ATE89814T1 - Fettsaeureamide als acyl-coa-inhibitoren: cholesterolacyltransferase. - Google Patents
Fettsaeureamide als acyl-coa-inhibitoren: cholesterolacyltransferase.Info
- Publication number
- ATE89814T1 ATE89814T1 AT88102644T AT88102644T ATE89814T1 AT E89814 T1 ATE89814 T1 AT E89814T1 AT 88102644 T AT88102644 T AT 88102644T AT 88102644 T AT88102644 T AT 88102644T AT E89814 T1 ATE89814 T1 AT E89814T1
- Authority
- AT
- Austria
- Prior art keywords
- fatty acids
- acyl
- cholesterolacyltransferase
- coa inhibitors
- coa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/017,960 US4716175A (en) | 1987-02-24 | 1987-02-24 | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| EP88102644A EP0283742B1 (en) | 1987-02-24 | 1988-02-23 | Fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE89814T1 true ATE89814T1 (de) | 1993-06-15 |
Family
ID=21785503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88102644T ATE89814T1 (de) | 1987-02-24 | 1988-02-23 | Fettsaeureamide als acyl-coa-inhibitoren: cholesterolacyltransferase. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4716175A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0283742B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH07121895B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR880009933A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE89814T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1336913C (cg-RX-API-DMAC7.html) |
| DE (1) | DE3881249T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK165406C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2056843T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI89593C (cg-RX-API-DMAC7.html) |
| HK (1) | HK148195A (cg-RX-API-DMAC7.html) |
| IE (1) | IE59998B1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX9203139A (cg-RX-API-DMAC7.html) |
| NO (1) | NO174043C (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ223410A (cg-RX-API-DMAC7.html) |
| PT (1) | PT86811B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA88604B (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| WO1991015464A1 (en) * | 1990-04-11 | 1991-10-17 | Warner-Lambert Company | Amide ester acat inhibitors |
| US5149709A (en) * | 1990-07-03 | 1992-09-22 | Schering Corporation | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
| KR960014797B1 (ko) * | 1990-07-25 | 1996-10-19 | 이다가끼 히로시 | 벤조피란 유도체, 그의 제조법 및 그것을 함유하는 의약 조성물 |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| ES2088574T3 (es) * | 1990-11-26 | 1996-08-16 | Taisho Pharmaceutical Co Ltd | Derivado de anilida. |
| FR2673625B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| AU660346B2 (en) * | 1991-12-25 | 1995-06-22 | Taisho Pharmaceutical Co., Ltd. | Anilide derivative |
| AU4028393A (en) * | 1992-05-28 | 1993-12-30 | Pfizer Inc. | New (N)-aryl and (N)-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (ACAT) |
| US5462958A (en) * | 1992-07-20 | 1995-10-31 | Eisai Co., Ltd. | Benzene derivatives and method of treating arteriosclerosis with benzene derivatives |
| US5321031A (en) * | 1992-09-23 | 1994-06-14 | Schering Corporation | 1,2-disubstituted ethyl amides as inhibitors of ACAT |
| CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5596001A (en) * | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| IT1265209B1 (it) * | 1993-11-22 | 1996-10-31 | Pierrel Spa | Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| EP0726247B1 (en) * | 1995-02-08 | 1998-07-08 | Nippon Shoji Kaisha, Limited | Aniline derivatives having a polyunsaturated fatty acid residue and use thereof |
| OA12173A (en) | 2000-02-02 | 2006-05-08 | Warner Lambert Co | Dual inhibitors of cholesterol ester and wax estersynthesis for sebaceous gland disorders. |
| IL146531A0 (en) * | 2000-03-16 | 2002-07-25 | Neurogen Corp | 5-substituted arylpyrimidines |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| EP1281399A3 (en) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production |
