AU2001240375A1 - Genetic silencing - Google Patents
Genetic silencingInfo
- Publication number
- AU2001240375A1 AU2001240375A1 AU2001240375A AU4037501A AU2001240375A1 AU 2001240375 A1 AU2001240375 A1 AU 2001240375A1 AU 2001240375 A AU2001240375 A AU 2001240375A AU 4037501 A AU4037501 A AU 4037501A AU 2001240375 A1 AU2001240375 A1 AU 2001240375A1
- Authority
- AU
- Australia
- Prior art keywords
- sequence
- gene
- cells
- cell
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/18—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with another compound as one donor, and incorporation of one atom of oxygen (1.14.18)
- C12Y114/18001—Tyrosinase (1.14.18.1)
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001240375A AU2001240375A1 (en) | 2000-03-17 | 2001-03-16 | Genetic silencing |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPQ6363A AUPQ636300A0 (en) | 2000-03-17 | 2000-03-17 | Genetic silencing |
AUPQ6363 | 2000-03-17 | ||
AUPR2700 | 2001-01-24 | ||
AUPR2700A AUPR270001A0 (en) | 2001-01-24 | 2001-01-24 | Genetic silencing |
PCT/AU2001/000297 WO2001070949A1 (fr) | 2000-03-17 | 2001-03-16 | Extinction genetique |
AU2001240375A AU2001240375A1 (en) | 2000-03-17 | 2001-03-16 | Genetic silencing |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001240375A1 true AU2001240375A1 (en) | 2001-10-03 |
Family
ID=25646282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001240375A Abandoned AU2001240375A1 (en) | 2000-03-17 | 2001-03-16 | Genetic silencing |
Country Status (12)
Country | Link |
---|---|
US (1) | US20030182672A1 (fr) |
EP (1) | EP1272629A4 (fr) |
JP (2) | JP2003527856A (fr) |
KR (1) | KR20020097198A (fr) |
CN (1) | CN1426466A (fr) |
AU (1) | AU2001240375A1 (fr) |
BR (1) | BR0109269A (fr) |
CA (1) | CA2403162A1 (fr) |
GB (1) | GB2377221B (fr) |
MX (1) | MXPA02009069A (fr) |
PL (1) | PL358230A1 (fr) |
WO (1) | WO2001070949A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US8846894B2 (en) | 2002-02-20 | 2014-09-30 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
CZ295108B6 (cs) | 1998-03-20 | 2005-05-18 | Benitec Australia Ltd | Syntetický gen obsahující dispergovanou nebo cizorodou deoxyribonukleovou molekulu a genový konstrukt obsahující tento syntetický gen |
EP2314700A1 (fr) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition et méthode destinées à l'attenuation in vivo et in vitro de l'expression génique utilisant de l'ARN double brin |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
US7531718B2 (en) | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
US7067722B2 (en) | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
IL148374A0 (en) | 1999-08-26 | 2002-09-12 | Calgene Llc | Plants with modified polyunsaturated fatty acids |
DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
WO2003070918A2 (fr) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Inhibition mediee par interference arn d'une expression genique faisant appel a des acides nucleiques interferants courts chimiquement modifies (sina) |
US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
CA2369944A1 (fr) | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Utilisation de l'inhibition genetique post-transcriptionnelle pour identifier les sequences d'acides nucleiques qui modulent la fonction d'une cellule |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
US20050148530A1 (en) | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
KR20040022449A (ko) | 2001-07-12 | 2004-03-12 | 유니버시티 오브 매사추세츠 | 유전자 불활성화를 매개하는 소형 간섭 rna의 생체내제조 |
JP2005508306A (ja) | 2001-07-23 | 2005-03-31 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
US10590418B2 (en) | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
US20050037989A1 (en) * | 2001-08-27 | 2005-02-17 | Lewis David L. | Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo |
US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
DE10202419A1 (de) | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
AU2003207708A1 (en) | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
MXPA04009134A (es) | 2002-03-21 | 2005-01-25 | Monsanto Technology Llc | Construcciones de acidos nucleicos y metodos para producir composiciones alteradas de aceite de semilla. |
US7166771B2 (en) | 2002-06-21 | 2007-01-23 | Monsanto Technology Llc | Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs |
US7566813B2 (en) | 2002-03-21 | 2009-07-28 | Monsanto Technology, L.L.C. | Nucleic acid constructs and methods for producing altered seed oil compositions |
US20040172667A1 (en) | 2002-06-26 | 2004-09-02 | Cooper Richard K. | Administration of transposon-based vectors to reproductive organs |
US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
WO2004015062A2 (fr) | 2002-08-12 | 2004-02-19 | New England Biolabs, Inc. | Procedes et compositions associes au silençage genique |
US7122361B2 (en) | 2002-10-10 | 2006-10-17 | Wyeth | Compositions employing a novel human kinase |
WO2004038026A2 (fr) | 2002-10-24 | 2004-05-06 | Wyeth | Compositions, organismes et procedes faisant appel a une nouvelle proteine phosphatase humaine |
AU2003298689A1 (en) | 2002-11-21 | 2004-06-18 | Wyeth | Methods for diagnosing rcc and other solid tumors |
WO2004050831A2 (fr) | 2002-11-27 | 2004-06-17 | Wyeth | Compositions, organismes et procedes faisant appel a une nouvelle kinase humaine |
WO2005009346A2 (fr) * | 2003-06-24 | 2005-02-03 | Mirus Corporation | Inhibition d'une fonction genique par distribution in vivo d'inhibiteurs d'expression genique a base de polynucleotides dans des cellules mammiferes |
EP1668116A4 (fr) | 2003-08-20 | 2007-08-15 | Northern Sydney And Central Co | Methodes pouvant ameliorer la viabilite d'un embryon |
EP1672064A4 (fr) * | 2003-09-22 | 2006-12-20 | Riken | Procede efficace de preparation d'une structure a repetition inversee d'adn |
DE10351149A1 (de) * | 2003-11-03 | 2005-06-30 | Beiersdorf Ag | Oligoribonukleotide zur Behandlung von unerwünschter Pigmentierung der Haut und der Haare durch RNA-Interferenz |
WO2005062881A2 (fr) | 2003-12-24 | 2005-07-14 | Transgenrx, Inc. | Therapie genique faisant intervenir des vecteurs de transposon |
CA2554212A1 (fr) | 2004-02-10 | 2005-08-25 | Sirna Therapeutics, Inc. | Inhibition induite par l'interference arn de l'expression genetique, a l'aide d'un acide nucleique interferant court multifonctionnel (sina multifonctionnel) |
CA2557532A1 (fr) | 2004-04-23 | 2005-11-10 | Angela M. Christiano | Inhibition d'un arnm associe a une proteine du gene hairless (sans poil) |
US7846438B2 (en) | 2004-08-03 | 2010-12-07 | Biogen Idec Ma Inc. | Methods of promoting neurite outgrowth with soluble TAJ polypeptides |
MX2007004310A (es) | 2004-10-13 | 2007-06-18 | Univ Georgia Res Found | Plantas transgenicas resistentes a nematodos. |
CA2610644A1 (fr) | 2005-05-31 | 2006-12-07 | Devgen Nv | Arni pour la lutte contre les insectes et les arachnides |
EP1931789B1 (fr) | 2005-09-20 | 2016-05-04 | BASF Plant Science GmbH | Methodes de regulation de l'expression genique utilisant ta-siarn |
WO2007043049A1 (fr) | 2005-10-11 | 2007-04-19 | Ben-Gurion University Of The Negev Research And Development Authority | Compositions permettant d'effectuer un silençage de l'expression de vdac1 et des utilisations de celles-ci |
CN103710429B (zh) | 2005-11-29 | 2016-03-30 | 剑桥企业有限公司 | 乳腺癌标志物 |
ES2550099T3 (es) | 2006-01-27 | 2015-11-04 | Biogen Ma Inc. | Antagonistas del receptor Nogo |
CN101421406B (zh) | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
FR2898908A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence |
CN102321626B (zh) | 2006-07-21 | 2014-12-10 | 赛伦斯治疗有限公司 | 用于抑制蛋白激酶3表达的方法 |
WO2008097197A1 (fr) | 2007-02-05 | 2008-08-14 | National University Of Singapore | Récepteur putatif de la cytokinine et ses méthodes d'utilisation |
BRPI0809130A8 (pt) | 2007-03-21 | 2021-11-03 | Brookhaven Science Ass Llc | Composições combinadas hairpin-antissenso e métodos para modulação da expressão |
PT2279265E (pt) | 2008-04-24 | 2014-12-09 | Newsouth Innovations Pty Ltd | Agrupamento de genes saxitoxina das cianobactérias e deteção de organismos cianotoxicos |
US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
WO2010036978A2 (fr) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Nouveaux vecteurs pour la production d'hormone de croissance |
WO2010036976A2 (fr) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Nouveaux vecteurs pour la production d'anticorps |
UY32145A (es) | 2008-09-29 | 2010-04-30 | Monsanto Technology Llc | Evento transgénico de soja mon87705 y métodos para detectar el mismo |
WO2010072676A1 (fr) * | 2008-12-22 | 2010-07-01 | Lek Pharmaceuticals D.D. | Vecteur d'expression de mammifère |
EP2241627A1 (fr) * | 2009-04-17 | 2010-10-20 | LEK Pharmaceuticals d.d. | Vecteur d'expression de mammifères |
US9150881B2 (en) | 2009-04-09 | 2015-10-06 | Proteovec Holding, L.L.C. | Production of proteins using transposon-based vectors |
ES2644055T3 (es) | 2009-06-05 | 2017-11-27 | Centenary Institute Of Cancer Medicine And Cell Biology | Moléculas terapéuticas y de diagnóstico |
KR101605932B1 (ko) | 2009-12-18 | 2016-03-24 | 노파르티스 아게 | Hsf1-관련 질환을 치료하기 위한 유기 조성물 |
JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
BR112014016870A2 (pt) | 2012-01-09 | 2017-06-27 | Huesken Dieter | composições orgânicas para tratar doenças relacionadas com beta-catenina |
BR112017016639A2 (pt) | 2015-02-02 | 2018-06-19 | Meiragtx Uk Ii Ltd | regulação da expressão genética pela modulação mediada de aptâmero de espalhamento alternativo |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5190931A (en) * | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
US5272065A (en) * | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
US5208149A (en) * | 1983-10-20 | 1993-05-04 | The Research Foundation Of State University Of New York | Nucleic acid constructs containing stable stem and loop structures |
US4766072A (en) * | 1985-07-17 | 1988-08-23 | Promega Corporation | Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence |
US5231020A (en) * | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
US5034323A (en) * | 1989-03-30 | 1991-07-23 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
US5714323A (en) * | 1991-08-30 | 1998-02-03 | The University Of Medecine And Dentistry Of New Jersey | Over expression of single-stranded molecules |
ES2166361T3 (es) * | 1992-02-19 | 2002-04-16 | State Of Oregon Acting By & Th | Produccion de plantas resistentes a los virus a traves de la introduccion de rna viral intraducible de sentido positivo. |
DE4208107A1 (de) * | 1992-03-13 | 1993-09-16 | Bayer Ag | Pseudorabies-virus (prv)-polynukleotide und ihre verwendung zur herstellung von virusresistenten eukaryotischen zellen |
US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
US5578716A (en) * | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
US5686649A (en) * | 1994-03-22 | 1997-11-11 | The Rockefeller University | Suppression of plant gene expression using processing-defective RNA constructs |
US6054299A (en) * | 1994-04-29 | 2000-04-25 | Conrad; Charles A. | Stem-loop cloning vector and method |
AU738592C (en) * | 1996-08-02 | 2002-07-25 | Lorus Therapeutics Inc. | Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase |
US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
WO1999032612A1 (fr) * | 1997-12-20 | 1999-07-01 | Genencor International, Inc. | Granules matriciels en lit fluidise |
US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
AUPP249298A0 (en) * | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
CZ295108B6 (cs) * | 1998-03-20 | 2005-05-18 | Benitec Australia Ltd | Syntetický gen obsahující dispergovanou nebo cizorodou deoxyribonukleovou molekulu a genový konstrukt obsahující tento syntetický gen |
ATE507299T1 (de) * | 1998-04-08 | 2011-05-15 | Commw Scient Ind Res Org | Verfahren und mittel zum erhalt von veränderten phänotypen |
EP2314700A1 (fr) * | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition et méthode destinées à l'attenuation in vivo et in vitro de l'expression génique utilisant de l'ARN double brin |
US6423885B1 (en) * | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
ES2336887T5 (es) * | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
BR0111839A (pt) * | 2000-06-23 | 2003-09-16 | Du Pont | Construções recombinantes, método para a redução da expressão de um mrna alvo ou qualquer mrna endógeno substancialmente similar, rna e método para a identificação ou seleção de um gene vegetal essencial |
US7109393B2 (en) * | 2000-08-15 | 2006-09-19 | Mendel Biotechnology, Inc. | Methods of gene silencing using inverted repeat sequences |
-
2001
- 2001-03-16 WO PCT/AU2001/000297 patent/WO2001070949A1/fr not_active Application Discontinuation
- 2001-03-16 PL PL01358230A patent/PL358230A1/xx not_active Application Discontinuation
- 2001-03-16 JP JP2001569332A patent/JP2003527856A/ja active Pending
- 2001-03-16 AU AU2001240375A patent/AU2001240375A1/en not_active Abandoned
- 2001-03-16 KR KR1020027012237A patent/KR20020097198A/ko not_active Application Discontinuation
- 2001-03-16 BR BR0109269-3A patent/BR0109269A/pt not_active Application Discontinuation
- 2001-03-16 CA CA002403162A patent/CA2403162A1/fr not_active Abandoned
- 2001-03-16 EP EP01911291A patent/EP1272629A4/fr not_active Withdrawn
- 2001-03-16 MX MXPA02009069A patent/MXPA02009069A/es unknown
- 2001-03-16 CN CN01808640A patent/CN1426466A/zh active Pending
- 2001-03-16 GB GB0224195A patent/GB2377221B/en not_active Expired - Lifetime
-
2002
- 2002-09-16 US US10/245,805 patent/US20030182672A1/en not_active Abandoned
-
2011
- 2011-08-19 JP JP2011179375A patent/JP2011229542A/ja active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US8846894B2 (en) | 2002-02-20 | 2014-09-30 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US7956176B2 (en) | 2002-09-05 | 2011-06-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
Also Published As
Publication number | Publication date |
---|---|
CA2403162A1 (fr) | 2001-09-27 |
US20030182672A1 (en) | 2003-09-25 |
EP1272629A4 (fr) | 2004-12-22 |
CN1426466A (zh) | 2003-06-25 |
JP2011229542A (ja) | 2011-11-17 |
MXPA02009069A (es) | 2004-04-05 |
GB0224195D0 (en) | 2002-11-27 |
EP1272629A1 (fr) | 2003-01-08 |
GB2377221B (en) | 2004-08-18 |
BR0109269A (pt) | 2002-12-17 |
WO2001070949A1 (fr) | 2001-09-27 |
JP2003527856A (ja) | 2003-09-24 |
PL358230A1 (en) | 2004-08-09 |
GB2377221A (en) | 2003-01-08 |
KR20020097198A (ko) | 2002-12-31 |
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