ATE524496T1 - Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung - Google Patents

Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung

Info

Publication number
ATE524496T1
ATE524496T1 AT01271394T AT01271394T ATE524496T1 AT E524496 T1 ATE524496 T1 AT E524496T1 AT 01271394 T AT01271394 T AT 01271394T AT 01271394 T AT01271394 T AT 01271394T AT E524496 T1 ATE524496 T1 AT E524496T1
Authority
AT
Austria
Prior art keywords
sulfation
anthithrombine
polysaccharide
production
effect
Prior art date
Application number
AT01271394T
Other languages
English (en)
Inventor
Pasqua Oreste
Giorgio Zoppetti
Original Assignee
Glycores 2000 Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/738,879 external-priority patent/US20030023079A1/en
Application filed by Glycores 2000 Srl filed Critical Glycores 2000 Srl
Application granted granted Critical
Publication of ATE524496T1 publication Critical patent/ATE524496T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01271394T 2000-12-18 2001-12-17 Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung ATE524496T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/738,879 US20030023079A1 (en) 2000-03-30 2000-12-18 Polysaccharides derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US09/950,003 US20020062019A1 (en) 2000-03-30 2001-09-12 Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
PCT/IB2001/002492 WO2002050125A2 (en) 2000-12-18 2001-12-17 Glycosaminoglycans derived from k5 polysaccharide having high antithrombin activity and process for their preparation

Publications (1)

Publication Number Publication Date
ATE524496T1 true ATE524496T1 (de) 2011-09-15

Family

ID=27113435

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01271394T ATE524496T1 (de) 2000-12-18 2001-12-17 Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung

Country Status (9)

Country Link
US (2) US20020062019A1 (de)
EP (1) EP1358215B1 (de)
JP (1) JP4267916B2 (de)
CN (1) CN1295251C (de)
AT (1) ATE524496T1 (de)
AU (1) AU2235802A (de)
CA (1) CA2432150C (de)
ES (1) ES2371232T3 (de)
WO (1) WO2002050125A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20032498A1 (it) * 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
CN1671744A (zh) * 2002-06-18 2005-09-21 格利考斯2000有限公司 低分子量过硫酸化多糖
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
ITMI20031618A1 (it) 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
US7655445B2 (en) * 2003-11-12 2010-02-02 Massachusetts Institute Of Technology Methods for synthesis of sulfated saccharides
JP2005290383A (ja) * 2004-04-05 2005-10-20 Seikagaku Kogyo Co Ltd ６−ｏ−硫酸化ｎ−アセチルヘパロサン及び造血幹細胞増殖助剤
US8450297B2 (en) * 2004-08-16 2013-05-28 Massachusetts Institute Of Technology Rapid two-step synthesis of anti-coagulants
WO2007058592A1 (en) * 2005-11-21 2007-05-24 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
CN103214591B (zh) 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
ITLO20130006A1 (it) 2013-11-06 2015-05-07 He E Biochimiche G Ronzoni S R Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
CN103698425B (zh) * 2013-12-12 2015-08-26 中国海洋大学 一种化学降解法获得及检测生物来源糖胺聚糖二糖的方法
WO2016159296A1 (ja) * 2015-03-31 2016-10-06 生化学工業株式会社 グリコサミノグリカンの硫酸化方法
CN107727762A (zh) * 2017-09-28 2018-02-23 山东大学 一种亚硝酸降解分析低分子肝素二糖结构的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230785B (it) 1989-07-14 1991-10-29 Italfarmaco Spa Processo per la preparazione di polisaccaridi eparino simili e prodotti ottenuti.
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
GB2286193A (en) 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such
AU2435795A (en) * 1994-05-06 1995-11-29 Glycomed Incorporated O-desulfated heparin derivatives, methods of making and uses thereof
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro

Also Published As

Publication number Publication date
US20050215518A1 (en) 2005-09-29
AU2235802A (en) 2002-07-01
WO2002050125A2 (en) 2002-06-27
EP1358215A2 (de) 2003-11-05
CN1531555A (zh) 2004-09-22
JP4267916B2 (ja) 2009-05-27
JP2004516345A (ja) 2004-06-03
CA2432150A1 (en) 2002-06-27
US20020062019A1 (en) 2002-05-23
WO2002050125A3 (en) 2002-08-22
EP1358215B1 (de) 2011-09-14
CN1295251C (zh) 2007-01-17
CA2432150C (en) 2010-04-13
ES2371232T3 (es) 2011-12-28

Similar Documents

Publication Publication Date Title
ATE524496T1 (de) Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung
ATE549402T1 (de) Alpha-isomaltosylglukosaccharidsynthase, verfahren zu deren herstellung und verwendung
ATE457037T1 (de) Verfahren zur herstellung von pektinhydrolyseprodukten
AU3926195A (en) Polysaccharides having a high iduronic acid content
ATE40555T1 (de) Verfahren zur organischen synthese von oligosacchariden,welche galactosamin- und uronsaeure-motive umfassen, oligosaccharide und ihre biologischen verwendungen.
DE69433177D1 (de) Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht
DE69628148D1 (de) Verfahren zur herstellung eines proteins
DE60025328D1 (de) Verfahren zur herstellung von mehrfach vernetzten hyaluronsäurederivaten
AU3026597A (en) Derivatives of k5 polysaccharide having high anticoagulant activity
DE60027695D1 (de) Verfahren zur herstellung von fibrinogen und fibronectin sowie proteinzusammesetzungen, welche damit herstellbar sind
DE59608011D1 (de) Verfahren zur herstellung von chitosan-glukan-komplexen, daraus herstellbaren massen und deren verwendung
DE60119711D1 (de) Verfahren zur herstellung von funktionalierten polyalkyleniminen, diese enthaltende zusammenstellungen und ihre verwendungen
JPS63191801A (ja) 多糖類の制御された解重合方法
CN1177865C (zh) K5多糖衍生的具有高抗凝和抗血栓形成活性的葡糖胺聚糖及其制备方法
DE68914236T2 (de) Verfahren zur Herstellung von Natriumhyaluronat durch Gärung.
DE60227595D1 (de) Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen
DE69112415T2 (de) Verfahren zur herstellung von glukose und fruktose aus sukrose.
ATE509117T1 (de) Herstellungsverfahren für hyaluronsäure oder ihre derivate
ATE516258T1 (de) Verfahren zur herstellung von monochloressigsäure
IL165808A0 (en) Low molecular weight k5-n,o-oversulfated polysaccharide process for the preparation thereof and pharmaceutical compositions containing the same
DE60038281D1 (de) Verfahren zur herstellung von optisch aktiven pyridinethanol-derivaten
LINDAHL Biosynthesis of heparin
ATE443709T1 (de) Verfahren zur herstellung von 9,10-dihydro-9-oxa- 10-organyl-oxyphosphaphenanthren-10-oxid oder - thion und an den phenylgruppen substituierten derivativen desselben
DE60314904D1 (de) Verfahren zur herstellung von chinoloncarboxylat-derivaten
DE50001459D1 (de) Beschichtungsverfahren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties