BRPI0316908B8 - preparo de suspensões aquosas estéreis incluindo ingredientes ativos cristalinos micronizados para inalação - Google Patents

preparo de suspensões aquosas estéreis incluindo ingredientes ativos cristalinos micronizados para inalação

Info

Publication number
BRPI0316908B8
BRPI0316908B8 BRPI0316908A BR0316908A BRPI0316908B8 BR PI0316908 B8 BRPI0316908 B8 BR PI0316908B8 BR PI0316908 A BRPI0316908 A BR PI0316908A BR 0316908 A BR0316908 A BR 0316908A BR PI0316908 B8 BRPI0316908 B8 BR PI0316908B8
Authority
BR
Brazil
Prior art keywords
preparation
active ingredients
sterile aqueous
aqueous suspensions
inhalation
Prior art date
Application number
BRPI0316908A
Other languages
English (en)
Other versions
BRPI0316908B1 (pt
BR0316908A (pt
Inventor
Capocchi Andréa
Pivetti Fausto
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of BR0316908A publication Critical patent/BR0316908A/pt
Publication of BRPI0316908B1 publication Critical patent/BRPI0316908B1/pt
Publication of BRPI0316908B8 publication Critical patent/BRPI0316908B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/02—Non-contaminated water, e.g. for industrial water supply
    • C02F2103/026—Treating water for medical or cosmetic purposes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

"preparo de suspensões aquosas estéreis incluindo ingredientes ativos cristalinos micronizados para inalação". mostra-se um processo para o preparo de suspensões aquosas estéreis com base em ingredientes ativos sob a forma de partículas cristalinas micronizadas destinados a administração por inalação. em particular, um processo para a preparação de suspensões aquosas estéreis com base em ingredientes farmacêuticos sob a forma de hidratos cristalizados é mostrado.
BRPI0316908A 2002-12-18 2003-12-17 preparo de suspensões aquosas estéreis incluindo ingredientes ativos cristalinos micronizados para inalação BRPI0316908B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002674A ITMI20022674A1 (it) 2002-12-18 2002-12-18 Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
PCT/EP2003/014386 WO2004054545A1 (en) 2002-12-18 2003-12-17 Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation

Publications (3)

Publication Number Publication Date
BR0316908A BR0316908A (pt) 2005-10-18
BRPI0316908B1 BRPI0316908B1 (pt) 2016-01-26
BRPI0316908B8 true BRPI0316908B8 (pt) 2021-05-25

Family

ID=32587870

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0316908A BRPI0316908B8 (pt) 2002-12-18 2003-12-17 preparo de suspensões aquosas estéreis incluindo ingredientes ativos cristalinos micronizados para inalação

Country Status (23)

Country Link
US (1) US8128909B2 (pt)
EP (1) EP1572153B1 (pt)
CN (1) CN100398095C (pt)
AT (1) ATE544445T1 (pt)
AU (1) AU2003294879A1 (pt)
BR (1) BRPI0316908B8 (pt)
CA (1) CA2510263C (pt)
DK (1) DK1572153T3 (pt)
EA (1) EA008122B1 (pt)
ES (1) ES2379349T3 (pt)
HK (1) HK1088217A1 (pt)
HR (1) HRP20050546B1 (pt)
IT (1) ITMI20022674A1 (pt)
MA (1) MA27702A1 (pt)
ME (2) MEP35208A (pt)
MX (1) MXPA05006441A (pt)
PL (1) PL213704B1 (pt)
PT (1) PT1572153E (pt)
RS (1) RS52151B (pt)
SI (1) SI1572153T1 (pt)
UA (1) UA87655C2 (pt)
WO (1) WO2004054545A1 (pt)
ZA (1) ZA200504897B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter
ITMI20020808A1 (it) * 2002-04-17 2003-10-17 Chiesi Farma Spa Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) * 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
ITMI20032054A1 (it) * 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
PE20050941A1 (es) * 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
EP1811981B1 (en) * 2004-10-12 2008-08-13 Merck Generics (UK) Limited Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister
EP1949891A1 (en) * 2004-10-12 2008-07-30 Generics (UK) Limited Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister
ES2388287T3 (es) 2005-01-20 2012-10-11 Eratech S.R.L. Procedimiento para la preparación de suspensiones concentradas de fármacos y kit correspondiente
EP1782797A1 (en) * 2005-11-02 2007-05-09 Pharmatex Italia Srl Process for the preparation of sterile powdered pharmaceutical compounds.
CN102014918A (zh) * 2007-04-20 2011-04-13 太阳医药工业有限公司 由微量沉淀产生的药学组合物
MY152789A (en) * 2007-07-31 2014-11-28 Otsuka Pharma Co Ltd Methods for producing aripiprazole suspension and freeze-dried formulation
PL2229148T3 (pl) * 2007-12-13 2014-08-29 Novartis Ag Sposób otrzymywania krystalicznych cząstek stałych substancji leczniczej
GB0806873D0 (en) * 2008-04-16 2008-05-21 Breath Ltd Steroid nebuliser formulation
CN101618019B (zh) * 2008-07-01 2011-08-03 上海通用药业股份有限公司 一种醋酸曲安奈德微粒及其制备方法和药物组合物
MX346749B (es) * 2011-01-12 2017-03-29 Intervet Int Bv Uso de intercambio de medio liquido por filtracion de flujo cruzado en la preparacion de suspensiones de farmaco.
ES2612257T3 (es) 2011-05-03 2017-05-16 Chiesi Farmaceutici S.P.A. Formulación de suspensión mejorada de dipropionato de beclometasona para administración mediante inhalación
JP4954345B1 (ja) * 2011-07-06 2012-06-13 アピ株式会社 医薬品原薬の無菌化精製装置
EP2847207B1 (en) * 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Fluticasone propionate nanocrystals
DE102012221219B4 (de) * 2012-11-20 2014-05-28 Jesalis Pharma Gmbh Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel
TN2017000077A1 (en) 2014-09-09 2018-07-04 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
EP3153606B1 (fr) * 2015-10-09 2019-10-09 Bgh Procede pour cristalliser des clathrates hydrates, et procede de purification d'un liquide aqueux utilisant les clathrates hydrates ainsi cristallises

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107715B (en) * 1981-10-19 1985-11-13 Glaxo Group Ltd Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it
US6187765B1 (en) * 1997-10-09 2001-02-13 Schering Corporation Mometasone furoate suspensions for nebulization
PL343491A1 (en) * 1998-04-18 2001-08-27 Glaxo Group Ltd Pharmaceutical aerosol formulation
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
IT1303692B1 (it) * 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
GB0015981D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
DK1476201T3 (da) * 2002-02-19 2009-03-30 Resolution Chemicals Ltd Solvent-baseret sterilisering af steroider

Also Published As

Publication number Publication date
EA200500833A1 (ru) 2006-02-24
AU2003294879A1 (en) 2004-07-09
HK1088217A1 (en) 2006-11-03
PL213704B1 (pl) 2013-04-30
HRP20050546A2 (en) 2005-10-31
SI1572153T1 (sl) 2012-05-31
US20070140980A1 (en) 2007-06-21
RS52151B (en) 2012-08-31
US8128909B2 (en) 2012-03-06
MEP35208A (en) 2011-02-10
MXPA05006441A (es) 2005-09-08
EP1572153B1 (en) 2012-02-08
DK1572153T3 (da) 2012-03-05
ZA200504897B (en) 2006-09-27
WO2004054545A1 (en) 2004-07-01
EP1572153A1 (en) 2005-09-14
BRPI0316908B1 (pt) 2016-01-26
EA008122B1 (ru) 2007-04-27
HRP20050546B1 (hr) 2014-05-23
ATE544445T1 (de) 2012-02-15
ME01084B (me) 2011-05-10
BR0316908A (pt) 2005-10-18
CA2510263A1 (en) 2004-07-01
UA87655C2 (ru) 2009-08-10
PL377345A1 (pl) 2006-01-23
CA2510263C (en) 2012-07-03
CN1735403A (zh) 2006-02-15
PT1572153E (pt) 2012-03-22
ITMI20022674A1 (it) 2004-06-19
ES2379349T3 (es) 2012-04-25
CN100398095C (zh) 2008-07-02
MA27702A1 (fr) 2006-01-02
RS72504A (en) 2006-10-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERACAO PARA:INT. CI.461K 9/14, A61P 11/00

Ipc: A61K 9/14 (2011.01), A61P 11/00 (2011.01)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/01/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF