PT88436A - Process for the preparation of modified plasminogen activators - Google Patents

Process for the preparation of modified plasminogen activators

Info

Publication number
PT88436A
PT88436A PT88436A PT8843688A PT88436A PT 88436 A PT88436 A PT 88436A PT 88436 A PT88436 A PT 88436A PT 8843688 A PT8843688 A PT 8843688A PT 88436 A PT88436 A PT 88436A
Authority
PT
Portugal
Prior art keywords
preparation
plasminogen activators
modified plasminogen
modified
activators
Prior art date
Application number
PT88436A
Other languages
English (en)
Other versions
PT88436B (pt
Inventor
Giovanni Cassani
Francesco Blasi
Federico Maria Robbiati
Marialuisa Nolli
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Publication of PT88436A publication Critical patent/PT88436A/pt
Publication of PT88436B publication Critical patent/PT88436B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
PT88436A 1987-09-07 1988-09-06 Processo para a preparacao de activadores de plasminogenio modificados PT88436B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878721023A GB8721023D0 (en) 1987-09-07 1987-09-07 Modified plasminogen activators

Publications (2)

Publication Number Publication Date
PT88436A true PT88436A (pt) 1989-07-31
PT88436B PT88436B (pt) 1992-11-30

Family

ID=10623401

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88436A PT88436B (pt) 1987-09-07 1988-09-06 Processo para a preparacao de activadores de plasminogenio modificados

Country Status (14)

Country Link
EP (1) EP0308716A3 (pt)
JP (1) JPH01117785A (pt)
KR (1) KR890005267A (pt)
CN (1) CN1033070A (pt)
AU (1) AU2196688A (pt)
DK (1) DK491988A (pt)
FI (1) FI883943A (pt)
GB (1) GB8721023D0 (pt)
HU (1) HUT47975A (pt)
IL (1) IL87638A (pt)
NO (1) NO883963L (pt)
NZ (1) NZ226050A (pt)
PT (1) PT88436B (pt)
ZA (1) ZA886401B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098840A (en) * 1986-07-03 1992-03-24 The Green Cross Corporation Human prourokinase mutants
AU5515790A (en) * 1989-05-18 1990-11-22 Green Cross Corporation, The Human prourokinase variants, methods of producing same, dna sequences, plasmids and hosts therefor
CA2025181A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting fungi
JPH0595786A (ja) * 1991-10-07 1993-04-20 Green Cross Corp:The 変異ヒトプロウロキナーゼ
US6120765A (en) * 1993-04-02 2000-09-19 Shiseido Co. Ltd. Urokinase plasminogen activator fragments
WO2006113732A2 (en) 2005-04-19 2006-10-26 Archer-Daniels-Midland Company Soluble non-caloric fiber composition and process of preparing the same
KR20140072201A (ko) 2006-07-05 2014-06-12 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제
DK2117571T3 (en) 2006-12-08 2017-05-08 Monopar Therapeutics Inc Urokinase-type plasminogen activator receptor epitope

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
EP0266032A1 (en) * 1986-08-29 1988-05-04 Beecham Group Plc Modified fibrinolytic enzyme
EP0299053A1 (en) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermal growth factor plasminogen activators

Also Published As

Publication number Publication date
DK491988A (da) 1989-03-08
EP0308716A2 (en) 1989-03-29
HUT47975A (en) 1989-04-28
JPH01117785A (ja) 1989-05-10
IL87638A (en) 1993-04-04
FI883943A0 (fi) 1988-08-26
DK491988D0 (da) 1988-09-05
NZ226050A (en) 1991-06-25
IL87638A0 (en) 1989-01-31
AU2196688A (en) 1989-06-08
KR890005267A (ko) 1989-05-13
PT88436B (pt) 1992-11-30
CN1033070A (zh) 1989-05-24
GB8721023D0 (en) 1987-10-14
NO883963D0 (no) 1988-09-06
EP0308716A3 (en) 1989-06-14
ZA886401B (en) 1989-07-26
NO883963L (no) 1989-03-08
FI883943A (fi) 1989-03-08

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920507

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19941130