AU2001253427B2 true AU2001253427B2 (en) 2007-02-08

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001253427A Ceased AU2001253427B2 (en) 2000-04-12 2001-04-12 A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group
AU5342701A Pending AU5342701A (en) 2000-04-12 2001-04-12 A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group

Family Applications After (1)

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AU5342701A Pending AU5342701A (en) 2000-04-12 2001-04-12 A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group

Country Status (12)

Country Link
US (2) US6933383B2 (https=)
EP (1) EP1274718B1 (https=)
JP (1) JP2003531148A (https=)
AT (1) ATE342912T1 (https=)
AU (2) AU2001253427B2 (https=)
CA (1) CA2406847C (https=)
CY (1) CY1105870T1 (https=)
DE (1) DE60123939T2 (https=)
DK (1) DK1274718T3 (https=)
ES (1) ES2273831T3 (https=)
PT (1) PT1274718E (https=)
WO (1) WO2001079255A1 (https=)

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US20180280370A1 (en) 2015-11-02 2018-10-04 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN109651475B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙的新方法
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN109734765B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙产品的制备方法
CN109734764B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙的制备方法
CN113621016B (zh) * 2021-09-06 2022-05-17 北京泛球生物科技有限公司 一种地屈孕酮关键中间体的合成方法

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Also Published As

Publication number Publication date
AU5342701A (en) 2001-10-30
US6933383B2 (en) 2005-08-23
US7728157B2 (en) 2010-06-01
JP2003531148A (ja) 2003-10-21
EP1274718A1 (en) 2003-01-15
WO2001079255A1 (en) 2001-10-25
CY1105870T1 (el) 2011-02-02
ES2273831T3 (es) 2007-05-16
US20030171576A1 (en) 2003-09-11
DK1274718T3 (da) 2007-02-12
CA2406847C (en) 2009-11-17
CA2406847A1 (en) 2001-10-25
ATE342912T1 (de) 2006-11-15
EP1274718B1 (en) 2006-10-18
DE60123939T2 (de) 2007-05-31
US20050187202A1 (en) 2005-08-25
DE60123939D1 (de) 2006-11-30
PT1274718E (pt) 2007-01-31

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired