ATE536864T1 - Metoprololsuccinat tabletten mit verlängerter freisetzung und verfahren für deren herstellung - Google Patents

Metoprololsuccinat tabletten mit verlängerter freisetzung und verfahren für deren herstellung

Info

Publication number
ATE536864T1
ATE536864T1 AT06252598T AT06252598T ATE536864T1 AT E536864 T1 ATE536864 T1 AT E536864T1 AT 06252598 T AT06252598 T AT 06252598T AT 06252598 T AT06252598 T AT 06252598T AT E536864 T1 ATE536864 T1 AT E536864T1
Authority
AT
Austria
Prior art keywords
extended release
production
metoprolol succinate
release tablets
succinate extended
Prior art date
Application number
AT06252598T
Other languages
English (en)
Inventor
Tomer Gold
Nava Shterman
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE536864T1 publication Critical patent/ATE536864T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
AT06252598T 2006-02-24 2006-05-18 Metoprololsuccinat tabletten mit verlängerter freisetzung und verfahren für deren herstellung ATE536864T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77670606P 2006-02-24 2006-02-24

Publications (1)

Publication Number Publication Date
ATE536864T1 true ATE536864T1 (de) 2011-12-15

Family

ID=36928616

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06252598T ATE536864T1 (de) 2006-02-24 2006-05-18 Metoprololsuccinat tabletten mit verlängerter freisetzung und verfahren für deren herstellung

Country Status (13)

Country Link
US (1) US20070202172A1 (de)
EP (1) EP1842534B1 (de)
JP (1) JP2009527554A (de)
KR (1) KR20080099334A (de)
CN (1) CN101516356A (de)
AT (1) ATE536864T1 (de)
BR (1) BRPI0621397A2 (de)
CA (1) CA2642340A1 (de)
IL (1) IL193357A0 (de)
MX (1) MX2008010877A (de)
PL (1) PL1842534T3 (de)
RU (1) RU2008136766A (de)
WO (1) WO2007097770A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI630207B (zh) 2005-12-13 2018-07-21 英塞特控股公司 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶
DE102008047910A1 (de) * 2008-09-19 2010-03-25 Molkerei Meggle Wasserburg Gmbh & Co. Kg Tablettierhilfsstoff auf Laktose- und Cellulosebasis
FR2936709B1 (fr) * 2008-10-02 2012-05-11 Ethypharm Sa Comprimes alcoolo-resistants.
DK2255791T3 (da) * 2009-04-03 2012-03-05 Zaklady Farmaceutyczne Polpharma Sa Forlænget-frigivelse-farmaceutisk sammensætning omfattende metoprololsuccinat
CN102008457B (zh) * 2009-09-04 2014-04-02 北京天衡药物研究院 酒石酸美托洛尔骨架缓释片
CA2785860A1 (en) * 2009-12-29 2011-07-28 Impax Laboratories, Inc. Gastroretentive solid oral dosage forms with swellable hydrophilic polymer
CN101773482B (zh) * 2009-12-30 2012-04-25 中国科学院上海药物研究所 一种三段式脉冲释药控释片及其制备方法
EP3050882B1 (de) 2010-03-10 2018-01-31 Incyte Holdings Corporation Piperidin-4-yl-azetidin-derivate als jak1-inhibitoren
PE20140832A1 (es) 2011-06-20 2014-07-14 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
CN103655480B (zh) * 2012-09-14 2016-12-21 中国人民解放军军事医学科学院毒物药物研究所 一种美托洛尔的缓释药物及其制备方法
PL2919766T3 (pl) 2012-11-15 2021-10-04 Incyte Holdings Corporation Postacie dawkowania ruksolitynibu o przedłużonym uwalnianiu
SG10201912203XA (en) 2013-08-07 2020-02-27 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
CA2977415A1 (en) 2015-03-03 2016-09-09 Saniona A/S Tesofensine, beta blocker combination formulation
EP3428184A1 (de) * 2017-07-09 2019-01-16 Universitätsklinikum Hamburg-Eppendorf Mittel zur behandlung von herz-kreislauf-erkrankung
EP3768378B1 (de) 2018-03-22 2025-08-06 InCarda Therapeutics, Inc. Neuartiges verfahren zur verlangsamung der ventrikulären rate
CN111419813A (zh) * 2020-05-09 2020-07-17 深圳市道科思医药有限公司 一种琥珀酸美托洛尔的缓释片剂及其制备方法
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
WO2022074681A1 (en) * 2020-10-08 2022-04-14 Harman Finochem Limited Pharmaceutical compositions with enhanced blend uniformity and content uniformity
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
US5246714A (en) * 1985-10-11 1993-09-21 Aktiebolaget Hassle Drug preparation
SE455836B (sv) * 1985-10-11 1988-08-15 Haessle Ab Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning
SE450087B (sv) * 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
JPH0819003B2 (ja) * 1988-09-27 1996-02-28 武田薬品工業株式会社 有核顆粒およびその製造法
JP3453186B2 (ja) * 1994-04-14 2003-10-06 共和薬品工業株式会社 徐放性マイクロカプセルおよびその製造方法
SE9402422D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
SE9803871D0 (sv) * 1998-11-11 1998-11-11 Pharmacia & Upjohn Ab Therapeutic method and formulation
US9358214B2 (en) * 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US7022342B2 (en) * 2002-03-28 2006-04-04 Andrx Corporation, Inc. Controlled release oral dosage form of beta-adrenergic blocking agents
US7314640B2 (en) * 2003-07-11 2008-01-01 Mongkol Sriwongjanya Formulation and process for drug loaded cores
ATE549015T1 (de) * 2003-10-31 2012-03-15 Hexal Ag Pharmazeutische wirkstoffhaltige formulierung mit überzug
DE10353186A1 (de) * 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz
WO2005084636A2 (en) * 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited A process for the preparation of controlled-release pharmaceutical composition of metoprolol
US20060204575A1 (en) * 2005-03-11 2006-09-14 Hengsheng Feng Amphetamine formulations

