MX9606135A - Esteres de acido 4-carbamoiloxi-piperidin-1-carboxilico: inhibidores de la absorcion del colesterol. - Google Patents
Esteres de acido 4-carbamoiloxi-piperidin-1-carboxilico: inhibidores de la absorcion del colesterol.Info
- Publication number
- MX9606135A MX9606135A MX9606135A MX9606135A MX9606135A MX 9606135 A MX9606135 A MX 9606135A MX 9606135 A MX9606135 A MX 9606135A MX 9606135 A MX9606135 A MX 9606135A MX 9606135 A MX9606135 A MX 9606135A
- Authority
- MX
- Mexico
- Prior art keywords
- cholesterol
- carbamoyloxy
- piperidine
- inhibitors
- carboxylic acid
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos que inhiben la enzima colesterol éster hidrolasa (CEH) de esta manera inhiben la formacion de colesterol esterificado. El colesterol esterificado se absorbe a través del intestino y por lo tanto la inhibicion de la enzima da por resultado la inhibicion de la absorcion del colesterol. Los compuestos de esta invencion inhiben la colesterol éster hidrolasa y tienen la formula (I), en donde Z es -Ar1, -Ar1-Ar2, -Ar1-O-Ar2, -Ar1-S-Ar2, (a), (b), (c), -AR1-(CH2)1-20-Ar2, -Ar1- (CH2)1-20-O-Ar2, Ar1-O-(CH2)1-20-Ar2, -Ar1-(CR6=CR6)1-3- Ar2 p -Ar1-NR7-Ar2; y A es un grupo de enlace de hidrocarburo el cual puede estar interrumpido por un hetero-átomo o un grupo cicloalquilo, arilo, heterocicloalquilo o un azacicloalquilo; y R4 y R5 son independientemente alquilo, alquenilo, acilo, alcoxicarbonilo o H o R4 y R5 conjuntamente con el nitrogeno interpuesto forman un anillo heterocíclico saturado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08259229 | 1994-06-13 | ||
PCT/US1995/004938 WO1995034539A1 (en) | 1994-06-13 | 1995-04-18 | 4-carbamoyloxy-piperidine-1-carboxylic acid esters: inhibitors of cholesterol absorption |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA96006135A MXPA96006135A (es) | 1998-01-01 |
MX9606135A true MX9606135A (es) | 1998-01-31 |
Family
ID=39165234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9606135A MX9606135A (es) | 1995-04-18 | 1995-04-18 | Esteres de acido 4-carbamoiloxi-piperidin-1-carboxilico: inhibidores de la absorcion del colesterol. |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX9606135A (es) |
-
1995
- 1995-04-18 MX MX9606135A patent/MX9606135A/es not_active IP Right Cessation
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Legal Events
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FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |