ATE548466T1 - Verfahren und zusammensetzungen zur verbesserung der genauigkeit bei einer nukleinsäuresynthesereaktion - Google Patents
Verfahren und zusammensetzungen zur verbesserung der genauigkeit bei einer nukleinsäuresynthesereaktionInfo
- Publication number
- ATE548466T1 ATE548466T1 AT06734692T AT06734692T ATE548466T1 AT E548466 T1 ATE548466 T1 AT E548466T1 AT 06734692 T AT06734692 T AT 06734692T AT 06734692 T AT06734692 T AT 06734692T AT E548466 T1 ATE548466 T1 AT E548466T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- improving
- synthesis reaction
- accuracy
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/046,448 US7482120B2 (en) | 2005-01-28 | 2005-01-28 | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
PCT/US2006/004638 WO2006081583A2 (en) | 2005-01-28 | 2006-01-30 | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE548466T1 true ATE548466T1 (de) | 2012-03-15 |
Family
ID=36582013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06734692T ATE548466T1 (de) | 2005-01-28 | 2006-01-30 | Verfahren und zusammensetzungen zur verbesserung der genauigkeit bei einer nukleinsäuresynthesereaktion |
Country Status (5)
Country | Link |
---|---|
US (1) | US7482120B2 (de) |
EP (1) | EP1848829B1 (de) |
AT (1) | ATE548466T1 (de) |
CA (1) | CA2599477A1 (de) |
WO (1) | WO2006081583A2 (de) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2281205A1 (en) * | 1997-02-12 | 1998-08-13 | Eugene Y. Chan | Methods and products for analyzing polymers |
AU2001282881B2 (en) * | 2000-07-07 | 2007-06-14 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
EP1354064A2 (de) * | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen |
US7668697B2 (en) * | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
EP1758981A4 (de) | 2004-05-28 | 2013-01-16 | Wafergen Inc | Vorrichtungen und verfahren für multiplex-analysen |
US20080076189A1 (en) * | 2006-03-30 | 2008-03-27 | Visigen Biotechnologies, Inc. | Modified surfaces for the detection of biomolecules at the single molecule level |
WO2008151023A2 (en) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
US8252911B2 (en) | 2008-02-12 | 2012-08-28 | Pacific Biosciences Of California, Inc. | Compositions and methods for use in analytical reactions |
US20090226906A1 (en) * | 2008-03-05 | 2009-09-10 | Helicos Biosciences Corporation | Methods and compositions for reducing nucleotide impurities |
WO2010141390A2 (en) * | 2009-06-05 | 2010-12-09 | Life Technologies Corporation | Nucleotide transient binding for sequencing methods |
WO2011014811A1 (en) | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
DK2816111T3 (en) | 2009-08-14 | 2016-06-06 | Epicentre Tech Corp | Methods, compositions, and kits for the generation of rRNA-depleted samples or isolation of rRNA from samples |
ES2628739T3 (es) | 2009-10-15 | 2017-08-03 | Ibis Biosciences, Inc. | Amplificación por desplazamiento múltiple |
AU2011249913B2 (en) | 2010-05-06 | 2014-09-11 | Ibis Biosciences, Inc. | Integrated sample preparation systems and stabilized enzyme mixtures |
JP2013530727A (ja) | 2010-07-23 | 2013-08-01 | エソテリックス ジェネティック ラボラトリーズ, エルエルシー | 差次的に提示される胎児のゲノム領域もしくは母親のゲノム領域の同定およびそれらの使用 |
AU2011301935B2 (en) | 2010-09-16 | 2015-06-11 | Ibis Biosciences, Inc. | Stabilization of ozone-labile fluorescent dyes by thiourea |
SG191409A1 (en) | 2010-12-27 | 2013-08-30 | Ibis Biosciences Inc | Nucleic acid sample preparation methods and compositions |
WO2013022778A1 (en) | 2011-08-05 | 2013-02-14 | Ibis Biosciences, Inc. | Nucleic acid sequencing by electrochemical detection |
WO2013063308A1 (en) | 2011-10-25 | 2013-05-02 | University Of Massachusetts | An enzymatic method to enrich for capped rna, kits for performing same, and compositions derived therefrom |
WO2013096838A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
US10150993B2 (en) | 2011-12-22 | 2018-12-11 | Ibis Biosciences, Inc. | Macromolecule positioning by electrical potential |
ES2626058T3 (es) | 2011-12-22 | 2017-07-21 | Ibis Biosciences, Inc. | Cebadores y métodos de amplificación |
ES2645418T3 (es) | 2011-12-22 | 2017-12-05 | Ibis Biosciences, Inc. | Amplificación de una secuencia de un ácido ribonucleico |
US9334491B2 (en) | 2011-12-22 | 2016-05-10 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
US9506113B2 (en) | 2011-12-28 | 2016-11-29 | Ibis Biosciences, Inc. | Nucleic acid ligation systems and methods |
US9803231B2 (en) | 2011-12-29 | 2017-10-31 | Ibis Biosciences, Inc. | Macromolecule delivery to nanowells |
AU2013208757A1 (en) | 2012-01-09 | 2014-07-24 | Oslo Universitetssykehus Hf | Methods and biomarkers for analysis of colorectal cancer |
EP2802666B1 (de) | 2012-01-13 | 2018-09-19 | Data2Bio | Genotypisierung durch eine sequenzierung der nächsten generation |
US9732387B2 (en) | 2012-04-03 | 2017-08-15 | The Regents Of The University Of Michigan | Biomarker associated with irritable bowel syndrome and Crohn's disease |
EP2844772B1 (de) | 2012-05-02 | 2018-07-11 | Ibis Biosciences, Inc. | Dna-sequenzierung |
US20150133310A1 (en) | 2012-05-02 | 2015-05-14 | Ibis Biosciences, Inc. | Nucleic acid sequencing systems and methods |
WO2014005076A2 (en) | 2012-06-29 | 2014-01-03 | The Regents Of The University Of Michigan | Methods and biomarkers for detection of kidney disorders |
ES2701750T3 (es) | 2012-10-16 | 2019-02-25 | Abbott Molecular Inc | Procedimientos para secuenciar un ácido nucleico |
US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
CN105378107A (zh) | 2013-03-14 | 2016-03-02 | 雅培分子公司 | 多重甲基化-特异性扩增系统和方法 |
EP2971154A4 (de) | 2013-03-14 | 2017-03-01 | Ibis Biosciences, Inc. | Nukleinsäurekontrollpanels |
US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
CA2905410A1 (en) | 2013-03-15 | 2014-09-25 | Abbott Molecular Inc. | Systems and methods for detection of genomic copy number changes |
WO2014150910A1 (en) | 2013-03-15 | 2014-09-25 | Ibis Biosciences, Inc. | Dna sequences to assess contamination in dna sequencing |
RU2698125C2 (ru) | 2013-08-19 | 2019-08-22 | Эбботт Молекьюлар Инк. | Библиотеки для секвенирования нового поколения |
US10768181B2 (en) | 2013-12-17 | 2020-09-08 | The Brigham And Women's Hospital, Inc. | Detection of an antibody against a pathogen |
WO2015107430A2 (en) | 2014-01-16 | 2015-07-23 | Oslo Universitetssykehus Hf | Methods and biomarkers for detection and prognosis of cervical cancer |
US10760109B2 (en) | 2014-06-06 | 2020-09-01 | The Regents Of The University Of Michigan | Compositions and methods for characterizing and diagnosing periodontal disease |
JP6784601B2 (ja) | 2014-06-23 | 2020-11-11 | ザ ジェネラル ホスピタル コーポレイション | シークエンシングによって評価されるゲノムワイドでバイアスのないDSBの同定(GUIDE−Seq) |
CN105392902B (zh) | 2014-06-24 | 2021-10-29 | 生物辐射实验室股份有限公司 | 数字式pcr条码化 |
CN106715718B (zh) | 2014-07-24 | 2021-07-06 | 雅培分子公司 | 用于检测和分析结核分枝杆菌的组合物和方法 |
US10208339B2 (en) | 2015-02-19 | 2019-02-19 | Takara Bio Usa, Inc. | Systems and methods for whole genome amplification |
US10641772B2 (en) | 2015-02-20 | 2020-05-05 | Takara Bio Usa, Inc. | Method for rapid accurate dispensing, visualization and analysis of single cells |
WO2016168561A1 (en) | 2015-04-15 | 2016-10-20 | Sundaresan Tilak K | Lna-based mutant enrichment next-generation sequencing assays |
ES2902125T3 (es) | 2015-07-14 | 2022-03-25 | Abbott Molecular Inc | Purificación de ácidos nucleicos utilizando óxidos de cobre-titanio u óxidos de magnesio-titanio |
US10526664B2 (en) | 2015-07-14 | 2020-01-07 | Abbott Molecular Inc. | Compositions and methods for identifying drug resistant tuberculosis |
US10077470B2 (en) | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
EP3325642B1 (de) | 2015-07-21 | 2020-05-27 | Omniome, Inc. | Verfahren zur nukleinsäuresequenzierung |
JP2018530536A (ja) | 2015-09-11 | 2018-10-18 | ザ ジェネラル ホスピタル コーポレイション | ヌクレアーゼDSBの完全照合およびシーケンシング(FIND−seq) |
KR20180053748A (ko) | 2015-09-30 | 2018-05-23 | 더 제너럴 하스피탈 코포레이션 | 시퀀싱(circle-seq)에 의한 절단 반응의 포괄적인 시험관내 보고 |
CN108431223A (zh) | 2016-01-08 | 2018-08-21 | 生物辐射实验室股份有限公司 | 每液滴分辨率下的多个珠 |
US10626390B2 (en) | 2016-02-08 | 2020-04-21 | RGENE, Inc. | Multiple ligase compositions, systems, and methods |
CN109477127A (zh) | 2016-03-14 | 2019-03-15 | R基因股份有限公司 | 超热稳定的赖氨酸-突变型ssDNA/RNA连接酶 |
AU2017254688B2 (en) | 2016-04-22 | 2020-05-14 | Pacific Biosciences Of California, Inc. | Nucleic acid sequencing method and system employing enhanced detection of nucleotide-specific ternary complex formation |
AU2017258523B2 (en) | 2016-04-29 | 2020-08-13 | Pacific Biosciences Of California, Inc. | Method of Nucleic Acid sequence determination |
CA3021769C (en) | 2016-04-29 | 2021-11-23 | Omniome, Inc. | Sequencing method employing ternary complex destabilization to identify cognate nucleotides |
US10597643B2 (en) | 2016-04-29 | 2020-03-24 | Omniome, Inc. | Polymerases engineered to reduce nucleotide-independent DNA binding |
US11091795B2 (en) | 2016-07-11 | 2021-08-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for diagnosing and treating arrhythmias |
US10676734B2 (en) | 2016-07-12 | 2020-06-09 | Life Technologies Corporation | Compositions and methods for detecting nucleic acid regions |
US11460405B2 (en) | 2016-07-21 | 2022-10-04 | Takara Bio Usa, Inc. | Multi-Z imaging and dispensing with multi-well devices |
WO2018034780A1 (en) | 2016-08-15 | 2018-02-22 | Omniome, Inc. | Sequencing method for rapid identification and processing of cognate nucleotide pairs |
US10443098B2 (en) | 2016-08-15 | 2019-10-15 | Omniome, Inc. | Method and system for sequencing nucleic acids |
WO2018042251A1 (en) | 2016-08-29 | 2018-03-08 | Oslo Universitetssykehus Hf | Chip-seq assays |
EP3555290B1 (de) | 2016-12-19 | 2022-11-02 | Bio-Rad Laboratories, Inc. | Markierte dna mit erhaltener tröpfchenmarkierungskontinuität |
AU2017386515B2 (en) | 2016-12-30 | 2021-08-19 | Pacific Biosciences Of California, Inc. | Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides |
CA3049722C (en) | 2017-01-10 | 2023-01-24 | Omniome, Inc. | Polymerases engineered to reduce nucleotide-independent dna binding |
SG11201906569XA (en) | 2017-01-20 | 2019-08-27 | Omniome Inc | Genotyping by polymerase binding |
CA3050241C (en) | 2017-01-20 | 2022-11-29 | Omniome, Inc. | Allele-specific capture of nucleic acids |
CA3050695C (en) | 2017-01-20 | 2024-02-20 | Omniome, Inc. | Process for cognate nucleotide detection in a nucleic acid sequencing workflow |
DK3354746T3 (da) | 2017-01-30 | 2019-09-02 | Gmi Gregor Mendel Inst Fuer Molekulare Pflanzenbiologie Gmbh | Nye spike-in-nukleotider til normalisering af sekvensdata |
US11492666B2 (en) | 2017-02-15 | 2022-11-08 | Pacific Biosciences Of California, Inc. | Distinguishing sequences by detecting polymerase dissociation |
US9951385B1 (en) | 2017-04-25 | 2018-04-24 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
AU2018279728B2 (en) | 2017-06-08 | 2023-07-20 | The Brigham And Women's Hospital, Inc. | Methods and compositions for identifying epitopes |
WO2018236918A1 (en) | 2017-06-20 | 2018-12-27 | Bio-Rad Laboratories, Inc. | MDA USING A BALL OLIGONUCLEOTIDE |
CN111356774B (zh) | 2017-06-26 | 2024-01-26 | 维也纳自然资源与生命科学大学 | 用于检测衰老细胞的新型生物标记物 |
CA3075932A1 (en) | 2017-09-20 | 2019-03-28 | Guardant Health, Inc. | Methods and systems for differentiating somatic and germline variants |
CA3079411C (en) | 2017-10-19 | 2023-12-05 | Omniome, Inc. | Simultaneous background reduction and complex stabilization in binding assay workflows |
EP3704247B1 (de) | 2017-11-02 | 2023-01-04 | Bio-Rad Laboratories, Inc. | Genomische analyse auf transposasebasis |
WO2019152395A1 (en) | 2018-01-31 | 2019-08-08 | Bio-Rad Laboratories, Inc. | Methods and compositions for deconvoluting partition barcodes |
US11512002B2 (en) | 2018-04-18 | 2022-11-29 | University Of Virginia Patent Foundation | Silica materials and methods of making thereof |
AU2019261218A1 (en) | 2018-04-26 | 2020-11-26 | Pacific Biosciences Of California, Inc. | Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes |
EP3788377A1 (de) | 2018-05-04 | 2021-03-10 | Abbott Laboratories | Hbv-diagnostische, prognostische und therapeutische verfahren und produkte |
US11180794B2 (en) | 2018-05-31 | 2021-11-23 | Omniome, Inc. | Methods and compositions for capping nucleic acids |
EP3802874A1 (de) | 2018-05-31 | 2021-04-14 | Omniome, Inc. | Erhöhtes signal-rausch-verhältnis bei der sequenzierung von nukleinsäuren |
WO2019236478A1 (en) | 2018-06-04 | 2019-12-12 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free nucleic acids |
AU2019310041A1 (en) | 2018-07-23 | 2021-02-04 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
AU2019312152A1 (en) | 2018-07-24 | 2021-02-18 | Pacific Biosciences Of California, Inc. | Serial formation of ternary complex species |
US11479816B2 (en) | 2018-08-20 | 2022-10-25 | Bio-Rad Laboratories, Inc. | Nucleotide sequence generation by barcode bead-colocalization in partitions |
WO2020047513A1 (en) | 2018-08-30 | 2020-03-05 | Guardant Health, Inc. | Methods and systems for detecting contamination between samples |
CN112930569A (zh) | 2018-08-31 | 2021-06-08 | 夸登特健康公司 | 无细胞dna中的微卫星不稳定性检测 |
WO2020096691A2 (en) | 2018-09-04 | 2020-05-14 | Guardant Health, Inc. | Methods and systems for detecting allelic imbalance in cell-free nucleic acid samples |
PL3814533T3 (pl) | 2018-09-20 | 2022-01-31 | Tamirna Gmbh | Sygnatury mikro-rna do przewidywania dysfunkcji wątroby |
SG11202103486YA (en) | 2018-10-31 | 2021-05-28 | Guardant Health Inc | Methods, compositions and systems for calibrating epigenetic partitioning assays |
US20240011086A1 (en) | 2018-11-15 | 2024-01-11 | Omniome, Inc. | Electronic detection of nucleic acid structure |
US10710076B2 (en) | 2018-12-04 | 2020-07-14 | Omniome, Inc. | Mixed-phase fluids for nucleic acid sequencing and other analytical assays |
WO2020132350A2 (en) | 2018-12-20 | 2020-06-25 | Omniome, Inc. | Temperature control for analysis of nucleic acids and other analytes |
EP3898969A1 (de) | 2018-12-20 | 2021-10-27 | Guardant Health, Inc. | Verfahren, zusammensetzungen und systeme zur verbesserung der rückgewinnung von nukleinsäuremolekülen |
CN113661249A (zh) | 2019-01-31 | 2021-11-16 | 夸登特健康公司 | 用于分离无细胞dna的组合物和方法 |
US11499189B2 (en) | 2019-02-14 | 2022-11-15 | Pacific Biosciences Of California, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
WO2020176659A1 (en) | 2019-02-27 | 2020-09-03 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free dna |
US11939636B2 (en) | 2019-05-31 | 2024-03-26 | Guardant Health, Inc. | Methods and systems for improving patient monitoring after surgery |
EP4045683A1 (de) | 2019-10-18 | 2022-08-24 | Omniome, Inc. | Verfahren und zusammensetzungen zum kappen von nukleinsäuren |
DK3812472T3 (da) | 2019-10-21 | 2023-02-20 | Univ Freiburg Albert Ludwigs | Virkelig uvildig in vitro-undersøgelse til profilering af off-target-aktivitet af en eller flere målspecifikke programmerbare nukleaser i celler (abnoba-seq) |
JP2023502752A (ja) | 2019-11-26 | 2023-01-25 | ガーダント ヘルス, インコーポレイテッド | メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム |
WO2021152586A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
WO2021214766A1 (en) | 2020-04-21 | 2021-10-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing viral infections and vaccines thereto |
EP4143338A1 (de) | 2020-04-30 | 2023-03-08 | Guardant Health, Inc. | Verfahren zur sequenzbestimmung unter verwendung partitionierter nukleinsäuren |
US20230203592A1 (en) | 2020-05-05 | 2023-06-29 | Akershus Universitetssykehus Hf | Compositions and methods for characterizing bowel cancer |
EP4146822A1 (de) | 2020-05-05 | 2023-03-15 | Pacific Biosciences of California, Inc. | Zusammensetzungen und verfahren zur modifizierung von polymerase-nukleinsäurekomplexen |
US20220025468A1 (en) | 2020-05-14 | 2022-01-27 | Guardant Health, Inc. | Homologous recombination repair deficiency detection |
WO2023282916A1 (en) | 2021-07-09 | 2023-01-12 | Guardant Health, Inc. | Methods of detecting genomic rearrangements using cell free nucleic acids |
EP4189111A1 (de) | 2020-07-30 | 2023-06-07 | Guardant Health, Inc. | Verfahren zur isolierung von zellfreier dna |
WO2022046947A1 (en) | 2020-08-25 | 2022-03-03 | Guardant Health, Inc. | Methods and systems for predicting an origin of a variant |
CA3193183A1 (en) | 2020-09-30 | 2022-04-07 | Andrew Kennedy | Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease |
WO2022140629A1 (en) | 2020-12-23 | 2022-06-30 | Guardant Health, Inc. | Methods and systems for analyzing methylated polynucleotides |
AU2022231055A1 (en) | 2021-03-05 | 2023-09-14 | Guardant Health, Inc. | Methods and related aspects for analyzing molecular response |
EP4305200A1 (de) | 2021-03-09 | 2024-01-17 | Guardant Health, Inc. | Nachweis des vorhandenseins eines tumors auf der basis von off-target-polynukleotidsequenzierungsdaten |
US20230360725A1 (en) | 2022-05-09 | 2023-11-09 | Guardant Health, Inc. | Detecting degradation based on strand bias |
WO2024107599A1 (en) | 2022-11-15 | 2024-05-23 | Guardant Health, Inc. | Method of predicting non-small cell lung cancer (nsclc) patient drug response or time until death or cancer progression from circulating tumor dna (ctdna) utilizing signals from both baseline ctdna level and longitudinal change of ctdna level over time |
Family Cites Families (162)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
JPS5941169B2 (ja) | 1975-12-25 | 1984-10-05 | シチズン時計株式会社 | エラストマ−ヒヨウジソウチ |
US4153855A (en) | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
US4344064A (en) | 1979-12-06 | 1982-08-10 | Western Electric Co., Inc. | Article carrying a distinctive mark |
US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
US5260433A (en) | 1982-06-23 | 1993-11-09 | Enzo Diagnostics, Inc. | Saccharide specific binding system labeled nucleotides |
US4707237A (en) | 1982-09-09 | 1987-11-17 | Ciba Corning Diagnostics Corp. | System for identification of cells by electrophoresis |
US5198540A (en) * | 1982-10-28 | 1993-03-30 | Hubert Koster | Process for the preparation of oligonucleotides in solution |
US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
DE3329892A1 (de) * | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
USRE34069E (en) | 1983-08-18 | 1992-09-15 | Biosyntech Gmbh | Process for the preparation of oligonucleotides |
US5360523A (en) | 1984-03-29 | 1994-11-01 | Li-Cor, Inc. | DNA sequencing |
US5258506A (en) | 1984-10-16 | 1993-11-02 | Chiron Corporation | Photolabile reagents for incorporation into oligonucleotide chains |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4865968A (en) | 1985-04-01 | 1989-09-12 | The Salk Institute For Biological Studies | DNA sequencing |
US4739044A (en) * | 1985-06-13 | 1988-04-19 | Amgen | Method for derivitization of polynucleotides |
US4863849A (en) | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
US5242797A (en) | 1986-03-21 | 1993-09-07 | Myron J. Block | Nucleic acid assay method |
US4811218A (en) * | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
US5242796A (en) | 1986-07-02 | 1993-09-07 | E. I. Du Pont De Nemours And Company | Method, system and reagents for DNA sequencing |
CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
US4994372A (en) * | 1987-01-14 | 1991-02-19 | President And Fellows Of Harvard College | DNA sequencing |
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US4994368A (en) * | 1987-07-23 | 1991-02-19 | Syntex (U.S.A.) Inc. | Amplification method for polynucleotide assays |
US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
US4962037A (en) | 1987-10-07 | 1990-10-09 | United States Of America | Method for rapid base sequencing in DNA and RNA |
US4793705A (en) | 1987-10-07 | 1988-12-27 | The United States Of America As Represented By The United States Department Of Energy | Single molecule tracking |
US4971903A (en) | 1988-03-25 | 1990-11-20 | Edward Hyman | Pyrophosphate-based method and apparatus for sequencing nucleic acids |
US4962020A (en) | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
CH679555A5 (de) * | 1989-04-11 | 1992-03-13 | Westonbridge Int Ltd | |
US4979824A (en) | 1989-05-26 | 1990-12-25 | Board Of Trustees Of The Leland Stanford Junior University | High sensitivity fluorescent single particle and single molecule detection apparatus and method |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US6346413B1 (en) * | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5112736A (en) | 1989-06-14 | 1992-05-12 | University Of Utah | Dna sequencing using fluorescence background electroblotting membrane |
ES2061042T3 (es) | 1989-06-14 | 1994-12-01 | Westonbridge Int Ltd | Microbomba perfeccionada. |
US5108892A (en) * | 1989-08-03 | 1992-04-28 | Promega Corporation | Method of using a taq dna polymerase without 5'-3'-exonuclease activity |
US5096554A (en) * | 1989-08-07 | 1992-03-17 | Applied Biosystems, Inc. | Nucleic acid fractionation by counter-migration capillary electrophoresis |
US5302509A (en) * | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
CA2028261C (en) | 1989-10-28 | 1995-01-17 | Won Suck Yang | Non-invasive method and apparatus for measuring blood glucose concentration |
KR910012538A (ko) | 1989-12-27 | 1991-08-08 | 야마무라 가쯔미 | 마이크로 펌프 및 그 제조 방법 |
US5091652A (en) * | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
WO1991011533A1 (en) * | 1990-01-26 | 1991-08-08 | E.I. Du Pont De Nemours And Company | Method for isolating primer extension products from template-directed dna polymerase reactions |
DE4006152A1 (de) | 1990-02-27 | 1991-08-29 | Fraunhofer Ges Forschung | Mikrominiaturisierte pumpe |
US5096388A (en) * | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5223414A (en) * | 1990-05-07 | 1993-06-29 | Sri International | Process for nucleic acid hybridization and amplification |
SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
US5259737A (en) | 1990-07-02 | 1993-11-09 | Seiko Epson Corporation | Micropump with valve structure |
US5529679A (en) | 1992-02-28 | 1996-06-25 | Hitachi, Ltd. | DNA detector and DNA detection method |
US6004744A (en) * | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US5518900A (en) | 1993-01-15 | 1996-05-21 | Molecular Tool, Inc. | Method for generating single-stranded DNA molecules |
US5762876A (en) | 1991-03-05 | 1998-06-09 | Molecular Tool, Inc. | Automatic genotype determination |
US5888819A (en) * | 1991-03-05 | 1999-03-30 | Molecular Tool, Inc. | Method for determining nucleotide identity through primer extension |
US5167784A (en) | 1991-09-04 | 1992-12-01 | Xerox Corporation | Sequencing large nucleic acid fragments |
DE4143343C2 (de) | 1991-09-11 | 1994-09-22 | Fraunhofer Ges Forschung | Mikrominiaturisierte, elektrostatisch betriebene Mikromembranpumpe |
US5265327A (en) | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
US5405747A (en) * | 1991-09-25 | 1995-04-11 | The Regents Of The University Of California Office Of Technology Transfer | Method for rapid base sequencing in DNA and RNA with two base labeling |
US5756285A (en) | 1991-09-27 | 1998-05-26 | Amersham Life Science, Inc. | DNA cycle sequencing |
US5674679A (en) | 1991-09-27 | 1997-10-07 | Amersham Life Science, Inc. | DNA cycle sequencing |
CA2123133C (en) * | 1991-11-07 | 2005-01-04 | Michael J. Heller | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5209834A (en) | 1992-03-09 | 1993-05-11 | The United States Of America As Represented By The United States Department Of Energy | Ordered transport and identification of particles |
US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
DE4220077A1 (de) | 1992-06-19 | 1993-12-23 | Bosch Gmbh Robert | Mikropumpe |
JPH0622798A (ja) | 1992-07-07 | 1994-02-01 | Hitachi Ltd | 塩基配列決定法 |
US5306403A (en) * | 1992-08-24 | 1994-04-26 | Martin Marietta Energy Systems, Inc. | Raman-based system for DNA sequencing-mapping and other separations |
US5403709A (en) * | 1992-10-06 | 1995-04-04 | Hybridon, Inc. | Method for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages |
AU671820B2 (en) | 1993-02-10 | 1996-09-12 | Promega Corporation | Non-radioactive DNA sequencing |
US5436149A (en) | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
US5547859A (en) | 1993-08-02 | 1996-08-20 | Goodman; Myron F. | Chain-terminating nucleotides for DNA sequencing methods |
US5659171A (en) | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
US5470710A (en) * | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
US5610287A (en) * | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
CH689836A5 (fr) | 1994-01-14 | 1999-12-15 | Westonbridge Int Ltd | Micropompe. |
US6028190A (en) * | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
DE69518743T2 (de) | 1994-03-08 | 2000-12-28 | Amersham Pharm Biotech Uk Ltd | Modifizierung von nukleotidanalogen |
US5872244A (en) * | 1994-09-02 | 1999-02-16 | Andrew C. Hiatt | 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds |
US5763594A (en) | 1994-09-02 | 1998-06-09 | Andrew C. Hiatt | 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds |
US6015668A (en) * | 1994-09-30 | 2000-01-18 | Life Technologies, Inc. | Cloned DNA polymerases from thermotoga and mutants thereof |
US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US5707506A (en) * | 1994-10-28 | 1998-01-13 | Battelle Memorial Institute | Channel plate for DNA sequencing |
US5514256A (en) | 1994-10-28 | 1996-05-07 | Battelle Memorial Institute | Apparatus for improved DNA sequencing |
US5556790A (en) | 1994-12-05 | 1996-09-17 | Pettit; John W. | Method for Automated DNA sequencing |
US5786142A (en) * | 1995-05-30 | 1998-07-28 | Visible Genetics Inc. | Electrophoresis and fluorescence detection method |
US5710628A (en) * | 1994-12-12 | 1998-01-20 | Visible Genetics Inc. | Automated electrophoresis and fluorescence detection apparatus and method |
US5599695A (en) * | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US5876187A (en) * | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US5795782A (en) * | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US6362002B1 (en) * | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
US5675155A (en) | 1995-04-26 | 1997-10-07 | Beckman Instruments, Inc. | Multicapillary fluorescent detection system |
WO1996038568A1 (en) * | 1995-05-31 | 1996-12-05 | Amersham Life Science, Inc. | Thermostable dna polymerases |
US5861287A (en) * | 1995-06-23 | 1999-01-19 | Baylor College Of Medicine | Alternative dye-labeled primers for automated DNA sequencing |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5733729A (en) * | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
SE9504099D0 (sv) * | 1995-11-16 | 1995-11-16 | Pharmacia Biotech Ab | A method of sequencing |
US5776767A (en) | 1995-12-12 | 1998-07-07 | Visible Genetics Inc. | Virtual DNA sequencer |
US5705018A (en) * | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
CA2240334C (en) | 1995-12-15 | 2008-07-22 | Amersham Life Science, Inc. | Thermostable dna polymerase from thermoanaerobacter thermohydrosulfuricus and mutant enzymes thereof with exonuclease activity removed |
CA2240667A1 (en) * | 1995-12-18 | 1997-06-26 | Washington University | Method for nucleic acid analysis using fluorescence resonance energy transfer |
US6361937B1 (en) * | 1996-03-19 | 2002-03-26 | Affymetrix, Incorporated | Computer-aided nucleic acid sequencing |
SE9601318D0 (sv) * | 1996-04-04 | 1996-04-04 | Pharmacia Biosensor Ab | Method for nucleic acid analysis |
US6432634B1 (en) * | 1996-04-18 | 2002-08-13 | Visible Genetics Inc. | Method, apparatus and kits for sequencing of nucleic acids using multiple dyes |
US5981956A (en) * | 1996-05-16 | 1999-11-09 | Affymetrix, Inc. | Systems and methods for detection of labeled materials |
US6221654B1 (en) * | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US6020457A (en) * | 1996-09-30 | 2000-02-01 | Dendritech Inc. | Disulfide-containing dendritic polymers |
US5858671A (en) * | 1996-11-01 | 1999-01-12 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
US6024925A (en) * | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
US6017702A (en) * | 1996-12-05 | 2000-01-25 | The Perkin-Elmer Corporation | Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate |
US5876934A (en) * | 1996-12-18 | 1999-03-02 | Pharmacia Biotech Inc. | DNA sequencing method |
US6828094B2 (en) * | 1996-12-20 | 2004-12-07 | Roche Diagnostics Gmbh | Method for the uncoupled, direct, exponential amplification and sequencing of DNA molecules with the addition of a second thermostable DNA polymerase and its application |
CA2281205A1 (en) * | 1997-02-12 | 1998-08-13 | Eugene Y. Chan | Methods and products for analyzing polymers |
US5837860A (en) * | 1997-03-05 | 1998-11-17 | Molecular Tool, Inc. | Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds |
US6117634A (en) * | 1997-03-05 | 2000-09-12 | The Reagents Of The University Of Michigan | Nucleic acid sequencing and mapping |
GB9716231D0 (en) * | 1997-07-31 | 1997-10-08 | Amersham Int Ltd | Base analogues |
US5882904A (en) * | 1997-08-04 | 1999-03-16 | Amersham Pharmacia Biotech Inc. | Thermococcus barossii DNA polymerase mutants |
CA2243985C (en) * | 1997-09-11 | 2004-08-10 | F. Hoffmann-La Roche Ag | Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes |
US6511803B1 (en) * | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US5976842A (en) * | 1997-10-30 | 1999-11-02 | Clontech Laboratories, Inc. | Methods and compositions for use in high fidelity polymerase chain reaction |
US6322968B1 (en) * | 1997-11-21 | 2001-11-27 | Orchid Biosciences, Inc. | De novo or “universal” sequencing array |
US6185030B1 (en) * | 1998-03-20 | 2001-02-06 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
US20030022207A1 (en) * | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
US6716394B2 (en) * | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
US6245507B1 (en) * | 1998-08-18 | 2001-06-12 | Orchid Biosciences, Inc. | In-line complete hyperspectral fluorescent imaging of nucleic acid molecules |
DE19844931C1 (de) * | 1998-09-30 | 2000-06-15 | Stefan Seeger | Verfahren zur DNS- oder RNS-Sequenzierung |
DE19849348A1 (de) * | 1998-10-26 | 2000-04-27 | Univ Ludwigs Albert | Linear Amplification mediated PCR (=LAM PCR) |
US6340750B1 (en) * | 1998-12-18 | 2002-01-22 | The Texas A&M University System | Through bond energy transfer in fluorescent dyes for labelling biological molecules |
US6361671B1 (en) * | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
CA2366289A1 (en) * | 1999-03-25 | 2000-09-28 | Radoje T. Drmanac | Solution-based methods and materials for sequence analysis by hybridization |
US6521428B1 (en) * | 1999-04-21 | 2003-02-18 | Genome Technologies, Llc | Shot-gun sequencing and amplification without cloning |
US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
AU7105300A (en) * | 1999-09-03 | 2001-04-10 | Lifebeam Technologies, Inc. | Optical system for rapid polymer analysis |
US6309836B1 (en) * | 1999-10-05 | 2001-10-30 | Marek Kwiatkowski | Compounds for protecting hydroxyls and methods for their use |
US6342326B1 (en) * | 2000-05-10 | 2002-01-29 | Beckman Coulter, Inc. | Synthesis and use of acyl fluorides of cyanine dyes |
US20030017461A1 (en) * | 2000-07-11 | 2003-01-23 | Aclara Biosciences, Inc. | Tag cleavage for detection of nucleic acids |
EP1354064A2 (de) * | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen |
AU2002217660A1 (en) * | 2001-01-12 | 2002-07-24 | Karolinska Innovations Ab | Substrate for fluorescence analysis |
US20040038206A1 (en) * | 2001-03-14 | 2004-02-26 | Jia Zhang | Method for high throughput assay of genetic analysis |
US20030027140A1 (en) * | 2001-03-30 | 2003-02-06 | Jingyue Ju | High-fidelity DNA sequencing using solid phase capturable dideoxynucleotides and mass spectrometry |
US6689478B2 (en) * | 2001-06-21 | 2004-02-10 | Corning Incorporated | Polyanion/polycation multilayer film for DNA immobilization |
US6613523B2 (en) * | 2001-06-29 | 2003-09-02 | Agilent Technologies, Inc. | Method of DNA sequencing using cleavable tags |
US6989267B2 (en) * | 2001-07-02 | 2006-01-24 | Agilent Technologies, Inc. | Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films |
US6995841B2 (en) * | 2001-08-28 | 2006-02-07 | Rice University | Pulsed-multiline excitation for color-blind fluorescence detection |
EP1438435B1 (de) * | 2001-08-31 | 2007-10-31 | Datascope Investment Corp. | Verfahren zur Blockierung von unspezifischen Hybridisierungen von Nukleinsäuresequenzen |
US6852492B2 (en) * | 2001-09-24 | 2005-02-08 | Intel Corporation | Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication |
US6982165B2 (en) * | 2001-09-24 | 2006-01-03 | Intel Corporation | Nucleic acid sequencing by raman monitoring of molecular deconstruction |
US20040054162A1 (en) * | 2001-10-30 | 2004-03-18 | Hanna Michelle M. | Molecular detection systems utilizing reiterative oligonucleotide synthesis |
AU2003224836A1 (en) * | 2002-04-12 | 2003-10-27 | Stratagene | Dual-labeled nucleotides |
EP1592810A2 (de) * | 2003-02-12 | 2005-11-09 | Genizon Svenska AB | Verfahren und vorrichtungen zur nukleinsäuresequenzierung |
DE602004021235D1 (de) * | 2003-02-21 | 2009-07-09 | Geneform Technologies Ltd | Verfahren, kits und reagenzien zur nukleinsäuresequenzierung |
-
2005
- 2005-01-28 US US11/046,448 patent/US7482120B2/en not_active Expired - Fee Related
-
2006
- 2006-01-30 AT AT06734692T patent/ATE548466T1/de active
- 2006-01-30 CA CA002599477A patent/CA2599477A1/en not_active Abandoned
- 2006-01-30 EP EP06734692A patent/EP1848829B1/de not_active Not-in-force
- 2006-01-30 WO PCT/US2006/004638 patent/WO2006081583A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US7482120B2 (en) | 2009-01-27 |
WO2006081583A3 (en) | 2006-10-19 |
EP1848829B1 (de) | 2012-03-07 |
EP1848829A2 (de) | 2007-10-31 |
US20060172313A1 (en) | 2006-08-03 |
CA2599477A1 (en) | 2006-08-03 |
WO2006081583A2 (en) | 2006-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE548466T1 (de) | Verfahren und zusammensetzungen zur verbesserung der genauigkeit bei einer nukleinsäuresynthesereaktion | |
ATE474938T1 (de) | Verfahren zur erhöhung der genauigkeit einer nukleinsäuresequenzierung | |
DE502006005581D1 (de) | Ukmischungen, ein verfahren zu deren herstellung, verfahren zur herstellung von verbund-formteilen und deren verwendung | |
SG170802A1 (en) | Systems and devices for sequence by synthesis analysis | |
ATE538127T1 (de) | 6-disubstituierte bicyclische nukleinsäureanaloga | |
WO2005118806A3 (en) | METHODS AND COMPOSITIONS INVOLVING MicroRNA | |
WO2008154401A3 (en) | Carbocyclic bicyclic nucleic acid analogs | |
DK1856257T3 (da) | Fremgangsmåder under anvendelser af oligonucleotid med dobbelt specificitet og oligonucleotid med dobbelt specificitet | |
SG152126A1 (en) | Process for stabilizing olefinically unsaturated monomers | |
ATE550441T1 (de) | Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren | |
DE602005027700D1 (de) | Verfahren zur nukleinsäureimmobilisierung | |
CA2620129C (en) | Diaminopyrimidines as p2x3 and p2x2/3 modulators | |
ATE427965T1 (de) | Antikírper gegen 25-hydroxyvitamin d | |
WO2010018563A3 (en) | Compositions and methods for the prognosis of lymphoma | |
WO2007005645A3 (en) | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts | |
WO2004092418A3 (en) | Global amplification using a randomly primed composite primer | |
WO2009045344A3 (en) | Error-free amplification of dna for clonal sequencing | |
WO2010031076A3 (en) | Conversion of prenyl derivatives to isoprene | |
BRPI0908926A2 (pt) | Compostos de policarbonato-poliorganosiloxano e/ou poliuretano-poliorganosiloxano | |
DE602005027859D1 (de) | An ein substrat gebundene dendrimere | |
WO2004069793A3 (en) | Novel 2-substituted cyclic amines as calcium sensing receptor modulators | |
WO2006060189A3 (en) | Curable silicone compositions incorporating a fluorescent detection system | |
DK1678254T3 (da) | Styrkeoptimerede polymerer med blandede oxyalkylen-enheder | |
WO2008146745A1 (ja) | 新規なリゾホスファチジン酸アシル基転移酵素遺伝子 | |
DE602005020185D1 (de) | Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4henprodukte für dieses verfahren |