ATE533760T1 - Indole-3-yl-carbonyl-piperidine derivate zur behandlung von angststörungen und depressionen durch antagonismus des v1a rezeptors - Google Patents

Indole-3-yl-carbonyl-piperidine derivate zur behandlung von angststörungen und depressionen durch antagonismus des v1a rezeptors

Info

Publication number
ATE533760T1
ATE533760T1 AT07857799T AT07857799T ATE533760T1 AT E533760 T1 ATE533760 T1 AT E533760T1 AT 07857799 T AT07857799 T AT 07857799T AT 07857799 T AT07857799 T AT 07857799T AT E533760 T1 ATE533760 T1 AT E533760T1
Authority
AT
Austria
Prior art keywords
antagonism
indole
carbonyl
depression
receptor
Prior art date
Application number
AT07857799T
Other languages
German (de)
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Raffaello Masciadri
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE533760T1 publication Critical patent/ATE533760T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07857799T 2006-12-28 2007-12-19 Indole-3-yl-carbonyl-piperidine derivate zur behandlung von angststörungen und depressionen durch antagonismus des v1a rezeptors ATE533760T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127307 2006-12-28
PCT/EP2007/064176 WO2008080842A1 (en) 2006-12-28 2007-12-19 Indoles

Publications (1)

Publication Number Publication Date
ATE533760T1 true ATE533760T1 (de) 2011-12-15

Family

ID=39198190

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07857799T ATE533760T1 (de) 2006-12-28 2007-12-19 Indole-3-yl-carbonyl-piperidine derivate zur behandlung von angststörungen und depressionen durch antagonismus des v1a rezeptors

Country Status (18)

Country Link
US (3) US20080167344A1 (zh)
EP (1) EP2125785B1 (zh)
JP (1) JP2010514726A (zh)
KR (1) KR101134255B1 (zh)
CN (1) CN101583609A (zh)
AR (1) AR064546A1 (zh)
AT (1) ATE533760T1 (zh)
AU (1) AU2007341377B2 (zh)
BR (1) BRPI0720968A2 (zh)
CA (1) CA2674133A1 (zh)
CL (1) CL2007003831A1 (zh)
ES (1) ES2375520T3 (zh)
MX (1) MX2009006920A (zh)
NO (1) NO20092356L (zh)
PE (1) PE20081401A1 (zh)
RU (1) RU2009124111A (zh)
TW (1) TWI345468B (zh)
WO (1) WO2008080842A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093578A1 (en) * 2009-02-10 2010-08-19 Glaxo Group Limited Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors
MY197370A (en) 2015-11-06 2023-06-14 Hoffmann La Roche Indolin-2-one derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
CA2166975C (en) * 1993-07-16 2005-04-05 Mark G. Bock Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
JPH0920779A (ja) * 1995-05-01 1997-01-21 Japan Tobacco Inc 縮合ヘテロ５員環アゼピン化合物類及びその医薬用途
JP2008539220A (ja) * 2005-04-26 2008-11-13 ファイザー・リミテッド バソプレシンアンタゴニストとしてのトリアゾール誘導体
CA2616063A1 (en) 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives as v1a receptor antagonists
RU2422442C2 (ru) 2005-07-29 2011-06-27 Ф. Хоффманн-Ля Рош Аг Производные индол-3-ил-карбонил-пиперидина и пиперазина
RU2009120443A (ru) * 2006-12-08 2011-01-20 Ф.Хоффманн-Ля Рош Аг (Ch) Индолы, действующие в качестве антагонистов рецептора v1a

Also Published As

Publication number Publication date
AU2007341377B2 (en) 2012-03-22
US8143281B2 (en) 2012-03-27
MX2009006920A (es) 2009-07-06
PE20081401A1 (es) 2008-10-24
US20080161315A1 (en) 2008-07-03
TW200835491A (en) 2008-09-01
KR20090094395A (ko) 2009-09-04
RU2009124111A (ru) 2011-02-10
AU2007341377A1 (en) 2008-07-10
CA2674133A1 (en) 2008-07-10
AR064546A1 (es) 2009-04-08
EP2125785A1 (en) 2009-12-02
EP2125785B1 (en) 2011-11-16
BRPI0720968A2 (pt) 2014-03-11
US20080161316A1 (en) 2008-07-03
US20080167344A1 (en) 2008-07-10
ES2375520T3 (es) 2012-03-01
WO2008080842A1 (en) 2008-07-10
KR101134255B1 (ko) 2012-04-12
TWI345468B (en) 2011-07-21
CN101583609A (zh) 2009-11-18
JP2010514726A (ja) 2010-05-06
CL2007003831A1 (es) 2008-07-11
NO20092356L (no) 2009-06-30

Similar Documents

Publication Publication Date Title
EP1874286A4 (en) METHOD AND COMPOSITIONS FOR TREATING ANXIETY STATE
ATE545418T1 (de) Zusammensetzungen und kits zur behandlung von influenza
ATE407927T1 (de) 3-phenyl-pyrazol-derivate als modulatoren des zur behandlung damit zusammenhängender störungen nützlichen 5-ht-2a-serotonin-rezeptors
ATE521365T1 (de) Kinin-antagonisten zur behandlung von blasenfunktionsstörung
DE502005007427D1 (de) 3-aminoindazole derivate und ihre verwendung zur behandlung sgk-bedingten krankheiten
DE602005015577D1 (de) Harnstoff-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden
DE602005017636D1 (de) Neue hydantoinderivate zur behandlung von obstruktiven atemwegserkrankungen
DE602007011908D1 (de) Verwendung von gpr119-rezeptoragonisten zur vermehrung der knochenmasse und zur behandlung von osteoporose sowie kombinationstherapie dafür
HK1133651A1 (en) Indazolyl amide derivatives for the treatment of glucocorticoid receptor mediated disorders
DE602007011906D1 (de) Tetrahydropyridothienpyrimidin-verbindungen und verwendung zur behandlung proliferativer erkrankungen
ATE516286T1 (de) 5-(ä1,3,4üoxadiazol-2-yl)-1h-indazol und 5-(ä1,3, 4üthiadiazol-2-yl)-1h-indazol derivate als sgk- inhibitoren zur behandlung von diabetes
GB0703909D0 (en) Treatment of anxiety disorders
EP1986639A4 (en) PHARMACEUTICAL COMPOSITIONS OF DEXTROMETHORPHANE AND CHINIDINE FOR THE TREATMENT OF DEPRESSION, FEAR STATES AND NEURODEEGENERATIVE DISEASES
DK1765355T3 (da) Benzoxazin til behandling af luftvejslidelser
HK1166983A1 (zh) 包含用於治療疾病或紊亂的化合物的固體形式，其組合物，及其用途
ATE534633T1 (de) Indazolderivate zur behandlung von hsp90- induzierten krankheiten
DE602007010303D1 (de) Verwendung von 3- (4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin--2,6-dion zur behandlung von mantelzelllymphomen
DE502005003904D1 (de) Tetrahydrobenzo (d) azepin-2-on derivate und ihre verwendung zur behandlung von kardiovaskulären krankheiten
ZA200901523B (en) Use of extracts for the treatment of viral disorders
SI1863476T1 (sl) Kombinacija antiholinergikov in antagonistov receptorja levkotriena za zdravljenje respiratornih bolezni
ATE482709T1 (de) Neue arzneimittelkombinationen zur behandlung von atemwegserkrankungen
DK1841433T3 (da) Præparat til behandling af lidelser i centralnervesystemet
HK1247943A1 (zh) 發育相關疾病的治療
DE602007011398D1 (de) Trialkylsilylbenzylaminocarboxyindole, indazole und indoline und ihre verwendung zur behandlung von cetp-vermittelten erkrankungen
DE602007008494D1 (de) Verwendung von Agomelatin zur Herstellung von Medikamenten zur Behandlung der generalisierten Angststörung