| KR20060129082A (ko) | 2004-03-05 | 2006-12-14 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과연관된 질환 또는 질병의 치료 방법 |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| EP2280766A1 (en) | 2007-12-11 | 2011-02-09 | CytoPathfinder, Inc. | Carboxamide compounds and their use as chemokine receptor agonists |
| EP3025727A1 (en) | 2008-10-02 | 2016-06-01 | The J. David Gladstone Institutes | Methods of treating liver disease |
| CA3186856A1 (en) | 2020-07-29 | 2022-02-03 | Ruth NALLEN | Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL120013C (cg-RX-API-DMAC7.html) * | 1958-04-14 | |||
| BE620639A (cg-RX-API-DMAC7.html) * | 1961-07-25 | |||
| SE353319B (cg-RX-API-DMAC7.html) * | 1964-08-15 | 1973-01-29 | Sumitomo Chemical Co | |
| DE1618959C3 (de) * | 1967-10-04 | 1978-12-14 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | Fettsäureamide und Verfahren zu ihrer Herstellung |
| DE2830351A1 (de) * | 1978-07-11 | 1980-01-24 | Consortium Elektrochem Ind | Acylanilide |
| GR69292B (cg-RX-API-DMAC7.html) * | 1979-06-25 | 1982-05-13 | May & Baker Ltd | |
| US4410697A (en) * | 1980-01-25 | 1983-10-18 | Reanal Finomvegyszergyar | Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives |
| US4749812A (en) * | 1985-05-27 | 1988-06-07 | Mitsui Toatsu Chemicals, Inc. | N-(3-chloro-4-isopropylphenyl) carboxamide derivative and selective herbicide |
| MA20552A1 (fr) * | 1985-10-11 | 1986-07-01 | Pan Medica Sa | Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations |
-
1987
- 1987-02-24 US US07/017,960 patent/US4716175A/en not_active Expired - Lifetime
-
1988
- 1988-01-26 IE IE20488A patent/IE59998B1/en not_active IP Right Cessation
- 1988-01-27 CA CA000557467A patent/CA1336913C/en not_active Expired - Fee Related
- 1988-01-28 ZA ZA88604A patent/ZA88604B/xx unknown
- 1988-02-04 NZ NZ223410A patent/NZ223410A/xx unknown
- 1988-02-19 FI FI880796A patent/FI89593C/fi not_active IP Right Cessation
- 1988-02-23 NO NO880774A patent/NO174043C/no unknown
- 1988-02-23 EP EP88102644A patent/EP0283742B1/en not_active Expired - Lifetime
- 1988-02-23 ES ES88102644T patent/ES2056843T3/es not_active Expired - Lifetime
- 1988-02-23 AT AT88102644T patent/ATE89814T1/de not_active IP Right Cessation
- 1988-02-23 JP JP63038777A patent/JPH07121895B2/ja not_active Expired - Lifetime
- 1988-02-23 DK DK094188A patent/DK165406C/da not_active IP Right Cessation
- 1988-02-23 PT PT86811A patent/PT86811B/pt not_active IP Right Cessation
- 1988-02-23 DE DE8888102644T patent/DE3881249T2/de not_active Expired - Fee Related
- 1988-02-24 KR KR1019880001910A patent/KR880009933A/ko not_active Abandoned
-
1992
- 1992-06-23 MX MX9203139A patent/MX9203139A/es unknown
-
1995
- 1995-09-14 HK HK148195A patent/HK148195A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK165406B (da) | 1992-11-23 |
| EP0283742B1 (en) | 1993-05-26 |
| DE3881249D1 (en) | 1993-07-01 |
| DE3881249T2 (de) | 1993-09-16 |
| CA1336913C (en) | 1995-09-05 |
| FI89593B (fi) | 1993-07-15 |
| AU610558B2 (en) | 1991-05-23 |
| DK94188D0 (da) | 1988-02-23 |
| JPS63253060A (ja) | 1988-10-20 |
| ES2056843T3 (es) | 1994-10-16 |
| US4716175B1 (cg-RX-API-DMAC7.html) | 1993-06-22 |
| FI880796A7 (fi) | 1988-08-25 |
| FI89593C (fi) | 1993-10-25 |
| PT86811A (pt) | 1988-03-01 |
| EP0283742A2 (en) | 1988-09-28 |
| NZ223410A (en) | 1989-11-28 |
| HK148195A (en) | 1995-09-22 |
| KR880009933A (ko) | 1988-10-05 |
| DK165406C (da) | 1993-04-13 |
| MX9203139A (es) | 1992-07-01 |
| ZA88604B (en) | 1989-09-27 |
| AU1135488A (en) | 1988-08-25 |
| DK94188A (da) | 1988-08-25 |
| PT86811B (pt) | 1992-05-29 |
| IE59998B1 (en) | 1994-05-18 |
| JPH07121895B2 (ja) | 1995-12-25 |
| NO880774L (no) | 1988-08-25 |
| NO174043B (no) | 1993-11-29 |
| EP0283742A3 (en) | 1989-07-26 |
| NO880774D0 (no) | 1988-02-23 |
| IE880204L (en) | 1988-08-24 |
| US4716175A (en) | 1987-12-29 |
| NO174043C (no) | 1994-03-09 |
| FI880796A0 (fi) | 1988-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |