|
US4749576A
(en)
*
|
1984-05-10 |
1988-06-07 |
Ciba-Geigy Corporation |
Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
|
|
JPS61218517A
(ja)
*
|
1985-03-25 |
1986-09-29 |
Bio Materiaru Yunibaasu:Kk |
経皮吸収製剤
|
|
FR2585246A1
(fr)
*
|
1985-07-26 |
1987-01-30 |
Cortial |
Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
|
|
US4794002A
(en)
*
|
1985-11-01 |
1988-12-27 |
Monsanto Company |
Modified polymeric surfaces and process for preparing same
|
|
JPH0643851B2
(ja)
*
|
1986-03-13 |
1994-06-08 |
大同メタル工業株式会社 |
軸受ユニット
|
|
US4983400A
(en)
*
|
1986-06-16 |
1991-01-08 |
Merck & Co., Inc. |
Controlled release combination of carbidopa/levodopa
|
|
US4780236A
(en)
*
|
1986-06-20 |
1988-10-25 |
Kiwi Brands, Inc. |
Lavoratory cleansing block containing polyethylene gycol disteatrate, guar gum and sodium chloride
|
|
US4743248A
(en)
*
|
1986-08-11 |
1988-05-10 |
Alza Corporation |
Dosage form for delivering acid sensitive beneficial agent
|
|
GB8620845D0
(en)
*
|
1986-08-28 |
1986-10-08 |
Reckitt & Colmann Prod Ltd |
Treatment of textile surfaces
|
|
EP0297650A1
(en)
*
|
1987-06-26 |
1989-01-04 |
Duphar International Research B.V |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
US5219575A
(en)
*
|
1987-06-26 |
1993-06-15 |
Duphar International Research B.V. |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
US4910015A
(en)
*
|
1987-10-19 |
1990-03-20 |
Massachusetts Institute Of Technology |
Surface-active polysiloxanes and drug releasing materials thereof
|
|
GB8801863D0
(en)
*
|
1988-01-28 |
1988-02-24 |
Fulmer Yarsley Ltd |
Pharmaceutical formulations with controlled drug release
|
|
US6440457B1
(en)
*
|
1993-05-27 |
2002-08-27 |
Alza Corporation |
Method of administering antidepressant dosage form
|
|
JPH10513471A
(ja)
|
1995-02-10 |
1998-12-22 |
メドトロニック、インコーポレイテッド |
鎮痛薬投与のための方法と装置
|
|
US5945125A
(en)
*
|
1995-02-28 |
1999-08-31 |
Temple University |
Controlled release tablet
|
|
US20030203036A1
(en)
|
2000-03-17 |
2003-10-30 |
Gordon Marc S. |
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
|
|
GB9703673D0
(en)
*
|
1997-02-21 |
1997-04-09 |
Bradford Particle Design Ltd |
Method and apparatus for the formation of particles
|
|
US6039968A
(en)
*
|
1997-06-24 |
2000-03-21 |
Hoechst Marion Roussel |
Intravaginal drug delivery device
|
|
DE19843904A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit polymerem Bindemittel
|
|
DE19843903A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit copolymerem Bindemittel
|
|
US6706283B1
(en)
|
1999-02-10 |
2004-03-16 |
Pfizer Inc |
Controlled release by extrusion of solid amorphous dispersions of drugs
|
|
US7943162B2
(en)
*
|
1999-10-21 |
2011-05-17 |
Alcon, Inc. |
Drug delivery device
|
|
AU783685B2
(en)
|
1999-12-23 |
2005-11-24 |
Pfizer Products Inc. |
Hydrogel-driven drug dosage form
|
|
US20030086972A1
(en)
*
|
2000-08-09 |
2003-05-08 |
Appel Leah E. |
Hydrogel-driven drug dosage form
|
|
GB0027357D0
(en)
*
|
2000-11-09 |
2000-12-27 |
Bradford Particle Design Plc |
Particle formation methods and their products
|
|
PL204644B1
(pl)
|
2001-07-23 |
2010-01-29 |
Alcon |
Okulistyczne urządzenie do podawania leków
|
|
DE60214697T2
(de)
*
|
2001-07-23 |
2007-09-13 |
Alcon Inc. |
Vorrichtung zur freisetzung eines ophthalmischen arzneimittels
|
|
US7300668B2
(en)
*
|
2001-10-29 |
2007-11-27 |
Massachusetts Institute Of Technology |
System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
|
|
GB0216562D0
(en)
|
2002-04-25 |
2002-08-28 |
Bradford Particle Design Ltd |
Particulate materials
|
|
US9339459B2
(en)
|
2003-04-24 |
2016-05-17 |
Nektar Therapeutics |
Particulate materials
|
|
GB0310636D0
(en)
*
|
2003-05-08 |
2003-06-11 |
Nektar Therapeutics Uk Ltd |
Particulate materials
|
|
BRPI0409962A
(pt)
|
2003-05-08 |
2006-04-25 |
Nektar Therapeutics Uk Ltd |
co-formulação particulada de uma substáncia ativa e um excipiente, composição farmacêutica ou nutricêutrica, produto farmacêutico ou nutricêutico, método para preparar uma co-formulação particulada de uma substáncia ativa e um excipiente, e, uso de uma substáncia ativa e um excipiente
|
|
JP2007526019A
(ja)
*
|
2003-07-10 |
2007-09-13 |
アルコン,インコーポレイティド |
眼科用薬物送達デバイス
|
|
US20060246109A1
(en)
*
|
2005-04-29 |
2006-11-02 |
Hossainy Syed F |
Concentration gradient profiles for control of agent release rates from polymer matrices
|
|
US8187639B2
(en)
*
|
2005-09-27 |
2012-05-29 |
Tissue Tech, Inc. |
Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
|
|
CN101316602B
(zh)
|
2005-09-27 |
2015-06-03 |
组织技术公司 |
羊膜制品和纯化的组合物及其使用方法
|
|
MX336930B
(es)
|
2005-11-28 |
2016-02-05 |
Marinus Pharmaceuticals |
Formulaciones de ganaxolona y metodos para la manufactura y el uso de las mismas.
|
|
US8246973B2
(en)
|
2006-06-21 |
2012-08-21 |
Advanced Cardiovascular Systems, Inc. |
Freeze-thaw method for modifying stent coating
|
|
CN101528830A
(zh)
|
2006-07-10 |
2009-09-09 |
麦德医像公司 |
超弹性环氧水凝胶
|
|
US20080090897A1
(en)
|
2006-08-11 |
2008-04-17 |
The Johns Hopkins University |
Compositions and methods for neuroprotectin
|
|
PT2530083T
(pt)
|
2006-09-22 |
2016-08-01 |
Pharmacyclics Llc |
Inibidores de tirosina cinase de bruton
|
|
JP5411141B2
(ja)
|
2007-09-10 |
2014-02-12 |
カルシメディカ,インク. |
細胞内カルシウムを調節する化合物
|
|
WO2009073734A2
(en)
|
2007-12-03 |
2009-06-11 |
Medipacs, Inc. |
Fluid metering device
|
|
US7981925B2
(en)
|
2008-08-27 |
2011-07-19 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
ES2559029T3
(es)
|
2009-04-24 |
2016-02-10 |
Tissue Tech, Inc. |
Composiciones que contienen al complejo HC.HA y metodos de uso de las mismas
|
|
WO2011032011A1
(en)
|
2009-09-10 |
2011-03-17 |
Medipacs, Inc. |
Low profile actuator and improved method of caregiver controlled administration of therapeutics
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
US9500186B2
(en)
|
2010-02-01 |
2016-11-22 |
Medipacs, Inc. |
High surface area polymer actuator with gas mitigating components
|
|
EP2558866B1
(en)
|
2010-04-15 |
2016-08-17 |
Tracon Pharmaceuticals, Inc. |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
|
DK2563776T3
(en)
|
2010-04-27 |
2016-09-19 |
Calcimedica Inc |
Relations that modulate intracellular calcium
|
|
EP2563759B1
(en)
|
2010-04-27 |
2022-04-06 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
MX342405B
(es)
|
2010-06-03 |
2016-09-28 |
Pharmacyclics Inc |
El uso de inhibidores de la tirosina quinasa de bruton (btk).
|
|
MX337711B
(es)
|
2010-08-27 |
2016-03-15 |
Calcimedica Inc |
Compuestos que modulan el calcio intracelular.
|
|
US8668675B2
(en)
|
2010-11-03 |
2014-03-11 |
Flugen, Inc. |
Wearable drug delivery device having spring drive and sliding actuation mechanism
|
|
US9808030B2
(en)
|
2011-02-11 |
2017-11-07 |
Grain Processing Corporation |
Salt composition
|
|
US9526770B2
(en)
|
2011-04-28 |
2016-12-27 |
Tissuetech, Inc. |
Methods of modulating bone remodeling
|
|
EP2717888B1
(en)
|
2011-06-10 |
2020-09-09 |
Tissuetech, Inc. |
Methods of processing fetal support tissues
|
|
AU2011376953B2
(en)
|
2011-09-13 |
2017-08-24 |
Pharmacyclics Llc |
Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
SI2800565T1
(sl)
|
2012-01-06 |
2020-10-30 |
Lundbeck La Jolla Research Center, Inc. |
Karbamatne spojine in metode izdelave in uporabe le-teh
|
|
WO2013138524A1
(en)
|
2012-03-14 |
2013-09-19 |
Medipacs, Inc. |
Smart polymer materials with excess reactive molecules
|
|
CA2875986C
(en)
|
2012-06-04 |
2020-06-09 |
Pharmacyclics, Inc. |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
|
JP2015528001A
(ja)
|
2012-07-11 |
2015-09-24 |
ティッシュテック,インク. |
Hc−ha/ptx3複合体を含む組成物およびその使用方法
|
|
AU2013323206B2
(en)
|
2012-09-28 |
2017-07-20 |
Fred Hutchinson Cancer Center |
Compounds and methods for preventing, treating and/or protecting against sensory hair cell death
|
|
US9512116B2
(en)
|
2012-10-12 |
2016-12-06 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
US9611263B2
(en)
|
2013-10-08 |
2017-04-04 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
JP6345786B2
(ja)
|
2013-12-05 |
2018-06-20 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼの阻害剤
|
|
WO2015164213A1
(en)
|
2014-04-23 |
2015-10-29 |
The Research Foundation For The State University Of New York |
A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith
|
|
TW201603818A
(zh)
|
2014-06-03 |
2016-02-01 |
組織科技股份有限公司 |
組成物及方法
|
|
US9764122B2
(en)
|
2014-07-25 |
2017-09-19 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having an occluding member
|
|
US9775978B2
(en)
|
2014-07-25 |
2017-10-03 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a retaining member
|
|
US9839644B2
(en)
|
2014-09-09 |
2017-12-12 |
ARKAY Therapeutics, LLC |
Formulations and methods for treatment of metabolic syndrome
|
|
US9359316B1
(en)
|
2014-11-25 |
2016-06-07 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic TRPV1 agonists
|
|
KR102557184B1
(ko)
|
2015-02-06 |
2023-07-18 |
유니버시티 오브 워싱톤 |
감각 유모 세포 사멸을 예방 또는 치료하기 위한 화합물 및 방법
|
|
US10227333B2
(en)
|
2015-02-11 |
2019-03-12 |
Curtana Pharmaceuticals, Inc. |
Inhibition of OLIG2 activity
|
|
US20160243288A1
(en)
|
2015-02-23 |
2016-08-25 |
Tissuetech, Inc. |
Apparatuses and methods for treating ophthalmic diseases and disorders
|
|
AU2016225000B2
(en)
|
2015-02-27 |
2021-04-01 |
Curtana Pharmaceuticals, Inc. |
Inhibition of Olig2 activity
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
|
MX2017014344A
(es)
|
2015-05-11 |
2018-04-11 |
Abide Therapeutics Inc |
Metodos para el tratamiento de la inflacion o el dolor neuropatico.
|
|
HK1250940A1
(zh)
|
2015-05-20 |
2019-01-18 |
Tissuetech, Inc. |
用於预防上皮细胞的增殖和上皮-间充质转换的组合物和方法
|
|
JP2018525411A
(ja)
|
2015-08-31 |
2018-09-06 |
ファーマサイクリックス エルエルシー |
多発性骨髄腫を治療するためのbtk阻害剤の組み合わせ
|
|
US10076650B2
(en)
|
2015-11-23 |
2018-09-18 |
Warsaw Orthopedic, Inc. |
Enhanced stylet for drug depot injector
|
|
JP2019505498A
(ja)
|
2015-12-16 |
2019-02-28 |
ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ |
Nk細胞におけるサイトカイン誘導性sh2タンパク質の阻害
|
|
US20190290650A1
(en)
|
2016-01-19 |
2019-09-26 |
Janssen Pharmaceutic Nv |
Formulations/compositions comprising a btk inhibitor
|
|
HK1259434A1
(zh)
|
2016-01-19 |
2019-11-29 |
Janssen Pharmaceutica Nv |
包含btk抑制剂的配制品/组合物
|
|
TW201733600A
(zh)
|
2016-01-29 |
2017-10-01 |
帝聖工業公司 |
胎兒扶持組織物及使用方法
|
|
WO2017147146A1
(en)
|
2016-02-23 |
2017-08-31 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic trpv1 agonists
|
|
CA3054674A1
(en)
|
2016-04-04 |
2017-12-10 |
Sinopia Biosciences, Inc. |
Treating extrapyramidal syndrome using trapidil
|
|
CN109562281B
(zh)
|
2016-05-25 |
2021-12-17 |
同心镇痛药物公司 |
酚类trpv1激动剂的前药与局部麻醉药和血管收缩剂联合用于改善局部麻醉
|
|
WO2017205769A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205766A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205762A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
US10549081B2
(en)
|
2016-06-23 |
2020-02-04 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a retaining member
|
|
US11090702B2
(en)
*
|
2016-06-28 |
2021-08-17 |
Trustees Of Tufts College |
Compositions and methods for delivery of active agents
|
|
PT3484862T
(pt)
|
2016-07-18 |
2021-11-17 |
Arthrosi Therapeutics Inc |
Compostos, composições e métodos para o tratamento ou a prevenção de um sintoma associado a gota ou hiperuricemia
|
|
EP3504195A4
(en)
|
2016-08-26 |
2020-01-29 |
Curtana Pharmaceuticals, Inc. |
Inhibition of olig2 activity
|
|
US10434261B2
(en)
|
2016-11-08 |
2019-10-08 |
Warsaw Orthopedic, Inc. |
Drug pellet delivery system and method
|
|
CA3043609A1
(en)
|
2016-11-16 |
2018-05-24 |
Abide Therapeutics, Inc. |
Pharmaceutical formulations
|
|
BR112019010003A2
(pt)
|
2016-11-16 |
2019-08-20 |
Abide Therapeutics Inc |
formas cristalinas de um inibidor de magl
|
|
CN111315385A
(zh)
|
2017-09-01 |
2020-06-19 |
华盛顿大学 |
用于预防或治疗感觉毛细胞死亡的化合物的晶型
|
|
US11685722B2
(en)
|
2018-02-28 |
2023-06-27 |
Curtana Pharmaceuticals, Inc. |
Inhibition of Olig2 activity
|
|
AU2019310118A1
(en)
|
2018-07-27 |
2021-03-11 |
Concentric Analgesics, Inc. |
Pegylated prodrugs of phenolic TRPV1 agonists
|
|
BR112021010708A2
(pt)
|
2018-12-06 |
2021-08-24 |
Arthrosi Therapeutics, Inc. |
Formas cristalinas de um composto para tratar ou prevenir gota ou hiperuricemia
|
|
EA202191543A1
(ru)
|
2018-12-06 |
2021-10-26 |
Артроси Терапьютикс, Инк. |
Способы лечения или профилактики подагры или гиперурикемии
|
|
CN114040760B
(zh)
|
2018-12-31 |
2025-05-09 |
拜欧米富士恩公司 |
Menin-mll相互作用的不可逆抑制剂
|
|
CA3133093A1
(en)
|
2019-03-15 |
2020-09-24 |
Unicycive Therapeutics, Inc. |
Nicorandil derivatives
|
|
CN115916180A
(zh)
|
2020-03-26 |
2023-04-04 |
希诺皮亚生物科学公司 |
同位素标记的曲匹地尔衍生物
|
|
CA3175210A1
(en)
|
2020-04-21 |
2021-10-28 |
Cheryl A. Grice |
Synthesis of a monoacylglycerol lipase inhibitor
|
|
TW202208357A
(zh)
|
2020-05-11 |
2022-03-01 |
美商克立弗治療學股份有限公司 |
VCP/p97抑制劑之結晶型及調配物
|
|
WO2022133064A1
(en)
|
2020-12-16 |
2022-06-23 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin-mll interaction
|
|
WO2022150525A1
(en)
|
2021-01-06 |
2022-07-14 |
Awakn Life Sciences |
Mdma in the treatment of alcohol use disorder
|
|
WO2022238507A1
(en)
|
2021-05-11 |
2022-11-17 |
Awakn Ls Europe Holdings Limited |
Therapeutic aminoindane compounds and compositions
|
|
WO2022256720A2
(en)
|
2021-06-03 |
2022-12-08 |
Arcadia Medicine, Inc. |
Enantiomeric entactogen compositions and methods of their use
|
|
JP2024531170A
(ja)
|
2021-08-11 |
2024-08-29 |
バイオメア フュージョン,インコーポレイテッド |
真性糖尿病に対するメニン-mll相互作用の共有結合性阻害剤
|
|
KR20240087693A
(ko)
|
2021-08-20 |
2024-06-19 |
바이오메아 퓨전, 인크. |
암 치료를 위한 비가역적 메닌-mll 억제제인 n-[4-[4-(4-모르폴리닐)-7h-피롤로[2,3-d]피리미딘-6-일]페닐]-4-[[3(r)-[(1-옥소-2-프로펜-1-일)아미노]-1-피페리디닐]메틸]-2-피리딘카르복스아미드의 결정질 형태
|
|
WO2023028091A1
(en)
|
2021-08-23 |
2023-03-02 |
Alexander Shulgin Research Institute |
Deuterated empathogens
|
|
US12180176B2
(en)
|
2021-08-23 |
2024-12-31 |
Alexander Shulgin Research Institute, Inc. |
Fluorinated empathogens
|
|
WO2023027966A1
(en)
|
2021-08-24 |
2023-03-02 |
Biomea Fusion, Inc. |
Pyrazine compounds as irreversible inhibitors of flt3
|
|
EP4395827A4
(en)
|
2021-08-31 |
2025-07-02 |
Cerespir Incorporated |
CO-CRYSTALS
|
|
CA3230779A1
(en)
|
2021-09-03 |
2023-03-09 |
Paul Daley |
Asymmetric allyl tryptamines
|
|
US20240409558A1
(en)
|
2021-09-13 |
2024-12-12 |
Biomea Fusion, Inc. |
Irreversible inhibitors of kras
|
|
US12465578B2
(en)
|
2021-09-25 |
2025-11-11 |
Alexander Shulgin Research Institute, Inc. |
Substituted alpha-ethyl phenylalkylamines
|
|
WO2023086341A1
(en)
|
2021-11-09 |
2023-05-19 |
Biomea Fusion, Inc. |
Inhibitors of kras
|
|
MX2024008057A
(es)
|
2021-12-30 |
2024-08-28 |
Biomea Fusion Inc |
Compuestos de pirazina como inhibidores de flt3.
|
|
WO2023139163A1
(en)
|
2022-01-19 |
2023-07-27 |
Awakn Ls Europe Holdings Limited |
1,3-benzodioxole esters and their therapeutic use
|
|
CA3244485A1
(en)
|
2022-02-16 |
2023-08-24 |
Awakn Ls Europe Holdings Limited |
BRIDGED CYCLIC COMPOUNDS AND THEIR THERAPEUTIC USE AS CNS AGENTS
|
|
US20250353854A1
(en)
|
2022-06-03 |
2025-11-20 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin
|
|
WO2024011142A1
(en)
|
2022-07-06 |
2024-01-11 |
Oppilan Pharma Limited |
Crystalline forms of an s1p receptor modulator
|
|
TW202430528A
(zh)
|
2023-01-18 |
2024-08-01 |
美商拜歐米富士恩股份有限公司 |
N-[4-[4-(4-嗎啉基)-7h-吡咯並[2,3-d]嘧啶-6-基]苯基]-4-[[3(r)-[(1-氧代-2-丙烯-1-基)氨基]-1-哌啶基]甲基]-2-吡啶甲醯胺的結晶形式作為menin-mll相互作用的共價抑制劑
|
|
WO2024243402A2
(en)
|
2023-05-24 |
2024-11-28 |
Unicycive Therapeutics Inc. |
Salt forms of nicorandil derivatives
|
|
WO2024249950A1
(en)
|
2023-06-02 |
2024-12-05 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin
|
|
WO2025072556A1
(en)
|
2023-09-26 |
2025-04-03 |
Unicycive Therapeutics, Inc. |
Amino acid prodrugs of nicorandil
|
|
WO2025194102A1
(en)
|
2024-03-15 |
2025-09-18 |
Unicycive Therapeutics, Inc. |
Pyridine modified nicorandil derivatives
|