ATE544445T1 - Herstellung von sterilen wässrigen suspensionen mit mikronisierten kristallinen wirkstoffen zur inhalation - Google Patents

Herstellung von sterilen wässrigen suspensionen mit mikronisierten kristallinen wirkstoffen zur inhalation

Info

Publication number
ATE544445T1
ATE544445T1 AT03785852T AT03785852T ATE544445T1 AT E544445 T1 ATE544445 T1 AT E544445T1 AT 03785852 T AT03785852 T AT 03785852T AT 03785852 T AT03785852 T AT 03785852T AT E544445 T1 ATE544445 T1 AT E544445T1
Authority
AT
Austria
Prior art keywords
active ingredients
sterile aqueous
aqueous suspensions
inhalation
production
Prior art date
Application number
AT03785852T
Other languages
English (en)
Inventor
Andrea Capocchi
Fausto Pivetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Application granted granted Critical
Publication of ATE544445T1 publication Critical patent/ATE544445T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/02—Non-contaminated water, e.g. for industrial water supply
    • C02F2103/026—Treating water for medical or cosmetic purposes
AT03785852T 2002-12-18 2003-12-17 Herstellung von sterilen wässrigen suspensionen mit mikronisierten kristallinen wirkstoffen zur inhalation ATE544445T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002674A ITMI20022674A1 (it) 2002-12-18 2002-12-18 Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
PCT/EP2003/014386 WO2004054545A1 (en) 2002-12-18 2003-12-17 Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation

Publications (1)

Publication Number Publication Date
ATE544445T1 true ATE544445T1 (de) 2012-02-15

Family

ID=32587870

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03785852T ATE544445T1 (de) 2002-12-18 2003-12-17 Herstellung von sterilen wässrigen suspensionen mit mikronisierten kristallinen wirkstoffen zur inhalation

Country Status (23)

Country Link
US (1) US8128909B2 (de)
EP (1) EP1572153B1 (de)
CN (1) CN100398095C (de)
AT (1) ATE544445T1 (de)
AU (1) AU2003294879A1 (de)
BR (1) BRPI0316908B8 (de)
CA (1) CA2510263C (de)
DK (1) DK1572153T3 (de)
EA (1) EA008122B1 (de)
ES (1) ES2379349T3 (de)
HK (1) HK1088217A1 (de)
HR (1) HRP20050546B1 (de)
IT (1) ITMI20022674A1 (de)
MA (1) MA27702A1 (de)
ME (2) ME01084B (de)
MX (1) MXPA05006441A (de)
PL (1) PL213704B1 (de)
PT (1) PT1572153E (de)
RS (1) RS52151B (de)
SI (1) SI1572153T1 (de)
UA (1) UA87655C2 (de)
WO (1) WO2004054545A1 (de)
ZA (1) ZA200504897B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter
ITMI20020808A1 (it) * 2002-04-17 2003-10-17 Chiesi Farma Spa Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
ITMI20032054A1 (it) * 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
ES2317306T3 (es) 2004-10-12 2009-04-16 Generics (Uk) Limited Procedimiento para la preparacion de formulaciones en aerosol en suspension, en el que las particulas se forman por precipitacion dentro de un frasco de aerosol.
EP1949891A1 (de) * 2004-10-12 2008-07-30 Generics (UK) Limited Verfahren zur Herstellung von Suspensionsaerosolformulierungen, wobei die Partikel durch Fällung im Innenkanister gebildet werden
ES2388287T3 (es) 2005-01-20 2012-10-11 Eratech S.R.L. Procedimiento para la preparación de suspensiones concentradas de fármacos y kit correspondiente
EP1782797A1 (de) * 2005-11-02 2007-05-09 Pharmatex Italia Srl Verfahren zur Herstellung von sterilen pulverförmigen pharmazeutischen Verbindungen
US20080262078A1 (en) * 2007-04-20 2008-10-23 Namdeo Alok B Pharmaceutical Compositions
RU2483711C2 (ru) 2007-07-31 2013-06-10 Оцука Фармасьютикал Ко., Лтд. Способы получения суспензии арипипразола и лиофилизированного состава
CA2707594C (en) * 2007-12-13 2015-08-18 Novartis Ag Process for preparing particulates of crystalline drug substance
GB0806873D0 (en) * 2008-04-16 2008-05-21 Breath Ltd Steroid nebuliser formulation
CN101618019B (zh) * 2008-07-01 2011-08-03 上海通用药业股份有限公司 一种醋酸曲安奈德微粒及其制备方法和药物组合物
BR112013016851B1 (pt) * 2011-01-12 2021-08-31 Intervet International B.V Método para preparar uma composição farmacêutica que compreende partículas de uma droga
CN103501791B (zh) 2011-05-03 2016-05-18 奇斯药制品公司 用于通过吸入给药的改良皮质类固醇悬浮制剂
JP4954345B1 (ja) * 2011-07-06 2012-06-13 アピ株式会社 医薬品原薬の無菌化精製装置
EP2847207B1 (de) * 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Nanokristalle von Fluticasonpropionat
DE102012221219B4 (de) * 2012-11-20 2014-05-28 Jesalis Pharma Gmbh Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel
RS60299B1 (sr) 2014-09-09 2020-07-31 Vectura Ltd Formulacija koja obuhvata glikopirolat, postupak i uređaj
ES2764495T3 (es) * 2015-10-09 2020-06-03 Bgh Procedimiento para cristalizar clatratos hidratos y procedimiento de purificación de un líquido acuoso usando los clatratos hidratos así cristalizados

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107715B (en) * 1981-10-19 1985-11-13 Glaxo Group Ltd Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it
US6187765B1 (en) * 1997-10-09 2001-02-13 Schering Corporation Mometasone furoate suspensions for nebulization
AP2000001961A0 (en) * 1998-04-18 2000-12-31 Glaxo Group Ltd Pharmaceutical aerosol formulation.
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
IT1303692B1 (it) * 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0015981D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
ES2318145T3 (es) * 2002-02-19 2009-05-01 Resolution Chemicals Limited Esterilizacion de esteroides por medio de disolventes.

Also Published As

Publication number Publication date
US8128909B2 (en) 2012-03-06
HRP20050546B1 (hr) 2014-05-23
SI1572153T1 (sl) 2012-05-31
CA2510263C (en) 2012-07-03
ME01084B (me) 2011-05-10
ITMI20022674A1 (it) 2004-06-19
UA87655C2 (ru) 2009-08-10
BR0316908A (pt) 2005-10-18
RS52151B (en) 2012-08-31
WO2004054545A1 (en) 2004-07-01
ZA200504897B (en) 2006-09-27
PL213704B1 (pl) 2013-04-30
CA2510263A1 (en) 2004-07-01
DK1572153T3 (da) 2012-03-05
MXPA05006441A (es) 2005-09-08
US20070140980A1 (en) 2007-06-21
RS72504A (en) 2006-10-27
HK1088217A1 (en) 2006-11-03
BRPI0316908B8 (pt) 2021-05-25
EA200500833A1 (ru) 2006-02-24
AU2003294879A1 (en) 2004-07-09
BRPI0316908B1 (pt) 2016-01-26
CN100398095C (zh) 2008-07-02
EP1572153A1 (de) 2005-09-14
MEP35208A (en) 2011-02-10
PL377345A1 (pl) 2006-01-23
EA008122B1 (ru) 2007-04-27
PT1572153E (pt) 2012-03-22
CN1735403A (zh) 2006-02-15
ES2379349T3 (es) 2012-04-25
EP1572153B1 (de) 2012-02-08
MA27702A1 (fr) 2006-01-02
HRP20050546A2 (en) 2005-10-31

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