Also Published As

Publication number Publication date
JP2009527554A (ja) 2009-07-30
MX2008010877A (es) 2008-11-25
PL1842534T3 (pl) 2012-05-31
US20070202172A1 (en) 2007-08-30
EP1842534B1 (de) 2011-12-14
CN101516356A (zh) 2009-08-26
RU2008136766A (ru) 2010-03-27
EP1842534A1 (de) 2007-10-10
IL193357A0 (en) 2009-05-04
BRPI0621397A2 (pt) 2012-04-17
KR20080099334A (ko) 2008-11-12
CA2642340A1 (en) 2007-08-30
WO2007097770A8 (en) 2007-12-06
WO2007097770A1 (en) 2007-08-30

Similar Documents

Publication Publication Date Title
ATE536864T1 (de) Metoprololsuccinat tabletten mit verlängerter freisetzung und verfahren für deren herstellung
ECSP11011439A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750
ATE460401T1 (de) 1,2,4,5-tetrahydro-3h-benzazepinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
PH12013502192A1 (en) Antibodies against human angiopoietin 2
CL2007003627A1 (es) Compuestos derivados de 3-h-pirazolopiridinas; metodo de preparacion; composicion farmaceutica; y uso para el tratamiento de enfermedades de crecimiento vascular desregulado tal como leucemia mielogena aguda, retinopatia, artritis reumatoide, psorias
AR053147A1 (es) Forma cristalina del clorhidrato de ivabradina, un procedimiento para su preparacion y composiciones farmaceuticas que la contienen
UY31524A1 (es) Nuevos compuestos 010
EA200900282A1 (ru) Применение полиолов для получения устойчивых полиморфных форм рифаксимина
IN2012DN01531A (de)
ATE556074T1 (de) Neue imidazoä1,5-aüpyridinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
ATE502024T1 (de) Diosmetin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
ECSP066376A (es) FORMA CRISTALINA GAMMA-d DEL CLORHIDRATO DE IVABRADINA, SU PROCEDIMIENTO DE PREPARACIÓN Y COMPOSICIONES FARMACÉUTICAS QUE LA CONTIENEN
ATE524469T1 (de) Alkinylarylverbindungen und salze davon, diese enthaltende pharmazeutische zusammensetzungen, verfahren zu deren herstellung und deren verwendungen
UY29839A1 (es) Ácidos fenoxiaceticos sustituidos, composiciones farmacéuticas conteniéndolos, procesos para su preparación y aplicaciones.
UY29223A1 (es) Ácidos fenoxiacéticos sustituidos, composiciones farmacéuticas que los contienen y procesos para su preparación
ATE482194T1 (de) Indolonderivate, verfahren zu deren herstellung und deren anwendungen
MA31445B1 (fr) Composition à libération modifiée comprenant un dérivé de somatostatine en microparticules
EP2399953A4 (de) Polychlorpropen-elastomer-zusammensetzung, verfahren zu deren herstellung sowie vulkanisat und formobjekt daraus
ATE500226T1 (de) Aripiprazolhemifumarat und verfahren zu dessen herstellung
ATE462408T1 (de) Pharmazeutische zusammensetzungen, enthaltend valatograst, und verfahren zu deren herstellung
ATE413875T1 (de) Zusammensetzungen enthaltend levetiracetam und verfahren zu deren herstellung.
MX2009008221A (es) Antagonista de receptor de cromeno s1p1.
ATE425961T1 (de) Salze substituierter allophansaureester und deren verwendung in arzneimitteln
ATE372992T1 (de) Indanyl-piperazinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
TW200718698A (en) Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof