ATE526948T1 - Verfahren zur herstellung einer mischformulierung aus mikrokügelchen mit verzögerter freisetzung durch ein kontinuierliches einstufiges verfahren - Google Patents

Verfahren zur herstellung einer mischformulierung aus mikrokügelchen mit verzögerter freisetzung durch ein kontinuierliches einstufiges verfahren

Info

Publication number
ATE526948T1
ATE526948T1 AT04748351T AT04748351T ATE526948T1 AT E526948 T1 ATE526948 T1 AT E526948T1 AT 04748351 T AT04748351 T AT 04748351T AT 04748351 T AT04748351 T AT 04748351T AT E526948 T1 ATE526948 T1 AT E526948T1
Authority
AT
Austria
Prior art keywords
continuous
microspheres
sustained release
step process
preparing
Prior art date
Application number
AT04748351T
Other languages
English (en)
Inventor
Hee Yong Lee
Sung Kyu Kim
Jung Soo Kim
Ji Suk Lee
Young Hwan Jung
Jung In Kim
Yun Mi Seo
Seung Gu Chang
Kee Don Park
Ho Il Choi
Original Assignee
Peptron Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36091378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE526948(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Peptron Co Ltd filed Critical Peptron Co Ltd
Application granted granted Critical
Publication of ATE526948T1 publication Critical patent/ATE526948T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT04748351T 2003-06-26 2004-06-25 Verfahren zur herstellung einer mischformulierung aus mikrokügelchen mit verzögerter freisetzung durch ein kontinuierliches einstufiges verfahren ATE526948T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2003-0042249A KR100466637B1 (ko) 2003-06-26 2003-06-26 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법
PCT/KR2004/001558 WO2004112752A1 (en) 2003-06-26 2004-06-25 Method of preparing mixed formulation of sustained release microspheres by continuous one-step process

Publications (1)

Publication Number Publication Date
ATE526948T1 true ATE526948T1 (de) 2011-10-15

Family

ID=36091378

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04748351T ATE526948T1 (de) 2003-06-26 2004-06-25 Verfahren zur herstellung einer mischformulierung aus mikrokügelchen mit verzögerter freisetzung durch ein kontinuierliches einstufiges verfahren

Country Status (7)

Country Link
US (1) US7399486B2 (de)
EP (1) EP1646366B1 (de)
JP (1) JP4072830B2 (de)
KR (1) KR100466637B1 (de)
AT (1) ATE526948T1 (de)
ES (1) ES2374623T3 (de)
WO (1) WO2004112752A1 (de)

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KR100453273B1 (ko) * 2003-09-04 2004-10-15 주식회사 펩트론 초음파 이중공급노즐을 이용한 서방성 미립구의 제조 방법
WO2006123360A2 (en) * 2005-03-01 2006-11-23 Sun Pharmaceutical Industries Limited Microspheres containing octreotide acetate
US20080286375A1 (en) * 2005-11-15 2008-11-20 Amorepacific Corporation Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate
KR101245919B1 (ko) * 2005-12-22 2013-03-20 노파르티스 아게 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드중합체를 포함하는 서방형 제제
KR100722607B1 (ko) * 2006-05-11 2007-05-28 주식회사 펩트론 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
UA99830C2 (uk) * 2007-06-06 2012-10-10 Дебио Ресшерчи Фармасютикю С.А. Фармацевтична композиція з пролонгованим вивільненням, виготовлена з мікрочастинок
US9107828B2 (en) * 2007-10-05 2015-08-18 Boston Scientific Scimed, Inc. Multi-component particles for injection and processes for forming the same
ES2324009B1 (es) * 2007-11-23 2010-05-21 Gp Pharm S.A. Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo.
JP6078217B2 (ja) 2008-01-15 2017-02-08 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 粉末化されたタンパク質組成物及びその作製方法
KR101921800B1 (ko) * 2008-01-30 2018-11-23 노파르티스 아게 옥트레오티드 및 3종의 선형 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
US8802126B2 (en) * 2008-06-30 2014-08-12 Abbott Cardiovascular Systems Inc. Polyester implantable medical device with controlled in vivo biodegradability
US20100086597A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for the sustained release of octreotide with a low initial burst
US20100189763A1 (en) * 2009-01-23 2010-07-29 Heather Nettles Controlled release systems from polymer blends
US20120172456A1 (en) * 2009-09-10 2012-07-05 Little Steven R Engineered microparticles for macromolecule delivery
WO2011079279A2 (en) * 2009-12-23 2011-06-30 Board Of Trustees Of The University Of Illinois Nanoconjugates and nanoconjugate formulations
US9287321B2 (en) 2010-05-26 2016-03-15 Samsung Electronics Co., Ltd. Magnetic tunnel junction device having amorphous buffer layers that are magnetically connected together and that have perpendicular magnetic anisotropy
BR112013016778A2 (pt) * 2010-12-30 2017-06-20 Feyecon Bv processo de desidratação que emprega um sal de colina líquido iônico
HUE037678T2 (hu) 2011-12-22 2018-09-28 Shandong luye pharmaceutical co ltd Triptorelin mikrogömbök gyógyászati kompozíciói
CA2902547A1 (en) * 2013-03-14 2014-09-25 Allergan, Inc. Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process
KR20180007322A (ko) * 2016-07-11 2018-01-22 주식회사 삼양바이오팜 고분자 마이크로스피어의 연속 제조방법 및 이를 위한 장치
CN108704141A (zh) * 2017-04-11 2018-10-26 皖西学院 一种药物缓控释载体材料及其制备方法
KR102412628B1 (ko) * 2017-08-28 2022-06-23 차의과학대학교 산학협력단 전기분무 기술을 이용한 루프롤라이드 함유 서방성 미립구의 제조방법
AU2018271379B2 (en) * 2017-11-30 2020-03-05 G2Gbio, Inc. Sustained release injection formulation comprising donepezil and method for preparing the same
CN111954522A (zh) * 2018-01-29 2020-11-17 约翰霍普金斯大学 用于包封和持续释放蛋白治疗剂的聚合物纳米颗粒组合物
KR20200051916A (ko) * 2018-11-05 2020-05-14 주식회사 메디포럼제약 고세렐린을 포함하는 실리카 하이드로겔 조성물
CN109512788B (zh) * 2019-01-23 2021-07-27 上海上药第一生化药业有限公司 醋酸曲普瑞林组合物及其冻干粉针剂、制备方法和应用
EP3939575A4 (de) 2019-03-14 2022-10-26 M. Technique Co., Ltd. Plga mikropartikel, formulierung davon mit verzögerter freisetzung und verfahren zu ihrer herstellung
WO2020222541A1 (ko) * 2019-04-30 2020-11-05 주식회사 엘지화학 캐스파제 저해제의 프로드럭
WO2021224999A1 (ja) 2020-05-08 2021-11-11 エム・テクニック株式会社 生理活性物質が均一に分散されたマイクロスフェアー及びそれを含有する徐放性製剤
JP6852943B1 (ja) * 2020-05-08 2021-03-31 エム・テクニック株式会社 主剤が均一に分散されたマイクロスフェアー及びそれを含有する徐放性製剤
KR20220163416A (ko) 2020-05-08 2022-12-09 엠. 테크닉 가부시키가이샤 생리 활성 물질이 균일하게 분산된 마이크로스피어 및 그것을 함유하는 서방성 제제

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Also Published As

Publication number Publication date
EP1646366A1 (de) 2006-04-19
US7399486B2 (en) 2008-07-15
ES2374623T3 (es) 2012-02-20
JP2005035994A (ja) 2005-02-10
US20070059363A1 (en) 2007-03-15
JP4072830B2 (ja) 2008-04-09
KR100466637B1 (ko) 2005-01-13
EP1646366A4 (de) 2008-08-20
KR20050001896A (ko) 2005-01-07
EP1646366B1 (de) 2011-10-05
WO2004112752A1 (en) 2004-12-29

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